@inproceedings{HunkerJungGossmannetal.2019, author = {Hunker, Jan and Jung, Alexander and Goßmann, Matthias and Linder, Peter and Staat, Manfred}, title = {Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {7 -- 8}, year = {2019}, abstract = {The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.}, language = {en} } @inproceedings{GrundmannBauerBorchersetal.2018, author = {Grundmann, Jan Thimo and Bauer, Waldemar and Borchers, Kai and Dumont, Etienne and Grimm, Christian D. and Ho, Tra-Mi and Jahnke, Rico and Lange, Caroline and Maiwald, Volker and Mikulz, Eugen and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Sasaki, Kaname and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Toth, Norbert and Wejmo, Elisabet and Biele, Jens and Krause, Christian and Cerotti, Matteo and Peloni, Alessandro and Dachwald, Bernd}, title = {Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing}, series = {2018 IEEE Aerospace Conference : 3-10 March 2018}, booktitle = {2018 IEEE Aerospace Conference : 3-10 March 2018}, isbn = {978-1-5386-2014-4}, pages = {20 Seiten}, year = {2018}, language = {en} } @inproceedings{RichterBraunsteinStaeudleetal.2018, author = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, T. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices}, series = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland}, booktitle = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland}, year = {2018}, language = {en} } @inproceedings{MarinovaKerroumiLintermannetal.2016, author = {Marinova, V. and Kerroumi, I. and Lintermann, A. and G{\"o}bbert, J.H. and Moulinec, C. and Rible, S. and Fournier, Y. and Behbahani, Mehdi}, title = {Numerical Analysis of the FDA Centrifugal Blood Pump}, series = {NIC Symposium 2016}, booktitle = {NIC Symposium 2016}, isbn = {978-3-95806-109-5}, pages = {355 -- 364}, year = {2016}, language = {de} } @inproceedings{BehbahaniRibleMoulinecetal.2015, author = {Behbahani, Mehdi and Rible, Sebastian and Moulinec, Charles and Fournier, Yvan and Nicolai, Mike and Crosetto, Paolo}, title = {Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing}, series = {World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering}, volume = {9}, booktitle = {World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering}, number = {5}, year = {2015}, language = {en} } @inproceedings{Behbahani2014, author = {Behbahani, Mehdi}, title = {An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress}, series = {Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014}, booktitle = {Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014}, pages = {Paper 125}, year = {2014}, language = {en} } @inproceedings{KahmannUschokWegmannetal.2018, author = {Kahmann, Stephanie Lucina and Uschok, Stephan and Wegmann, Kilian and M{\"u}ller, Lars-P. and Staat, Manfred}, title = {Biomechanical multibody model with refined kinematics of the elbow}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {11 Seiten}, year = {2018}, abstract = {The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent.}, language = {en} } @inproceedings{TranMatthiesStavroulakisetal.2018, author = {Tran, Ngoc Trinh and Matthies, Hermann G. and Stavroulakis, Georgios Eleftherios and Staat, Manfred}, title = {Direct plastic structural design by chance constrained programming}, series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK}, pages = {12 Seiten}, year = {2018}, abstract = {We propose a stochastic programming method to analyse limit and shakedown of structures under random strength with lognormal distribution. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit or the shakedown limit. The edge-based smoothed finite element method (ES-FEM) using three-node linear triangular elements is used.}, language = {en} } @inproceedings{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Pectopexy to repair vaginal vault prolapse: a finite element approach}, series = {Proceedings CMBBE 2018}, booktitle = {Proceedings CMBBE 2018}, editor = {Fernandes, P.R. and Tavares, J. M.}, year = {2018}, abstract = {The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient's anatomy and the surgeon's preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes.}, language = {en} } @inproceedings{GrundmannMessBieleetal.2017, author = {Grundmann, Jan Thimo and Meß, Jan-Gerd and Biele, Jens and Seefeldt, Patric and Dachwald, Bernd and Spietz, Peter and Grimm, Christian D. and Spr{\"o}witz, Tom and Lange, Caroline and Ulamec, Stephan}, title = {Small spacecraft in small solar system body applications}, series = {IEEE Aerospace Conference 2017, Big Sky, Montana, USA}, booktitle = {IEEE Aerospace Conference 2017, Big Sky, Montana, USA}, organization = {IEEE Aerospace Conference}, isbn = {978-1-5090-1613-6}, doi = {10.1109/AERO.2017.7943626}, pages = {1 -- 20}, year = {2017}, language = {en} }