An enzyme-based reversible CNOT logic gate realized in a flow system
- An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
| Author: | Fiona Moseley, Jan Halamek, Friederike Kramer, Arshak PoghossianORCiD, Michael Josef SchöningORCiD, Evgeny Katz |
|---|---|
| DOI: | https://doi.org/10.1039/C4AN00133H |
| ISSN: | 1364-5528 (E-Journal) ; 0003-2654 (Print) |
| Parent Title (English): | Analyst |
| Publisher: | Royal Society of Chemistry |
| Place of publication: | Cambridge |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2014 |
| Date of the Publication (Server): | 2014/02/05 |
| Volume: | 139 |
| Issue: | 8 |
| First Page: | 1839 |
| Last Page: | 1842 |
| Link: | https://doi.org/10.1039/C4AN00133H |
| Zugriffsart: | campus |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Royal Society of Chemistry (RSC) |
