@incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @incollection{AzatKerimkulovaMansurovetal.2020, author = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard}, title = {The Use of Fusicoccin as Anticancer Compound}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {New York}, isbn = {978-0-429-42864-7}, doi = {10.1201/9780429428647-8}, pages = {149 -- 172}, year = {2020}, abstract = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.}, language = {en} } @incollection{BaierBraunerBrillowskietal.2023, author = {Baier, Ralph and Brauner, Philipp and Brillowski, Florian and Dammers, Hannah and Liehner, Luca and P{\"u}tz, Sebastian and Schneider, Sebastian and Schollemann, Alexander and Steuer-Dankert, Linda and Vervier, Luisa and Gries, Thomas and Leicht-Scholten, Carmen and Mertens, Alexander and Nagel, Saskia K. and Schuh, G{\"u}nther and Ziefle, Martina and Nitsch, Verena}, title = {Human-centered work design for the internet of production}, series = {Internet of production - fundamentals, applications and proceedings}, booktitle = {Internet of production - fundamentals, applications and proceedings}, editor = {Brecher, Christian and Schuh, G{\"u}nther and van der Alst, Wil and Jarke, Matthias and Piller, Frank T. and Padberg, Melanie}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-98062-7}, doi = {10.1007/978-3-030-98062-7_19-1}, pages = {1 -- 23}, year = {2023}, abstract = {Like all preceding transformations of the manufacturing industry, the large-scale usage of production data will reshape the role of humans within the sociotechnical production ecosystem. To ensure that this transformation creates work systems in which employees are empowered, productive, healthy, and motivated, the transformation must be guided by principles of and research on human-centered work design. Specifically, measures must be taken at all levels of work design, ranging from (1) the work tasks to (2) the working conditions to (3) the organizational level and (4) the supra-organizational level. We present selected research across all four levels that showcase the opportunities and requirements that surface when striving for human-centered work design for the Internet of Production (IoP). (1) On the work task level, we illustrate the user-centered design of human-robot collaboration (HRC) and process planning in the composite industry as well as user-centered design factors for cognitive assistance systems. (2) On the working conditions level, we present a newly developed framework for the classification of HRC workplaces. (3) Moving to the organizational level, we show how corporate data can be used to facilitate best practice sharing in production networks, and we discuss the implications of the IoP for new leadership models. Finally, (4) on the supra-organizational level, we examine overarching ethical dimensions, investigating, e.g., how the new work contexts affect our understanding of responsibility and normative values such as autonomy and privacy. Overall, these interdisciplinary research perspectives highlight the importance and necessary scope of considering the human factor in the IoP.}, language = {en} } @incollection{BallmannBouckeBraun2003, author = {Ballmann, Josef and Boucke, Alexander and Braun, Carsten}, title = {Aeroelastic sensitivity in the transonic regime}, series = {Symposium Transsonicum IV : proceedings of the IUTAM symposium held in G{\"o}ttingen, Germany, 2 - 6 September 2002 / ed. by Helmut Sobieczky. Fluid mechanics and its applications. Vol. 73}, booktitle = {Symposium Transsonicum IV : proceedings of the IUTAM symposium held in G{\"o}ttingen, Germany, 2 - 6 September 2002 / ed. by Helmut Sobieczky. Fluid mechanics and its applications. Vol. 73}, publisher = {Kluwer Academic}, address = {Dordrecht}, isbn = {978-94-010-3998-7}, pages = {225 -- 236}, year = {2003}, language = {en} } @incollection{BarnatBosseTight2017, author = {Barnat, Miriam and Bosse, Elke and Tight, Malcolm}, title = {The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education}, series = {Theory and Method in Higher Education Research. Vol 3}, booktitle = {Theory and Method in Higher Education Research. Vol 3}, publisher = {Emerald Publishing Limited}, isbn = {978-1-78743-222-2}, doi = {10.1108/S2056-375220170000003001}, pages = {1 -- 19}, year = {2017}, abstract = {The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research.}, language = {en} } @incollection{BechstedtBergHackeretal.1995, author = {Bechstedt, U. and Berg, Georg P. A. and Hacker, U. and Hardt, Arno and H{\"u}rlimann, W. and Maier, R. and Martin, S. and Meissburger, J. and R{\"o}mer, J. G. M. and Possen, P. von and Sagefka, T.}, title = {BIG KARL and COSY}, series = {The art and science of magnet design. A Festschrift in honor of Klaus Halbach. Vol. 1}, booktitle = {The art and science of magnet design. A Festschrift in honor of Klaus Halbach. Vol. 1}, publisher = {Lawrence Berkeley Lab., Univ. of California}, address = {Berkeley, CA.