@article{UysalFiratCreutzetal.2022,
  author    = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes},
  series = {membranes},
  volume    = {2023},
  journal   = {membranes},
  number    = {13(1)},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/membranes13010022},
  pages     = {Artikel 22},
  year      = {2022},
  abstract  = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.},
  language  = {en}
}
@article{GrottkeBraunschweigPhilippenetal.2010,
  author    = {Grottke, O. and Braunschweig, T. and Philippen, B. and Gatzweiler, Karl-Heinz and Gronloh, N. and Staat, Manfred and Rossaint, R. and Tolba, R.},
  title     = {A new model for blunt liver injuries in the swine},
  series = {European Surgical Research},
  volume    = {44},
  journal   = {European Surgical Research},
  number    = {2},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9921},
  doi       = {10.1159/000265053},
  pages     = {65 -- 73},
  year      = {2010},
  abstract  = {Background: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. Materials and Methods: A dilutional coagulopathy of 80\% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 ± 19 N (n = 4) or 355 ± 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. Results: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 ± 35 N, both the survival time (30 ± 9 min; p = 0.006) and blood loss (68 ± 16 ml min-1, p = 0.002) were significantly different as compared to injuries with 224 ± 19 N (survival time: 76 ± 20 min, blood loss: 23 ± 4 ml min-1). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. Conclusion: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.},
  language  = {en}
}
@article{LinderBecklerDoerretal.2019,
  author    = {Linder, Peter and Beckler, Matthias and Doerr, Leo and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Staat, Manfred and Gossmann, Matthias},
  title     = {A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {99},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article number 106595},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1056-8719},
  doi       = {10.1016/j.vascn.2019.05.162},
  year      = {2019},
  language  = {en}
}
@article{PookhalilAmoabedinyTabeshetal.2016,
  author    = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow},
  title     = {A new approach for semiempirical modeling of mechanical blood trauma},
  series = {The international journal of artificial organs},
  volume    = {39},
  journal   = {The international journal of artificial organs},
  number    = {4},
  publisher = {Sage},
  address   = {London},
  issn      = {1724-6040},
  doi       = {10.5301/ijao.5000474},
  pages     = {171 -- 177},
  year      = {2016},
  abstract  = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.},
  language  = {en}
}
@article{LeschingerBirgelHackletal.2019,
  author    = {Leschinger, Tim and Birgel, Stefan and Hackl, Michael and Staat, Manfred and M{\"u}ller, Lars-Peter and Wegmann, Kilian},
  title     = {A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair},
  series = {Computer Methods in Biomechanics and Biomedical Engineering},
  journal   = {Computer Methods in Biomechanics and Biomedical Engineering},
  number    = {Early view},
  publisher = {Taylor \& Francis},
  address   = {London},
  doi       = {10.1080/10255842.2019.1572749},
  year      = {2019},
  language  = {en}
}
@article{DittusTuryshevDachwaldetal.2005,
  author    = {Dittus, H. and Turyshev, S. G. and Dachwald, Bernd and Blome, Hans-Joachim},
  title     = {A Mission to Explore the Pioneer Anomaly},
  series = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)},
  journal   = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)},
  publisher = {ESA Publ. Div.},
  address   = {Noordwijk},
  isbn      = {9290928999},
  pages     = {3 -- 10},
  year      = {2005},
  language  = {en}
}
@article{KonstantinidisFloresMartinezDachwaldetal.2015,
  author    = {Konstantinidis, Konstantinos and Flores Martinez, Claudio and Dachwald, Bernd and Ohndorf, Andreas and Dykta, Paul and Bowitz, Pascal and Rudolph, Martin and Digel, Ilya and Kowalski, Julia and Voigt, Konstantin and F{\"o}rstner, Roger},
  title     = {A lander mission to probe subglacial water on Saturn's moon enceladus for life},
  series = {Acta astronautica},
  volume    = {Vol. 106},
  journal   = {Acta astronautica},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1879-2030 (E-Journal); 0094-5765 (Print)},
  pages     = {63 -- 89},
  year      = {2015},
  language  = {en}
}
@inproceedings{NguyenRaatschenStaat2010,
  author    = {Nguyen, N.-H. and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {A hyperelastic model of biological tissue materials in tubular organs},
  year      = {2010},
  language  = {en}
}
@article{GossmannThomasHorvathetal.2020,
  author    = {Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter},
  title     = {A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {105},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article 106843},
  publisher = {Elsevier},
  address   = {New York, NY},
  doi       = {10.1016/j.vascn.2020.106843},
  year      = {2020},
  language  = {en}
}
@article{TopcuMadabhushiStaat2022,
  author    = {Top{\c{c}}u, Murat and Madabhushi, Gopal S.P. and Staat, Manfred},
  title     = {A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius},
  series = {International Journal of Solids and Structures},
  volume    = {239-240},
  journal   = {International Journal of Solids and Structures},
  number    = {Art. No. 111464},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {0020-7683},
  doi       = {10.1016/j.ijsolstr.2022.111464},
  year      = {2022},
  abstract  = {A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.},
  language  = {en}
}