TY  - CHAP
A1  - Pfetsch, Marc E.
A1  - Abele, Eberhard
A1  - Altherr, Lena
A1  - Bölling, Christian
A1  - Brötz, Nicolas
A1  - Dietrich, Ingo
A1  - Gally, Tristan
A1  - Geßner, Felix
A1  - Groche, Peter
A1  - Hoppe, Florian
A1  - Kirchner, Eckhard
A1  - Kloberdanz, Hermann
A1  - Knoll, Maximilian
A1  - Kolvenbach, Philip
A1  - Kuttich-Meinlschmidt, Anja
A1  - Leise, Philipp
A1  - Lorenz, Ulf
A1  - Matei, Alexander
A1  - Molitor, Dirk A.
A1  - Niessen, Pia
A1  - Pelz, Peter F.
A1  - Rexer, Manuel
A1  - Schmitt, Andreas
A1  - Schmitt, Johann M.
A1  - Schulte, Fiona
A1  - Ulbrich, Stefan
A1  - Weigold, Matthias
T1  - Strategies for mastering uncertainty
T2  - Mastering uncertainty in mechanical engineering
N2  - This chapter describes three general strategies to master uncertainty in technical systems: robustness, flexibility and resilience. It builds on the previous chapters about methods to analyse and identify uncertainty and may rely on the availability of technologies for particular systems, such as active components. Robustness aims for the design of technical systems that are insensitive to anticipated uncertainties. Flexibility increases the ability of a system to work under different situations. Resilience extends this characteristic by requiring a given minimal functional performance, even after disturbances or failure of system components, and it may incorporate recovery. The three strategies are described and discussed in turn. Moreover, they are demonstrated on specific technical systems.
Y1  - 2021
SN  - 978-3-030-78353-2
U6  - http://dx.doi.org/10.1007/978-3-030-78354-9_6
N1  - Part of the Springer Tracts in Mechanical Engineering book series (STME)
SP  - 365
EP  - 456
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Picard, A.
A1  - Schütze, A.
T1  - Die Ausbildungsfoundry pro-mst und das virtuelle Technologielabor: Ein Konzept für eine exzellente praktische MST-Ausbildung in einem modernen Reinraum zu niedrigen Gesamtkosten. Picard, A.; Kämper, K.-P.; Schütze, A.
JF  - Mikrosystemtechnik-Kongress 2005 : 10. bis 12. Oktober 2005 in Freiburg ; gemeinsame Veranstaltung von: Bundesministerium für Bildung und Forschung (BMBF) ... / organisiert von: GMM VDE/VDI-Gesellschaft Mikroelektronik, Mikro- und Feinwerktechnik ... Chairman: Roland Zengerle
Y1  - 2005
SN  - 3-8007-2926-1
N1  - Mikrosystemtechnik-Kongress <2005, Freiburg, Breisgau>
SP  - 127
PB  - VDE-Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Picard, A.
A1  - Schütze, A.
A1  - Wallach, D.
T1  - Adopting the Foundry Concept of Semiconductor Fabrication on Educational Schemes and the Virtual Technology Lab (VTL). Picard, A.; Kämper, K.-P.; Schütze, A.; Wallach, D.; Walter, T.
JF  - Mst-News (2006)
Y1  - 2006
SN  - 0948-3128
SP  - 15, 16
EP  - u. 35
ER  - 
TY  - JOUR
A1  - Kurz, R.
A1  - Linder, Peter
A1  - Trzewik, Jürgen
A1  - Rüffer, M.
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Rothermel, A.
A1  - Robitzki, A.
A1  - Temiz Artmann, Aysegül
T1  - Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes
JF  - Medical and Biological Engineering and Computing
N2  - The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.
Y1  - 2010
U6  - http://dx.doi.org/10.1007/s11517-009-0552-y
SN  - 1741-0444
VL  - 48
IS  - 1
SP  - 59
EP  - 65
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Kern, Alexander
A1  - Krichel, Frank
A1  - Neskakis, Apostolos
A1  - Müller, Klaus-Peter (u.a.)
T1  - Lightning protection design of a renewable energy hybrid-system without power mains connection
Y1  - 2001
N1  - International Conference on Renewable Energies for Islands <2001, Crete>
ER  - 
TY  - JOUR
A1  - Krause, Gregor
A1  - Forsyth, Paul A.
A1  - Peter, Till
T1  - Robuste Filter in der Energieversorgung / Paul A. Forsyth, Gregor Krause, Till Peter
JF  - ETZ. 114 (1993), H. 22
Y1  - 1993
N1  - Printausgabe: Aachen  Eupener Str.: 23 Z 133; Jülich: 63 ZS 035
SP  - 1382
EP  - 1385
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Merten, Sabine
A1  - Brill, Manfred
A1  - Picard, Antoni (u.a.)
