@article{StadlerZerlinDigeletal.2008, author = {Stadler, Andreas M. and Zerlin, Kay and Digel, Ilya and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in red blood cells}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {724 -- 724}, year = {2008}, language = {en} } @article{StadlerDigelArtmannetal.2008, author = {Stadler, A. M. and Digel, Ilya and Artmann, Gerhard and Embs, Jan P. and Zaccai, Joe and B{\"u}ldt, Georg}, title = {Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature}, series = {Biophysical Journal. 95 (2008), H. 11}, journal = {Biophysical Journal. 95 (2008), H. 11}, isbn = {1542-0086}, pages = {5449 -- 5461}, year = {2008}, language = {en} } @article{StadlerEmbsDigeletal.2008, author = {Stadler, Andreas M. and Embs, Jan P. and Digel, Ilya and Artmann, Gerhard and Unruh, Tobias and B{\"u}ldt, Georg and Zaccai, Guiseppe}, title = {Cytoplasmic water and hydration layer dynamics in human red blood cells}, series = {Journal of the American Chemical Society. 50 (2008), H. 130}, journal = {Journal of the American Chemical Society. 50 (2008), H. 130}, isbn = {1520-5126}, pages = {16852 -- 16853}, year = {2008}, language = {en} } @article{DigelKayserArtmann2008, author = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard}, title = {Molecular processes in biological thermosensation}, series = {Journal of Biophysics. 2008 (2008)}, journal = {Journal of Biophysics. 2008 (2008)}, isbn = {1687-8000}, pages = {1 -- 9}, year = {2008}, language = {en} } @article{StadlerGarveyBocahutetal.2012, author = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.}, title = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics}, series = {Journal of the Royal Society Interface}, volume = {9}, journal = {Journal of the Royal Society Interface}, number = {76}, publisher = {The Royal Society}, address = {London}, issn = {1742-5689}, doi = {10.1098/rsif.2012.0364}, pages = {2845 -- 2855}, year = {2012}, abstract = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.}, language = {en} } @article{ZerlinDigelStadleretal.2007, author = {Zerlin, Kay and Digel, Ilya and Stadler, Andreas M. and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions}, series = {Regenerative medicine. 2 (2007), H. 5}, journal = {Regenerative medicine. 2 (2007), H. 5}, isbn = {1746-0751}, pages = {573 -- 573}, year = {2007}, language = {en} } @article{DigelZhubanovaNojimaetal.2004, author = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, series = {Biotechnologija : teorija i praktika (2004)}, journal = {Biotechnologija : teorija i praktika (2004)}, isbn = {1028-9399}, pages = {46 -- 52}, year = {2004}, language = {en} } @article{ArtmannZerlinDigeletal.2007, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.}, title = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{ArtmannDigelLinderetal.2008, author = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz}, title = {Mechanism of haemoglobin sensing body temperature}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {754 -- 754}, year = {2008}, language = {en} } @article{MaggakisKelemenDigelArtmann2005, author = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard}, title = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility}, series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, journal = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, pages = {324 -- 326}, year = {2005}, language = {en} } @inproceedings{SchlemmerPorstBassametal.2017, author = {Schlemmer, Katharina and Porst, Dariusz and Bassam, Rasha and Artmann, Gerhard and Digel, Ilya}, title = {Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {100 -- 101}, year = {2017}, language = {en} } @book{StaatDigelTrzewiketal.2024, author = {Staat, Manfred and Digel, Ilya and Trzewik, J{\"u}rgen and Sielemann, Stefanie and Erni, Daniel and Zylka, Waldemar}, title = {Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-65-3}, doi = {10.17185/duepublico/81475}, pages = {40 Seiten}, year = {2024}, language = {en} } @article{SponagelBaroudSteffenetal.2002, author = {Sponagel, Stefan and Baroud, G. and Steffen, T. and Wu, J.