@inproceedings{KronigerHorikawaFunkeetal.2021, author = {Kroniger, Daniel and Horikawa, Atsushi and Funke, Harald and Pf{\"a}ffle, Franziska}, title = {Numerical investigation of micromix hydrogen flames at different combustor pressure levels}, series = {The Proceedings of the International Conference on Power Engineering (ICOPE)}, booktitle = {The Proceedings of the International Conference on Power Engineering (ICOPE)}, doi = {10.1299/jsmeicope.2021.15.2021-0237}, pages = {4 Seiten}, year = {2021}, abstract = {This study investigates the influence of pressure on the temperature distribution of the micromix (MMX) hydrogen flame and the NOx emissions. A steady computational fluid dynamic (CFD) analysis is performed by simulating a reactive flow with a detailed chemical reaction model. The numerical analysis is validated based on experimental investigations. A quantitative correlation is parametrized based on the numerical results. We find, that the flame initiation point shifts with increasing pressure from anchoring behind a downstream located bluff body towards anchoring upstream at the hydrogen jet. The numerical NOx emissions trend regarding to a variation of pressure is in good agreement with the experimental results. The pressure has an impact on both, the residence time within the maximum temperature region and on the peak temperature itself. In conclusion, the numerical model proved to be adequate for future prototype design exploration studies targeting on improving the operating range.}, language = {en} } @article{MonakhovaDiehl2021, author = {Monakhova, Yulia and Diehl, Bernd W.K.}, title = {Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard}, series = {Talanta}, volume = {222}, journal = {Talanta}, number = {Article number: 121504}, publisher = {Elsevier}, isbn = {0039-9140}, doi = {10.1016/j.talanta.2020.121504}, year = {2021}, abstract = {Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).}, language = {en} } @article{AlbannaConzenWeissetal.2021, author = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, number = {12}, issn = {1664-2295}, doi = {10.3389/fneur.2021.690183}, pages = {1 -- 15}, year = {2021}, abstract = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.}, language = {en} } @article{Golland2021, author = {Golland, Alexander}, title = {Neuregelungen zum Datenschutz: Ein Update f{\"u}r Website-Betreiber. Reform des Telekommunikations- und Telemedienrechts verabschiedet}, series = {NWB Rechnungswesen - BBK}, journal = {NWB Rechnungswesen - BBK}, number = {14}, isbn = {0340-9848}, pages = {672 -- 674}, year = {2021}, language = {de} } @masterthesis{Muehl2021, type = {Bachelor Thesis}, author = {M{\"u}hl, Leonie}, title = {Neues Erscheinungsbild f{\"u}r den APX: Redesign des LVR - Arch{\"a}ologischen Park Xanten und des R{\"o}mermuseums}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {90 Seiten}, year = {2021}, abstract = {Der Arch{\"a}ologische Park Xanten (APX) gilt als Deutschlands einziger arch{\"a}ologischer Freiluftpark. Er zeichnet sich im Verbund mit dem R{\"o}mermuseum durch seine Lage auf dem historischen Grund einer r{\"o}mischen Metropole und seine kontinuierliche Forschungsaktivit{\"a}t aus und bietet so ein einzigartiges Umfeld von kultureller Relevanz. Ziel dieses Projektes war es, ein neues Erscheinungsbild zu entwickeln, welches klar die Thematik des Parks in den Medien erkennbar macht. Das Corporate Design dient dazu, die Inhalte des Verbundes in einem einheitlichen System medien{\"u}bergreifend zu pr{\"a}sentieren. Das Design unterst{\"u}tzt den APX in seiner Funktion als Begegnungs- und Bildungsst{\"a}tte. Aufgrund dessen ist es im Hinblick auf das Ziel relevant, das Interesse an Kulturgeschichte und Forschung zu wecken.}, language = {de} } @masterthesis{Khalaimova2021, type = {Bachelor Thesis}, author = {Khalaimova, Karina}, title = {Neuerfindung der Ligaturen}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {43 Seiten}, year = {2021}, abstract = {Gegenstand des Projekts ist, Ligaturen als erweiterte Mittel der Informations{\"u}bertragung einzusetzen. Ligaturen als zus{\"a}tzliches Instrument sollen die visuelle Komponente des Textes unterst{\"u}tzen, ihm die gewisse Frische einhauchen und ihn hiermit insgesamt sichtbarer, origineller und moderner machen. Der Einsatzbereich erstreckt sich hierbei in die verschiedensten Bereiche hin {\"u}ber Design und Werbung, als auch im Handel oder in sozialen Bereichen. Hierbei kann eine große Anzahl an W{\"o}rtern neue Formen annehmen und mithin an neuem Leben und Bedeutung gewinnen, was sicherlich die allgemeinen Sprachmittel bereichern wird. Auf einer historischen Basis und mit Hilfe der Dekonstruktion wurden neue Formen der Ligaturen geschaffen — seltsame, kontroverse, auff{\"a}llige und einzigartige.