@article{EmontsBuyel2023,
  author    = {Emonts, Jessica and Buyel, Johannes Felix},
  title     = {An overview of descriptors to capture protein properties - Tools and perspectives in the context of QSAR modeling},
  series = {Computational and Structural Biotechnology Journal},
  journal   = {Computational and Structural Biotechnology Journal},
  number    = {21},
  publisher = {Research Network of Computational and Structural Biotechnology},
  address   = {Gotenburg},
  issn      = {2001-0370 (online-ressource)},
  doi       = {10.1016/j.csbj.2023.05.022},
  pages     = {3234 -- 3247},
  year      = {2023},
  abstract  = {Proteins are important ingredients in food and feed, they are the active components of many pharmaceutical products, and they are necessary, in the form of enzymes, for the success of many technical processes. However, production can be challenging, especially when using heterologous host cells such as bacteria to express and assemble recombinant mammalian proteins. The manufacturability of proteins can be hindered by low solubility, a tendency to aggregate, or inefficient purification. Tools such as in silico protein engineering and models that predict separation criteria can overcome these issues but usually require the complex shape and surface properties of proteins to be represented by a small number of quantitative numeric values known as descriptors, as similarly used to capture the features of small molecules. Here, we review the current status of protein descriptors, especially for application in quantitative structure activity relationship (QSAR) models. First, we describe the complexity of proteins and the properties that descriptors must accommodate. Then we introduce descriptors of shape and surface properties that quantify the global and local features of proteins. Finally, we highlight the current limitations of protein descriptors and propose strategies for the derivation of novel protein descriptors that are more informative.},
  language  = {en}
}
@article{RieplPettrakFaulstichetal.2010,
  author    = {Riepl, Herbert Matthias and Pettrak, J{\"u}rgen and Faulstich, Martin and Herrmann, Wolfgang Anton},
  title     = {Self metathesis of fatty alcohols and amines to provide monomers for polyester and polyamide products},
  series = {Macromolecular Symposia},
  volume    = {293},
  journal   = {Macromolecular Symposia},
  number    = {1},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-3900 (eISSN)},
  doi       = {10.1002/masy.200900041},
  pages     = {39 -- 42},
  year      = {2010},
  abstract  = {Self metathesis of oleochemicals offers a variety of bifunctional compounds, that can be used as monomer for polymer production. Many precursors are in huge scales available, like oleic acid ester (biodiesel), oleyl alcohol (tensides), oleyl amines (tensides, lubricants). We show several ways to produce and separate and purify C18-α,ω-bifunctional compounds, using Grubbs 2nd Generation catalysts, starting from technical grade educts.},
  language  = {en}
}
@article{GrosshauserPettrak2023,
  author    = {Großhauser, Christian and Pettrak, J{\"u}rgen},
  title     = {Die Rolle des Wasserstoffs in der Abwasserbehandlung},
  series = {Wasser und Abfall},
  journal   = {Wasser und Abfall},
  number    = {7/8},
  publisher = {Springer Fachmedien},
  address   = {Wiesbaden},
  issn      = {1436-9095},
  doi       = {10.1007/s35152-023-1444-4},
  year      = {2023},
  abstract  = {Die Bereitstellung von nachhaltig erzeugtem Wasserstoff als Energietr{\"a}ger und Rohstoff ist eine wichtige Schl{\"u}sseltechnologie sowohl als Ersatz f{\"u}r fossile Energietr{\"a}ger, aber auch als Produkt im Zusammenhang mit Kreislaufprozessen. In der Abwasserbehandlung bestehen verschiedene M{\"o}glichkeiten Wasserstoff herzustellen. Mehrere Wege, m{\"o}gliche Synergien, aber auch deren Nachteile werden vorgestellt.},
  language  = {de}
}
@article{RakeEnningKurthetal.1994,
  author    = {Rake, Heinrich and Enning, Manfred and Kurth, Johannes and Schr{\"o}der, Walter},
  title     = {Automatic uncoupler completes automation at the hump},
  series = {RGI - Railway Gazette International},
  volume    = {150},
  journal   = {RGI - Railway Gazette International},
  number    = {6},
  publisher = {Reed Business},
  address   = {Sutton},
  issn      = {0373-5346},
  pages     = {371 -- 374},
  year      = {1994},
  language  = {en}
}
@article{RakeSchwanhaeusserFrederichetal.1993,
  author    = {Rake, Heinrich and Schwanh{\"a}ußer, Wulf and Frederich, Fritz and Enning, Manfred},
  title     = {Automatisierung von Ablaufanlagen mit dem Kupplungsroboter},
  series = {ETR - Eisenbahntechnische Rundschau},
  journal   = {ETR - Eisenbahntechnische Rundschau},
  number    = {4},
  publisher = {DVV Media Group},
  address   = {Hamburg},
  issn      = {0013-2845},
  pages     = {249 -- 254},
  year      = {1993},
  language  = {de}
}
@article{ManfredMaySutter2020,
  author    = {Manfred, Enning and May, J{\"o}rg and Sutter, Stefan},
  title     = {Innovation am G{\"u}terwagen am Beispiel der Automatischen Bremsprobe},
  series = {ETR - Eisenbahntechnische Rundschau},
  journal   = {ETR - Eisenbahntechnische Rundschau},
  number    = {12},
  publisher = {DVV Media Group},
  address   = {Hamburg},
  issn      = {0013-2845},
  pages     = {14 -- 19},
