@article{OrtnerHauserSchmadereretal.2019,
  author    = {Ortner, Marion and Hauser, Christine and Schmaderer, Christoph and Muggenthaler, Claudia and Hapfelmeier, Alexander and Sorg, Christian and Diehl-Schmid, Janine and Kurz, Alexander and F{\"o}rstl, Hans and Ikenberg, Benno and Kotliar, Konstantin and Holger, Poppert and Grimmer, Timo},
  title     = {Decreased vascular pulsatility in Alzheimer's disease dementia measured by transcranial color-coded duplex sonography},
  series = {Neuropsychiatric disease and treatment},
  journal   = {Neuropsychiatric disease and treatment},
  number    = {15},
  publisher = {Dove Medical Press},
  address   = {Albany, Auckland},
  issn      = {1178-2021},
  doi       = {10.2147/NDT.S225754},
  pages     = {3487 -- 3499},
  year      = {2019},
  abstract  = {Purpose: Impaired paravascular drainage of β-Amyloid (Aβ) has been proposed as a contributing cause for sporadic Alzheimer's disease (AD), as decreased cerebral blood vessel pulsatility and subsequently reduced propulsion in this pathway could lead to the accumulation and deposition of Aβ in the brain. Therefore, we hypothesized that there is an increased impairment in pulsatility across AD spectrum. Patients and Methods: Using transcranial color-coded duplex sonography (TCCS) the resistance and pulsatility index (RI; PI) of the middle cerebral artery (MCA) in healthy controls (HC, n=14) and patients with AD dementia (ADD, n=12) were measured. In a second step, we extended the sample by adding patients with mild cognitive impairment (MCI) stratified by the presence (MCI-AD, n=8) or absence of biomarkers (MCI-nonAD, n=8) indicative for underlying AD pathology, and compared RI and PI across the groups. To control for atherosclerosis as a confounder, we measured the arteriolar-venular-ratio of retinal vessels. Results: Left and right RI (p=0.020; p=0.027) and left PI (p=0.034) differed between HC and ADD controlled for atherosclerosis with AUCs of 0.776, 0.763, and 0.718, respectively. The RI and PI of MCI-AD tended towards ADD, of MCI-nonAD towards HC, respectively. RIs and PIs were associated with disease severity (p=0.010, p=0.023). Conclusion: Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed.},
  language  = {en}
}
@article{KnoedlerRuehlEmontsetal.2019,
  author    = {Kn{\"o}dler, Matthias and R{\"u}hl, Clemens and Emonts, Jessica and Buyel, Johannes Felix},
  title     = {Seasonal weather changes affect the yield and quality of recombinant proteins produced in transgenic tobacco plants in a greenhouse setting},
  series = {Frontiers in Plant Science},
  journal   = {Frontiers in Plant Science},
  number    = {10},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-462X (online-ressource)},
  doi       = {10.3389/fpls.2019.01245},
  pages     = {13 Seiten},
  year      = {2019},
  abstract  = {Transgenic plants have the potential to produce recombinant proteins on an agricultural scale, with yields of several tons per year. The cost-effectiveness of transgenic plants increases if simple cultivation facilities such as greenhouses can be used for production. In such a setting, we expressed a novel affinity ligand based on the fluorescent protein DsRed, which we used as a carrier for the linear epitope ELDKWA from the HIV-neutralizing antibody 2F5. The DsRed-2F5-epitope (DFE) fusion protein was produced in 12 consecutive batches of transgenic tobacco (Nicotiana tabacum) plants over the course of 2 years and was purified using a combination of blanching and immobilized metal-ion affinity chromatography (IMAC). The average purity after IMAC was 57 ± 26\% (n = 24) in terms of total soluble protein, but the average yield