}, title = {Parameter identification for cement infiltration of osteoporotic bone}, series = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...}, journal = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...}, publisher = {Balkema}, address = {Lisse [u.a.]}, isbn = {90-5809-394-8}, pages = {55 -- 58}, year = {2002}, language = {en} } @article{SponagelAkbayBeckeretal.1980, author = {Sponagel, Stefan and Akbay, U. and Becker, E. and Krozer, S.}, title = {Instability of slow viscometric flow}, series = {Mechanics Research Communications. 7 (1980), H. 4}, journal = {Mechanics Research Communications. 7 (1980), H. 4}, isbn = {0093-6413}, pages = {199 -- 204}, year = {1980}, language = {en} } @article{SponagelAdbayBeckeretal.1980, author = {Sponagel, Stefan and Adbay, U. and Becker, E. and Krozer, S.}, title = {A possible cause of viscoelastic turbulence}, series = {Rheology : proceedings of the 8th International Congress of Rheology, held in Naples, Italy, September 1 - 5, 1980 / Hrsg. von Giovanni Astarita, Vol. 2}, journal = {Rheology : proceedings of the 8th International Congress of Rheology, held in Naples, Italy, September 1 - 5, 1980 / Hrsg. von Giovanni Astarita, Vol. 2}, publisher = {Plenum Pr.}, address = {New York}, isbn = {0-306-40465-6}, pages = {79 -- 84}, year = {1980}, language = {en} } @article{SponagelAkbayBecker1985, author = {Sponagel, Stefan and Akbay, U. and Becker, E.}, title = {Instability of plane Couette flow of viscoelastic liquids}, series = {Journal of non-Newtonian fluid mechanics. 18 (1985), H. 2}, journal = {Journal of non-Newtonian fluid mechanics. 18 (1985), H. 2}, isbn = {0377-0257}, pages = {123 -- 141}, year = {1985}, language = {en} } @article{SponagelBaroudFalketal.2004, author = {Sponagel, Stefan and Baroud, G. and Falk, R. and Crookshank, M.}, title = {Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen}, series = {Journal of Biomechanics. 37 (2004), H. 2}, journal = {Journal of Biomechanics. 37 (2004), H. 2}, isbn = {0021-9290}, pages = {189 -- 196}, year = {2004}, language = {en} } @article{SponagelBaroudFalketal.2004, author = {Sponagel, Stefan and Baroud, G. and Falk, R. and Crookshank, M.}, title = {Corrigendum to "Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration". Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T.}, series = {Journal of Biomechanics. 37 (2004), H. 2}, journal = {Journal of Biomechanics. 37 (2004), H. 2}, isbn = {0021-9290}, pages = {1802}, year = {2004}, language = {en} } @article{SponagelKilthauSpies1987, author = {Sponagel, Stefan and Kilthau, G. and Spies, K. H.}, title = {Sealing mechanism of lip seals}, series = {Eleventh 11th International Conference on Fluid Sealing : proceedings of the 11th Internat. Conference on Fluid Sealing, held at Cannes, France 8 - 10 April, 1987 / organised and sponsored by BHRA, the Fluid Engineering Centre. Ed. B. S. Nau}, journal = {Eleventh 11th International Conference on Fluid Sealing : proceedings of the 11th Internat. Conference on Fluid Sealing, held at Cannes, France 8 - 10 April, 1987 / organised and sponsored by BHRA, the Fluid Engineering Centre. Ed. B. S. Nau}, publisher = {Elsevier}, address = {London}, isbn = {3-540-51383-3}, pages = {748 -- 772}, year = {1987}, language = {en} } @misc{SponagelWachowitz1992, author = {Sponagel, Stefan and Wachowitz, Waldemar}, title = {Shaft seal : United States Patent 5,143,385 ; date of patent: Sep. 1, 1992 / assignee: Firma Carl Freudenberg}, publisher = {[United States Patent and Trademark Office]}, address = {[Alexandria, VA]}, pages = {5 S. : Ill.}, year = {1992}, language = {en} } @misc{SponagelGrafGross1989, author = {Sponagel, Stefan and Graf, G{\"u}nter and Groß, Heinz}, title = {Method for manufacturing a sealing ring : United States Patent 4,861,536 ; date of patent: Aug. 12, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel}, publisher = {[United States Patent and Trademark Office]}, address = {[Alexandria, VA]}, pages = {5 S. : Ill.