@article{FinkenbergerSchlaich2014, author = {Finkenberger, Isabel Maria and Schlaich, Christoph}, title = {Mehr als Wohnen. Vom Zusammenleben in integrierten Nachbarschaften}, series = {APuZ - Aus Politik und Zeitgeschichte}, volume = {2014}, journal = {APuZ - Aus Politik und Zeitgeschichte}, number = {20-21}, publisher = {Bundeszentrale f{\"u}r politische Bildung - bpb}, address = {Bonn}, issn = {2194-3621}, pages = {46 -- 52}, year = {2014}, abstract = {Neue D{\"o}rfer braucht das Land! D{\"o}rfer in der Stadt und D{\"o}rfer auf dem Land (…). Die Planung und Gestaltung nachhaltiger Raumsysteme, die durch ein neues Verst{\"a}ndnis des gemeinschaftlichen Besitzes (und dessen Nutzung) ressourcenfressende Individualisierungstendenzen unserer Gesellschaft {\"u}berwinden, aber zugleich gr{\"o}ßtm{\"o}glichen Freiraum f{\"u}r eine individuelle Pers{\"o}nlichkeitsentfaltung zur Verf{\"u}gung stellen." Dieses Zitat der Hamburger Initiative "Wir sind Dorf" beschreibt eine aktuelle Diskussion in unserer Gesellschaft, die sowohl in der Forschung und forschungsgeleiteten Initiativen, in Politik und Planung als auch in der B{\"u}rger-schaft stattfindet. Sie wird nicht nur auf wissenschaftlichen Veranstaltungen gef{\"u}hrt, sondern auch in konkreten Projekten f{\"u}r integrative Lebenswelten, die Fragestellungen von Ern{\"a}hrung und Energieversorgung, von Arbeit und {\"O}konomie, aber auch eines neuen r{\"a}umlichen und sozialen Miteinanders einbeziehen. Anders als bei den weit verbreiteten Baugruppen geht es nicht ausschließlich um die Schaffung von Wohnraum. Die Nachbarschaftsidee verbindet das Bed{\"u}rfnis nach gemeinschaftlichem Wohnen und Wirtschaften mit einer neuen Werteorientierung, die auf pers{\"o}nlicher Verantwortungs{\"u}bernahme beruht.}, language = {de} } @article{Finkenberger2014, author = {Finkenberger, Isabel Maria}, title = {Vox populi. (Transformations-)potenziale nachkriegsmoderner Freiraumressourcen}, series = {Stadt+Gr{\"u}n}, volume = {2014}, journal = {Stadt+Gr{\"u}n}, number = {1}, publisher = {Patzer}, address = {Berlin}, issn = {0948-9770}, pages = {31 -- 35}, year = {2014}, abstract = {Heute wie damals werden die großz{\"u}gigen und offenen Siedlungsstrukturen der ersten Nachkriegsjahrzehnte mit ihrem hohen Anteil an "Gr{\"u}n" vielfach gesch{\"a}tzt und als solche nicht grundlegend hinterfragt. "Gr{\"u}n" verheißt im Allgemeinen Licht, Luft und Sonne, Freizeit und Erholung und gilt als etwas W{\"u}nschenswertes im st{\"a}dtischen Kontext. Unbeachtet bleibt, dass dem Begriff "Gr{\"u}n" zun{\"a}chst keine Eigenschaften oder Qualit{\"a}ten zugewiesen sind - er sagt noch lange nichts {\"u}ber dessen r{\"a}umliche Qualit{\"a}t, dessen Nutzbarkeit, Erreichbarkeit und Zug{\"a}nglichkeit aus. Abstandsgr{\"u}n und Straßenbegleitgr{\"u}n ist eben auch "Gr{\"u}n". Neben einer quantitativen Argumentation, welche {\"o}kologischen Aspekte wie Biotopvernetzung, Stadt- und Mikroklima ber{\"u}cksichtigt, sollten wir verst{\"a}rkt qualitativ denken und damit die Grundlage f{\"u}r einen erweiterten und wesentlich differenzierteren Diskurs {\"u}ber urbane Freir{\"a}ume ebnen.}, language = {de} } @article{YangKriechbaumerAlbrachtetal.2014, author = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn}, title = {A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans}, series = {Journal of Orthopaedic Translation}, volume = {2}, journal = {Journal of Orthopaedic Translation}, number = {4}, publisher = {Elsevier}, address = {Singapore}, issn = {2214-0328}, doi = {10.1016/j.jot.2014.07.078}, pages = {238 -- 238}, year = {2014}, language = {en} } @article{GollandEngling2014, author = {Golland, Alexander and Engling, Christoph}, title = {a-i3/BSI Symposium 2014: Sicherheit von Daten und Identit{\"a}ten angesichts NSA und Big Data}, series = {DSB Datenschutz-Berater}, volume = {38}, journal = {DSB Datenschutz-Berater}, number = {7-8}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, isbn = {0170-7256}, pages = {165 -- 166}, year = {2014}, language = {de} } @article{Golland2014, author = {Golland, Alexander}, title = {Datenschutz durch modulare Zertifizierung: Trusted Cloud-Pilotprojekt bringt neuen Ansatz}, series = {DSB Datenschutz-Berater}, volume = {38}, journal = {DSB Datenschutz-Berater}, number = {10}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, isbn = {0170-7256}, pages = {213 -- 215}, year = {2014}, language = {de} } @article{AltherrEdererLorenzetal.2014, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Experimental validation of an enhanced system synthesis approach}, series = {Operations Research Proceedings 2014}, journal = {Operations Research Proceedings 2014}, editor = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit}, publisher = {Springer}, address = {Basel}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_1}, pages = {6}, year = {2014}, abstract = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.}, language = {en} } @article{ButenwegSchmittRosen2014, author = {Butenweg, Christoph and Schmitt, T. and Rosen, B.}, title = {Seismische Einwirkungen auf erdverlegte Rohrleitungen}, series = {Bauingenieur}, volume = {89}, journal = {Bauingenieur}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {316 -- 324}, year = {2014}, abstract = {Die erdbebensichere Auslegung von erdverlegten Rohrleitungssystemen ist von wesentlicher Bedeutung zur Sicherstellung der Funktionalit{\"a}t der Versorgungsinfrastruktur nach einem Erdbebenereignis. Zur Vermeidung von Netzausf{\"a}llen ist es erforderlich, die r{\"a}umlich weit ausgedehnten Leitungssysteme mit geeigneten rechnerischen Modellen seismisch zu bemessen. Der vorliegende Beitrag behandelt die Beanspruchung von Rohrleitungssystemen durch seismische Welleneinwirkung und stellt geeignete N{\"a}herungsans{\"a}tze und ein detailliertes Rechenmodell f{\"u}r seismische Leitungsanalysen vor. Mit den Ans{\"a}tzen wird in Berechnungsbeispielen der Einfluss wesentlicher Parameter auf die seismisch induzierten Dehnungen in Rohrleitungssystemen untersucht.}, language = {de} } @article{HentschkeHagerHojdis2014, author = {Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils}, title = {Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers}, series = {Journal of Applied Polymer Science}, volume = {131}, journal = {Journal of Applied Polymer Science}, number = {18}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-4628}, doi = {10.1002/app.40806}, pages = {1 -- 9}, year = {2014}, abstract = {Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of "bonds" between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.}, language = {en} } @article{AkimbekovDigelOHerasetal.2014, author = {Akimbekov, N.Sh. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments}, series = {Experimental Biology}, volume = {60}, journal = {Experimental Biology}, number = {1/2}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {144 -- 148}, year = {2014}, abstract = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.}, language = {en} } @article{AkimbekovDigelZhubanova2014, author = {Akimbekov, N. Sh. and Digel, Ilya and Zhubanova, A. A.}, title = {Advantages of creation of e-books in training of specialists biologists and biotechnologists}, series = {KazNU Bulletin. Biology series.}, volume = {60}, journal = {KazNU Bulletin. Biology series.}, number = {1}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {249 -- 252}, year = {2014}, abstract = {The necessity of e-books as a primary of learning, its opportunities for realization of competence during training biologist and biotechnologist specialists are determined. Definitions and requirements to the e-books, its advantages in comparison with traditional textbooks, and the ways of creation of e-books in the SunRav BookEditor program are considered.