@article{AlbannaConzenWeissetal.2021, author = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, number = {12}, issn = {1664-2295}, doi = {10.3389/fneur.2021.690183}, pages = {1 -- 15}, year = {2021}, abstract = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.}, language = {en} } @article{AlbannaKotliarLuekeetal.2018, author = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander}, title = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis}, series = {Plos one}, volume = {13}, journal = {Plos one}, number = {10}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0204689}, pages = {e0204689}, year = {2018}, abstract = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.}, language = {en} } @article{DashevskyLanzlKotliar2011, author = {Dashevsky, Alexey V. and Lanzl, Ines M. and Kotliar, Konstantin}, title = {Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal}, series = {Graefe's Archive for Clinical and Experimental Ophthalmology}, volume = {249}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {0721-832x}, pages = {565 -- 573}, year = {2011}, language = {en} } @article{QuittmannMeskemperAlbrachtetal.2020, author = {Quittmann, Oliver J. and Meskemper, Joshua and Albracht, Kirsten and Abel, Thomas and Foitschik, Tina and Str{\"u}der, Heiko K.}, title = {Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs}, series = {Journal of Electromyography and Kinesiology}, volume = {51}, journal = {Journal of Electromyography and Kinesiology}, number = {Article 102402}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1050-6411}, doi = {10.1016/j.jelekin.2020.102402}, year = {2020}, abstract = {Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.}, language = {en} } @article{BehbahaniMaiWalugaetal.2010, author = {Behbahani, Mehdi and Mai, A. and Waluga, C. and Bergmann, B. and Tran, L. and Vonderstein, K. and Behr, M. and Mottaghy, K.}, title = {Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions}, series = {Acta Physiologica}, volume = {198}, journal = {Acta Physiologica}, number = {Supplement 677}, isbn = {1748-1716}, pages = {185}, year = {2010}, language = {en} } @article{BehbahaniProbstMaietal.2010, author = {Behbahani, Mehdi and Probst, M. and Mai, A. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.}, title = {Numerical Prediction of Blood Damage in Biomedical Devices}, year = {2010}, language = {en} } @article{BehbahaniTranJockenhoeveletal.2011, author = {Behbahani, Mehdi and Tran, L. and Jockenh{\"o}vel, S. and Behr, M. and Mottaghy, K.}, title = {Numerical prediction of thrombocyte reactions for application to a vascular flow model}, series = {British Journal of Surgery}, volume = {98}, journal = {British Journal of Surgery}, number = {S5}, publisher = {Oxford University Press}, address = {Oxford}, isbn = {1365-2168}, pages = {S17}, year = {2011}, language = {en} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow}, series = {National Journal Glaucoma}, volume = {Vol. 5}, journal = {National Journal Glaucoma}, number = {No. 4}, issn = {2078-4104}, pages = {37 -- 49}, year = {2006}, language = {ru} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds}, series = {Journal of Glaucoma}, volume = {Vol. 6}, journal = {Journal of Glaucoma}, number = {1}, issn = {2078-4104}, pages = {61 -- 68}, year = {2007}, language = {ru} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli}, series = {National Journal Glaucoma}, volume = {Vol. 6}, journal = {National Journal Glaucoma}, number = {No. 2}, issn = {2078-4104}, pages = {64 -- 71}, year = {2007}, language = {ru} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation}, series = {National journal Glaucoma}, volume = {Vol. 5}, journal = {National journal Glaucoma}, number = {No. 3}, issn = {2078-4104}, pages = {62 -- 73}, year = {2006}, language = {ru} } @article{YangKriechbaumerAlbrachtetal.2015, author = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and Br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn}, title = {On the relationship between tibia torsional deformation and regional muscle contractions in habitual human exercises in vivo}, series = {Journal of Biomechanics}, volume = {48}, journal = {Journal of Biomechanics}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2014.12.031}, pages = {456 -- 464}, year = {2015}, language = {en} } @article{MiciliValterOflazetal.2013, author = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes}, series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, volume = {Vol. 227}, journal = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, number = {No. 4}, publisher = {Sage}, address = {London}, issn = {0046-2039 (Print) ; 2041-3033 (E-Journal)}, pages = {393 -- 401}, year = {2013}, language = {en} } @article{HorbachStaat2018, author = {Horbach, Andreas and Staat, Manfred}, title = {Optical strain measurement for the modeling of surgical meshes and their porosity}, series = {Current Directions in Biomedical Engineering}, volume = {Band 4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0045}, pages = {181 -- 184}, year = {2018}, abstract = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimal Solar Sail Trajectories for Missions to the Outer Solar System}, series = {Journal of guidance, control, and dynamics. 28 (2005), H. 6}, journal = {Journal of guidance, control, and dynamics. 28 (2005), H. 6}, isbn = {0162-3192}, pages = {1187 -- 1193}, year = {2005}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Optimal Solar Sail Trajectories for Missions to the Outer Solar System}, series = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, journal = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, publisher = {American Inst. of Aeronautics and Astronautics}, address = {Reston, Va.}, pages = {2 CD-ROMs}, year = {2004}, language = {en} } @article{DachwaldOhndorfSeboldt2005, author = {Dachwald, Bernd and Ohndorf, A. and Seboldt, W.}, title = {Optimierung der Lageregelung von Raumfahrzeugen mit Niedrigschubantrieb mittels evolution{\"a}rer neuronaler Regler / A. Ohndorf ; B. Dachwald ; W. Seboldt}, series = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, journal = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, publisher = {DGLR}, address = {Bonn}, pages = {1971 -- 1978}, year = {2005}, language = {de} } @article{DachwaldSeboldt2002, author = {Dachwald, Bernd and Seboldt, W.