@article{TakenagaBiselliSchnitzleretal.2014,
  author    = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing},
  series = {Physica status solidi A : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330464},
  pages     = {1410 -- 1415},
  year      = {2014},
  abstract  = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.},
  language  = {en}
}
@article{ImmelGrothHuhnetal.2011,
  author    = {Immel, Timo A. and Groth, Ulrich and Huhn, Thomas and {\"O}hlschl{\"a}ger, Peter},
  title     = {Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice},
  series = {PLoS ONE},
  volume    = {6},
  journal   = {PLoS ONE},
  number    = {3},
  publisher = {Plos},
  address   = {San Francisco, California, US},
  doi       = {10.1371/journal.pone.0017869},
  pages     = {e17869},
  year      = {2011},
  abstract  = {The anticancer activity of titanium complexes has been known since the groundbreaking studies of K{\"o}pf and K{\"o}pf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.},
  language  = {en}
}
@article{OehlschlaegerSpiesAlvarezetal.2011,
  author    = {{\"O}hlschl{\"a}ger, Peter and Spies, Elmar and Alvarez, Gerardo and Quetting, Michael and Groettrup, Marcus},
  title     = {The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA},
  series = {International Journal of Cancer. 128 (2011), H. 2},
  journal   = {International Journal of Cancer. 128 (2011), H. 2},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1097-0215},
  pages     = {473 -- 481},
  year      = {2011},
  language  = {en}
}
@article{OehlschlaegerMichelOsenetal.2002,
  author    = {{\"O}hlschl{\"a}ger, Peter and Michel, Nico and Osen, Wolfram and Freyschmidt, Eva-Jasmin},
  title     = {T cell response to human papillomavirus 16 E7 in mice: comparison of Cr release assay, intracellular IFN-gamma production, ELISPOT and tetramer staining / Michel, Nico ; {\"O}hlschl{\"a}ger, Peter ; Osen, Wolfram ; Freyschmidt, Eva-Jasmin ; Gut{\"o}hrlein, Heidrun ;},
  series = {Intervirology. 45 (2002)},
  journal   = {Intervirology. 45 (2002)},
  isbn      = {1423-0100},
  pages     = {290 -- 299},
  year      = {2002},
  language  = {en}
}
@article{ImmelGruetzkeSpaeteetal.2012,
  author    = {Immel, Timo and Gr{\"u}tzke, Martin and Sp{\"a}te, Anne-Katrin and Groth, Ulrich and {\"O}hlschl{\"a}ger, Peter and Huhn, Thomas},
  title     = {Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy},
  series = {Chemical Communications},
  volume    = {48},
  journal   = {Chemical Communications},
  number    = {46},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1364-548X},
  doi       = {10.1039/C2CC31624B},
  pages     = {5790 -- 5792},
  year      = {2012},
  abstract  = {Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.},
  language  = {en}
}
@article{HenkenOosterhuisOehlschlaegeretal.2012,
  author    = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.},
  title     = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7},
  series = {Vaccine},
  volume    = {30},
  journal   = {Vaccine},
  number    = {28},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0264-410X},
  doi       = {10.1016/j.vaccine.2012.04.013},
  pages     = {4259 -- 4266},
  year      = {2012},
  abstract  = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.},
  language  = {en}
}
@article{OosterhuisOehlschlaegerBergetal.2011,
  author    = {Oosterhuis, Koen and {\"O}hlschl{\"a}ger, Peter and Berg, Joost H. van den and Toebes, Mireille and Gomez, Raquel and Schumacher, Ton N. and Haanen, John B.},
  title     = {Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7},
  series = {International Journal of Cancer},
  volume    = {129},
  journal   = {International Journal of Cancer},
  number    = {2},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1097-0215},
  pages     = {397 -- 406},
  year      = {2011},
  language  = {en}
}
@article{OehlschlaegerCorvinusOrthetal.2005,
  author    = {{\"O}hlschl{\"a}ger, Peter and Corvinus, Florian M. and Orth, Carina and Moriggl, Richard},
  title     = {Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth / Corvinus, Florian, Moriggl, Richard ; Tsareva, Svetlana A. ; Wagner, Stefan ; Pfitzner, Edith B. ; Baus, Daniela ; Kaufmann, Roland : Huber, Luka},
  series = {Neoplasia. 7 (2005), H. 6},
  journal   = {Neoplasia. 7 (2005), H. 6},
  isbn      = {1476-5586},
  pages     = {545 -- 555},
  year      = {2005},
  language  = {en}
}
@article{OehlschlaegerSteinbergSehretal.2005,
  author    = {{\"O}hlschl{\"a}ger, Peter and Steinberg, Thorsten and Sehr, Peter and Osen, Wolfram},
  title     = {Modification of HPV 16 E7 genes: correlation between the level of protein expression and CTL response after immunization of C57BL/6 mice / Steinberg, Thorsten ; {\"O}hlschl{\"a}ger, Peter ; Sehr, Peter ; Osen, Wolfram ; Gissmann, Lutz},
  series = {Vaccine. 23 (2005), H. 9},
  journal   = {Vaccine. 23 (2005), H. 9},
  isbn      = {0264-410X},
  pages     = {1149 -- 1157},
  year      = {2005},
  language  = {en}
}
@article{OehlschlaegerOsenDelletal.2003,
  author    = {{\"O}hlschl{\"a}ger, Peter and Osen, Wolfram and Dell, Kerstin and Faath, Stefan},
  title     = {Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice / {\"O}hlschl{\"a}ger, Peter ; Osen, Wolfram ; Dell, Kerstin ; Faath, Stefan ; Garcea Robert L: ; Jochmus, Ingrid ; M{\"u}ller, Martin, Pawlita,},
  series = {Journal of Virology. 77 (2003), H. 8},
  journal   = {Journal of Virology. 77 (2003), H. 8},
  isbn      = {1098-5514},
  pages     = {4635 -- 4645},
  year      = {2003},
  language  = {en}
}