@inproceedings{JabbariBhattaraiAndingetal.2017,
  author    = {Jabbari, Medisa and Bhattarai, Aroj and Anding, Ralf and Staat, Manfred},
  title     = {Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse},
  series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  editor    = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-9814801-9-1},
  doi       = {10.17185/duepublico/43984},
  pages     = {118 -- 119},
  year      = {2017},
  language  = {en}
}
@inproceedings{BhattaraiFrotscherStaat2015,
  author    = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred},
  title     = {Biomechanical study of the female pelvic floor dysfunction using the finite element method},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@inproceedings{BirgelLeschingerWegmannetal.2017,
  author    = {Birgel, Stefan and Leschinger, Tim and Wegmann, Kilian and Staat, Manfred},
  title     = {Calculation of muscle forces and joint reaction loads in shoulder area via an OpenSim based computer calculation},
  series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West},
  editor    = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-9814801-9-1},
  doi       = {10.17185/duepublico/43984},
  pages     = {116 -- 117},
  year      = {2017},
  language  = {en}
}
@article{BirgelLeschingerWegmannetal.2018,
  author    = {Birgel, Stefan and Leschinger, Tim and Wegmann, Kilian and Staat, Manfred},
  title     = {Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model},
  series = {tm - Technisches Messen},
  volume    = {85},
  journal   = {tm - Technisches Messen},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2196-7113},
  doi       = {10.1515/teme-2017-0114},
  pages     = {321 -- 330},
  year      = {2018},
  abstract  = {Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und {\"u}berpr{\"u}ften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen f{\"u}r den Supraspinatus und Deltoideus. Zus{\"a}tzlich wird der Einfluss auf die Gelenkstabilit{\"a}t betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus.},
  language  = {en}
}
@article{KnoxBruggemannGossmannetal.2020,
  author    = {Knox, Ronald and Bruggemann, Andrea and Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter},
  title     = {Combining physiological relevance and throughput for in vitro cardiac contractility measurement},
  series = {Biophysical Journal},
  volume    = {118},
  journal   = {Biophysical Journal},
  number    = {Issue 3, Supplement 1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0006-3495},
  doi       = {10.1016/j.bpj.2019.11.3104},
  pages     = {570a},
  year      = {2020},
  abstract  = {Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these.},
  language  = {en}
}
@article{SchierenKleinschmidtSchmutzetal.2019,
  author    = {Schieren, Mark and Kleinschmidt, Joris and Schmutz, Axel and Loop, Torsten and Gatzweiler, Karl-Heinz and Staat, Manfred and Wappler, Frank and Defosse, Jerome},
  title     = {Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study},
  series = {Anaesthesia},
  volume    = {74},
  journal   = {Anaesthesia},
  number    = {12},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  isbn      = {1365-2044},
  doi       = {10.1111/anae.14815},
  year      = {2019},
  language  = {en}
}
@incollection{BhattaraiFrotscherStaat2018,
  author    = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred},
  title     = {Computational Analysis of Pelvic Floor Dysfunction},
  series = {Women's Health and Biomechanics},
  booktitle = {Women's Health and Biomechanics},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-71574-2},
  doi       = {10.1007/978-3-319-71574-2_17},
  pages     = {217 -- 230},
  year      = {2018},
  abstract  = {Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence.},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Computational comparison of different textile implants to correct apical prolapse in females},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  doi       = {10.1515/cdbme-2018-0159},
  pages     = {661 -- 664},
  year      = {2018},
  abstract  = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.},
  language  = {en}
}
@article{FrotscherKochStaat2015,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred},
  title     = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes},
  series = {Journal of biomechanical engineering},
  volume    = {Vol. 137},
  journal   = {Journal of biomechanical engineering},
  number    = {iss. 7},
  publisher = {ASME},
  address   = {New York},
  issn      = {1528-8951 (E-Journal); 0148-0731 (Print)},
  doi       = {10.1115/1.4030173},
  pages     = {071002-1 -- 071002-7},
  year      = {2015},
  language  = {en}
}
@inproceedings{JungStaat2016,
  author    = {Jung, Alexander and Staat, Manfred},
  title     = {Computing olympic gold: Ski jumping as an example},
  series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen},
  editor    = {Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-06-6},
  doi       = {10.17185/duepublico/40821},
  pages     = {54 -- 55},
  year      = {2016},
  language  = {en}
}