A new approach for semiempirical modeling of mechanical blood trauma

  • Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Author:Ali Pookhalil, Ghassem Amoabediny, Hadi Tabesh, Mehdi BehbahaniORCiD, Khosrow Mottaghy
DOI:https://doi.org/10.5301/ijao.5000474
ISSN:1724-6040
Parent Title (English):The international journal of artificial organs
Publisher:Sage
Place of publication:London
Document Type:Article
Language:English
Year of Completion:2016
Date of the Publication (Server):2016/04/19
Volume:39
Issue:4
First Page:171
Last Page:177
Link:https://doi.org/10.5301/ijao.5000474
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Sage