TY  - JOUR
A1  - Dadfar, Dryed Mohammadali
A1  - Camozzi, Denise
A1  - Darguzyte, Milita
A1  - Roemhild, Karolin
A1  - Varvarà, Paola
A1  - Metselaar, Josbert
A1  - Banala, Srinivas
A1  - Straub, Marcel
A1  - Güver, Nihan
A1  - Engelmann, Ulrich M.
A1  - Slabu, Ioana
A1  - Buhl, Miriam
A1  - Leusen, Jan van
A1  - Kögerler, Paul
A1  - Hermanns-Sachweh, Benita
A1  - Schulz, Volkmar
A1  - Kiessling, Fabian
A1  - Lammers, Twan
T1  - Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance
T2  - Journal of Nanobiotechnology
N2  - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.
Y1  - 2020
UR  - https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/9190
SN  - 1477-3155
VL  - 18
IS  - Article number 22
SP  - 1
EP  - 13
PB  - Nature Portfolio
ER  -