TY  - CONF
A1  - Rabner, Arthur
A1  - Shacham, Yosi
T1  - A concept for a sensitive micro total analysis system for high throughput fluorescence imaging
N2  - This paper discusses possible methods for on-chip fluorescent imaging for integrated bio-sensors. The integration of optical and electro-optical accessories, according to suggested methods, can improve the performance of fluorescence imaging. It can boost the signal to background ratio by a few orders of magnitudes in comparison to conventional discrete setups. The methods that are present in this paper are oriented towards building reproducible arrays for high-throughput micro total analysis systems (µTAS). The first method relates to side illumination of the fluorescent material placed into microcompartments of the lab-on-chip. Its significance is in high utilization of excitation energy for low concentration of fluorescent material. The utilization of a transparent µLED chip, for the second method, allows the placement of the excitation light sources on the same optical axis with emission detector, such that the excitation and emission rays are directed controversly. The third method presents a spatial filtering of the excitation background.
KW  - Biosensor
KW  - Fluorescence
KW  - imaging
KW  - lab-on-chip
KW  - fluidic
KW  - lenslet array
KW  - LED chip
KW  - image sensor
KW  - biosensor
Y1  - 2006
UR  - https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/115
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:a96-opus-1456
ER  -