}, year = {1989}, language = {en} } @misc{SponagelGrafGross1989, author = {Sponagel, Stefan and Graf, G{\"u}nter and Groß, Heinz}, title = {Method for the manufacture of a sealing ring with a sealing lip having hydrodynamically acting return elements : United States Patent 4,850,097 ; date of patent: Jul. 25, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel}, publisher = {[United States Patent and Trademark Office]}, address = {[Alexandria, VA]}, pages = {4 S. : Ill.}, year = {1989}, language = {en} } @article{BehbahaniBehrHormesetal.2009, author = {Behbahani, Mehdi and Behr, M. and Hormes, M. and Steinseifer, U. and Arora, D. and Coronado, O. and Pasquali, M.}, title = {A Review of Computational Fluid Dynamics Analysis of Blood Pumps}, series = {European Journal of Applied Mathematics. 20 (2009), H. 4}, journal = {European Journal of Applied Mathematics. 20 (2009), H. 4}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, pages = {363 -- 397}, year = {2009}, language = {en} } @article{BehbahaniFinocchiaroHeinkeetal.2009, author = {Behbahani, Mehdi and Finocchiaro, Thomas and Heinke, Stefanie and Leßmann, Marc}, title = {Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung f{\"u}r die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma}, series = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5}, journal = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5}, isbn = {0013-5585}, pages = {269 -- 281}, year = {2009}, language = {en} } @article{BehbahaniBehrNicolaietal.2008, author = {Behbahani, Mehdi and Behr, Marek and Nicolai, Mike and Probst, Markus}, title = {Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM}, series = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, journal = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, publisher = {Forschungszentrum}, address = {J{\"u}lich}, isbn = {978-3-9810843-5-1}, pages = {325 -- 332}, year = {2008}, language = {en} } @article{BehbahaniNicolaiProbstetal.2007, author = {Behbahani, Mehdi and Nicolai, M. and Probst, M. and Behr, M.}, title = {Simulation of Blood Flow in a Ventricular Assist Device}, series = {inSIDE. 5 (2007), H. 1}, journal = {inSIDE. 5 (2007), H. 1}, pages = {28 -- 31}, year = {2007}, language = {en} } @article{BehbahaniBehrAroraetal.2006, author = {Behbahani, Mehdi and Behr, M. and Arora, D. and Coronado, O. and Pasquali, M.}, title = {CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.}, series = {Artificial Organs. 30 (2006), H. 11}, journal = {Artificial Organs. 30 (2006), H. 11}, isbn = {1525-1594}, pages = {A45 -- A46}, year = {2006}, language = {en} } @article{SteinseiferKashefiHormesetal.2009, author = {Steinseifer, Ulrich and Kashefi, Ali and Hormes, Marcus and Schoberer, Mark and Orlikowsky, Thorsten and Behbahani, Mehdi and Behr, Marek and Schmitz-Rode, Thomas}, title = {Miniaturization of ECMO Systems : Engineering Challenges and Methods}, series = {Artificial Organs. 33 (2009), H. 5}, journal = {Artificial Organs. 33 (2009), H. 5}, isbn = {1525-1594}, pages = {A55 -- A55}, year = {2009}, language = {en} } @article{BehbahaniProbstMaietal.2010, author = {Behbahani, Mehdi and Probst, M. and Mai, A. and Tran, L. and Vonderstein, K. and Keschenau, P. and Linde, T. and Steinseifer, U. and Behr, M. and Mottaghy, K.}, title = {The influence of high shear on thrombosis and hemolysis in artificial organs}, series = {Artificial Organs}, volume = {33}, journal = {Artificial Organs}, number = {7}, isbn = {0391-3988}, pages = {426 -- 426}, year = {2010}, language = {en} } @article{JansenBehbahaniLaumenetal.2010, author = {Jansen, Sebastian and Behbahani, Mehdi and Laumen, Marco and Kaufmann, Tim and Hormes, Marcus and Schmitz-Rode, Thomas and Behr, Marek and Steinseifer, Ulrich}, title = {3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques}, year = {2010}, language = {en} } @article{BehbahaniTranJockenhoeveletal.2011, author = {Behbahani, Mehdi and Tran, L. and Jockenh{\"o}vel, S. and Behr, M. and Mottaghy, K.