@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{CehreliAkpinarTemizArtmannetal.2015,
  author    = {Cehreli, Ruksan and Akpinar, Hale and Temiz Artmann, Ayseg{\"u}l and Sagol, Ozgul},
  title     = {Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis},
  series = {Gastroenterology Research},
  volume    = {8},
  journal   = {Gastroenterology Research},
  number    = {5},
  issn      = {1918-2813},
  doi       = {10.14740/gr683w},
  pages     = {265 -- 273},
  year      = {2015},
  language  = {en}
}
@article{GrundmannDachwaldGrimmetal.2015,
  author    = {Grundmann, Jan Thimo and Dachwald, Bernd and Grimm, Christian D. and Kahle, Ralph and Koch, Aaron Dexter and Krause, Christian and Lange, Caroline and Quantius, Dominik and Ulamec, Stephan},
  title     = {Spacecraft for Hypervelocity Impact Research - An Overview of Capabilities, Constraints and the Challenges of Getting There},
  series = {Procedia Engineering},
  volume    = {Vol. 103},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.04.021},
  pages     = {151 -- 158},
  year      = {2015},
  language  = {en}
}
@inproceedings{GrundmannLangeDachwaldetal.2015,
  author    = {Grundmann, Jan Thimo and Lange, Caroline and Dachwald, Bernd and Grimm, Christian and Koch, Aaron and Ulamec, Stephan},
  title     = {Small Spacecraft in Planetary Defence Related Applications-Capabilities, Constraints, Challenges},
  series = {IEEE Aerospace Conference},
  booktitle = {IEEE Aerospace Conference},
  pages     = {1 -- 18},
  year      = {2015},
  abstract  = {In this paper we present an overview of the characteristics and peculiarities of small spacecraft missions related to planetary defence applications. We provide a brief overview of small spacecraft missions to small solar system bodies. On this background we present recent missions and selected projects and related studies at the German Aerospace Center, DLR, that contribute to planetary defence related activities. These range from Earth orbit technology demonstrators to active science missions in interplanetary space. We provide a summary of experience from recently flown missions with DLR participation as well as a number of studies. These include PHILAE, the lander recently arrived on comet 67P/Churyumov-Gerasimenko aboard ESA's ROSETTA comet rendezvous mission, and the Mobile Asteroid Surface Scout, MASCOT, now underway to near-Earth asteroid (162173) 1999 JU3 aboard the Japanese sample-return probe HAYABUSA-2. We introduce the differences between the conventional methods employed in the design, integration and testing of large spacecraft and the new approaches developed by small spacecraft projects. We expect that the practical experience that can be gained from projects on extremely compressed timelines or with high-intensity operation phases on a newly explored small solar system body can contribute significantly to the study, preparation and realization of future planetary defence related missions. One is AIDA (Asteroid Impact \& Deflection Assessment), a joint effort of ESA,JHU/APL, NASA, OCA and DLR, combining JHU/APL's DART (Double Asteroid Redirection Test) and ESA's AIM (Asteroid Impact Monitor) spacecraft in a mission towards near-Eath binary asteroid (65803) Didymos.},
  language  = {en}
}
@article{FrotscherKochStaat2015,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred},
  title     = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes},
  series = {Journal of biomechanical engineering},
  volume    = {Vol. 137},
  journal   = {Journal of biomechanical engineering},
  number    = {iss. 7},
  publisher = {ASME},
  address   = {New York},
  issn      = {1528-8951 (E-Journal); 0148-0731 (Print)},
  doi       = {10.1115/1.4030173},
  pages     = {071002-1 -- 071002-7},
  year      = {2015},
  language  = {en}
}
@incollection{TranStaat2015,
  author    = {Tran, Thanh Ngoc and Staat, Manfred},
  title     = {Uncertainty multimode failure and shakedown analysis of shells},
  series = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...},
  booktitle = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online)},
  doi       = {10.1007/978-3-319-12928-0_14},
  pages     = {279 -- 298},
  year      = {2015},
  abstract  = {This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results.},
  language  = {en}
}
@inproceedings{DuongNguyenStaat2015,
  author    = {Duong, Minh Tuan and Nguyen, N. H. and Staat, Manfred},
  title     = {Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM)},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@article{KonstantinidisFloresMartinezDachwaldetal.2015,
  author    = {Konstantinidis, Konstantinos and Flores Martinez, Claudio and Dachwald, Bernd and Ohndorf, Andreas and Dykta, Paul and Bowitz, Pascal and Rudolph, Martin and Digel, Ilya and Kowalski, Julia and Voigt, Konstantin and F{\"o}rstner, Roger},
  title     = {A lander mission to probe subglacial water on Saturn's moon enceladus for life},
  series = {Acta astronautica},
  volume    = {Vol. 106},
  journal   = {Acta astronautica},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1879-2030 (E-Journal); 0094-5765 (Print)},
  pages     = {63 -- 89},
  year      = {2015},
  language  = {en}
}
@inproceedings{PirovanoSeefeldtDachwaldetal.2015,
  author    = {Pirovano, Laura and Seefeldt, Patric and Dachwald, Bernd and Noomen, Ron},
  title     = {Attitude and Orbital Dynamics Modeling for an Uncontrolled Solar-Sail Experiment in Low-Earth Orbit},
  series = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany},
  booktitle = {25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany},
  pages     = {15 S.},
  year      = {2015},
  language  = {en}
}
@inproceedings{SeefeldtBauerDachwaldetal.2015,
  author    = {Seefeldt, Patric and Bauer, Waldemar and Dachwald, Bernd and Grundmann, Jan Thimo and Straubel, Marco and Sznajder, Maciej and T{\´o}th, Norbert and Zander, Martin E.},
  title     = {Large lightweight deployable structures for planetary defence: solar sail propulsion, solar concentrator payloads, large-scale photovoltaic power},
  series = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy},
  booktitle = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy},
  pages     = {24},
  year      = {2015},
  language  = {en}
}