@article{PoghossianSchoening2003, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {"High-order" hybrid FET module for (bio)chemical and physical sensing}, series = {Integrated analytical systems / ed. by Salvador Alegret}, journal = {Integrated analytical systems / ed. by Salvador Alegret}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, isbn = {0-444-51037-0}, pages = {587 -- 623}, year = {2003}, language = {en} } @article{Schoening2005, author = {Sch{\"o}ning, Michael Josef}, title = {"Playing around" with field-effect sensors on the basis of EIS structures, LAPS and ISFETs}, series = {Sensors. 5 (2005), H. 3}, journal = {Sensors. 5 (2005), H. 3}, isbn = {1424-8220}, pages = {126 -- 138}, year = {2005}, language = {en} } @article{Schoening2004, author = {Sch{\"o}ning, Michael Josef}, title = {"Voltohmmetry" - a new transducer principle for electrochemical sensors}, series = {Ultrathin electrochemical chemo- and biosensors : technology and performance / Vladimir M. Mirsky}, journal = {Ultrathin electrochemical chemo- and biosensors : technology and performance / Vladimir M. Mirsky}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-21285-X}, pages = {117 -- 140}, year = {2004}, language = {en} } @article{BuniatyanMatirosyanAbouzaretal.2009, author = {Buniatyan, V. V. and Matirosyan, N. W. and Abouzar, Maryam H. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Schubert, J. and Khachatryan, V. R. and Soukiassyan, G. R.}, title = {(Ba,Sr)TiO3 based electrolyte-insulator-semiconductor pHsensors: comparitive study}, series = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, journal = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, pages = {71 -- 74}, year = {2009}, language = {en} } @article{PoghossianLuethSchultzeetal.2001, author = {Poghossian, Arshak and L{\"u}th, H. and Schultze, J. W. and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical and physical microsensor array using an identical transducer principle}, series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, journal = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, publisher = {Elsevier [u.a.]}, address = {Amsterdam [u.a.]}, isbn = {0-08-044014-2}, pages = {243 -- 249}, year = {2001}, language = {en} } @incollection{YoshinobuKrauseMiyamotoetal.2018, author = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM}, series = {Label-free biosensing: advanced materials, devices and applications}, booktitle = {Label-free biosensing: advanced materials, devices and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-75219-8}, pages = {103 -- 132}, year = {2018}, abstract = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.}, language = {en} } @article{MuschallikMolinnusBongaertsetal.2017, author = {Muschallik, Lukas and Molinnus, Denise and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Siegert, Petra and Selmer, Thorsten}, title = {(R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme}, series = {Journal of Biotechnology}, volume = {258}, journal = {Journal of Biotechnology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2017.07.020}, pages = {41 -- 50}, year = {2017}, abstract = {The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33-43\%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development.}, language = {en} } @inproceedings{RoderburgSchoening2008, author = {Roderburg, Katharina and Sch{\"o}ning, Michael Josef}, title = {1. Graduierten-Tagung : 9. September 2008 / [Hrsg.: K. Roderburg ; M. J. Sch{\"o}ning]}, organization = {FH Aachen, University of Applied Sciences / Graduiertentagung <1, 2008>}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3125}, year = {2008}, abstract = {Tagungsband der Graduiertentagung der FH Aachen, in dem Doktorandinnen und Doktoranden und ihre Forschungsbereiche vorgestellt werden}, subject = {Aachen / Fachhochschule Aachen}, language = {de} } @inproceedings{SchubertSchoening2010, author = {Schubert, Nicole and Sch{\"o}ning, Michael Josef}, title = {3. Graduiertentagung der FH Aachen}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3386}, year = {2010}, abstract = {Doktoranden der FH Aachen stellen ihre wissenschaftlichen Arbeiten aus verschiedenen Fachdisziplinen vor.}, subject = {Graduiertentagung}, language = {mul} } @article{AchtsnichtToedterNiehuesetal.2019, author = {Achtsnicht, Stefan and T{\"o}dter, Julia and Niehues, Julia and Tel{\"o}ken, Matthias and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian}, title = {3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection}, series = {Sensors}, volume = {19}, journal = {Sensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s19010148}, pages = {15 Seiten}, year = {2019}, abstract = {For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.}, language = {en} }