}, pages = {19 -- 28}, year = {1995}, language = {en} } @incollection{BensbergAuthCzarnecki2021, author = {Bensberg, Frank and Auth, Gunnar and Czarnecki, Christian}, title = {Finding the perfect RPA match : a criteria-based selection method for RPA solutions}, series = {Robotic process automation : Management, technology, applications}, booktitle = {Robotic process automation : Management, technology, applications}, editor = {Czarnecki, Christian and Fettke, Peter}, publisher = {De Gruyter}, address = {Oldenbourg}, isbn = {978-3-11-067677-8}, doi = {10.1515/9783110676693-201}, pages = {47 -- 75}, year = {2021}, abstract = {The benefits of robotic process automation (RPA) are highly related to the usage of commercial off-the-shelf (COTS) software products that can be easily implemented and customized by business units. But, how to find the best fitting RPA product for a specific situation that creates the expected benefits? This question is related to the general area of software evaluation and selection. In the face of more than 75 RPA products currently on the market, guidance considering those specifics is required. Therefore, this chapter proposes a criteria-based selection method specifically for RPA. The method includes a quantitative evaluation of costs and benefits as well as a qualitative utility analysis based on functional criteria. By using the visualization of financial implications (VOFI) method, an application-oriented structure is provided that opposes the total cost of ownership to the time savings times salary (TSTS). For the utility analysis a detailed list of functional criteria for RPA is offered. The whole method is based on a multi-vocal review of scientific and non-scholarly literature including publications by business practitioners, consultants, and vendors. The application of the method is illustrated by a concrete RPA example. The illustrated structures, templates, and criteria can be directly utilized by practitioners in their real-life RPA implementations. In addition, a normative decision process for selecting RPA alternatives is proposed before the chapter closes with a discussion and outlook.}, language = {en} } @incollection{BensbergBuscherCzarnecki2019, author = {Bensberg, Frank and Buscher, Gandalf and Czarnecki, Christian}, title = {Digital transformation and IT topics in the consulting industry: a labor market perspective}, series = {Advances in consulting research : recent findings and practical cases}, booktitle = {Advances in consulting research : recent findings and practical cases}, editor = {Nissen, Volker}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-95998-6}, doi = {10.1007/978-3-319-95999-3_16}, pages = {341 -- 357}, year = {2019}, abstract = {Information technologies, such as big data analytics, cloud computing, cyber physical systems, robotic process automation, and the internet of things, provide a sustainable impetus for the structural development of business sectors as well as the digitalization of markets, enterprises, and processes. Within the consulting industry, the proliferation of these technologies opened up the new segment of digital transformation, which focuses on setting up, controlling, and implementing projects for enterprises from a broad range of sectors. These recent developments raise the question, which requirements evolve for IT consultants as important success factors of those digital transformation projects. Therefore, this empirical contribution provides indications regarding the qualifications and competences necessary for IT consultants in the era of digital transformation from a labor market perspective. On the one hand, this knowledge base is interesting for the academic education of consultants, since it supports a market-oriented design of adequate training measures. On the other hand, insights into the competence requirements for consultants are considered relevant for skill and talent management processes in consulting practice. Assuming that consulting companies pursue a strategic human resource management approach, labor market information may also be useful to discover strategic behavioral patterns.}, language = {en} } @incollection{BhattaraiFrotscherStaat2018, author = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred}, title = {Computational Analysis of Pelvic Floor Dysfunction}, series = {Women's Health and Biomechanics}, booktitle = {Women's Health and Biomechanics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-71574-2}, doi = {10.1007/978-3-319-71574-2_17}, pages = {217 -- 230}, year = {2018}, abstract = {Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence.}, language = {en} } @incollection{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Mechanics of soft tissue reactions to textile mesh implants}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_11}, pages = {251 -- 275}, year = {2018}, abstract = {For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment.}, language = {en} }