}, title = {Optimization of Interplanetary Rendezvous Trajectories for Solar Sailcraft Using a Neurocontroller}, series = {A collection of technical papers / AIAA Astrodynamics Specialist Conference : Monterey, California, 5 - 8 August 2002. - Vol. 2}, journal = {A collection of technical papers / AIAA Astrodynamics Specialist Conference : Monterey, California, 5 - 8 August 2002. - Vol. 2}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-549-9}, pages = {1263 -- 1270}, year = {2002}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Optimization of Interplanetary Solar Sailcraft Trajectories Using Evolutionary Neurocontrol}, series = {Journal of guidance, control, and dynamics. 27 (2004), H. 1}, journal = {Journal of guidance, control, and dynamics. 27 (2004), H. 1}, isbn = {0162-3192}, pages = {66 -- 72}, year = {2004}, language = {en} } @article{DachwaldOhndorfGill2009, author = {Dachwald, Bernd and Ohndorf, A. and Gill, E.}, title = {Optimization of low-thrust Earth-Moon transfers using evolutionary neurocontrol / Ohndorf, A. ; Dachwald, B. ; Gill, E.}, series = {IEEE Congress on Evolutionary Computation, 2009. CEC '09.}, journal = {IEEE Congress on Evolutionary Computation, 2009. CEC '09.}, isbn = {978-1-4244-2958-5}, pages = {358 -- 364}, year = {2009}, language = {en} } @article{JungMuellerStaat2019, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Optimization of the flight technique in ski jumping: the influence of wind}, number = {Early view}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jbiomech.2019.03.023}, year = {2019}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol}, series = {Acta Astronautica. 57 (2005), H. 2-8}, journal = {Acta Astronautica. 57 (2005), H. 2-8}, isbn = {0094-5765}, pages = {175 -- 185}, year = {2005}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol}, series = {Acta Astronautica}, volume = {57}, journal = {Acta Astronautica}, number = {2-8}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, isbn = {1879-2030}, pages = {175 -- 185}, year = {2005}, abstract = {Searching optimal interplanetary trajectories for low-thrust spacecraft is usually a difficult and time-consuming task that involves much experience and expert knowledge in astrodynamics and optimal control theory. This is because the convergence behavior of traditional local optimizers, which are based on numerical optimal control methods, depends on an adequate initial guess, which is often hard to find, especially for very-low-thrust trajectories that necessitate many revolutions around the sun. The obtained solutions are typically close to the initial guess that is rarely close to the (unknown) global optimum. Within this paper, trajectory optimization problems are attacked from the perspective of artificial intelligence and machine learning. Inspired by natural archetypes, a smart global method for low-thrust trajectory optimization is proposed that fuses artificial neural networks and evolutionary algorithms into so-called evolutionary neurocontrollers. This novel method runs without an initial guess and does not require the attendance of an expert in astrodynamics and optimal control theory. This paper details how evolutionary neurocontrol works and how it could be implemented. The performance of the method is assessed for three different interplanetary missions with a thrust to mass ratio <0.15mN/kg (solar sail and nuclear electric).}, language = {en} } @article{DachwaldCarnelliVasile2007, author = {Dachwald, Bernd and Carnelli, I. and Vasile, M.}, title = {Optimizing low-thrust gravity assist interplanetary trajectories using evolutionary neurocontrollers / I. Carnelli ; B. Dachwald ; M. Vasile}, series = {IEEE Congress on Evolutionary Computation, 2007 : CEC 2007 ; 25 - 28 September 2007, Singapore}, journal = {IEEE Congress on Evolutionary Computation, 2007 : CEC 2007 ; 25 - 28 September 2007, Singapore}, publisher = {IEEE Service Center}, address = {Piscataway, NJ}, isbn = {978-1-424-41339-3}, pages = {965 -- 972}, year = {2007}, language = {en} } @article{SadykovDigelTemizArtmannetal.2009, author = {Sadykov, Rustam and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Artmann, Gerhard and Savitskaya, Irina and Zhubanova, Azhar}, title = {Oral lead exposure induces dysbacteriosis in rats}, series = {Journal of Occupational Health. 51 (2009) (2009), H. 1}, journal = {Journal of Occupational Health. 51 (2009) (2009), H. 1}, isbn = {1348-9585}, pages = {64 -- 73}, year = {2009}, language = {en} } @article{SponagelUnger1998, author = {Sponagel, Stefan and Unger, J.}, title = {Organisation und Strukturierung technischer Messungen}, series = {Werkstattstechnik. 88 (1998), H. 5}, journal = {Werkstattstechnik. 88 (1998), H. 5}, isbn = {1436-5006}, pages = {223 -- 226}, year = {1998}, language = {de} } @article{RauschHarbrechtKahmannetal.2020, author = {Rausch, Valentin and Harbrecht, Andreas and Kahmann, Stephanie Lucina and Fenten, Thomas and Jovanovic, Nebojsa and Hackl, Michael and M{\"u}ller, Lars P. and Staat, Manfred and Wegmann, Kilian}, title = {Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws}, series = {The Journal of Hand Surgery}, volume = {45}, journal = {The Journal of Hand Surgery}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2020.04.010}, pages = {987.e1 -- 987.e8}, year = {2020}, abstract = {Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties.}, language = {en} } @article{SponagelBaroudSteffenetal.2002, author = {Sponagel, Stefan and Baroud, G. and Steffen, T. and Wu, J.}, title = {Parameter identification for cement infiltration of osteoporotic bone}, series = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...}, journal = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...}, publisher = {Balkema}, address = {Lisse [u.a.]}, isbn = {90-5809-394-8}, pages = {55 -- 58}, year = {2002}, language = {en} } @article{DachwaldMengaliQuartaetal.2006, author = {Dachwald, Bernd and Mengali, Giovanni and Quarta, Alessandrao A. and Macdonald, Malcolm}, title = {Parametric Model and Optimal Control of Solar Sails with Optical Degradation}, series = {Journal of guidance, control, and dynamics. 29 (2006), H. 5}, journal = {Journal of guidance, control, and dynamics. 