TY  - GEN
A1  - Behbahani, Mehdi
A1  - Nam, J.
A1  - Waluga, C.
A1  - Behr, Marek
A1  - Pasquali, M.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs
T2  - ASAIO Journal
N2  - Purpose of Study: Thrombosis-related complications are among the leading causes for morbidity and mortality in patients who depend on artificial organs. For the prediction of platelet behavior both the flow conditions inside the device and the thrombogenic properties of the blood-contacting surfaces must be considered. Platelet reactions under the influence of well-defined shear rates are experimentally evaluated and numerically simulated. The approach is intended for the analysis of VAD and oxygenator design.

Methods Used: A mathematical model of platelet activation, adhesion and aggregation has been implemented into a finite element CFD (Computational Fluid Dynamics) code. The approach is based on the advective and diffusive transport equations for resting and activated platelets and platelet released agonists. Experiments with citrate-anticoagulated freshly-drawn whole blood are performed in a perfusion flow chamber as well as in a system of rotating cylinders for Couette and Taylor-vortex flow. Different biomaterials are used. The activation, adhesion and aggregation are quantified using scanning electron microscopy and flow cytometry.

Summary of Results: Regions and flow conditions with a high potential for thrombus growth could be identified. The experiments clearly show the influence of the blood contacting material and governing shear rates. Numerical analysis can explain observed adhesion patterns and the degree of thrombus formation
Y1  - 2011
UR  - https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/4491
SN  - 1538-943X
N1  - 56th annual conference, American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
VL  - 56
IS  - 2
SP  - 85
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  -