@article{WeldenNagamineKomesuWagneretal.2021, author = {Welden, Rene and Nagamine Komesu, Cindy A. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment}, series = {Electrochemical Science Advances}, volume = {2}, journal = {Electrochemical Science Advances}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {2698-5977}, doi = {10.1002/elsa.202100131}, pages = {1 -- 5}, year = {2021}, abstract = {Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.}, language = {en} } @article{JablonskiPoghossianKeusgenetal.2021, author = {Jablonski, Melanie and Poghossian, Arshak and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Detection of plant virus particles with a capacitive field-effect sensor}, series = {Analytical and Bioanalytical Chemistry}, volume = {413}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer Nature}, address = {Cham}, issn = {1618-2650}, doi = {10.1007/s00216-021-03448-8}, pages = {5669 -- 5678}, year = {2021}, abstract = {Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bjoern and Staeudle, Benjamin and Attias, Julia and Suess, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity}, series = {npj Microgravity}, volume = {7}, journal = {npj Microgravity}, number = {Article number: 32}, publisher = {Springer Nature}, address = {New York}, issn = {2373-8065}, doi = {10.1038/s41526-021-00155-7}, pages = {7 Seiten}, year = {2021}, abstract = {Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70\% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle-series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bj{\"o}rn and St{\"a}udle, Benjamin and Attias, Julia and S{\"u}ss, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, J{\"o}rn and Green, David A. and Albracht, Kirsten}, title = {Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities}, series = {Scientific reports}, volume = {11}, journal = {Scientific reports}, number = {Article number: 22555}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-021-00527-9}, pages = {13 Seiten}, year = {2021}, abstract = {The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.}, language = {en} } @article{TippkoetterRoth2020, author = {Tippk{\"o}tter, Nils and Roth, Jasmine}, title = {Purified Butanol from Lignocellulose - Solvent-Impregnated Resins for an Integrated Selective Removal}, series = {Chemie Ingenieur Technik}, volume = {92}, journal = {Chemie Ingenieur Technik}, number = {11}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1522-2640}, doi = {10.1002/cite.202000200}, pages = {1741 -- 1751}, year = {2020}, abstract = {In traditional microbial biobutanol production, the solvent must be recovered during fermentation process for a sufficient space-time yield. Thermal separation is not feasible due to the boiling point of n-butanol. As an integrated and selective solid-liquid separation alternative, solvent impregnated resins (SIRs) were applied. Two polymeric resins were evaluated and an extractant screening was conducted. Vacuum application with vapor collection in fixed-bed column as bioreactor bypass was successfully implemented as butanol desorption step. In course of further increasing process economics, fermentation with renewable lignocellulosic substrates was conducted using Clostridium acetobutylicum. Utilization of SIR was shown to be a potential strategy for solvent removal from fermentation broth, while application of a bypass column allows for product removal and recovery at once.}, language = {en} } @article{PfaffGidaszewskiSchmidt2020, author = {Pfaff, Raphael and Gidaszewski, Lars and Schmidt, Bernd}, title = {Ber{\"u}cksichtigung von No Fault Found im Diagnose- und Instandhaltungssystem von Schienenfahrzeugen}, series = {ETR - Eisenbahntechnische Rundschau}, journal = {ETR - Eisenbahntechnische Rundschau}, number = {5}, publisher = {DVV Media Group}, address = {Hamburg}, issn = {0013-2845}, pages = {56 -- 59}, year = {2020}, abstract = {Intermittierende und nicht reproduzierbare Fehler, auch als No Fault Found bezeichnet, treten in praktisch allen Bereichen auf und sorgen f{\"u}r hohe Kosten. Diese sind h{\"a}ufig auf unpr{\"a}zise Fehlerbeschreibungen zur{\"u}ckzuf{\"u}hren. Im vorliegenden Beitrag werden Anpassungen der Vorgehensweise bei der Entwicklung und Anpassungen des Diagnosesystems vorgeschlagen.}, language = {de} } @article{DachwaldUlamecPostbergetal.2020, author = {Dachwald, Bernd and Ulamec, Stephan and Postberg, Frank and Sohl, Frank and Vera, Jean-Pierre de and Christoph, Waldmann and Lorenz, Ralph D. and Hellard, Hugo and Biele, Jens and Rettberg, Petra}, title = {Key technologies and instrumentation for subsurface exploration of ocean worlds}, series = {Space Science Reviews}, volume = {216}, journal = {Space Science Reviews}, number = {Art. 83}, publisher = {Springer}, address = {Dordrecht}, issn = {1572-9672}, doi = {10.1007/s11214-020-00707-5}, pages = {45}, year = {2020}, abstract = {In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter's moon Europa and Saturn's moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or - in the case of Enceladus - plume-fly-through missions.