29 (2006), H. 5}, isbn = {0162-3192}, pages = {1170 -- 1178}, year = {2006}, language = {en} } @article{KohlerKirschnerHermannsStaatetal.2018, author = {Kohler, Annette and Kirschner-Hermanns, Ruth and Staat, Manfred and Brehmer, Bernhard}, title = {Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz}, series = {Aktuelle Urologie}, volume = {49}, journal = {Aktuelle Urologie}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {1438-8820}, doi = {10.1055/s-0043-120616}, pages = {47 -- 51}, year = {2018}, abstract = {Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau h{\"a}ufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidit{\"a}t nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnr{\"o}hre, Geb{\"a}rmutter und Enddarm sowie die muskul{\"a}ren und ligament{\"o}sen Strukturen des kleinen Beckens durch Fertilit{\"a}tsphase, m{\"o}gliche Schwangerschaften, Geburten und Menopausen-Phase, {\"u}ber das „normale Altern" hinaus, gravierenden Ver{\"a}nderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process.}, language = {de} } @article{SpietzSproewitzSeefeldtetal.2021, author = {Spietz, Peter and Spr{\"o}witz, Tom and Seefeldt, Patric and Grundmann, Jan Thimo and Jahnke, Rico and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Reershemius, Siebo and Renger, Thomas and Ruffer, Michael and Sasaki, Kaname and Sznajder, Maciej and T{\´o}th, Norbert and Ceriotti, Matteo and Dachwald, Bernd and Macdonald, Malcolm and McInnes, Colin and Seboldt, Wolfgang and Quantius, Dominik and Bauer, Waldemar and Wiedemann, Carsten and Grimm, Christian D. and Hercik, David and Ho, Tra-Mi and Lange, Caroline and Schmitz, Nicole}, title = {Paths not taken - The Gossamer roadmap's other options}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.044}, pages = {2912 -- 2956}, year = {2021}, language = {en} } @article{VantStaatBaroud2008, author = {Vant, Christianne and Staat, Manfred and Baroud, Gamal}, title = {Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, pages = {527 -- 539}, year = {2008}, language = {en} } @article{ScholzRomagnoliDachwaldetal.2011, author = {Scholz, Christina and Romagnoli, Daniele and Dachwald, Bernd and Theil, Stephan}, title = {Performance analysis of an attitude control system for solar sails using sliding masses}, series = {Advances in Space Research}, volume = {48}, journal = {Advances in Space Research}, number = {11}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, pages = {1822 -- 1835}, year = {2011}, language = {en} } @article{AminTemizArtmannArtmannetal.2009, author = {Amin, Rashid and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Lazarovici, Philip and Lelkes, Peter I.}, title = {Permeability of an In Vitro Model of Blood Brain Barrier (BBB)}, series = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, journal = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, isbn = {978-3-540-92841-6}, pages = {81 -- 84}, year = {2009}, language = {en} } @article{KuchlerGuenthnerRibeiroetal.2023, author = {Kuchler, Timon and G{\"u}nthner, Roman and Ribeiro, Andrea and Hausinger, Renate and Streese, Lukas and W{\"o}hnl, Anna and Kesseler, Veronika and Negele, Johanna and Assali, Tarek and Carbajo-Lozoya, Javier and Lech, Maciej and Adorjan, Kristina and Stubbe, Hans Christian and Hanssen, Henner and Kotliar, Konstantin and Haller, Berhard and Heemann, Uwe and Schmaderer, Christoph}, title = {Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation}, volume = {26}, publisher = {Springer Nature}, address = {Dordrecht}, doi = {10.1007/s10456-023-09885-6}, pages = {547 -- 563}, year = {2023}, abstract = {Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42\% ± 1.77\% vs. 4.64\% ± 2.59\%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5-190.2] vs. 189.1 [179.4-197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] vs. 0.88 [0.8-0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = - 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.}, language = {en} } @article{ArinkinDigelPorstetal.2014, author = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application}, series = {BMC bioinformatics}, volume = {15}, journal = {BMC bioinformatics}, number = {55}, issn = {1471-2105}, doi = {10.1186/1471-2105-15-55}, pages = {1 -- 8}, year = {2014}, abstract = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.}, language = {en} } @article{HeiligersSchoutetensDachwald2021, author = {Heiligers, Jeannette and Schoutetens, Frederic and Dachwald, Bernd}, title = {Photon-sail equilibria in the alpha centauri system}, series = {Journal of Guidance, Control, and Dynamics}, volume = {44}, journal = {Journal of Guidance, Control, and Dynamics}, number = {5}, issn = {1533-3884}, doi = {10.2514/1.G005446}, pages = {1053 -- 1061}, year = {2021}, language = {en} } @article{ArtmannZerlinDigeletal.2007, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.}, title = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{DuongNguyenStaat2015, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Staat, Manfred}, title = {Physical response of hyperelastic models for composite materials and soft tissues}, series = {Asia pacific journal on computational engineering}, volume = {2}, journal = {Asia pacific journal on computational engineering}, number = {3 (December 2015)}, issn = {2196-1166}, doi = {10.1186/s40540-015-0015-x}, pages = {1 -- 18}, year = {2015}, language = {en} } @article{SavitskayaKistaubayevaDigeletal.2017, author = {Savitskaya, I. S. and Kistaubayeva, A. S. and Digel, Ilya and Shokatayeva, D. H.}, title = {Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials}, series = {Eurasian Chemico-Technological Journal}, volume = {19}, journal = {Eurasian Chemico-Technological Journal}, number = {3}, issn = {2522-4867}, doi = {10.18321/ectj670}, pages = {255 -- 264}, year = {2017}, language = {en} } @article{KotliarKoshitzSvetlovaetal.2006, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlova, O. V. and Zaseeva, M. V.}, title = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli}, series = {Glaukoma (2006)}, journal = {Glaukoma (2006)}, publisher = {-}, pages = {35 -- 53}, year = {2006}, language = {en} } @article{KotliarKoshitzSvetlowaetal.2006, author = {Kotliar, Konstantin and Koshitz, I. N. and Svetlowa, O. V. and Zaseeva, M. V.