of pure DFE (12 mg kg-1) showed substantial variation (± 97 mg kg-1, n = 24) which correlated with seasonal changes. Specifically, we found that temperature peaks (>28°C) and intense illuminance (>45 klx h-1) were associated with lower DFE yields after purification, reflecting the loss of the epitope-containing C-terminus in up to 90\% of the product. Whereas the weather factors were of limited use to predict product yields of individual harvests conducted for each batch (spaced by 1 week), the average batch yields were well approximated by simple linear regression models using two independent variables for prediction (illuminance and plant age). Interestingly, accumulation levels determined by fluorescence analysis were not affected by weather conditions but positively correlated with plant age, suggesting that the product was still expressed at high levels, but the extreme conditions affected its stability, albeit still preserving the fluorophore function. The efficient production of intact recombinant proteins in plants may therefore require adequate climate control and shading in greenhouses or even cultivation in fully controlled indoor farms.},
  language  = {en}
}
@incollection{Stapenhorst2019,
  author    = {Stapenhorst, Carolin},
  title     = {Werkzeuge und ihre Wirkungsmacht},
  series = {Werkbund Akademiereihe. hefte 19-20 / 2017-2018},
  booktitle = {Werkbund Akademiereihe. hefte 19-20 / 2017-2018},
  editor    = {Deutscher Werkbund NW e.V.,},
  isbn      = {978-3-00-062587-9},
  pages     = {62 -- 74},
  year      = {2019},
  language  = {de}
}
@article{EnningSchmidtWilbring2019,
  author    = {Enning, Manfred and Schmidt, Bernd and Wilbring, Daniela},
  title     = {Auf dem Weg zur autonomen Anschlussbedienung},
  series = {Privatbahn-Magazin},
  journal   = {Privatbahn-Magazin},
  number    = {3},
  publisher = {Bahn Media},
  address   = {Suhlendorf},
  issn      = {1865-0163},
  pages     = {40 -- 43},
  year      = {2019},
  language  = {de}
}
@inproceedings{PfaffSchmidtWilbringetal.2019,
  author    = {Pfaff, Raphael and Schmidt, Bernd and Wilbring, Daniela and Franzen, Julian},
  title     = {Wagon4.0 - the smart wagon for improved integration into Industry 4.0 plants},
  series = {Proceedings of the International Heavy Haul Association STS Conference 2019},
  booktitle = {Proceedings of the International Heavy Haul Association STS Conference 2019},
  pages     = {7 Seiten},
  year      = {2019},
  abstract  = {In many instances, freight vehicles exchange load or information with plants that are or will soon be Industry4.0 plants. The Wagon4.0 concept, as developed in close cooperation with e.g. port or mine operations, offers a maximum in railway operational efficiency while providing strong business cases already in the respective plant interaction. The Wagon4.0 consists of main components, a power supply, data network, sensors, actuators and an operating system, the so called WagonOS. The Wagon OS is implemented in a granular, self-sufficient manner, to allow basic features such as WiFi-Mesh and train christening in remote areas without network connection. Furthermore, the granularity of the operating system allows to extend the familiar app concept to freight rail rolling stock, making it possible to use specialised actuators for certain applications, e.g. an electrical parking brake or an auxiliary drive. In order to facilitate migration to the Wagon4.0 for existing fleets, a migration concept featuring five levels of technical adaptation was developed. The present paper investigates the benefits of Wagon4.0-implementations for the particular challenges of heavy haul operations by focusing on train christening, ep-assisted braking, autonomous last mile and traction boost operation as well as improved maintenance schedules},