}, language = {en} } @article{FingerGoettenBraunetal.2020, author = {Finger, Felix and G{\"o}tten, Falk and Braun, Carsten and Bil, Cees}, title = {Mass, primary energy, and cost: the impact of optimization objectives on the initial sizing of hybrid-electric general aviation aircraft}, series = {CEAS Aeronautical Journal}, volume = {2020}, journal = {CEAS Aeronautical Journal}, number = {11}, publisher = {Springer}, address = {Heidelberg}, issn = {1869-5590}, doi = {10.1007/s13272-020-00449-8}, pages = {713 -- 730}, year = {2020}, abstract = {For short take-off and landing (STOL) aircraft, a parallel hybrid-electric propulsion system potentially offers superior performance compared to a conventional propulsion system, because the short-take-off power requirement is much higher than the cruise power requirement. This power-matching problem can be solved with a balanced hybrid propulsion system. However, there is a trade-off between wing loading, power loading, the level of hybridization, as well as range and take-off distance. An optimization method can vary design variables in such a way that a minimum of a particular objective is attained. In this paper, a comparison between the optimization results for minimum mass, minimum consumed primary energy, and minimum cost is conducted. A new initial sizing algorithm for general aviation aircraft with hybrid-electric propulsion systems is applied. This initial sizing methodology covers point performance, mission performance analysis, the weight estimation process, and cost estimation. The methodology is applied to the design of a STOL general aviation aircraft, intended for on-demand air mobility operations. The aircraft is sized to carry eight passengers over a distance of 500 km, while able to take off and land from short airstrips. Results indicate that parallel hybrid-electric propulsion systems must be considered for future STOL aircraft.}, language = {en} } @article{EggertMoulen2020, author = {Eggert, Mathias and Moulen, Tobias}, title = {Selektion von Gesch{\"a}ftsprozessen zur Anwendung von Robotic Process Automation am Beispiel einer Versicherung}, series = {HMD Praxis der Wirtschaftsinformatik}, volume = {57}, journal = {HMD Praxis der Wirtschaftsinformatik}, number = {6}, publisher = {Springer}, address = {Weinheim}, issn = {1436-3011}, doi = {10.1365/s40702-020-00665-0}, pages = {1150 -- 1162}, year = {2020}, abstract = {H{\"a}ufig bremsen geringe IT-Ressourcen, fehlende Softwareschnittstellen oder eine veraltete und komplex gewachsene Systemlandschaft die Automatisierung von Gesch{\"a}ftsprozessen. Robotic Process Automation (RPA) ist eine vielversprechende Methode, um Gesch{\"a}ftsprozesse oberfl{\"a}chenbasiert und ohne gr{\"o}ßere Systemeingriffe zu automatisieren und Medienbr{\"u}che abzubauen. Die Auswahl der passenden Prozesse ist dabei f{\"u}r den Erfolg von RPA-Projekten entscheidend. Der vorliegende Beitrag liefert daf{\"u}r Selektionskriterien, die aus einer qualitativen Inhaltanalyse von elf Interviews mit RPA-Experten aus dem Versicherungsumfeld resultieren. Das Ergebnis umfasst eine gewichtetet Liste von sieben Dimensionen und 51 Prozesskriterien, welche die Automatisierung mit Softwarerobotern beg{\"u}nstigen bzw. deren Nichterf{\"u}llung eine Umsetzung erschweren oder sogar verhindern. Die drei wichtigsten Kriterien zur Auswahl von Gesch{\"a}ftsprozessen f{\"u}r die Automatisierung mittels RPA umfassen die Entlastung der an dem Prozess mitwirkenden Mitarbeiter (Arbeitnehmer{\"u}berlastung), die Ausf{\"u}hrbarkeit des Prozesses mittels Regeln (Regelbasierte Prozessteuerung) sowie ein positiver Kosten-Nutzen-Vergleich. Praktiker k{\"o}nnen diese Kriterien verwenden, um eine systematische Auswahl von RPA-relevanten Prozessen vorzunehmen. Aus wissenschaftlicher Perspektive stellen die Ergebnisse eine Grundlage zur Erkl{\"a}rung des Erfolgs und Misserfolgs von RPA-Projekten dar.}, language = {de} } @article{WingensMayPfaff2019, author = {Wingens, Niklas and May, J{\"o}rg and Pfaff, Raphael}, title = {Betrieblich-technische Innovationsans{\"a}tze zur Bremsprobe nach einer Prozess{\"a}nderung}, series = {Eisenbahntechnische Rundschau : ETR ; Zeitschrift f{\"u}r die gesamte Eisenbahntechnik}, journal = {Eisenbahntechnische Rundschau : ETR ; Zeitschrift f{\"u}r die gesamte Eisenbahntechnik}, number = {5}, publisher = {DVV Media Group}, address = {Hamburg}, issn = {0013-2845}, pages = {5}, year = {2019}, language = {de} }