@article{LempiaeinenCouttetBolognanietal.2012,
  author    = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.},
  title     = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion},
  series = {Toxicological Sciences},
  volume    = {131},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {10.1093/toxsci/kfs303},
  pages     = {375 -- 386},
  year      = {2012},
  abstract  = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.},
  language  = {en}
}
@article{LeursMezoOehlschlaegeretal.2012,
  author    = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena},
  title     = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety},
  series = {Peptide Science},
  volume    = {98},
  journal   = {Peptide Science},
  number    = {1},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-0282},
  doi       = {10.1002/bip.21640},
  pages     = {1 -- 10},
  year      = {2012},
  abstract  = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.},
  language  = {en}
}
@incollection{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Wirkungen der Er{\"o}ffnung des Insolvenzverfahrens : \S\S 129, 132, 133, 144, 145},
  series = {Bankenkommentar zum Insolvenzrecht. - 2. Aufl.},
  booktitle = {Bankenkommentar zum Insolvenzrecht. - 2. Aufl.},
  publisher = {Finanz Colloquium},
  address   = {Heidelberg},
  isbn      = {978-3-943170-03-0},
  pages     = {1145 -- 1585},
  year      = {2012},
  language  = {de}
}
@article{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Zur Rechtsscheinhaftung bei Handeln einer Unternehmergesellschaft unter dem Rechtsformzusatz „GmbH" : Urteil vom 12.06.2012 - II ZR 256/11 : Anmerkung},
  series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  journal   = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  number    = {Ausg. 11},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {1611-1095},
  pages     = {339268},
  year      = {2012},
  language  = {de}
}
@article{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Rechtsprobleme bei der Liquidation der GmbH und der Gewinnaussch{\"u}ttung trotz bestehenden Anspruchs gegen den Gesellschafter : BGH, Urteil vom 23.04.2012 - II ZR 252/10 : Anmerkung},
  series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  journal   = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  number    = {Ausg. 10},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {1611-1095},
  pages     = {338415},
  year      = {2012},
  language  = {de}
}
@article{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Vollzug der Schenkung einer Unterbeteiligung : BGH, Urteil vom 29.11.2011 - II ZR 306/09 : Anmerkung},
  series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  journal   = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  number    = {Ausg. 4},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {1611-1095},
  pages     = {330150},
  year      = {2012},
  language  = {de}
}
@article{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Die Kostentragungspflicht bei der Aussonderung von Gegenst{\"a}nden, insbesondere bei Aufwendungen f{\"u}r den Ausbau einer Sache},
  series = {Insb{\"u}ro : Zeitschrift f{\"u}r Insolvenzsachbearbeitung und Entschuldungsverfahren},
  journal   = {Insb{\"u}ro : Zeitschrift f{\"u}r Insolvenzsachbearbeitung und Entschuldungsverfahren},
  number    = {H. 3},
  publisher = {Wolters Kluwer},
  address   = {K{\"o}ln},
  issn      = {1863-0731},
  pages     = {88 -- 89},
  year      = {2012},
  language  = {de}
}
@misc{LindelGreiserWaxmanetal.2012,
  author    = {Lindel, Tomasz Dawid and Greiser, Andreas and Waxman, Patrick and Dietterle, Martin and Seifert, Frank and Fontius, Ulrich and Renz, Wolfgang and Dieringer, Matthias A. and Frauenrath, Tobias and Schulz-Menger, Jeanette and Niendorf, Thoralf and Ittermann, Bernd},
  title     = {Cardiac CINE MRI at 7 T using a transmit array},
  series = {2012 ISMRM Annual Meeting Proceedings},
  journal   = {2012 ISMRM Annual Meeting Proceedings},
  issn      = {1545-4428},
  year      = {2012},
  abstract  = {With its need for high SNR and short acquisition times, Cardiac MRI (CMR) is an intriguing target application for ultrahigh field MRI. Due to the sheer size of the upper torso, however, the known RF issues of 7T MRI are also most prominent in CMR. Recent years brought substantial progress but the full potential of the ultrahigh field for CMR is yet to be exploited. Parallel transmission (pTx) is a promising approach in this context and several groups have already reported B1 shimming for 7T CMR. In such a static pTx application amplitudes and phases of all Tx channels are adjusted individually but otherwise imaging techniques established in current clinical practice 1.5 T and 3 T are applied. More advanced forms of pTx as spatially selective excitation (SSE) using Transmit SENSE promise additional benefits like faster imaging with reduced fields of view or improved SAR control. SSE requires the full dynamic capabilities of pTx, however, and for the majority of today's implemented pTx hardware the internal synchronization of the Tx array does not easily permit external triggering as needed for CMR. Here we report a software solution to this problem and demonstrate the feasibility of CINE CMR at 7 T using a Tx array.},
  language  = {en}
}
@inproceedings{LoPiparoKernMazzetti2012,
  author    = {Lo Piparo, G. B. and Kern, Alexander and Mazzetti, C.},
  title     = {Some masterpoints about risk due to lightning},
  series = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna},
  booktitle = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  organization    = {International Conference on Lightning Protection <2012, Wien>},
  isbn      = {978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)},
  pages     = {1 -- 6},
  year      = {2012},
  language  = {en}
}
@article{LoebSchartnerDachwaldetal.2012,
  author    = {Loeb, Horst Wolfgang and Schartner, Karl-Heinz and Dachwald, Bernd and Ohndorf, Andreas and Seboldt, Wolfgang},
  title     = {Interstellar heliopause probe},
  series = {Труды МАИ},
  journal   = {Труды МАИ},
  number    = {60},
  publisher = {Moskauer Staatliches Luftfahrtinstitut (МАИ)},
  address   = {Moskau},
  pages     = {2 -- 2},
  year      = {2012},
  abstract  = {There is common agreement within the scientific community that in order to understand our local galactic environment it will be necessary to send a spacecraft into the region beyond the solar wind termination shock. Considering distances of 200 AU for a new mission, one needs a spacecraft traveling at a speed of close to 10 AU/yr in order to keep the mission duration in the range of less than 25 yrs, a transfer time postulated by European Space Agency (ESA). Two propulsion options for the mission have been proposed and discussed so far: the solar sail propulsion and the ballistic/radioisotope-electric propulsion (REP). As a further alternative, we here investigate a combination of solar-electric propulsion (SEP) and REP. The SEP stage consists of six 22-cms diameter RIT-22 ion thrusters working with a high specific impulse of 7377 s corresponding to a positive grid voltage of 5 kV. Solar power of 53 kW at begin of mission (BOM) is provided by a lightweight solar array.},
  language  = {en}
}