@article{SpelthahnSchaffrathCoppeetal.2010, author = {Spelthahn, Heiko and Schaffrath, Sophie and Coppe, Thomas and Rufi, Frederic and Sch{\"o}ning, Michael Josef}, title = {Development of an electrolyte-insulator-semiconductor (EIS) based capacitive heavy metal sensor for the detection of Pb2+ und Cd2+ ions}, series = {Physica status solidi (a) : applications and material science}, volume = {207}, journal = {Physica status solidi (a) : applications and material science}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.200983306}, pages = {930 -- 934}, year = {2010}, abstract = {Chalcogenide glass materials as membranes for potentiometric sensors for chemical analysis in solutions have been studied since more than 20 years. In this work, an electrolyte-insulator-semiconductor structure was combined with chalcogenide glass membranes prepared by means of the pulsed laser deposition technique. Depending on the membrane composition a selectivity to different ions (Cd2+ and Pb2+) is achieved. The different sensor membranes have been physically characterised using microscopy, ellipsometry, profilometry, atomic force microscopy (AFM), scanning electron microscopy (SEM) and Rutherford backscattering spectrometry (RBS). The electrochemical behaviour has been investigated via capacitance/voltage (C/V) and constant capacitance (ConCap) measurements and results in a Cd2+ sensitivity of 23.1 ± 0.6 mV per decade in a linear range from 7 × 10-6 to 10-2 mol/l and 24.4 ± 0.5 mV per decade in a linear range from 5 × 10-6 to 10-2 mol/l for Pb2+, respectively.}, language = {en} } @article{SiqueiraBaeckerPoghossianetal.2010, author = {Siqueira, Jos{\´e} R. Jr. and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices}, series = {Physica status solidi (a). 207 (2010), H. 4}, journal = {Physica status solidi (a). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {781 -- 786}, year = {2010}, language = {en} } @article{SiqueiraMakiPaulovichetal.2010, author = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor}, series = {Analytical Chemistry (2010)}, journal = {Analytical Chemistry (2010)}, isbn = {0003-2700}, pages = {61 -- 65}, year = {2010}, language = {en} } @article{SchoeningKirchnerNgetal.2010, author = {Sch{\"o}ning, Michael Josef and Kirchner, Patrick and Ng, Yue Ann and Spelthahn, Heiko and Schneider, Andreas and Henkel, Hartmut and Friedrich, Peter and Kolstad, Jens and Berger, J{\"o}rg and Keusgen, Michael}, title = {Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {787 -- 792}, year = {2010}, language = {en} } @article{ScholzLeyDachwaldetal.2010, author = {Scholz, A. and Ley, Wilfried and Dachwald, Bernd and Miau, J. J. and Juang, J. C.}, title = {Flight results of the COMPASS-1 picosatellite mission}, series = {Acta Astronautica. 67 (2010), H. 9-10}, journal = {Acta Astronautica. 67 (2010), H. 9-10}, isbn = {0094-5765}, pages = {1289 -- 1298}, year = {2010}, language = {en} } @article{SchmittSchollCaietal.2010, author = {Schmitt, Robert and Scholl, Ingrid and Cai, Yu and Xia, Ji and Dziwoki, Paul and Harding, Martin and Pavim, Alberto}, title = {Machine vision system for inline inspection in carbide insert production}, series = {Proceedings of the 36th International MATADOR Conference}, journal = {Proceedings of the 36th International MATADOR Conference}, publisher = {Springer}, address = {Berlin}, isbn = {978-1-84996-431-9}, doi = {10.1007/978-1-84996-432-6_77}, pages = {339 -- 342}, year = {2010}, abstract = {In steps of the production chain of carbide inserts, such as unloading or packaging, the conformity test of the insert type is done manually, which causes a statistic increase of errors due to monotony and fatigue of the worker and the wide variety of the insert types. A machine vision system is introduced that captures digital frames of the inserts in the production line, analyses inspects automatically and measures four quality features: coating colour, edge radius, plate shape and chip-former geometry. This new method has been tested on several inserts of different types and has shown that the prevalent insert types can be inspected and robustly classified in real production environment and therefore improves the manufacturing automation.