@article{HenkenOosterhuisOehlschlaegeretal.2012,
  author    = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.},
  title     = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7},
  series = {Vaccine},
  volume    = {30},
  journal   = {Vaccine},
  number    = {28},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0264-410X},
  doi       = {10.1016/j.vaccine.2012.04.013},
  pages     = {4259 -- 4266},
  year      = {2012},
  abstract  = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.},
  language  = {en}
}
@article{HerzwurmKramsPietschetal.2012,
  author    = {Herzwurm, Georg and Krams, Benedikt and Pietsch, Wolfram and Schockert, Sixten},
  title     = {Report from the 3rd international workshop on requirements prioritization for customer oriented software development (RePriCo'12)},
  series = {ACM SIGSOFT Software Engineering Notes},
  volume    = {37},
  journal   = {ACM SIGSOFT Software Engineering Notes},
  number    = {4},
  publisher = {Association for Computing Machinery},
  address   = {New York},
  issn      = {0163-5948},
  doi       = {10.1145/2237796.2237817},
  pages     = {32 -- 34},
  year      = {2012},
  abstract  = {Prioritization is an essential task within requirements engineering to cope with complexity and to establish focus properly. The 3rd Workshop on Requirements Prioritization for customer oriented Software Development (RePriCo'12) focused on requirements prioritization and adjacent themes in the context of customer oriented development of bespoke and standard software. Five submissions have been accepted for the proceedings and for presentation. The report summarizes and points out key findings.},
  language  = {en}
}
@book{HoepnerSchminke2012,
  author    = {Hoepner, Gert and Schminke, Lutz H.},
  title     = {Dialog-Marketing und E-Commerce : ein anwendungsorientiertes und konzeptionelles Kompendium f{\"u}r Praxis und Ausbildung},
  publisher = {Uni-ed. GmbH},
  address   = {Berlin},
  isbn      = {978-3-942171-23-6},
  pages     = {XXXI, 339 S.: graph. Darst.},
  year      = {2012},
  language  = {de}
}
@inproceedings{HoffschmidtAlexopoulos2012,
  author    = {Hoffschmidt, Bernhard and Alexopoulos, Spiros},
  title     = {Perspektiven f{\"u}r Solarthermische Kraftwerke im Sonneng{\"u}rtel},
  series = {Energiewende : Aspekte, Optionen, Herausforderungen : Vortr{\"a}ge auf der DPG-Fr{\"u}hjahrstagung Arbeitskreis Energie in der Deutschen Physikalischen Gesellschaft Berlin, 26. bis 28. M{\"a}rz 2012 / hrsg. von Hardo Bruhns},
  booktitle = {Energiewende : Aspekte, Optionen, Herausforderungen : Vortr{\"a}ge auf der DPG-Fr{\"u}hjahrstagung Arbeitskreis Energie in der Deutschen Physikalischen Gesellschaft Berlin, 26. bis 28. M{\"a}rz 2012 / hrsg. von Hardo Bruhns},
  publisher = {DPG},
  address   = {Baf Honnef},
  pages     = {81 -- 93},
  year      = {2012},
  language  = {de}
}
@incollection{HoffschmidtAlexopoulosGoettscheetal.2012,
  author    = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and G{\"o}ttsche, Joachim and Sauerborn, Markus},
  title     = {High concentration solar collectors},
  series = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications},
  volume    = {3},
  booktitle = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {978-0-08-087873-7},
  doi       = {10.1016/B978-0-08-087872-0.00306-1},
  pages     = {165 -- 209},
  year      = {2012},
  abstract  = {Solar thermal concentrated power is an emerging technology that provides clean electricity for the growing energy market. To the solar thermal concentrated power plant systems belong the parabolic trough, the Fresnel collector, the solar dish, and the central receiver system. For high-concentration solar collector systems, optical and thermal analysis is essential. There exist a number of measurement techniques and systems for the optical and thermal characterization of the efficiency of solar thermal concentrated systems. For each system, structure, components, and specific characteristics types are described. The chapter presents additionally an outline for the calculation of system performance and operation and maintenance topics. One main focus is set to the models of components and their construction details as well as different types on the market. In the later part of this chapter, different criteria for the choice of technology are analyzed in detail.},
  language  = {en}
}
@incollection{HoffschmidtAlexopoulosRauetal.2012,
  author    = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and Rau, Christoph and Sattler, Johannes, Christoph and Anthrakidis, Anette and Teixeira Boura, Cristiano Jos{\´e} and O'Connor, P. and Hilger, Patrick},
  title     = {Concentrating solar power},
  series = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications},
  volume    = {3},
  booktitle = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {978-0-08-087872-0},
  doi       = {10.1016/B978-0-08-087872-0.00319-X},
  pages     = {595 -- 636},
  year      = {2012},
  language  = {en}
}
@article{HuckPoghossianWagneretal.2012,
  author    = {Huck, Christina and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Combined amperometric/field-effect sensor for the detection of dissolved hydrogen},