T1  - Vom virtuellen Wafer zum realen Drucksensor: Information – Communication – Knowledge engineering education today
JF  - Schriftenreihe Ingenieurpädagogik : Hochschule für Bildungswissenschaften in Klagenfurt ; Band 49
Y1  - 2003
N1  - Referate des 32. Symposiums der Internationalen Gesellschaft für Ingenieurpädagogik,
SP  - 318
EP  - 321
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Picard, Antoni
A1  - Brill, Manfred
A1  - Cassel, Detlef (u.a.)
T1  - The Virtual Cleanroom – a new tool in teaching MST process technologies
JF  - mst news International newsletter on micro - nano Integration (2003)
Y1  - 2003
SN  - 0948-3128
SP  - 35
EP  - 36
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Picard, Antoni
A1  - Brill, Manfred
A1  - Cassel, Detlef (u.a.)
T1  - Neue Medien für die praktische MST Ausbildung
JF  - Rundschau, FH Kaiserslautern,. Ausgabe Ju (2002)
Y1  - 2002
SP  - 14
EP  - 15
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Merten, Sabine
A1  - Brill, Manfred
A1  - Picard, Antoni (u.a.)
T1  - Vom virtuellen Wafer zum realen Drucksensor: Bildungsnetzwerke verbessern die Ausbildung in Hochtechnologien.
JF  - Kooperation und Arbeit in vernetzten Welten : Tagungsband der GFA-Herbstkonferenz 2003, Aachen, 29. September - 01. Oktober 2003 / Holger Luczak (Hrsg.)
Y1  - 2003
SN  - 3-935089-71-6
N1  - Konferenz-Einzelbericht: GfA Herbstkonf, HerbstKonf. der Gesellschaft für Arbeitswissenschaft
SP  - 238
EP  - 241
PB  - Ergonomia-Verl.
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Merten, Sabine
A1  - Brill, Manfred
A1  - Cassel, Detlev (u.a.)
T1  - Virtuelle Sensor-Fertigung: Hightech mit LabVIEW
JF  - Virtuelle Instrumente in der Praxis : Messtechnik, Automatisierung ; Begleitband zum Kongress VIP 2003 / Rahman Jamal ; Hans Jaschinski (Hrsg.)
Y1  - 2003
SN  - 3-7785-2908-0
N1  - Konferenz-Einzelbericht: Praxiswissen Elektronik-Industrie: Messtechnik -Automatisierung
SP  - 465
EP  - 470
PB  - Hüthig
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Berg, U.
A1  - Begemann, M.
A1  - Hagemann, B. (u.a.)
T1  - Series production and testing of a micro motor. Serienfertigung und Prüfung eines Mikromotors
JF  - Actuator 98 : 6th International Conference on New Actuators ; 17 - 19 June, 1998, Bremen, Germany ; conference proceedings / ed.: Hubert Borgmann ...
Y1  - 1998
SN  - 3-933339-00-6
N1  - Konferenz-Einzelbericht: ACTUATOR, Internat. Conf. on New Actuators
SP  - 552
EP  - 555
PB  - Messe Bremen
CY  - Bremen
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Schmitt, W.
A1  - Wesner, D. A.
A1  - Güntherodt, G.
T1  - Thickness dependence of the spin- and angle-resolved photoemission of ultrathin, epitaxial Ni(111)/W(110) layers
JF  - Applied Physics A: Materials Science and Processing. 49 (1989), H. 6
Y1  - 1989
SN  - 1432-0630
SP  - 573
EP  - 578
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Berg, U.
A1  - Wolf, A.
A1  - Lehr, H.
T1  - Entwicklung von Linsenhaltern für ein SMIF-kompatibles Magazinsystem und deren Fertigung durch Mikrospritzguß. Berg, U.; Kämper, K.-P.; Wolf, A.; Lehr, H.; Ehrfeld, W.
JF  - Produktionstechnik für Mikrosysteme. IPA-Seminar, 5. und 6. November 1996, Stuttgart. Pro Mikro. Fraunhofer-Institut für Produktionstechnik und Automatisierung -IPA-, Stuttgart
Y1  - 1996
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
A1  - Dingerdissen, Uwe [u.a.]
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrößenverteilungen und deren Herstellverfahren : Offenlegungschrift DE19533486A1 ; Veröffentlichungstag im Patentblatt: 13.03.1997 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günter Lauth ...
Y1  - 1997
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Sparla, Peter
A1  - Benning, W.
A1  - Sieprath, A.
T1  - Berührungslose 3D-Vermessung von Sickerwasserschächten im Deponiebereich
JF  - Vermessungswesen und Raumordnung : VR. 57 (1995), H. 7-8
Y1  - 1995
SN  - 0340-5141
SP  - 397
EP  - 407
ER  - 
TY  - JOUR
A1  - Prume, Klaus
A1  - Peter, F.