}, language = {ru} } @article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @article{ScheerMclaughlinRodeetal.2014, author = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.}, title = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057885}, pages = {1022 -- 1030}, year = {2014}, abstract = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.}, language = {en} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{LuisierLempiaeinenScherbichleretal.2014, author = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.}, title = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors}, series = {Toxicological Sciences}, volume = {139}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1094-2025}, doi = {https://doi.org/10.1093/toxsci/kfu038}, pages = {501 -- 511}, year = {2014}, abstract = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.}, language = {en} } @article{KrollLudwigsKaesling2014, author = {Kroll-Ludwigs, Kathrin and Kaesling, Katharina}, title = {Family Law and Culture in Europe: Developments, Challenges and Opportunities - Konferenz der Commission on European Family Law vom 29.-31. August 2013, Bonn}, series = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, journal = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, number = {3}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {0943-3929}, pages = {673 -- 676}, year = {2014}, abstract = {Vor dem Hintergrund zunehmender gesellschaftlicher Ver{\"a}nderungen bei den Lebens- und Familienformen hat es sich die Commission on European Family Law (CEFL) seit 2001 zum Ziel gesetzt, unverbindliche Regelungsvorschl{\"a}ge f{\"u}r ein europaweit einheitliches Familienrecht zu schaffen. Die Vorstellung und Diskussion dieser auf rechtsvergleichender Basis erstellten Principles erfolgt auf den regelm{\"a}ßig veranstalteten Tagungen der CEFL. Die nunmehr f{\"u}nfte Konferenz zum Thema „Family Law and Culture in Europe - Developments, Challenges and Opportunities" fand erstmals in Deutschland statt. Ausgerichtet wurde die Veranstaltung, zu der ca. 200 Teilnehmerinnen und Teilnehmern aus Wissenschaft und Praxis aus insgesamt 33 L{\"a}ndern angereist waren, von Nina Dethloff (Direktorin des Instituts f{\"u}r Deutsches, Europ{\"a}isches und Internationales Familienrecht an der Universit{\"a}t Bonn), Katharina Boele-Woelki (Direktorin des Utrecht Centre for European Research into Family Law und Preistr{\"a}gerin des Anneliese Maier-Forschungspreises der Alexander von Humboldt-Stiftung) und Werner Gephart (Direktor des K{\"a}te Hamburger Kollegs „Recht als Kultur").}, language = {de} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Divided Government and the Adoption of Economic Reforms}, series = {CESifo DICE Report - Journal for Institutional Comparison}, volume = {12}, journal = {CESifo DICE Report - Journal for Institutional Comparison}, number = {4}, publisher = {Ifo Institute for Economic Research}, address = {M{\"u}nchen}, issn = {1612-0663}, pages = {47 -- 52}, year = {2014}, language = {en} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Do politicians shirk when reelection is certain? Evidence from the German parliament}, series = {European Journal of Political Economy}, volume = {36}, journal = {European Journal of Political Economy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0176-2680}, doi = {10.1016/j.ejpoleco.2014.07.001}, pages = {55 -- 70}, year = {2014}, abstract = {Does stiffer electoral competition reduce political shirking? For a micro-analysis of this question, I construct a new data set spanning the years 2005 to 2012 covering biographical and political information about German Members of Parliament (MPs), including their attendance rates in voting sessions. For the parliament elected in 2009, I show that indeed opposition party MPs who expect to face a close race in their district show significantly and relevantly lower absence rates in parliament beforehand. MPs of governing parties seem not to react significantly to electoral competition. These results are confirmed by an analysis of the parliament elected in 2005, by several robustness checks, and also by employing an instrumental variable strategy exploiting convenient peculiarities of the German electoral system. The study also shows how MPs elected via party lists react to different levels of electoral competition.