TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
A2  - Artmann, Gerhard
A2  - Temiz Artmann, Aysegül
A2  - Zhubanova, Azhar A.
A2  - Digel, Ilya
T1  - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.
Y1  - 2018
UR  - https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/8365
SN  - 978-981-10-7904-7
SP  - 233
EP  - 250
PB  - Springer
CY  - Singapore
ER  -