  year      = {2020},
  abstract  = {Mit der Digitalen Automatischen Kupplung beginnt ein neues Kapitel des Schieneng{\"u}terverkehrs, in dem zusammengestellte Wagen sich automatisch in wenigen Minuten abfahrbereit machen, ohne dass der Mensch eingreifen muss. Eines des gr{\"o}ßten Hemmnisse der umweltfreundlichen Schiene wird dann entfallen. Notwendig ist jetzt eine Diskussion {\"u}ber den Umfang und die Systemgrenzen der Automatischen Bremsprobe.},
  language  = {de}
}
@article{EnningSchmidtWilbring2019,
  author    = {Enning, Manfred and Schmidt, Bernd and Wilbring, Daniela},
  title     = {Auf dem Weg zur autonomen Anschlussbedienung},
  series = {Privatbahn-Magazin},
  journal   = {Privatbahn-Magazin},
  number    = {3},
  publisher = {Bahn Media},
  address   = {Suhlendorf},
  issn      = {1865-0163},
  pages     = {40 -- 43},
  year      = {2019},
  language  = {de}
}
@article{EnningPfaff2017,
  author    = {Enning, Manfred and Pfaff, Raphael},
  title     = {G{\"u}terwagen 4.0 - Mehr als nur technischer Fortschritt},
  series = {Privatbahn-Magazin},
  journal   = {Privatbahn-Magazin},
  number    = {2},
  publisher = {Bahn Media},
  address   = {Suhlendorf},
  issn      = {1865-0163},
  pages     = {21 -- 25},
  year      = {2017},
  abstract  = {Lokomotiven sind dank modernster Konzepte der Antriebstechnik heute energiesparend und umweltfreundlich. Eine Ausr{\"u}stung mit Telematik und Assistenzfunktionen ist Standard. Auf der Strecke zeigt sich moderne Technik in Form elektronischer Stellwerke und Zugsicherungssysteme und in Rangier- und Abstellanlagen als EOW-Technik. Am G{\"u}terwagen hingegen ist der technische Fortschritt komplett vorbeigegangen. Auch beim modernsten Wagen (Abb. 1) ist die einzige „Automatik"-Funktion die zentral {\"u}ber die Hauptluftleitung (HL) versorgte und bet{\"a}tigte Luftbremse.},
  language  = {de}
}
@article{EnningPfaff2016,
  author    = {Enning, Manfred and Pfaff, Raphael},
  title     = {Digitalisierung bringt mehr G{\"u}ter auf die Schiene},
  series = {Sonderprojekte ATM/MTZ},
  volume    = {21},
  journal   = {Sonderprojekte ATM/MTZ},
  number    = {6 (suppl.)},
  publisher = {Springer Fachmedien},
  address   = {Wiesbaden},
  issn      = {2509-4610},
  doi       = {10.1007/s41491-016-0570-7},
  pages     = {34 -- 37},
  year      = {2016},
  language  = {de}
}
@article{AsarStapenhorst2020,
  author    = {Asar, Hande and Stapenhorst, Carolin},
  title     = {Zvi Hecker: Drawing on drawing},
  series = {Archives of Design Research},
  volume    = {33},
  journal   = {Archives of Design Research},
  number    = {3},
  publisher = {Korean Society of Design Science},
  address   = {Seongnam},
  issn      = {1226-8046},
  doi       = {10.15187/adr.2020.08.33.3.45},
  pages     = {45 -- 53},
  year      = {2020},
  abstract  = {Background: Architectural representation, nurtured by the interaction between design thinking and design action, is inherently multi-layered. However, the representation object cannot always reflect these layers. Therefore, it is claimed that these reflections and layerings can gain visibility through 'performativity in personal knowledge', which basically has a performative character. The specific layers of representation produced during the performativity in personal knowledge permit insights about the 'personal way of designing' [1]. Therefore, the question, 'how can these layered drawings be decomposed to understand the personal way of designing', can be defined as the beginning of the study. On the other hand, performativity in personal knowledge in architectural design is handled through the relationship between explicit and tacit knowledge and representational and non-representational theory. To discuss the practical dimension of these theoretical relations, Zvi Hecker's drawing of the Heinz-Galinski-School is examined as an example. The study aims to understand the relationships between the layers by decomposing a layered drawing analytically in order to exemplify personal ways of designing. Methods: The study is based on qualitative research methodologies. First, a model has been formed through theoretical readings to discuss the performativity in personal knowledge. This model is used to understand the layered representations and to research the personal way of designing. Thus, one drawing of Hecker's Heinz-Galinski-School project is chosen. Second, its layers are decomposed to detect and analyze diverse objects, which hint to different types of design tools and their application. Third, Zvi Hecker's statements of the design process are explained through the interview data [2] and other sources. The obtained data are compared with each other. Results: By decomposing the drawing, eleven layers are defined. These layers are used to understand the relation between the design idea and its representation. They can also be thought of as a reading system. In other words, a method to discuss Hecker's performativity in personal knowledge is developed. Furthermore, the layers and their interconnections are described in relation to Zvi Hecker's personal way of designing. Conclusions: It can be said that layered representations, which are associated with the multilayered structure of performativity in personal knowledge, form the personal way of designing.},
  language  = {en}
}