}, language = {en} } @article{Tran2014, author = {Tran, Duc Hung}, title = {Multiple corporate governance attributes and the cost of capital - Evidence from Germany}, series = {The British Accounting Review}, volume = {46}, journal = {The British Accounting Review}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0890-8389}, doi = {https://doi.org/10.1016/j.bar.2014.02.003}, pages = {179 -- 197}, year = {2014}, abstract = {This paper investigates the extent to which corporate governance affects the cost of debt and equity capital of German exchange-listed companies. I examine corporate governance along three dimensions: financial information quality, ownership structure and board structure. The results suggest that firms with high levels of financial transparency and bonus compensations face lower cost of equity. In addition, block ownership is negatively related to firms' cost of equity when the blockholders are other firms, managers or founding-family members. Consistent with the conjecture that agency costs increase with firm size, I find significant cost of debt effects only in the largest German companies. Here, the creditors demand lower cost of debt from firms with block ownerships held by corporations or banks. My findings demonstrate that a uniform set of governance attributes is unlikely to satisfy suppliers of debt and equity capital equally.}, language = {en} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Gestaltung des Anstellungsvertrags - Der Compliance-Beauftragte}, series = {Arbeit und Arbeitsrecht : AuA}, journal = {Arbeit und Arbeitsrecht : AuA}, number = {7}, publisher = {Huss Medien}, address = {Berlin}, issn = {0323-4568}, pages = {400 -- 403}, year = {2014}, abstract = {Ein Compliance-Beauftragter soll daf{\"u}r Sorge tragen, dass aus dem Unternehmen heraus keine Rechtsverletzungen begangen werden. Aber welche rechtlichen Notwendigkeiten und M{\"o}glichkeiten resultieren daraus f{\"u}r die Gestaltung des Anstellungsvertrags?}, language = {de} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Der neue gesetzliche Mindestlohn - was gilt und was Unternehmen k{\"u}nftig beachten m{\"u}ssen}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {521 -- 524}, year = {2014}, abstract = {Ab dem 1.1.2015 ist es soweit: Deutschland erh{\"a}lt einen fl{\"a}chendeckenden und weitgehend branchenunabh{\"a}ngigen gesetzlichen Mindestlohn. Danach haben grunds{\"a}tzlich alle abh{\"a}ngig besch{\"a}ftigten Arbeitnehmer einen Anspruch auf eine Entlohnung von wenigstens 8,50 EUR brutto je Arbeitsstunde. Die Auswirkungen d{\"u}rften enorm sein. Das Bundesministerium f{\"u}r Arbeit und Soziales geht jedenfalls davon aus, dass aufgrund der Einf{\"u}hrung des gesetzlichen Mindestlohns mehrere Millionen Besch{\"a}ftigte einen h{\"o}heren Lohn beanspruchen k{\"o}nnen. Der nachfolgende Beitrag gibt einen {\"U}berblick {\"u}ber die wesentlichen Inhalte des gesetzlichen Mindestlohns und Hinweise f{\"u}r Anwendungsprobleme in der betrieblichen Praxis.