}, title = {Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar}, series = {Glaukoma (2006)}, journal = {Glaukoma (2006)}, publisher = {-}, pages = {51 -- 70}, year = {2006}, language = {en} } @article{StadlerGarveyEmbsetal.2014, author = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe}, title = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study}, series = {Biochimica et biophysica acta (BBA): General Subjects}, volume = {1840}, journal = {Biochimica et biophysica acta (BBA): General Subjects}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-8006 (E-Journal); 0304-4165 (Print)}, doi = {10.1016/j.bbagen.2014.06.007}, pages = {2989 -- 2999}, year = {2014}, language = {en} } @article{ArtmannBaeumlerVoigtetal.2000, author = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]}, title = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.}, series = {Journal of Microencapsulation. 17 (2000), H. 5}, journal = {Journal of Microencapsulation. 17 (2000), H. 5}, isbn = {1464-5246}, pages = {651 -- 655}, year = {2000}, language = {en} } @article{Staat2004, author = {Staat, Manfred}, title = {Plastic collapse analysis of longitudinally flawed pipes and vessels}, series = {Nuclear Engineering and Design. 234 (2004), H. 1-3}, journal = {Nuclear Engineering and Design. 234 (2004), H. 1-3}, isbn = {0029-5493}, pages = {25 -- 43}, year = {2004}, language = {en} } @article{Staat2004, author = {Staat, Manfred}, title = {Plastic collapse analysis of longitudinally flawed pipes and vessels}, year = {2004}, abstract = {Improved collapse loads of thick-walled, crack containing pipes and vessels are suggested. Very deep cracks have a residual strength which is better modelled by a global limit load. In all burst tests, the ductility of pressure vessel steels was sufficiently high whereby the burst pressure could be predicted by limit analysis with no need to apply fracture mechanics. The relative prognosis error increases however, for long and deep defects due to uncertainties of geometry and strength data.}, subject = {Druckbeh{\"a}lter}, language = {en} } @article{ArampatzisPeperBierbaumetal.2010, author = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten}, title = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain}, series = {Journal of Biomechanics}, volume = {43}, journal = {Journal of Biomechanics}, number = {16}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2010.08.014}, pages = {3073 -- 3079}, year = {2010}, abstract = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.}, language = {en} } @article{ArampatzisKaramanidisMademlietal.2009, author = {Arampatzis, Adamantios and Karamanidis, Kiros and Mademli, Lida and Albracht, Kirsten}, title = {Plasticity of the human tendon to short and long-term mechanical loading}, series = {Exercise and Sport Sciences Reviews}, volume = {37}, journal = {Exercise and Sport Sciences Reviews}, number = {2}, issn = {1538-3008}, doi = {10.1097/JES.0b013e31819c2e1d}, pages = {66 -- 72}, year = {2009}, language = {en} } @article{MichaelMayerWeberetal.2017, author = {Michael, Hackl and Mayer, Katharina and Weber, Mareike and Staat, Manfred and van Riet, Roger and Burkhart, Klau Josef and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis}, series = {The journal of hand surgery}, volume = {42}, journal = {The journal of hand surgery}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2017.05.014}, pages = {834.e1 -- 834.e7}, year = {2017}, language = {en} } @article{MaggakisKelemenDigelArtmann2005, author = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard}, title = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility}, series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, journal = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, pages = {324 -- 326}, year = {2005}, language = {en} } @article{CiritsisHorbachStaatetal.2018, author = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas}, title = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo}, series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, volume = {106}, journal = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, number = {2}, publisher = {Wiley}, address = {New York, NY}, issn = {1552-4981}, doi = {10.1002/jbm.b.33877}, pages = {827 -- 833}, year = {2018}, abstract = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.}, language = {en} } @article{KotliarKozlovaLanzl2009, author = {Kotliar, Konstantin and Kozlova, Tatiana V. and Lanzl, Ines M.}, title = {Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations}, series = {Biomedizinische Technik = Biomedical Engineering}, volume = {54}, journal = {Biomedizinische Technik = Biomedical Engineering}, number = {1}, publisher = {-}, isbn = {1862-278X}, pages = {14 -- 22}, year = {2009}, language = {en} } @article{JayaramanMummidisettyLoeschetal.2019, author = {Jayaraman, Chandrasekaran and Mummidisetty, Chaitanya Krishna and Loesch, Alexandra and Kaur, Sandi and Hoppe-Ludwig, Shenan and Staat, Manfred and Jayaraman, Arun}, title = {Postural and metabolic benefits of using a forearm support walker in older adults with impairments}, series = {Archives of Physical Medicine and Rehabilitation}, volume = {Volume 100}, journal = {Archives of Physical Medicine and Rehabilitation}, number = {Issue 4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0003-9993}, doi = {10.1016/j.apmr.2018.10.001}, pages = {638 -- 647}, year = {2019}, language = {en} } @article{DachwaldBaturkinCoverstoneetal.2006, author = {Dachwald, Bernd and Baturkin, Volodymyr and Coverstone, Victoria L. and Dietrich, Benjamin and Garbe, Gregory P. and G{\"o}rlich, Marianne and Leipold, Manfred and Lura, Franz and Macdonald, Malcolm and McInnes, Colin R. and Mengali, Giovanni and Quatra, Alessandro A. and Rios-Reyes, Leonel and Scheeres, Daniel J. and Seboldt, Wolfgang and Wie, Bong}, title = {Potential Effects of Optical Solar Sail Degradation on Interplanetary Trajectory Design}, series = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, journal = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-527-X}, pages = {2569 -- 2592}, year = {2006}, language = {en} } @article{DachwaldSeboldtMacdonaldetal.2005, author = {Dachwald, Bernd and Seboldt, Wolfgang and Macdonald, Malcolm and Mengali, Giovanni and Quatra, Alessandro A. and McInnes, Colin R. and Rios-Reyes, Leonel and Scheerers, Daniel J. and Wie, Bong and G{\"o}rlich, Marianne and Lura, Franz and Diedrich, Benjamin and Baturkin, Volodymyr and Coverstone, Victoria L. and Leipold, Manfred and Garbe, Gregory P.