@article{RoethSlabuKolvenbachetal.2015, author = {R{\"o}th, A. and Slabu, I. and Kolvenbach, K. and Engelmann, Ulrich M. and Baumann, M. and Schmitz-Rode, T. and Trahms, L. and Neumann, U.}, title = {Aufnahmekinetik von magnetischen Nanopartikeln zur Tumortherapie in humanen Pankreaskarzinomzelllinien}, series = {Zeitschrift f{\"u}r Gastroenterologie}, volume = {53}, journal = {Zeitschrift f{\"u}r Gastroenterologie}, number = {8}, publisher = {Thieme}, address = {Stuttgart}, issn = {1439-7803}, doi = {10.1055/s-0035-1559529}, pages = {KC139}, year = {2015}, language = {de} } @article{EngelmannBuhlBaumannetal.2017, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Baumann, Martin and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia}, series = {Current Directions in Biomedical Engineering}, volume = {3}, journal = {Current Directions in Biomedical Engineering}, number = {2}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2017-0096}, pages = {457 -- 460}, year = {2017}, language = {en} } @article{ChenJostVolkeretal.2017, author = {Chen, Chao and Jost, Peter and Volker, Hanno and Kaminski, Marvin and Wirtssohn, Matti R. and Engelmann, Ulrich M. and Kr{\"u}ger, K. and Schlich, Franziska F. and Schlockermann, Carl and Lobo, Ricardo P.S.M. and Wuttig, Matthias}, title = {Dielectric properties of amorphous phase-change materials}, series = {Physical Review B}, volume = {95}, journal = {Physical Review B}, number = {9}, issn = {2469-9950}, doi = {10.1103/PhysRevB.95.094111}, pages = {Article number 094111}, year = {2017}, language = {en} } @article{RoethSlabuEngelmannetal.2017, author = {R{\"o}th, A.A. and Slabu, I. and Engelmann, Ulrich M. and Baumann, M. and Schmitz-Rode, T. and Neumann, U. P.}, title = {Targeting von gastroenterologischen Tumoren mittels magnetischer Nanopartikel zur hyperthermischen Therapie}, series = {Zeitschrift f{\"u}r Gastroenterologie}, volume = {55}, journal = {Zeitschrift f{\"u}r Gastroenterologie}, number = {8}, publisher = {Thieme}, address = {Stuttgart}, doi = {10.1055/s-0037-1605124}, pages = {KV-384}, year = {2017}, language = {de} } @article{EngelmannRoethEberbecketal.2018, author = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells}, series = {Scientific Reports}, volume = {8}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-018-31553-9}, pages = {Article number 13210}, year = {2018}, abstract = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.}, language = {en} } @article{EngelmannBuhlDraacketal.2018, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications}, series = {IEEE Magnetic Letters}, volume = {9}, journal = {IEEE Magnetic Letters}, number = {Article number 8519617}, publisher = {IEEE}, address = {New York, NY}, issn = {1949-307X}, doi = {10.1109/LMAG.2018.2879034}, year = {2018}, abstract = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.}, language = {en} } @article{EngelmannShashaTeemanetal.2019, author = {Engelmann, Ulrich M. and Shasha, Carolyn and Teeman, Eric and Slabu, Iona and Krishnan, Kannan M.}, title = {Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic N{\´e}el-Brown Langevin simulation}, series = {Journal of Magnetism and Magnetic Materials}, volume = {471}, journal = {Journal of Magnetism and Magnetic Materials}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-8853}, doi = {10.1016/j.jmmm.2018.09.041}, pages = {450 -- 456}, year = {2019}, language = {en} } @article{EngelmannSeifertMuesetal.2019, author = {Engelmann, Ulrich M. and Seifert, Julian and Mues, Benedikt and Roitsch, Stefan and M{\´e}nager, Christine and Schmidt, Annette M. and Slabu, Ioana}, title = {Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels}, series = {Journal of Magnetism and Magnetic Materials}, volume = {471}, journal = {Journal of Magnetism and Magnetic Materials}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-8853}, doi = {10.1016/j.jmmm.2018.09.113}, pages = {486 -- 494}, year = {2019}, language = {en} } @phdthesis{Engelmann2019, author = {Engelmann, Ulrich M.}, title = {Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy}, publisher = {Infinite Science Publishing}, address = {L{\"u}beck}, isbn = {978-3-945954-58-4}, year = {2019}, language = {en} } @misc{Engelmann2019, author = {Engelmann, Ulrich M.}, title = {Gespr{\"a}chsf{\"u}hrungskompetenzen f{\"u}r Naturwissenschaftler und Ingenieure. Maßnahmen zur F{\"o}rderung und curricularen Verankerung von Gespr{\"a}chsf{\"u}hrungskompetenzen an Fachhochschulen}, publisher = {Deutsche Gesellschaft f{\"u}r Sprechwissenschaft und Sprecherziehung (DGSS e.V.)}, address = {Aachen}, doi = {10.13140/RG.2.2.34026.98248}, pages = {121 Seiten}, year = {2019}, language = {de} }