@article{BiselliRolefDunkeretal.1994, author = {Biselli, Manfred and Rolef, G. and Dunker, R. and Wandrey, Christian}, title = {Optimization of antibody production in a fluidized bed bioreactor / Rolef, G. ; Biselli, M. ; Dunker, R. ; Wandrey, C.}, series = {Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier}, journal = {Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier}, publisher = {Butterworth-Heinemann}, address = {Oxford}, isbn = {0750618450}, pages = {481 -- 484}, year = {1994}, language = {en} } @article{PilasMarianoKeusgenetal.2015, author = {Pilas, Johanna and Mariano, K. and Keusgen, M. and Selmer, Thorsten and Sch{\"o}ning, Michael Josef}, title = {Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes}, series = {Procedia Engineering}, volume = {120}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.08.702}, pages = {532 -- 535}, year = {2015}, language = {en} } @article{PilasYaziciSelmeretal.2017, author = {Pilas, Johanna and Yazici, Yasemen and Selmer, Thorsten and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate}, series = {Electrochimica Acta}, volume = {251}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.07.119}, pages = {256 -- 262}, year = {2017}, abstract = {The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4\% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.}, language = {en} } @article{MuellerLeiseLorenzetal.2020, author = {M{\"u}ller, Tim M. and Leise, Philipp and Lorenz, Imke-Sophie and Altherr, Lena and Pelz, Peter F.}, title = {Optimization and validation of pumping system design and operation for water supply in high-rise buildings}, series = {Optimization and Engineering}, volume = {2021}, journal = {Optimization and Engineering}, number = {22}, publisher = {Springer}, issn = {1573-2924}, doi = {10.1007/s11081-020-09553-4}, pages = {643 -- 686}, year = {2020}, abstract = {The application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps' characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer's point of view, keeping in mind the economically important trade-off between investment and operation costs.}, language = {en} } @article{KernKloetersPferdemenges2010, author = {Kern, Alexander and Kl{\"o}ters, Georg and Pferdemenges, J{\"o}rg}, title = {Optimised protection against lightning for the signalling and safety systems of level crossings on non-electrified railway lines}, series = {RTR : European Rail Technology Review}, volume = {50}, journal = {RTR : European Rail Technology Review}, number = {2}, isbn = {0079-9548}, year = {2010}, language = {en} } @article{DammSauerbornFendetal.2017, author = {Damm, Marc Andr{\´e} and Sauerborn, Markus and Fend, Thomas and Herrmann, Ulf}, title = {Optimisation of a urea selective catalytic reduction system with a coated ceramic mixing element}, series = {Journal of ceramic science and technology}, volume = {8}, journal = {Journal of ceramic science and technology}, number = {1}, publisher = {G{\"o}ller}, address = {Baden-Baden}, isbn = {2190-9385 (Print)}, issn = {2190-9385 (Online)}, doi = {10.4416/JCST2016-00056}, pages = {19 -- 24}, year = {2017}, language = {en} } @article{KirchnerOberlaenderFriedrichetal.2011, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Friedrich, Peter and Berger, J{\"o}rg and Suso, Henri-Pierre and Kupyna, Andriy and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1235 -- 1240}, year = {2011}, language = {en} } @article{SchwarzerHafnerKrings1994, author = {Schwarzer, Klemens and Hafner, B. and Krings, D.}, title = {Optimierung von solarthermischen Kochersystemen}, series = {Energiewirtschaftliche Tagesfragen. 44 (1994), H. 9}, journal = {Energiewirtschaftliche Tagesfragen. 44 (1994), H. 9}, isbn = {0720-6240}, pages = {44 -- 46}, year = {1994}, language = {de} } @article{DachwaldOhndorfSeboldt2005, author = {Dachwald, Bernd and Ohndorf, A. and Seboldt, Wolfgang}, title = {Optimierung der Lageregelung von Raumfahrzeugen mit Niedrigschubantrieb mittels evolution{\"a}rer neuronaler Regler / A. Ohndorf ; B. Dachwald ; W. Seboldt}, series = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, journal = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, publisher = {DGLR}, address = {Bonn}, pages = {1971 -- 1978}, year = {2005}, language = {de} } @article{Weigand1991, author = {Weigand, Christoph}, title = {Optimale Maschinenjustierung}, series = {Technische Hochschule / Bibliothek: Wissenschaftliche Zeitschrift. 37 (1991)}, journal = {Technische Hochschule / Bibliothek: Wissenschaftliche Zeitschrift. 37 (1991)}, isbn = {0043-6917}, pages = {167 -- 175}, year = {1991}, language = {de} }