}, title = {Potential Solar Sail Degradation Effects on Trajectory and Attitude Control}, series = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, journal = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-765-3}, pages = {2 CD-ROMs}, year = {2005}, language = {en} } @article{SavitskayaZhantlessovaKistaubayevaetal.2023, author = {Savitskaya, Irina and Zhantlessova, Sirina and Kistaubayeva, Aida and Ignatova, Ludmila and Shokatayeva, Dina and Sinyavsky, Yuriy and Kushugulova, Almagul and Digel, Ilya}, title = {Prebiotic cellulose-pullulan matrix as a "vehicle" for probiotic biofilm delivery to the host large intestine}, series = {Polymers}, journal = {Polymers}, number = {16(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/polym16010030}, pages = {Artikel 30}, year = {2023}, abstract = {This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3\%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies.}, language = {en} } @article{KezerashviliDachwald2021, author = {Kezerashvili, Roman Ya and Dachwald, Bernd}, title = {Preface: Solar sailing: Concepts, technology, and missions II}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.037}, pages = {2559 -- 2560}, year = {2021}, language = {en} } @article{RauschKahmannBaltschunetal.2020, author = {Rausch, Valentin and Kahmann, Stephanie Lucina and Baltschun, Christoph and Staat, Manfred and M{\"u}ller, Lars P. and Wegmann, Kilian}, title = {Pressure distribution to the distal biceps tendon at the radial tuberosity: a biomechanical study}, series = {The Journal of Hand Surgery}, volume = {45}, journal = {The Journal of Hand Surgery}, number = {8}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2020.01.006}, pages = {776.e1 -- 776.e9}, year = {2020}, abstract = {Purpose Mechanical impingement at the narrow radioulnar space of the tuberosity is believed to be an etiological factor in the injury of the distal biceps tendon. The aim of the study was to compare the pressure distribution at the proximal radioulnar space between 2 fixation techniques and the intact state. Methods Six right arms and 6 left arms from 5 female and 6 male frozen specimens were used for this study. A pressure transducer was introduced at the height of the radial tuberosity with the intact distal biceps tendon and after 2 fixation methods: the suture-anchor and the cortical button technique. The force (N), maximum pressure (kPa) applied to the radial tuberosity, and the contact area (mm²) of the radial tuberosity with the ulna were measured and differences from the intact tendon were detected from 60° supination to 60° pronation in 15° increments with the elbow in full extension and in 45° and 90° flexion of the elbow. Results With the distal biceps tendon intact, the pressures during pronation were similar regardless of extension and flexion and were the highest at 60° pronation with 90° elbow flexion (23.3 ± 53.5 kPa). After repair of the tendon, the mean peak pressure, contact area, and total force showed an increase regardless of the fixation technique. Highest peak pressures were found using the cortical button technique at 45° flexion of the elbow and 60° pronation. These differences were significantly different from the intact tendon. The contact area was significantly larger in full extension and 15°, 30°, and 60° pronation using the cortical button technique. Conclusions Pressures on the distal biceps tendon at the radial tuberosity increase during pronation, especially after repair of the tendon. Clinical relevance Mechanical impingement could play a role in both the etiology of primary distal biceps tendon ruptures and the complications occurring after fixation of the tendon using certain techniques.}, language = {en} } @article{Digel2011, author = {Digel, Ilya}, title = {Primary thermosensory events in cells}, series = {Transient receptor potential channels / Md. Shahidul Islam, ed.}, journal = {Transient receptor potential channels / Md. Shahidul Islam, ed.}, publisher = {Springer}, address = {Dordrecht [u.a.]}, isbn = {978-94-007-0264-6}, pages = {451 -- 468}, year = {2011}, language = {en} } @article{Staat1996, author = {Staat, Manfred}, title = {Probabilistic assessment of the fracture mechanics behaviour of an HTR-module primary circuit pressure boundary}, series = {Nuclear Engineering and Design. 160 (1996), H. 1-2}, journal = {Nuclear Engineering and Design. 160 (1996), H. 1-2}, isbn = {0029-5493}, pages = {221 -- 236}, year = {1996}, language = {en} } @article{TranKreissigStaat2009, author = {Tran, Thanh Ngoc and Kreißig, R. and Staat, Manfred}, title = {Probabilistic limit and shakedown analysis of thin plates and shells}, series = {Structural safety. 31 (2009), H. 1}, journal = {Structural safety. 31 (2009), H. 1}, publisher = {-}, isbn = {0167-4730}, pages = {1 -- 18}, year = {2009}, language = {en} } @article{StaatHeitzer2003, author = {Staat, Manfred and Heitzer, M.}, title = {Probabilistic limit and shakedown problems}, series = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M; Heitzer, M.}, journal = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M; Heitzer, M.}, publisher = {John von Neumann Institute for Computing (NIC)}, address = {J{\"u}lich}, isbn = {3-00-010001-6}, pages = {217 -- 268}, year = {2003}, language = {en} } @article{Staat1992, author = {Staat, Manfred}, title = {Probabilistische Bewertung des bruchmechanischen Verhaltens der Prim{\"a}rkreisdruckumschließung eines HTR-Moduls}, year = {1992}, language = {de} } @article{Staat1996, author = {Staat, Manfred}, title = {Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability}, series = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, journal = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, address = {Vienna}, pages = {43 -- 55}, year = {1996}, language = {en} } @article{KoppSchmeetsGosauetal.2019, author = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders}, title = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application}, series = {In Vivo}, volume = {33}, journal = {In Vivo}, number = {3}, issn = {1791-7549}, doi = {10.21873/invivo.11536}, pages = {757 -- 762}, year = {2019}, language = {en} } @article{JiminezGermanBehbahaniMiettinenetal.2013, author = {Jiminez German, Salvador and Behbahani, Mehdi and Miettinen, Susanna and Grijpma, Dirk W. and Haimi, Suvi P.