}, language = {de} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Die arbeitsrechtliche Stellung des Prokuristen - Handelsrechtlicher Kompetenzzuwachs mit arbeitsrechtlichen Konsequenzen}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {21}, publisher = {NWB-Verlag}, address = {Herne}, issn = {1860-9449}, pages = {1591 -- 1596}, year = {2014}, abstract = {Die Besch{\"a}ftigung von Prokuristen ist g{\"a}ngige betriebliche Praxis. Unternehmen stehen dabei immer wieder vor der Frage, ob und welche Arbeitnehmer sie zu Prokuristen bestellen sollen. Nicht selten bleiben hierbei die arbeitsrechtlichen Konsequenzen, die mit der Bestellung eines Arbeitnehmers zum Prokuristen einhergehen k{\"o}nnen, unber{\"u}cksichtigt, wie diverse Gerichtsentscheidungen zeigen. Dieser Beitrag soll einen {\"U}berblick {\"u}ber die arbeitsrechtlichen Folgen bei der Besch{\"a}ftigung von Prokuristen geben und der betrieblichen Praxis somit gleichzeitig als Entscheidungshilfe dienen, wenn es um das Ob und Wie der m{\"o}glichen Bestellung eines Arbeitnehmers zum Prokuristen geht.}, language = {de} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @article{Wilke2014, author = {Wilke, Thomas}, title = {Gebaute Geschichte in Turin}, series = {Kunsttexte.de}, volume = {2014}, journal = {Kunsttexte.de}, number = {1}, publisher = {Humboldt-Universit{\"a}t zu Berlin}, address = {Berlin}, issn = {1618-8101}, doi = {10.18452/7197}, pages = {13 Seiten}, year = {2014}, abstract = {St{\"a}dte sind Stein gewordene Geschichte. Ihre realisierte Form erm{\"o}glicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der f{\"u}hrenden Barockmetropolen Europas beeinflusste.}, language = {de} } @article{HoehrPaulssenBenardetal.2014, author = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul}, title = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron}, series = {Nuclear medicine and biology}, volume = {41}, journal = {Nuclear medicine and biology}, number = {5}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-9614}, doi = {10.1016/j.nucmedbio.2013.12.016}, pages = {401 -- 406}, year = {2014}, abstract = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.}, language = {en} } @article{JoerissenHeger2014, author = {J{\"o}rissen, J{\"o}rg and Heger, Michael}, title = {Zur Wirkung hochschuldidaktisch fundierter und in den Fachbereichen verankerter Lehrveranstaltungsevaluation}, series = {Qualit{\"a}t in der Wissenschaft (QiW)}, volume = {8}, journal = {Qualit{\"a}t in der Wissenschaft (QiW)}, number = {2+3}, publisher = {Universit{\"a}tsverlag Webler}, address = {Bielefeld}, issn = {1860-3041}, pages = {70 -- 80}, year = {2014}, language = {de} } @article{TippkoetterDuweWiesenetal.2014, author = {Tippk{\"o}tter, Nils and Duwe, Anna-Maria and Wiesen, Sebastian and Sieker, Tim and Ulber, Roland}, title = {Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids}, series = {Bioresource Technology}, volume = {167}, journal = {Bioresource Technology}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.biortech.2014.06.052}, pages = {447 -- 455}, year = {2014}, abstract = {The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10\% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9\%, 17\% and 23\% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17\% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23\% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹.}, language = {en} } @article{AlKaidyDuweHusteretal.2014, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Sieker, Tim and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnologie und Bioverfahrenstechnik - Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {12}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201400083}, pages = {2215 -- 2225}, year = {2014}, abstract = {Biotechnologie und die mit ihr verbundenen technischen Prozesse pr{\"a}gen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und t{\"a}glichen Gebrauchsg{\"u}tern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verst{\"a}ndnis zellul{\"a}rer Vorg{\"a}nge k{\"o}nnen mittlerweile Produktionsst{\"a}mme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik k{\"o}nnen so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.