A1  - Rüdiger, A.
A1  - Dittmann, R.
T1  - Analysis of shape effects on the piezoresponse in ferroelectric nanograins with and without adsorbates / Peter, F. ; Rüdiger, A. ; Dittmann, R. ; Waser, R. ; Szot, K. ; Reichenberg, B. ; Prume, K. ;
JF  - Applied Physics Letters  . 87 (2005), H. 8
Y1  - 2005
SN  - 0003-6951
SP  - 082901
EP  - 082901-3
ER  - 
TY  - JOUR
A1  - Fischer, W. A.
A1  - Dören, Horst-Peter
A1  - Janke, Dieter
T1  - Aluminium nitride probes for application in iron melts
JF  - Archiv für das Eisenhüttenwesen. 52 (1981), H. 3
Y1  - 1981
SN  - 0003-8962
SP  - 91
EP  - 98
ER  - 
TY  - CHAP
A1  - Land, Ingmar
A1  - A., Peter
A1  - Gligorevic, Snjezana
T1  - Computation of symbol-wise mutual information in transmission systems with logAPP decoders and application to EXIT charts
T2  - 5th International ITG Conference on Source and Channel Coding (SCC) : January 14 - 16, 2004, Erlangen ; conference record. (ITG-Fachbericht ; 181)
Y1  - 2004
SN  - 3-8007-2802-8
SP  - 195
EP  - 202
PB  - VDE-Verl.
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Henken, F. E.
A1  - Oosterhuis, K.
A1  - Öhlschläger, Peter
A1  - Bosch, L.
A1  - Hooijberg, E.
A1  - Haanen, J. B. A. G.
A1  - Steenbergen, R. D. M.
T1  - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7
JF  - Vaccine
N2  - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.vaccine.2012.04.013
SN  - 0264-410X
VL  - 30
IS  - 28
SP  - 4259
EP  - 4266
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kowalski, Julia
A1  - Linder, Peter
A1  - Zierke, S.
A1  - Wulfen, B. van
A1  - Clemens, J.
A1  - Konstantinidis, K.
A1  - Ameres, G.
A1  - Hoffmann, R.
A1  - Mikucki, J.
A1  - Tulaczyk, S.
A1  - Funke, O.
A1  - Blandfort, D.
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Hiecker, S.
A1  - Plescher, Engelbert
A1  - Schöngarth, Sarah
A1  - Dachwald, Bernd
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Eliseev, D.
A1  - Heinen, D.
A1  - Scholz, F.
A1  - Wiebusch, C.
A1  - Macht, S.
A1  - Bestmann, U.
A1  - Reineking, T.
A1  - Zetzsche, C.
A1  - Schill, K.
A1  - Förstner, R.
A1  - Niedermeier, H.
A1  - Szumski, A.
A1  - Eissfeller, B.
A1  - Naumann, U.
A1  - Helbing, K.
T1  - Navigation technology for exploration of glacier ice with maneuverable melting probes
JF  - Cold Regions Science and Technology
N2  - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.coldregions.2015.11.006
SN  - 0165-232X
IS  - 123
SP  - 53
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Belavy, Daniel L.
A1  - Albracht, Kirsten
A1  - Bruggemann, Gert-Peter
A1  - Vergroesen, Pieter-Paul A.
A1  - Dieen, Jaap H. van
T1  - Can exercise positively influence the intervertebral disc?
JF  - Sports Medicine
N2  - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.
KW  - Intradiscal Pressure
KW  - Annulus Fibrosus
KW  - Disc Degeneration
KW  - Nucleus Pulposus
KW  - Intervertebral Disc
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s40279-015-0444-2
SN  - 1179-2035
VL  - 46
IS  - 4
SP  - 473
EP  - 485
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Wehlitz, V.
A1  - Kayser, Peter
A1  - Figiel-Lange, A.
A1  - Bassam, R.
A1  - Rundstedt, F. von
T1  - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids
JF  - Plant Pathology
N2  - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.
Y1  - 2018
U6  - http://dx.doi.org/10.1111/ppa.12750
SN  - 1365-3059
VL  - 67
IS  - 2
SP  - 358
EP  - 365
PB  - Wiley
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Roeth, Anjali A.J.
A1  - Eberbeck, Dietmar
A1  - Buhl, Eva Miriam
A1  - Neumann, Ulf Peter
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells
JF  - Scientific Reports
N2  - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells.
Y1  - 2018
U6  - http://dx.doi.org/10.1038/s41598-018-31553-9
SN  - 2045-2322
VL  - 8
IS  - 1
SP  - Article number 13210
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, D.