}, title = {Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes}, series = {Macromolecular symposia}, volume = {Vol. 334}, journal = {Macromolecular symposia}, number = {Iss. 1}, publisher = {Wiley}, address = {Weinheim}, issn = {0258-0322}, pages = {133 -- 142}, year = {2013}, language = {en} } @article{BlomeSeboldtDachwaldetal.2004, author = {Blome, Hans-Joachim and Seboldt, Wolfgang and Dachwald, Bernd and Richter, Lutz}, title = {Proposal for an integrated European Space Exploration Study}, series = {Space Debris and Space Traffic Management Symposium 2004 : proceedings of the International Academy of Astronautics Space Debris and Space Traffic Management Symposium, held in conjunction with the 55th International Astronautical Congress (IAC), October 4 - 8, 2004, Vancouver, British Columbia, Canada / ed. by Joerg Bendisch}, journal = {Space Debris and Space Traffic Management Symposium 2004 : proceedings of the International Academy of Astronautics Space Debris and Space Traffic Management Symposium, held in conjunction with the 55th International Astronautical Congress (IAC), October 4 - 8, 2004, Vancouver, British Columbia, Canada / ed. by Joerg Bendisch}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-523-7}, pages = {XI, 432 S. : Ill., graph. Darst.}, year = {2004}, language = {en} } @article{DigelZerlinTemizArtmannetal.2007, author = {Digel, Ilya and Zerlin, Kay and Temiz Artmann, Ayseg{\"u}l and Engels, S.}, title = {Protein dynamics in thermosensation}, series = {Regenerative medicine. 2 (2007), H. 5}, journal = {Regenerative medicine. 2 (2007), H. 5}, isbn = {1746-0751}, pages = {533 -- 533}, year = {2007}, language = {en} } @article{HacklMuellerStaatetal.2016, author = {Hackl, Michael and M{\"u}ller, Lars-Peter and Staat, Manfred and Kahmann, Stephanie Lucina and Wegmann, Kilian}, title = {Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {148 -- 149}, year = {2016}, abstract = {Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.}, language = {en} } @article{KotliarBaumannVilseretal.2011, author = {Kotliar, Konstantin and Baumann, Marcus and Vilser, Walthard and Lanzl, Ines M.}, title = {Pulse wave velocity in retinal arteries of healthy volunteers}, series = {British Journal of Ophthalmology (eBJO)}, volume = {95}, journal = {British Journal of Ophthalmology (eBJO)}, number = {11}, publisher = {BMJ Publ. Group}, address = {London}, isbn = {1468-2079}, pages = {675 -- 679}, year = {2011}, language = {en} } @article{HacklWegmannKahmannetal.2017, author = {Hackl, Michael and Wegmann, Kilian and Kahmann, Stephanie Lucina and Heinze, Nicolai and Staat, Manfred and Neiss, Wolfram F. and Scaal, Martin and M{\"u}ller, Lars P.}, title = {Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow}, series = {Knee Surgery, Sports Traumatology, Arthroscopy}, volume = {25}, journal = {Knee Surgery, Sports Traumatology, Arthroscopy}, number = {7}, publisher = {Springer}, address = {Berlin}, issn = {1433-7347}, doi = {10.1007/s00167-017-4468-z}, pages = {2280 -- 2288}, year = {2017}, language = {en} } @article{WiescherKotliarNeuhannetal.2010, author = {Wiescher, A. and Kotliar, Konstantin and Neuhann, T. and Lanzl, Ines M.}, title = {Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten}, series = {Der Ophthalmologe}, volume = {105}, journal = {Der Ophthalmologe}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1433-0423}, doi = {10.1007/s00347-007-1586-x}, pages = {389 -- 392}, year = {2010}, abstract = {Ein 34-j{\"a}hriger m{\"a}nnlicher Patient stellte sich zur Abkl{\"a}rung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel f{\"u}r ihn selbst sichtbare, weißliche Tr{\"u}bung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gr{\"a}serpollen und eine Unvertr{\"a}glichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt. Zus{\"a}tzlich leidet der Patient an stark ausgepr{\"a}gtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert.}, language = {de} } @article{KotliarLanzlWittaetal.2000, author = {Kotliar, Konstantin and Lanzl, Ines M. and Witta, Birka and Vilser, Walthard}, title = {Reaktion retinaler Gef{\"a}ßdurchmesser auf 100 \% O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden / Lanzl, Ines M. ; Witta, Birke ; Kotliar, Konstantin ; Vilser, Walthard}, series = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde. 217 (2000), H. 4}, journal = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde. 217 (2000), H. 4}, publisher = {-}, isbn = {1439-3999}, pages = {231 -- 235}, year = {2000}, language = {de} } @article{TemizArtmannKurulgandemirciFıratetal.2021, author = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard}, title = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers}, series = {SHOCK}, journal = {SHOCK}, publisher = {Wolters Kluwer}, address = {K{\"o}ln}, issn = {1540-0514}, doi = {10.1097/SHK.0000000000001845}, year = {2021}, language = {en} } @article{HacklLeschingerStaatetal.2016, author = {Hackl, Michael and Leschinger, T. and Staat, Manfred and M{\"u}ller, Lars-Peter and Wegmann, Kilian}, title = {Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {130 -- 131}, year = {2016}, abstract = {Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.}, language = {en} } @article{CapriMorsianiSantoroetal.2019, author = {Capri, Miriam and Morsiani, Cristina and Santoro, Aurelia and Moriggi, Manuela and Conte, Maria and Martucci, Morena and Bellavista, Elena and Fabbri, Cristina and Giampieri, Enrico and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Canepari, Monica and Longa, Emanuela and Giulio, Irene Di and Bottinelli, Roberto and Cerretelli, Paolo and Salvioli, Stefano and Gelfi, Cecilia and Franceschi, Claudio and Narici, Marco and Rittweger, J{\"o}rn}, title = {Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting}, series = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, volume = {33}, journal = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, number = {4}, doi = {10.1096/fj.201801625R}, pages = {5168 -- 5180}, year = {2019}, language = {en} } @article{StaeudleSeynnesLapsetal.2021, author = {St{\"a}udle, Benjamin and Seynnes, Olivier and Laps, Guido and G{\"o}ll, Fabian and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten}, title = {Recovery from achilles tendon repair: a combination of Postsurgery Outcomes and Insufficient remodeling of muscle and tendon}, series = {Medicine \& Science in Sports \& Exercise}, volume = {53}, journal = {Medicine \& Science in Sports \& Exercise}, number = {7}, publisher = {American College of Sports Medicine}, address = {Philadelphia, Pa.