TY  - JOUR
A1  - Chloé, Radermacher
A1  - Malyaran, Hanna
A1  - Craveiro, Rogerio Bastos
A1  - Peglow, Sarah
A1  - Behbahani, Mehdi
A1  - Pufe, Thomas
A1  - Wolf, Michael
A1  - Neuss, Sabine
T1  - Mechanical loading on cementoblasts: a mini review
T2  - Osteologie
N2  - Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments.
KW  - Cementoblast
KW  - Compression
KW  - Tension
KW  - Mechanotransduction
KW  - Forces
Y1  - 2022
UR  - https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/10071
SN  - 1019-1291
VL  - 31
IS  - 2
SP  - 111
EP  - 118
PB  - Thieme
CY  - Stuttgart
ER  -