}, title = {Numerical prediction of thrombocyte reactions for application to a vascular flow model}, series = {British Journal of Surgery}, volume = {98}, journal = {British Journal of Surgery}, number = {S5}, publisher = {Oxford University Press}, address = {Oxford}, isbn = {1365-2168}, pages = {S17}, year = {2011}, language = {en} } @article{BehbahaniTranWalugaetal.2009, author = {Behbahani, Mehdi and Tran, L. and Waluga, C. and Behr, M. and Oedekoven, B. and Mottaghy, K.}, title = {Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices}, series = {The International Journal of Artificial Organs. 32 (2009), H. 7}, journal = {The International Journal of Artificial Organs. 32 (2009), H. 7}, isbn = {0391-3988}, pages = {398 -- 398}, year = {2009}, language = {en} } @article{BehbahaniNamWalugaetal.2010, author = {Behbahani, Mehdi and Nam, J. and Waluga, C. and Behr, M. and Pasquali, M. and Mottaghy, K.}, title = {Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs}, doi = {10.1097/01.mat.0000369377.65122.a3}, year = {2010}, language = {en} } @article{JansenBehbahaniLaumenetal.2010, author = {Jansen, S. V. and Behbahani, Mehdi and Laumen, M. and Kaufmann, T. and Hormes, M. and Behr, M. and Schmitz-Rode, T. and Steinseifer, U.}, title = {Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation}, year = {2010}, language = {en} } @article{NamAroraBehbahanietal.2010, author = {Nam, J. and Arora, D. and Behbahani, Mehdi and Probst, M. and Benkowski, R. and Behr, M. and Pasquali, M.}, title = {New computational method in hemolysis analysis for artificial heart pump}, year = {2010}, language = {en} } @article{BehbahaniProbstMaietal.2010, author = {Behbahani, Mehdi and Probst, M. and Mai, A. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.}, title = {Numerical Prediction of Blood Damage in Biomedical Devices}, year = {2010}, language = {en} } @article{ProbstBehbahaniBorrmannetal.2010, author = {Probst, M. and Behbahani, Mehdi and Borrmann, E. and Elgeti, S. and Nicolai, M. and Behr, M.}, title = {Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices}, year = {2010}, language = {en} } @article{BehbahaniWalugaStocketal.2009, author = {Behbahani, Mehdi and Waluga, C. and Stock, S. and Mai, A. and Bergmann, B. and Behr, M. and Tran, L. and Vonderstein, K. and Scheidt, H. and Oedekoven, B. and Mottaghy, K.}, title = {Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth}, year = {2009}, language = {en} } @article{BehbahaniMaiBergmannetal.2010, author = {Behbahani, Mehdi and Mai, A. and Bergmann, B. and Waluga, C. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.}, title = {Modeling and Numerical Simulation of Blood Damage}, year = {2010}, language = {en} } @article{BehbahaniWalugaArltetal.2008, author = {Behbahani, Mehdi and Waluga, C. and Arlt, S. and Behr, M. and Mottaghy, K.}, title = {Computational Analysis of Platelet Aggregation in a Taylor-Couette System}, series = {The International Journal of Artificial Organs. 31 (2008), H. 7}, journal = {The International Journal of Artificial Organs. 31 (2008), H. 7}, isbn = {0391-3988}, pages = {643}, year = {2008}, language = {en} } @article{BehbahaniMaiWalugaetal.2010, author = {Behbahani, Mehdi and Mai, A. and Waluga, C. and Bergmann, B. and Tran, L. and Vonderstein, K. and Behr, M. and Mottaghy, K.}, title = {Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions}, series = {Acta Physiologica}, volume = {198}, journal = {Acta Physiologica}, number = {Supplement 677}, isbn = {1748-1716}, pages = {185}, year = {2010}, language = {en} } @article{JiminezGermanBehbahaniMiettinenetal.2013, author = {Jiminez German, Salvador and Behbahani, Mehdi and Miettinen, Susanna and Grijpma, Dirk W. and Haimi, Suvi P.}, title = {Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes}, series = {Macromolecular symposia}, volume = {Vol. 334}, journal = {Macromolecular symposia}, number = {Iss. 1}, publisher = {Wiley}, address = {Weinheim}, issn = {0258-0322}, pages = {133 -- 142}, year = {2013}, language = {en} } @article{PookhalilAmoabedinyTabeshetal.2016, author = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow}, title = {A new approach for semiempirical modeling of mechanical blood trauma}, series = {The international journal of artificial organs}, volume = {39}, journal = {The international journal of artificial organs}, number = {4}, publisher = {Sage}, address = {London}, issn = {1724-6040}, doi = {10.5301/ijao.5000474}, pages = {171 -- 177}, year = {2016}, abstract = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.