  language  = {en}
}
@inproceedings{WilbringEnningPfaffetal.2019,
  author    = {Wilbring, Daniela and Enning, Manfred and Pfaff, Raphael and Schmidt, Bernd},
  title     = {Neue Perspektiven f{\"u}r die Bahn in der Produktions- und Distributionslogistik durch Prozessautomation},
  series = {IRSA 2019: Tagungsband, Proceedings},
  booktitle = {IRSA 2019: Tagungsband, Proceedings},
  editor    = {de Doncker, Rik W. and Nießen, Nils and Schindler, Christian},
  publisher = {RWTH Aachen},
  address   = {Aachen},
  doi       = {10.18154/RWTH-2020-00014},
  pages     = {128 -- 142},
  year      = {2019},
  abstract  = {Deutschland braucht mehr Eisenbahn um CO2-Emissionen aus dem Verkehr zu reduzieren. Sie muss zum R{\"u}ckgrat aktueller Logistikprozesse, z.B. bei Kaufmannsg{\"u}tern und E-Commerce, werden. Dies geht nicht ohne neuartige betriebliche Konzepte und eine Transformation des G{\"u}terwagens von einem „dummen St{\"u}ck Stahl" zu einem modernen Werkzeug der Logistik. Als „G{\"u}terwagen 4.0" wird ein kommunikativer und kooperativer G{\"u}terwagen verstanden, der die Voraussetzung zur Automatisierung aller Prozesse der Zugvorbereitung bereitstellt, sich aber ansonsten vollkommen kompatibel mit heutigen Betriebsverfahren im Hauptlauf pr{\"a}sentiert. Durch Kommunikation zwischen G{\"u}terwagen und umgebenden intelligenten Systemen im Sinne eines „Internet der Dinge" gelingt damit unter Anderem die Realisierung hoch effizienter Gleisanschlussverkehre, die der G{\"u}terbahn neue M{\"a}rkte abseits der klassisch bahn-affinen Verkehre erschließen und letztlich den Wandel zu einer nachhaltigen G{\"u}termobilit{\"a}t f{\"o}rdern.},
  language  = {de}
}
@incollection{Stapenhorst2019,
  author    = {Stapenhorst, Carolin},
  title     = {Heimat entwerfen?},
  series = {Das Eigene und das Fremde - Heimat in Zeiten der Mobilit{\"a}t},
  booktitle = {Das Eigene und das Fremde - Heimat in Zeiten der Mobilit{\"a}t},
  editor    = {Hasse, J{\"u}rgen},
  publisher = {Karl Alber},
  address   = {Baden-Baden},
  isbn      = {978-3-495-49029-7 (print)},
  doi       = {10.5771/9783495817568},
  pages     = {215 -- 246},
  year      = {2019},
  language  = {de}
}
@book{StapenhorstMeerbach2019,
  author    = {Stapenhorst, Carolin and Meerbach, Kerstin},
  title     = {Studie zur forschungsbezogenen Lehre an der Fakult{\"a}t f{\"u}r Architektur der RWTH Aachen},
  publisher = {RWTH Aachen},
  address   = {Aachen},
  doi       = {10.18154/rWth-2019-06163},
  pages     = {140 Seiten},
  year      = {2019},
  language  = {de}
}
@inproceedings{HunsdiekChwallek2019,
  author    = {Hunsdiek, Niklas J.A. and Chwallek, Constanze},
  title     = {External venturing activities and the influence of the chief technology officer},
  series = {G-Forum Jahreskonferenz 2019},
  booktitle = {G-Forum Jahreskonferenz 2019},
  pages     = {6 Seiten},
  year      = {2019},
  language  = {en}
}
@misc{BiewendtBlaschkeBoehnert2019,
  author    = {Biewendt, Marcel and Blaschke, Florian and B{\"o}hnert, Arno},
  title     = {The rebound effect: a critical and systematic review on the current state of affairs},
  series = {Abstracts of the International Conference on Sustainable Economy and Agriculture},
  journal   = {Abstracts of the International Conference on Sustainable Economy and Agriculture},
  editor    = {Koponicsne Gy{\"o}rke, Diana},
  publisher = {Universit{\"a}t Kaposv{\´a}r},
  address   = {Kaposv{\´a}r},
  isbn      = {978-615-5599-72-9},
  pages     = {101 -- 101},
  year      = {2019},
  language  = {en}
}