  series = {Sensors and actuators B: Chemical},
  volume    = {187},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2012.10.050},
  pages     = {168 -- 173},
  year      = {2012},
  abstract  = {Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3\% (v/v) with a slope of 198.4 ± 13.7 nA/\% (v/v) and 14.9 ± 0.5 mV/\% (v/v), respectively.},
  language  = {en}
}
@article{HoetterFateriGebhardt2012,
  author    = {H{\"o}tter, Jan-Steffen and Fateri, Miranda and Gebhardt, Andreas},
  title     = {Prozessoptimierung des SLM-Prozesses mit hoch-reflektiven und thermisch sehr gut leitenden Materialien durch systematische Parameterfindung und begleitende Simulationen am Beispiel von Silber},
  series = {RTejournal - Forum f{\"u}r Rapid Technologie},
  volume    = {9},
  journal   = {RTejournal - Forum f{\"u}r Rapid Technologie},
  number    = {1},
  publisher = {Fachhoschule Aachen},
  address   = {Aachen},
  issn      = {1614-0923},
  url       = {http://nbn-resolving.de/urn:nbn:de:0009-2-33639},
  pages     = {1 -- 14},
  year      = {2012},
  abstract  = {Additive Manufacturing durch Aufschmelzen von Metallpulvern hat sich auf breiter Front als Herstellverfahren, auch f{\"u}r Endprodukte, etabliert. Besonders f{\"u}r die Variante des Selective Laser Melting (SLM) sind Anwendungen in der Zahntechnik bereits weit verbreitet und der Einsatz in sensitiven Branchen wie der Luftfahrt ist in greifbare N{\"a}he ger{\"u}ckt. Deshalb werden auch vermehrt Anstrengungen unternommen, um bisher nicht verarbeitete Materialien zu qualifizieren. Dies sind vorzugsweise Nicht-Eisen- und Edelmetalle, die sowohl eine sehr hohe Reflektivit{\"a}t als auch eine sehr gute W{\"a}rmeleitf{\"a}higkeit aufweisen - beides Eigenschaften, die die Beherrschung des Laser-Schmelzprozesses erschweren und nur kleine Prozessfenster zulassen. Die Arbeitsgruppe SLM des Lehr- und Forschungsgebietes Hochleistungsverfahren der Fertigungstechnik hat sich unter der Randbedingung einer kleinen und mit geringer Laserleistung ausgestatteten SLM Maschine der Aufgabe gewidmet und am Beispiel von Silber die Parameterfelder f{\"u}r Einzelspuren und wenig komplexe Geometrien systematisch untersucht. Die Arbeiten wurden von FEM Simulationen begleitet und durch metallographische Untersuchungen verifiziert. Die Ergebnisse bilden die Grundlage zur schnellen Parameterfindung bei komplexen Geometrien und bei Ver{\"a}nderungen der Zusammensetzung, wie sie bei zuk{\"u}nftigen Legierungen zu erwarten sind. Die Ergebnisse werden exemplarisch auf unterschiedliche Geometrien angewandt und entsprechende Bauteile gezeigt.},
  language  = {de}
}
@article{HoetterFateriGebhardt2012,
  author    = {H{\"o}tter, Jan-Steffen and Fateri, Miranda and Gebhardt, Andreas},
  title     = {Selective laser melting of metals: desktop machines open up new chances even for small companies},
  series = {Advanced materials research},
  volume    = {622-623},
  journal   = {Advanced materials research},
  publisher = {Trans Tech Publ.},
  address   = {Baech},
  issn      = {1662-8985 (E-Journal); 1022-6680 (Print)},
  doi       = {10.4028/www.scientific.net/AMR.622-623.461},
  pages     = {461 -- 465},
  year      = {2012},
  abstract  = {Additive manufacturing (AM) of metal parts by using Selective Laser Melting (SLM) has become a powerful tool mostly in the area of automotive, aerospace engineering and others. Especially in the field of dentistry, jewelry and related branches that require individualized or even one-of-a-kind products, the direct digital manufacturing process opens up new ways of design and manufacturing. In these fields, mostly small and medium sized businesses (SME) are operating which do not have sufficient human and economic resources to invest in this technology. But to stay competitive, the application of AM can be regarded as a necessity. In this situation a new desktop machine (Realizer SLM 50) was introduced that cost about 1/3 of a shop floor SLM machine and promises small quality parts. To find out whether the machine really is an alternative for SMEs the University of Applied Science, Aachen, Germany, designed, build and optimized typical parts from the dentistry and the jewelry branches using CoCr and silver material, the latter being new with this application. The paper describes the SLM procedure and how to find and optimize the most important parameters. The test is accompanied by digital simulation in order to verify the build parameters and to plan future builds. The procedure is shown as well as the resulting parts made from CoCr and silver material.},
  language  = {en}
}
@incollection{Huening2012,
  author    = {H{\"u}ning, Felix},
  title     = {PowerMOSFETs f{\"u}r Elektromotoren im Automobil : Vom Fensterheber zum EPS},
  series = {Elektronik im Kraftfahrzeug : Innovationen bei Systemen und Komponenten ; mit 7 Tabellen},
  booktitle = {Elektronik im Kraftfahrzeug : Innovationen bei Systemen und Komponenten ; mit 7 Tabellen},
  editor    = {Schmitz, G{\"u}nter},
  publisher = {Expert Verlag},
  address   = {Renningen},
  isbn      = {978-3-8169-3110-2},
  pages     = {71 -- 81},
  year      = {2012},
  language  = {de}
}