}, language = {en} } @article{KoppSchunckGosauetal.2020, author = {Kopp, Alexander and Schunck, Laura and Gosau, Martin and Smeets, Ralf and Burg, Simon and Fuest, Sandra and Kr{\"o}ger, Nadja and Zinser, Max and Krohn, Sebastian and Behbahani, Mehdi and K{\"o}pf, Marius and Lauts, Lisa and Rutkowski, Rico}, title = {Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {18 art. no. 6704}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms21186704}, year = {2020}, abstract = {In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.}, language = {en} } @article{BrockhausBehbahaniMurisetal.2021, author = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.}, title = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept}, series = {Artificial Organs}, volume = {45}, journal = {Artificial Organs}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.14046}, pages = {1513 -- 1521}, year = {2021}, abstract = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.}, language = {en} } @phdthesis{Behbahani2011, author = {Behbahani, Mehdi}, title = {Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices}, publisher = {Verlag Dr. Hut}, address = {M{\"u}nchen}, isbn = {978-3-8439-0134-5}, year = {2011}, language = {en} } @article{MandekarHollandThielenetal.2022, author = {Mandekar, Swati and Holland, Abigail and Thielen, Moritz and Behbahani, Mehdi and Melnykowycz, Mark}, title = {Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG}, series = {Sensors}, volume = {22}, journal = {Sensors}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s22041568}, pages = {1 -- 19}, year = {2022}, abstract = {Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG.}, language = {en} } @article{TranMottaghyArltKoerferetal.2017, author = {Tran, Linda and Mottaghy, K. and Arlt-K{\"o}rfer, Sabine and Waluga, Christian and Behbahani, Mehdi}, title = {An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system}, series = {Biomedizinische Technik}, volume = {62}, journal = {Biomedizinische Technik}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0013-5585}, doi = {10.1515/bmt-2015-0034}, pages = {383 -- 392}, year = {2017}, language = {en} } @article{KoppSchmeetsGosauetal.2019, author = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders}, title = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application}, series = {In Vivo}, volume = {33}, journal = {In Vivo}, number = {3}, issn = {1791-7549}, doi = {10.21873/invivo.11536}, pages = {757 -- 762}, year = {2019}, language = {en} } @inproceedings{MandekarJentschLutzetal.2021, author = {Mandekar, Swati and Jentsch, Lina and Lutz, Kai and Behbahani, Mehdi and Melnykowycz, Mark}, title = {Earable design analysis for sleep EEG measurements}, series = {UbiComp '21}, booktitle = {UbiComp '21}, doi = {10.1145/3460418.3479328}, pages = {171 -- 175}, year = {2021}, abstract = {Conventional EEG devices cannot be used in everyday life and hence, past decade research has been focused on Ear-EEG for mobile, at-home monitoring for various applications ranging from emotion detection to sleep monitoring. As the area available for electrode contact in the ear is limited, the electrode size and location play a vital role for an Ear-EEG system. In this investigation, we present a quantitative study of ear-electrodes with two electrode sizes at different locations in a wet and dry configuration. Electrode impedance scales inversely with size and ranges from 450 kΩ to 1.29 MΩ for dry and from 22 kΩ to 42 kΩ for wet contact at 10 Hz. For any size, the location in the ear canal with the lowest impedance is ELE (Left Ear Superior), presumably due to increased contact pressure caused by the outer-ear anatomy. The results can be used to optimize signal pickup and SNR for specific applications. We demonstrate this by recording sleep spindles during sleep onset with high quality (5.27 μVrms).}, language = {en} }