}, language = {en} } @article{SchlamannYoonMaderwaldetal.2010, author = {Schlamann, Marc and Yoon, Min-Suk and Maderwald, Stefan and Pietrzyk, Thomas and Bitz, Andreas and Gerwig, Marcus and Forsting, Michael and Ladd, Susanne C. and Ladd, Mark E. and Kastrup, Oliver}, title = {Short term effects of magnetic resonance imaging on excitability of the motor cortex at 1.5T and 7T}, series = {Academic Radiology}, volume = {17}, journal = {Academic Radiology}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1076-6332}, doi = {10.1016/j.acra.2009.10.004}, pages = {277 -- 281}, year = {2010}, abstract = {Rationale and Objectives The increasing spread of high-field and ultra-high-field magnetic resonance imaging (MRI) scanners has encouraged new discussion of the safety aspects of MRI. Few studies have been published on possible cognitive effects of MRI examinations. The aim of this study was to examine whether changes are measurable after MRI examinations at 1.5 and 7 T by means of transcranial magnetic stimulation (TMS). Materials and Methods TMS was performed in 12 healthy, right-handed male volunteers. First the individual motor threshold was specified, and then the cortical silent period (SP) was measured. Subsequently, the volunteers were exposed to the 1.5-T MRI scanner for 63 minutes using standard sequences. The MRI examination was immediately followed by another TMS session. Fifteen minutes later, TMS was repeated. Four weeks later, the complete setting was repeated using a 7-T scanner. Control conditions included lying in the 1.5-T scanner for 63 minutes without scanning and lying in a separate room for 63 minutes. TMS was performed in the same way in each case. For statistical analysis, Wilcoxon's rank test was performed. Results Immediately after MRI exposure, the SP was highly significantly prolonged in all 12 subjects at 1.5 and 7 T. The motor threshold was significantly increased. Fifteen minutes after the examination, the measured value tended toward normal again. Control conditions revealed no significant differences. Conclusion MRI examinations lead to a transient and highly significant alteration in cortical excitability. This effect does not seem to depend on the strength of the static magnetic field.}, language = {en} } @article{SchlamannVoigtMaderwaldetal.2010, author = {Schlamann, Marc and Voigt, Melanie A. and Maderwald, Stefan and Bitz, Andreas and Kraff, Oliver and Ladd, Susanne C. and Ladd, Mark E. and Forsting, Michael and Wilhelm, Hans}, title = {Exposure to high-field MRI does not affect cognitive function}, series = {Journal of Magnetic Resonance Imaging}, volume = {31}, journal = {Journal of Magnetic Resonance Imaging}, number = {5}, publisher = {Wiley-Liss}, address = {New York}, issn = {1522-2586}, doi = {10.1002/jmri.22065}, pages = {1061 -- 1066}, year = {2010}, abstract = {Purpose To assess potential cognitive deficits under the influence of static magnetic fields at various field strengths some studies already exist. These studies were not focused on attention as the most vulnerable cognitive function. Additionally, mostly no magnetic resonance imaging (MRI) sequences were performed. Materials and Methods In all, 25 right-handed men were enrolled in this study. All subjects underwent one MRI examination of 63 minutes at 1.5 T and one at 7 T within an interval of 10 to 30 days. The order of the examinations was randomized. Subjects were referred to six standardized neuropsychological tests strictly focused on attention immediately before and after each MRI examination. Differences in neuropsychological variables between the timepoints before and after each MRI examination were assessed and P-values were calculated Results Only six subtests revealed significant differences between pre- and post-MRI. In these tests the subjects achieved better results in post-MRI testing than in pre-MRI testing (P = 0.013-0.032). The other tests revealed no significant results. Conclusion The improvement in post-MRI testing is only explicable as a result of learning effects. MRI examinations, even in ultrahigh-field scanners, do not seem to have any persisting influence on the attention networks of human cognition immediately after exposure.}, language = {en} } @article{ScheerRossKapelyukhetal.2010, author = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland}, title = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice}, series = {Drug Metabolism and Disposition}, volume = {38}, journal = {Drug Metabolism and Disposition}, number = {7}, publisher = {ASPET}, address = {Bethesda}, issn = {1521-009X}, doi = {10.1124/dmd.109.031872}, pages = {1046 -- 1053}, year = {2010}, abstract = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.}, language = {en} } @article{RossPlummerRodeetal.2010, author = {Ross, Jillian and Plummer, Simon M. and Rode, Anja and Scheer, Nico and Bower, Conrad C. and Vogel, Ortwin and Henderson, Colin J. and Wolf, C. Roland and Elcombe, Clifford R.}, title = {Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo}, series = {Toxicological Sciences}, volume = {116}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1096-0929}, doi = {10.1093/toxsci/kfq118}, pages = {452 -- 466}, year = {2010}, abstract = {Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.}, language = {en} }