@incollection{ZhubanovaMansurovDigel2020,
  author    = {Zhubanova, Azhar A. and Mansurov, Zulkhair A. and Digel, Ilya},
  title     = {Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4800-27-3},
  doi       = {10.1201/9780429428647-18},
  pages     = {353 -- 378},
  year      = {2020},
  abstract  = {This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.},
  language  = {en}
}
@article{TranStaat2020,
  author    = {Tran, Ngoc Trinh and Staat, Manfred},
  title     = {Direct plastic structural design under lognormally distributed strength by chance constrained programming},
  series = {Optimization and Engineering},
  volume    = {21},
  journal   = {Optimization and Engineering},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1573-2924},
  doi       = {10.1007/s11081-019-09437-2},
  pages     = {131 -- 157},
  year      = {2020},
  abstract  = {We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements.},
  language  = {en}
}
@article{StreeseKotliarDeiserothetal.2020,
  author    = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner},
  title     = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial},
  series = {Scandinavian Journal of Medicine and Science in Sports},
  volume    = {30},
  journal   = {Scandinavian Journal of Medicine and Science in Sports},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1600-0838},
  doi       = {10.1111/sms.13560},
  pages     = {272 -- 280},
  year      = {2020},
  abstract  = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.},
  language  = {en}
}
@article{SmithKotliarLammertynetal.2020,
  author    = {Smith, Wayne and Kotliar, Konstantin and Lammertyn, Leandi and Ramoshaba, Nthai E. and Vilser, Walthard and Huisman, Hugo W. and Schutte, Aletta E.},
  title     = {Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study},
  series = {Microvascular Research},
  volume    = {128},
  journal   = {Microvascular Research},
  number    = {Article 103937},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0026-2862},
  doi       = {10.1016/j.mvr.2019.103937},
  year      = {2020},
  abstract  = {Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8\%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.},
  language  = {en}
}
@incollection{SavitskayaKistaubayevaAkimbekovetal.2020,
  author    = {Savitskaya, Irina S. and Kistaubayeva, Aida S. and Akimbekov, Nuraly and Digel, Ilya and Shokatayeva, Dina and Zhubanova, Azhar Achmet},
  title     = {Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4800-27-3},
  doi       = {10.1201/9780429428647-12},
  pages     = {229 -- 267},
  year      = {2020},
  abstract  = {Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.},
  language  = {en}
}
@article{RauschKahmannBaltschunetal.2020,
  author    = {Rausch, Valentin and Kahmann, Stephanie Lucina and Baltschun, Christoph and Staat, Manfred and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {Pressure distribution to the distal biceps tendon at the radial tuberosity: a biomechanical study},
  series = {The Journal of Hand Surgery},
  volume    = {45},
  journal   = {The Journal of Hand Surgery},
  number    = {8},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0363-5023},
  doi       = {10.1016/j.jhsa.2020.01.006},
  pages     = {776.e1 -- 776.e9},
  year      = {2020},
  abstract  = {Purpose Mechanical impingement at the narrow radioulnar space of the tuberosity is believed to be an etiological factor in the injury of the distal biceps tendon. The aim of the study was to compare the pressure distribution at the proximal radioulnar space between 2 fixation techniques and the intact state. Methods Six right arms and 6 left arms from 5 female and 6 male frozen specimens were used for this study. A pressure transducer was introduced at the height of the radial tuberosity with the intact distal biceps tendon and after 2 fixation methods: the suture-anchor and the cortical button technique. The force (N), maximum pressure (kPa) applied to the radial tuberosity, and the contact area (mm²) of the radial tuberosity with the ulna were measured and differences from the intact tendon were detected from 60° supination to 60° pronation in 15° increments with the elbow in full extension and in 45° and 90° flexion of the elbow. Results With the distal biceps tendon intact, the pressures during pronation were similar regardless of extension and flexion and were the highest at 60° pronation with 90° elbow flexion (23.3 ± 53.5 kPa). After repair of the tendon, the mean peak pressure, contact area, and total force showed an increase regardless of the fixation technique. Highest peak pressures were found using the cortical button technique at 45° flexion of the elbow and 60° pronation. These differences were significantly different from the intact tendon. The contact area was significantly larger in full extension and 15°, 30°, and 60° pronation using the cortical button technique. Conclusions Pressures on the distal biceps tendon at the radial tuberosity increase during pronation, especially after repair of the tendon. Clinical relevance Mechanical impingement could play a role in both the etiology of primary distal biceps tendon ruptures and the complications occurring after fixation of the tendon using certain techniques.},
  language  = {en}
}
@article{RauschHarbrechtKahmannetal.2020,
  author    = {Rausch, Valentin and Harbrecht, Andreas and Kahmann, Stephanie Lucina and Fenten, Thomas and Jovanovic, Nebojsa and Hackl, Michael and M{\"u}ller, Lars P. and Staat, Manfred and Wegmann, Kilian},
  title     = {Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws},
  series = {The Journal of Hand Surgery},
  volume    = {45},
  journal   = {The Journal of Hand Surgery},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0363-5023},
  doi       = {10.1016/j.jhsa.2020.04.010},
  pages     = {987.e1 -- 987.e8},
  year      = {2020},
  abstract  = {Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties.},
  language  = {en}
}
@article{RamoshabaHuismanLammertynetal.2020,
  author    = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne},
  title     = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study},
  series = {Hypertension Research},
  journal   = {Hypertension Research},
  number    = {43},
  publisher = {Springer Nature},
  address   = {Osaka},
  issn      = {1348-4214},
  doi       = {10.1038/s41440-020-0487-0},
  pages     = {1231 -- 1238},
  year      = {2020},
  abstract  = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.},
  language  = {en}
}
@article{QuittmannMeskemperAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Meskemper, Joshua and Albracht, Kirsten and Abel, Thomas and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs},
  series = {Journal of Electromyography and Kinesiology},
  volume    = {51},
  journal   = {Journal of Electromyography and Kinesiology},
  number    = {Article 102402},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1050-6411},
  doi       = {10.1016/j.jelekin.2020.102402},
  year      = {2020},
  abstract  = {Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.},
  language  = {en}
}
@article{QuittmannAbelAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Meskemper, Joshua and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants},
  series = {European Journal of Applied Physiology},
  journal   = {European Journal of Applied Physiology},
  number    = {120},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-020-04373-x},
  pages     = {1403 -- 1415},
  year      = {2020},
  abstract  = {Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training.},
  language  = {en}
}