@article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @inproceedings{KazukiKobayashiHirabayashietal.2019, author = {Kazuki, Yasuhiro and Kobayashi, Kaoru and Hirabayashi, Masumi and Abe, Satoshi and Kajitani, Naoyo and Kazuki, Kanoko and Takehara, Shoko and Takiguchi, Masato and Satoh, Daisuke and Kuze, Jiro and Sakuma, Tetsushi and Kaneko, Takehito and Mashimo, Tomoji and Osamura, Minori and Hashimoto, Mari and Wakatsuki, Riko and Hirashima, Rika and Fujiwara, Ryoichi and Deguchi, Tsuneo and Kurihara, Atsushi and Tsukazaki, Yasuko and Senda, Naoto and Yamamoto, Takashi and Scheer, Nico and Oshimura, Mitsuo}, title = {Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism}, series = {PNAS Proceedings of the National Academy of Sciences of the United States of America}, volume = {116}, booktitle = {PNAS Proceedings of the National Academy of Sciences of the United States of America}, number = {8}, issn = {1091-6490}, doi = {10.1073/pnas.1808255116}, pages = {3072 -- 3081}, year = {2019}, language = {en} } @inproceedings{GierseKraemerDaabetal.2013, author = {Gierse, Andreas and Kr{\"a}mer, Stefan and Daab, Dominique J. and Hessel, Joana and Baader, Fabian and M{\"u}ller, Brigitte S. and Wagner, Tobias and Gdalewitsch, Georg and Plescher, Engelbert and Pf{\"u}tzenreuter, Lysan}, title = {Experimental in-flight modal-analysis of a sounding rocket structure}, series = {21st ESA Symposium on Rocket and Ballon related Research}, booktitle = {21st ESA Symposium on Rocket and Ballon related Research}, isbn = {9789290922858}, pages = {341 -- 346}, year = {2013}, language = {en} } @article{HueningHillgaertnerReke2019, author = {H{\"u}ning, Felix and Hillg{\"a}rtner, Michael and Reke, Michael}, title = {Rolling Labs - Teaching Vehicle Electronics from the Beginning}, series = {International Journal of Engineering Pedagogy (iJEP)}, volume = {9}, journal = {International Journal of Engineering Pedagogy (iJEP)}, number = {1}, issn = {2192-4880}, doi = {10.3991/ijep.v9i1.9241}, pages = {34 -- 49}, year = {2019}, language = {en} } @inproceedings{KunfermannDrumm2005, author = {Kunfermann, Philipp and Drumm, Christian}, title = {Lifting XML schemas to ontologies - the concept finder algorithm}, series = {MEDIATE 2005 First International Workshop on Mediation in Semantic Web Services Proceedings of the First International Workshop on Mediation in Semantic Web Services (MEDIATE 2005)}, booktitle = {MEDIATE 2005 First International Workshop on Mediation in Semantic Web Services Proceedings of the First International Workshop on Mediation in Semantic Web Services (MEDIATE 2005)}, pages = {113 -- 122}, year = {2005}, language = {en} } @inproceedings{DrummLemckeOberle2006, author = {Drumm, Christian and Lemcke, Jens and Oberle, Daniel}, title = {Integrating Semantic Web Services and Business Process Management: A Real Use Case}, series = {Proceedings of the ESWC 2006 Workshop Semantics for Business Process Management 2006 (SBPM 2006), June 2006}, booktitle = {Proceedings of the ESWC 2006 Workshop Semantics for Business Process Management 2006 (SBPM 2006), June 2006}, pages = {15 Seiten}, year = {2006}, language = {en} } @incollection{DrummLemckeOberle2007, author = {Drumm, Christian and Lemcke, Jens and Oberle, Daniel}, title = {Business Process Management And Semantic Technologies}, series = {The Semantic Web}, booktitle = {The Semantic Web}, publisher = {Springer}, address = {Boston, MA}, isbn = {978-0-387-48531-7}, doi = {10.1007/978-0-387-48531-7_10}, pages = {207 -- 239}, year = {2007}, language = {en} } @inproceedings{WeberMarkovicDrumm2007, author = {Weber, Ingo and Markovic, Ivan and Drumm, Christian}, title = {A conceptual framework for composition in business process management}, series = {Business Information Systems : 10th International Conference, BIS 2007, Poznan, Poland, April 25-27, 2007. Proceedings}, booktitle = {Business Information Systems : 10th International Conference, BIS 2007, Poznan, Poland, April 25-27, 2007. Proceedings}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-540-72035-5}, doi = {10.1007/978-3-540-72035-5_5}, pages = {54 -- 66}, year = {2007}, language = {en} } @inproceedings{DrummSchmittDoetal.2007, author = {Drumm, Christian and Schmitt, Matthias and Do, Hong-Hai and Rahm, Erhard}, title = {Quickmig: automatic schema matching for data migration projects}, series = {Proceedings of the 2007 ACM Conference on Information and Knowledge Management / CIKM'07, Lisboa, Portugal, Nov. 6 - 10, 2007}, booktitle = {Proceedings of the 2007 ACM Conference on Information and Knowledge Management / CIKM'07, Lisboa, Portugal, Nov. 6 - 10, 2007}, isbn = {978-1-59593-803-9}, doi = {10.1145/1321440.1321458}, pages = {107 -- 116}, year = {2007}, language = {en} } @article{RauppSchmittWalzetal.2018, author = {Raupp, Sebastian M. and Schmitt, Marcel and Walz, Anna-Lena and Diehm, Ralf and Hummel, Helga and Scharfer, Philip and Schabel, Wilhelm}, title = {Slot die stripe coating of low viscous fluids}, series = {Journal of Coatings Technology and Research}, volume = {15}, journal = {Journal of Coatings Technology and Research}, number = {5}, publisher = {Springer}, issn = {1935-3804}, doi = {10.1007/s11998-017-0039-y}, pages = {899 -- 911}, year = {2018}, abstract = {Slot die coating is applied to deposit thin and homogenous films in roll-to-roll and sheet-to-sheet applications. The critical step in operation is to choose suitable process parameters within the process window. In this work, we investigate an upper limit for stripe coatings. This maximum film thickness is characterized by stripe merging which needs to be avoided in a stable process. It is shown that the upper limit reduces the process window for stripe coatings to a major extent. As a result, stripe coatings at large coating gaps and low viscosities are only possible for relatively thick films. Explaining the upper limit, a theory of balancing the side pressure in the gap region in the cross-web direction has been developed.}, language = {en} }