}, language = {de} } @article{MontiWaldvogelRitzmannetal.2021, author = {Monti, Elena and Waldvogel, Janice and Ritzmann, Ramona and Freyler, Kathrin and Albracht, Kirsten and Helm, Michael and De Cesare, Niccol{\`o} and Pavan, Piero and Reggiani, Carlo and Gollhofer, Albert and Narici, Marco Vincenzo}, title = {Muscle in variable gravity: "I do not know where I am, but I know what to do"}, series = {Frontiers in Physiology}, volume = {12}, journal = {Frontiers in Physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2021.714655}, pages = {19 Seiten}, year = {2021}, abstract = {Performing tasks, such as running and jumping, requires activation of the agonist and antagonist muscles before (motor unit pre-activation) and during movement performance (Santello and Mcdonagh, 1998). A well-timed and regulated muscle activation elicits a stretch-shortening cycle (SSC) response, naturally occurring in bouncing movements (Ishikawa and Komi, 2004; Taube et al., 2012). By definition, the SSC describes the stretching of a pre-activated muscle-tendon complex immediately followed by a muscle shortening in the concentric push-off phase (Komi, 1984). Given the importance of SSC actions for human movement, it is not surprising that many studies investigated the biomechanics of this phenomenon; in particular, drop jumps (DJs) represent a good paradigm to study muscle fascicle and tendon behavior in ballistic movements involving the SSC. Within a DJ, three main phases [pre-activation, braking, and push-off (PO; Komi, 2000)] have been recognized and extensively studied in common and challenging conditions, such as changes in load, falling height, or simulated hypo-gravity (Avela et al., 1994; Arampatzis et al., 2001; Fukashiro et al., 2005; Ishikawa et al., 2005; Sousa et al., 2007; Ritzmann et al., 2016; Helm et al., 2020). These studies show that the timing and amount of triceps-surae muscle-tendon unit pre-activation in DJs are differentially regulated based on the load applied to the muscle, being optimal in normal "Earth" gravity conditions (Avela et al., 1994), but decreased in simulated hypo-gravity, hyper-gravity (Avela et al., 1994; Ritzmann et al., 2016), or unknown conditions (i.e., unknown falling heights; Helm et al., 2020). Some authors indicated that, when falling from heights different from the optimal one [defined as the drop height giving a maximum DJ performance indicated as peak ground reaction force (GRF) or jump high], electromyographic (EMG) activity of the plantar flexors increases from lower than optimal to higher than optimal heights (Ishikawa and Komi, 2004; Sousa et al., 2007). These findings highlight the ability of the central nervous system to regulate the timing and amount of pre-activation according to different jumping conditions, thus regulating muscle fascicle length, tendon and joint stiffness as well as position, in order to safely land on the ground and quickly re-bounce. Similarly, to pre-activation, also in the braking phase, the plantar flexors are differentially regulated. In optimal height (i.e., load) jumping conditions, gastrocnemius medialis (GM) fascicles shorten at early ground contact (possibly due to the intervention of the stretch reflex; Gollhofer et al., 1992) and behave quasi-isometrically in the late braking phase, enabling tendon elongation, and storage of elastic energy (Gollhofer et al., 1992; Fukashiro et al., 2005; Sousa et al., 2007). When increasing the falling height (augmenting the impact GRF), the quasi-isometric behavior of fascicles disappears, and fast fascicle lengthening occurs (Ishikawa et al., 2005; Sousa et al., 2007). In the third and last PO phase, fascicles shorten and the tendon releases the elastic energy previously stored. Bobbert et al. (1987) reported no influence of jumping height on the work done and on the net vertical impulse assessed during PO; this observation suggests that, despite an optimal DJ performance might be achieved only in specific conditions (falling heights, loads), the central nervous system seems to be able to regulate muscle behavior in order to effectively perform the required task also in challenging situations. Although the regulation of triceps-surae muscle-tendon unit in DJs has been extensively investigated, very few studies focused on sarcomeres behavior during the performance of this SSC movement (Kurokawa et al., 2003; Fukashiro et al., 2005, 2006). Sarcomeres represent muscle contractile units and are known to express different amounts of force depending on their length (Gordon et al., 1966; Walker and Schrodt, 1974); thus, understanding the time course of their responses during DJs is fundamental to gain further insights into muscle force-generating capacity. In vivo measurement of sarcomere length in humans has been so far been performed only in static positions and under highly controlled experimental conditions (Llewellyn et al., 2008; Sanchez et al., 2015). Instead, human sarcomere length estimation (achieved by dividing GM measured fascicle length for a fixed sarcomere number) in dynamic contractions provided an indirect measure of sarcomere operating range during squat jump, countermovement jump, and DJ (Fukashiro et al., 2005, 2006; Kurokawa et al., 2003). The results of these studies showed that sarcomeres operate in the ascending limb of their length-tension (L-T) relationship in all types of jumps, and particularly so in DJ. However, most of the available observations on sarcomere and muscle fascicle behavior were made in condition of constant gravity. Thus, in order to understand how sarcomere and muscle fascicle length are regulated in variable gravity conditions, we performed experiments in a parabolic flight, involving variable gravity levels, ranging from about zero-g to about double the Earth's gravity (1 g; Waldvogel et al., 2021). Specifically, the aims of the present study were as follows: 1. To investigate the ability of the neuromuscular system in regulating fascicle length in response to conditions of variable gravity. 