A1  - Herique, A.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Responsive integrated small spacecraft solar sail and payload design concepts and missions
T2  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)
N2  - Asteroid mining has the potential to greatly reduce the cost of in-space manufacturing, production of propellant for space transportation and consumables for crewed spacecraft, compared to launching the required resources from Earth’s deep gravity well. This paper discusses the top-level mission architecture and trajectory design for these resource-return missions, comparing high-thrust trajectories with continuous low-thrust solar-sail trajectories. This work focuses on maximizing the economic Net Present Value, which takes the time-cost of finance into account and therefore balances the returned resource mass and mission duration. The different propulsion methods will then be compared in terms of maximum economic return, sets of attainable target asteroids, and mission flexibility. This paper provides one more step towards making commercial asteroid mining an economically viable reality by integrating trajectory design, propulsion technology and economic modelling.
Y1  - 2019
N1  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)At: Aachen, Germany
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, D.
A1  - Herique, A.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettenmeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Responsive exploration and asteroid characterization through integrated solar sail and lander development using small spacecraft technologies
T2  - IAA Planetary Defense Conference
N2  - In parallel to the evolution of the Planetary Defense Conference, the exploration of small solar system bodies has advanced from fast fly-bys on the sidelines of missions to the planets to the implementation of dedicated sample-return and in-situ analysis missions. Spacecraft of all sizes have landed, touch-and-go sampled, been gently beached, or impacted at hypervelocity on asteroid and comet surfaces. More have flown by close enough to image their surfaces in detail or sample their immediate environment, often as part of an extended or re-purposed mission. And finally, full-scale planetary defense experiment missions are in the making. Highly efficient low-thrust propulsion is increasingly applied beyond commercial use also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another development in the same years is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities. The on-going NASA OSIRIS-REx and JAXA HAYABUSA2 missions exemplify the trend as well as the upcoming NEA SCOUT mission or the landers MINERVA-II and MASCOT recently deployed on Ryugu. We outline likely as well as possible and efficient routes of continuation of all these developments towards a propellant-less and highly efficient class of spacecraft for small solar system body exploration: small spacecraft solar sails designed for carefree handling and equipped with carried landers and application modules, for all asteroid user communities –planetary science, planetary defence, and in-situ resource utilization. This projection builds on the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)² solar sail at DLR Cologne and in the 20 years since. It draws on the background of extensive trajectory optimization studies, the qualified technology of the DLR GOSSAMER-1 deployment demonstrator, and the MASCOT asteroid lander. These enable ‘now-term’ as well as near-term hardware solutions, and thus responsive fast-paced development. Mission types directly applicable to planetary defense include: single and Multiple NEA Rendezvous ((M)NR) for mitigation precursor, target monitoring and deflection follow-up tasks; sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation; and deployable membrane based methods to modify the asteroid’s properties or interact with it. The DLR-ESTEC GOSSAMER Roadmap initiated studies of missions uniquely feasible with solar sails such as Displaced L1 (DL1) space weather advance warning and monitoring and Solar Polar Orbiter (SPO) delivery which demonstrate the capability of near-term solar sails to achieve NEA rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. For those mission types using separable payloads, such as SPO, (M)NR and RKI, design concepts can be derived from the separable Boom Sail Deployment Units characteristic of DLR GOSSAMER solar sail technology, nanolanders like MASCOT, or microlanders like the JAXA-DLR Jupiter Trojan Asteroid Lander for the OKEANOS mission which can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. These are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms.
Y1  - 2019
N1  - Conference: IAA Planetary Defense ConferenceAt: Washington DC, USA
29.04-03.05.2019
ER  - 
TY  - CHAP
A1  - Butenweg, Christoph
A1  - Marinković, Marko
A1  - Pavese, Alberto
A1  - Lanese, Igor
A1  - Hoffmeister, Benno
A1  - Pinkawa, Marius
A1  - Vulcu, Mihai-Cristian
A1  - Bursi, Oreste
A1  - Nardin, Chiara
A1  - Paolacci, Fabrizio
A1  - Quinci, Gianluca
A1  - Fragiadakis, Michalis
A1  - Weber, Felix
A1  - Huber, Peter
A1  - Renault, Philippe
A1  - Gündel, Max
A1  - Dyke, Shirley
A1  - Ciucci, M.
A1  - Marino, A.
T1  - Seismic performance of multi-component systems in special risk industrial facilities
T2  - 17. World Conference on Earthquake Engineering , Sendai , Japan , 17WCEE , 2021-09-27 - 2021-10-02
N2  - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results.
KW  - industrial facilities
KW  - piping
KW  - installations
KW  - seismic loading
KW  - earthquakes
Y1  - 2021
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - http://dx.doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  -