@article{WeckesserGriessmeierSchmidtetal.1998, author = {Weckesser, Martin and Grießmeier, Martin and Schmidt, Daniela and Sonnenberg, Frank and Ziemons, Karl and Kemna, Lars and Holschbach, Marcus and Langen, Karl-J. and M{\"u}ller-G{\"a}rtner, Hans-W.}, title = {Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent}, series = {European Journal of Nuclear Medicine}, volume = {25}, journal = {European Journal of Nuclear Medicine}, number = {2}, isbn = {1619-7089}, pages = {150 -- 156}, year = {1998}, abstract = {Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7\%±6.1\% (range 2.7\%-25.0\%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, C. and Porst, Dariusz and B{\"u}ldt, G.}, title = {Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß {\"u}ber versteckte Materialeigenschaften zellul{\"a}rer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; B{\"u}ldt, G. ; Chien, Shu}, series = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, journal = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, isbn = {1862-278}, pages = {446 -- 447}, year = {1998}, language = {en} } @article{ReisselStammFoerthetal.1998, author = {Reißel, Martin and Stamm, H. and F{\"o}rth, G. and G{\"o}ssing, H. P.}, title = {CA-Betriebsfestigkeitsoptimierung eines Vorderwagens / Stamm, H. ; F{\"o}rth, G. ; G{\"o}ssing, H. P. ; K{\"o}ttgen, V. B. ; Mawick, G. ; Reißel, M.}, series = {Berechnung und Simulation im Fahrzeugbau, Numerical Analysis and Simulation in Vehicle Engineering, Tagung, W{\"u}rzburg, DE, 24.-25. Sep, 1998}, journal = {Berechnung und Simulation im Fahrzeugbau, Numerical Analysis and Simulation in Vehicle Engineering, Tagung, W{\"u}rzburg, DE, 24.-25. Sep, 1998}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf}, isbn = {3-18-091411-4}, pages = {229 -- 244}, year = {1998}, language = {de} } @article{ReisselJungKoettgenetal.1998, author = {Reißel, Martin and Jung, L. and K{\"o}ttgen, V. and M{\"a}scher, G.}, title = {Betriebsfestigkeit eines PKW-Schwenklagers / Jung, L. ; K{\"o}ttgen, V. ; M{\"a}scher, G. ; Reißel, M. ; Zhang, G.}, series = {Materialpr{\"u}fung : MP. 40 (1998), H. 10}, journal = {Materialpr{\"u}fung : MP. 40 (1998), H. 10}, isbn = {0025-5300}, pages = {388 -- 393}, year = {1998}, language = {de} } @article{SponagelUnger1998, author = {Sponagel, Stefan and Unger, J.}, title = {Organisation und Strukturierung technischer Messungen}, series = {Werkstattstechnik. 88 (1998), H. 5}, journal = {Werkstattstechnik. 88 (1998), H. 5}, isbn = {1436-5006}, pages = {223 -- 226}, year = {1998}, language = {de} } @article{Dikta1998, author = {Dikta, Gerhard}, title = {On Semiparametric Random Censorship Models}, series = {Journal of Statistical Planning and Inference. 66 (1998), H. 2}, journal = {Journal of Statistical Planning and Inference. 66 (1998), H. 2}, isbn = {0378-3758}, pages = {253 -- 279}, year = {1998}, language = {en} } @article{StulpeBugajskiHellwig1998, author = {Stulpe, Werner and Bugajski, S. and Hellwig, K.-E.}, title = {On Fuzzy Random Variables and Statistical Maps. Bugajski, S.; Hellwig, K.-E.; Stulpe, W.}, series = {Reports on Mathematical Physics. 41 (1998), H. 1}, journal = {Reports on Mathematical Physics. 41 (1998), H. 1}, isbn = {0034-4877}, pages = {1 -- 11}, year = {1998}, language = {en} } @article{StulpeRuch1998, author = {Stulpe, Werner and Ruch, Ernst}, title = {Proof of the Mixing Theorem for Statistical Systems in Classical Physics. Ruch, Ernst; Stulpe, Werner}, series = {Acta Applicandae Mathematicae. 53 (1998), H. 3}, journal = {Acta Applicandae Mathematicae. 53 (1998), H. 3}, isbn = {1572-9036}, pages = {329 -- 352}, year = {1998}, language = {en} } @article{Stulpe1998, author = {Stulpe, Werner}, title = {On the Representation of Quantum Mechanics on a Classical Sample Space}, series = {International Journal of Theoretical Physics. 37 (1998), H. 1}, journal = {International Journal of Theoretical Physics. 37 (1998), H. 1}, isbn = {1572-9575}, pages = {349 -- 356}, year = {1998}, language = {en} } @article{HillenJansenUnglaubenetal.1998, author = {Hillen, Walter and Jansen, N. and Unglauben, F. and Indefrey, R.}, title = {Multimediale Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen.}, series = {Bildverarbeitung f{\"u}r die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. M{\"a}rz 1998 in Aachen / Thomas Lehmann ... (Hrsg.)}, journal = {Bildverarbeitung f{\"u}r die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. M{\"a}rz 1998 in Aachen / Thomas Lehmann ... (Hrsg.)}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3540638857}, pages = {373 -- 377}, year = {1998}, language = {de} }