2. To estimate sarcomere operative length in the different DJ phases, in order to calculate its theoretical force production and its possible modulation in conditions of variable gravity. We hypothesized that muscle fascicles would be differentially regulated in different gravity conditions compared to 1 g, particularly in anticipation of landing and re-bouncing in unknown gravity levels. In addition, we hypothesized that sarcomeres would operate in the upper part of the ascending limb of their L-T relationship, possibly lengthening during the braking phase (especially in hyper-gravity) while operating quasi-isometrically in 1 g.}, language = {en} } @article{PourshahidiAchtsnichtNambipareecheeetal.2021, author = {Pourshahidi, Ali Mohammad and Achtsnicht, Stefan and Nambipareechee, Mrinal Murali and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim}, title = {Multiplex detection of magnetic beads using offset field dependent frequency mixing magnetic detection}, series = {Sensors}, volume = {21}, journal = {Sensors}, number = {17}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s21175859}, pages = {16 Seiten}, year = {2021}, abstract = {Magnetic immunoassays employing Frequency Mixing Magnetic Detection (FMMD) have recently become increasingly popular for quantitative detection of various analytes. Simultaneous analysis of a sample for two or more targets is desirable in order to reduce the sample amount, save consumables, and save time. We show that different types of magnetic beads can be distinguished according to their frequency mixing response to a two-frequency magnetic excitation at different static magnetic offset fields. We recorded the offset field dependent FMMD response of two different particle types at frequencies ƒ₁ + n⋅ƒ₂, n = 1, 2, 3, 4 with ƒ₁ = 30.8 kHz and ƒ₂ = 63 Hz. Their signals were clearly distinguishable by the locations of the extremes and zeros of their responses. Binary mixtures of the two particle types were prepared with different mixing ratios. The mixture samples were analyzed by determining the best linear combination of the two pure constituents that best resembled the measured signals of the mixtures. Using a quadratic programming algorithm, the mixing ratios could be determined with an accuracy of greater than 14\%. If each particle type is functionalized with a different antibody, multiplex detection of two different analytes becomes feasible.}, language = {en} } @inproceedings{KloeserKohlKraftetal.2021, author = {Kl{\"o}ser, Lars and Kohl, Philipp and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Multi-attribute relation extraction (MARE): simplifying the application of relation extraction}, series = {Proceedings of the 2nd International Conference on Deep Learning Theory and Applications DeLTA - Volume 1}, booktitle = {Proceedings of the 2nd International Conference on Deep Learning Theory and Applications DeLTA - Volume 1}, publisher = {SciTePress}, address = {Set{\´u}bal}, isbn = {978-989-758-526-5}, doi = {10.5220/0010559201480156}, pages = {148 -- 156}, year = {2021}, abstract = {Natural language understanding's relation extraction makes innovative and encouraging novel business concepts possible and facilitates new digitilized decision-making processes. Current approaches allow the extraction of relations with a fixed number of entities as attributes. Extracting relations with an arbitrary amount of attributes requires complex systems and costly relation-trigger annotations to assist these systems. We introduce multi-attribute relation extraction (MARE) as an assumption-less problem formulation with two approaches, facilitating an explicit mapping from business use cases to the data annotations. Avoiding elaborated annotation constraints simplifies the application of relation extraction approaches. The evaluation compares our models to current state-of-the-art event extraction and binary relation extraction methods. Our approaches show improvement compared to these on the extraction of general multi-attribute relations.}, language = {en} } @masterthesis{MeinersSchneider2021, type = {Bachelor Thesis}, author = {Meiners, Sonja and Schneider, Sophie}, title = {MULO - Multifunktionale Objekte: Eine Serie multifunktionaler Wohnobjekte}, publisher = {FH Aachen}, address = {Aachen}, pages = {137 Seiten}, year = {2021}, abstract = {Mit MULO wurde eine Serie multifunktionaler Objekte f{\"u}r den Wohnbereich entworfen. In Zeiten des {\"U}berangebots und des st{\"a}ndigen Wohnraumwechsels soll der Nutzer dieser Objekte mit einem modernen und schlichten Design unterst{\"u}tzt werden, das zu jedem Anlass passt. Die minimalistische {\"A}sthetik mit hohem Komfort orientiert sich dabei an den Bed{\"u}rfnissen des Endverbrauchers. Als Verwandlungsk{\"u}nstler bereichert MULO jeden Wohnraum. Die gesamte Serie ist unter der Ber{\"u}cksichtigung der schnelllebigen und sich wandelnden Welt entworfen worden. Mit multifunktionalen Objekten ist das Produkt den flexiblen Anforderungen und Bed{\"u}rfnissen des Menschen gewachsen. Die Bereiche Wohnen, Leben, Arbeiten, Schlafen und Entspannen werden durch das Sofa- , das Tisch- und das Keramik-System optimal abgedeckt. Durch die Verwendung von nachhaltigen und recycelbaren Materialien, setzt MULO ein kleines Statement und hinterl{\"a}sst nachhaltig Eindruck.}, language = {de} }