}, issn = {1530-0315}, doi = {10.1249/MSS.0000000000002592}, pages = {1356 -- 1366}, year = {2021}, abstract = {Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle-tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force-length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force-length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13\% ± 10\%, 105\% ± 28\%, and 54\% ± 24\%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32\% ± 12\%) and with greater pennation angles (31\% ± 26\%). A mean deficit in plantarflexion moment of 31\% ± 10\% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.}, language = {en} } @article{TemizArtmannBaskurtMeiselman1997, author = {Temiz Artmann, Ayseg{\"u}l and Baskurt, O. K. and Meiselman, H. J.}, title = {Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J.}, series = {Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2}, journal = {Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2}, isbn = {0022-2143}, pages = {183 -- 190}, year = {1997}, language = {en} } @article{DachwaldMengaliQuartaetal.2007, author = {Dachwald, Bernd and Mengali, Giovanni and Quarta, Alessandro A. and Circi, Christian}, title = {Refined Solar Sail Force Model with Mission Application / Giovanni Mengali ; Alessandro A. Quarta , Christian Circi ; Bernd Dachwald}, series = {Journal of Guidance, Control, and Dynamics. 30 (2007), H. 2}, journal = {Journal of Guidance, Control, and Dynamics. 30 (2007), H. 2}, isbn = {0162-3192}, pages = {512 -- 520}, year = {2007}, language = {en} } @article{SponagelBecker1984, author = {Sponagel, Stefan and Becker, E.}, title = {Reibungsfreie, ebene Diffusorstr{\"o}mung mit beliebigem Einlaufprofil. E. Becker, S. Sponagel}, series = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik: ZAMM. 64 (1984)}, journal = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik: ZAMM. 64 (1984)}, isbn = {0044-2267}, pages = {T174 -- T177}, year = {1984}, language = {de} } @article{StaatHeitzer2000, author = {Staat, Manfred and Heitzer, M.}, title = {Reliability Analysis of Elasto-Plastic Structures under Variable Loads}, series = {Inelastic analysis of structures under variable loads : theory and engineering applications / Maier, G.; Weichert, D. [ed]}, journal = {Inelastic analysis of structures under variable loads : theory and engineering applications / Maier, G.; Weichert, D. [ed]}, publisher = {Kluwer Academic Publ.}, address = {Dordrecht}, isbn = {0-7923-6645-X}, pages = {269 -- 288}, year = {2000}, language = {en} } @article{TranPhamVuetal.2009, author = {Tran, Thanh Ngoc and Pham, Phu Tinh and Vu, D. K. and Staat, Manfred}, title = {Reliability Analysis of Inelastic Shell Structures Under Variable Loads}, series = {Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter}, journal = {Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter}, publisher = {Springer Netherland}, address = {Berlin}, isbn = {978-1-4020-9633-4}, pages = {135 -- 156}, year = {2009}, language = {en} } @article{StaatFioriniLensaetal.1997, author = {Staat, Manfred and Fiorini, G. L. and Lensa, W. von and Burgazzi, L.}, title = {Reliability Methods for Passive Safety Functions}, series = {Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations}, journal = {Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations}, address = {Pisa}, year = {1997}, language = {en} } @article{Staat1995, author = {Staat, Manfred}, title = {Reliability of an HTR-module primary circuit pressure boundary Influences, sensitivity, and comparison with a PWR}, series = {Nuclear Engineering and Design. 158 (1995), H. 2-3}, journal = {Nuclear Engineering and Design. 158 (1995), H. 2-3}, isbn = {0029-5493}, pages = {333 -- 340}, year = {1995}, language = {en} } @article{QuittmannAbelAlbrachtetal.2019, author = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Str{\"u}der, Heiko K.}, title = {Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants}, series = {Sports Biomechanics}, journal = {Sports Biomechanics}, number = {Article in press}, publisher = {Taylor \& Francis}, address = {London}, issn = {1752-6116}, doi = {10.1080/14763141.2019.1593496}, year = {2019}, language = {en} } @article{Staat1993, author = {Staat, Manfred}, title = {Reliability of the Primary Circuit Pressure Boundary of an HTR-Module under Accident Conditions}, series = {Safety and reliability assessment : an integral approach ; ESREL'93 ; proceedings of the European Safety and Reliability Conference, Munich, Germany, May 10th - 12th 1993 / Kafka, P. [ed]}, journal = {Safety and reliability assessment : an integral approach ; ESREL'93 ; proceedings of the European Safety and Reliability Conference, Munich, Germany, May 10th - 12th 1993 / Kafka, P. [ed]}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0-444-81561-9}, pages = {331 -- 342}, year = {1993}, language = {en} } @article{AggeloussisGiannakouAlbrachtetal.2010, author = {Aggeloussis, Nickos and Giannakou, Erasmia and Albracht, Kirsten and Arampatzis, Adamantios}, title = {Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo}, series = {Gait and Posture}, volume = {31}, journal = {Gait and Posture}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0966-6362}, doi = {10.1016/j.gaitpost.2009.08.249}, pages = {73 -- 77}, year = {2010}, abstract = {The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38-63 mm; pennation angle: RMS = ∼1.5°, range: 22-32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.}, language = {en} } @article{DigelTrzewikDemircietal.2004, author = {Digel, Ilya and Trzewik, J{\"u}rgen and Demirci, Taylan and Temiz Artmann, Ayseg{\"u}l}, title = {Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1042 -- 1043}, year = {2004}, language = {en} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{ArtmannSchmidSchoenbeinGrebeetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]}, title = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne}, series = {Drug Development Research. 14 (1988), H. 3-4}, journal = {Drug Development Research. 14 (1988), H. 3-4}, isbn = {1098-2299}, pages = {205 -- 211}, year = {1988}, language = {en} } @article{StreeseKotliarDeiserothetal.2020, author = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner}, title = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial}, series = {Scandinavian Journal of Medicine and Science in Sports}, volume = {30}, journal = {Scandinavian Journal of Medicine and Science in Sports}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1600-0838}, doi = {10.1111/sms.13560}, pages = {272 -- 280}, year = {2020}, abstract = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.}, language = {en} } @article{RamoshabaHuismanLammertynetal.2020, author = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne}, title = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study}, series = {Hypertension Research}, journal = {Hypertension Research}, number = {43}, publisher = {Springer Nature}, address = {Osaka}, issn = {1348-4214}, doi = {10.1038/s41440-020-0487-0}, pages = {1231 -- 1238}, year = {2020}, abstract = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.}, language = {en} } @article{KotliarHanssenEberhardtetal.2013, author = {Kotliar, Konstantin and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Schmaderer, Christoph and Halle, Martin and Heemann, Uwe and Baumann, M.}, title = {Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects}, series = {Microcirculation}, journal = {Microcirculation}, publisher = {Wiley}, address = {Malden}, issn = {1549-8719}, year = {2013}, language = {en} } @article{AlbannaConzenWeissetal.2016, author = {Albanna, W. and Conzen, C. and Weiss, M. and Clusmann, H. and Fuest, M. and Mueller, M. and Brockmann, M.A. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Hoellig, A. and Seiz, M. and Thom{\´e}, C. and Kotliar, Konstantin and Schubert, G.A.}, title = {Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study}, series = {PLoS ONE}, volume = {11}, journal = {PLoS ONE}, number = {7}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0158781}, pages = {13 Seiten}, year = {2016}, abstract = {Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3\%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.}, language = {en} } @article{SmithKotliarLammertynetal.2020, author = {Smith, Wayne and Kotliar, Konstantin and Lammertyn, Leandi and Ramoshaba, Nthai E. and Vilser, Walthard and Huisman, Hugo W. and Schutte, Aletta E.}, title = {Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study}, series = {Microvascular Research}, volume = {128}, journal = {Microvascular Research}, number = {Article 103937}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0026-2862}, doi = {10.1016/j.mvr.2019.103937}, year = {2020}, abstract = {Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8\%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.}, language = {en} } @article{KotliarVilserNageletal.2004, author = {Kotliar, Konstantin and Vilser, Walthatd and Nagel, Edgar and Lanzl, Ines M.}, title = {Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M.}, series = {Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5}, publisher = {-}, isbn = {1435-702X}, pages = {377 -- 392}, year = {2004}, language = {en} } @article{NeumaierKotliarHaerenetal.2021, author = {Neumaier, Felix and Kotliar, Konstantin and Haeren, Roel Hubert Louis and Temel, Yasin and L{\"u}ke, Jan Niklas and Seyam, Osama and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Schubert, Gerrit Alexander and Schneider, Toni and Albanna, Walid}, title = {Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, publisher = {Frontiers}, doi = {10.3389/fneur.2021.659890}, pages = {1 -- 11}, year = {2021}, language = {en} } @article{MenzelKotliarLanzl2009, author = {Menzel, C. and Kotliar, Konstantin and Lanzl, I.}, title = {Retrospektive Untersuchung jahreszeitlich bedingter Einflussfaktoren auf den Augeninnendruck therapierter Glaukompatienten}, series = {Der Ophthalmologe}, volume = {106}, journal = {Der Ophthalmologe}, number = {11}, publisher = {-}, isbn = {1433-0423}, pages = {1006 -- 1011}, year = {2009}, language = {de} } @article{KurulganDemirciDemirciLinderetal.2012, author = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells}, series = {Journal of Bioscience and Bioengineering}, volume = {113}, journal = {Journal of Bioscience and Bioengineering}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1347-4421}, doi = {10.1016/j.jbiosc.2012.03.019}, pages = {212 -- 219}, year = {2012}, abstract = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.}, language = {en} } @article{KolditzAlbinBrueggemannetal.2016, author = {Kolditz, Melanie and Albin, Thivaharan and Br{\"u}ggemann, Gert-Peter and Abel, Dirk and Albracht, Kirsten}, title = {Robotergest{\"u}tztes System f{\"u}r ein verbessertes neuromuskul{\"a}res Aufbautraining der Beinstrecker}, series = {at - Automatisierungstechnik}, volume = {64}, journal = {at - Automatisierungstechnik}, number = {11}, publisher = {De Gruyter}, address = {Berlin}, issn = {2196-677X}, doi = {10.1515/auto-2016-0044}, pages = {905 -- 914}, year = {2016}, abstract = {Neuromuskul{\"a}res Aufbautraining der Beinstrecker ist ein wichtiger Bestandteil in der Rehabilitation und Pr{\"a}vention von Muskel-Skelett-Erkrankungen. Effektives Training erfordert hohe Muskelkr{\"a}fte, die gleichzeitig hohe Belastungen von bereits gesch{\"a}digten Strukturen bedeuten. Um trainingsinduzierte Sch{\"a}digungen zu vermeiden, m{\"u}ssen diese Kr{\"a}fte kontrolliert werden. Mit heutigen Trainingsger{\"a}ten k{\"o}nnen diese Ziele allerdings nicht erreicht werden. F{\"u}r ein sicheres und effektives Training sollen durch den Einsatz der Robotik, Sensorik, eines Regelkreises sowie Muskel-Skelett-Modellen Belastungen am Zielgewebe direkt berechnet und kontrolliert werden. Auf Basis zweier Vorstudien zu m{\"o}glichen Stellgr{\"o}ßen wird der Aufbau eines robotischen Systems vorgestellt, das sowohl f{\"u}r Forschungszwecke als auch zur Entwicklung neuartiger Trainingsger{\"a}te verwendet werden kann.}, language = {de} }