}, language = {de} } @article{WiesenTippkoetterMuffleretal.2014, author = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Nils and Ulber, Roland}, title = {Adsorptive Vorbehandlung von Rohglycerin f{\"u}r die 1,3-Propandiol Fermentation mit Clostridium diolis}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {1-2}, publisher = {Wiley-VCH}, address = {Weinheim}, doi = {10.1002/cite.201300080}, pages = {129 -- 135}, year = {2014}, abstract = {Bei der Gewinnung von Fetts{\"a}uren aus Pflanzen{\"o}len, z. B. zur Herstellung von Biopolymeren, oder bei der Biodiesel- und Seifenproduktion, f{\"a}llt Glycerin als Nebenprodukt an. Bei der Biokonversion dieses Rohstoffes zu 1,3-Propandiol wird der Produktionsorganismus Clostridium diolis durch Verunreinigungen im Rohglycerin gehemmt. Als inhibierende Substanzen konnten freie Fetts{\"a}uren identifiziert werden. Mithilfe eines adsorptiven Aufarbeitungsverfahrens ist es gelungen, die Fetts{\"a}uren zu entfernen und die Konversionseffizienz zu 1,3-Propandiol zu erh{\"o}hen.}, language = {de} } @article{TippkoetterWollnySucketal.2014, author = {Tippk{\"o}tter, Nils and Wollny, Steffen and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense}, series = {Engineering in Life Sciences}, volume = {14}, journal = {Engineering in Life Sciences}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1618-2863}, doi = {10.1002/elsc.201300113}, pages = {425 -- 432}, year = {2014}, abstract = {A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.}, language = {en} } @article{PasteurTippkoetterKampeisetal.2014, author = {Pasteur, Aline and Tippk{\"o}tter, Nils and Kampeis, Percy and Ulber, Roland}, title = {Optimization of high gradient magnetic separation filter units for the purification of fermentation products}, series = {IEEE TRANSACTIONS ON MAGNETICS}, volume = {50}, journal = {IEEE TRANSACTIONS ON MAGNETICS}, number = {10}, publisher = {IEEE}, address = {New York, NY}, issn = {0018-9464}, doi = {10.1109/TMAG.2014.2325535}, pages = {Artikel 5000607}, year = {2014}, abstract = {High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments.}, language = {en} } @article{MaasVosLagemaatetal.2014, author = {Maas, Marnix C. and Vos, Eline K. and Lagemaat, Miriam W. and Bitz, Andreas and Orzada, Stephan and Kobus, Thiele and Kraff, Oliver and Maderwald, Stefan and Ladd, Mark E. and Scheenen, Tom W. J.}, title = {Feasibility of T₂-weighted turbo spin echo imaging of the human prostate at 7 tesla}, series = {Magnetic Resonance in Medicine}, volume = {71}, journal = {Magnetic Resonance in Medicine}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.24818}, pages = {1711 -- 1719}, year = {2014}, abstract = {Purpose To demonstrate that high quality T₂-weighted (T2w) turbo spin-echo (TSE) imaging of the complete prostate can be achieved routinely and within safety limits at 7 T, using an external transceive body array coil only. Methods Nine healthy volunteers and 12 prostate cancer patients were scanned on a 7 T whole-body system. Preparation consisted of B₀ and radiofrequency shimming and localized flip angle calibration. T₁ and T₂ relaxation times were measured and used to define the T2w-TSE protocol. T2w imaging was performed using a TSE sequence (pulse repetition time/echo time 3000-3640/71 ms) with prolonged excitation and refocusing pulses to reduce specific absorption rate. Results High quality T2w TSE imaging was performed in less than 2 min in all subjects. Tumors of patients with gold-standard tumor localization (MR-guided biopsy or prostatectomy) were well visualized on 7 T imaging (n = 3). The number of consecutive slices achievable within a 10-g averaged specific absorption rate limit of 10 W/kg was ≥28 in all subjects, sufficient for full prostate coverage with 3-mm slices in at least one direction. Conclusion High quality T2w TSE prostate imaging can be performed routinely and within specific absorption rate limits at 7 T with an external transceive body array.}, language = {en} } @article{PyschnyDoeringFeldmann2014, author = {Pyschny, D. and D{\"o}ring, Bernd and Feldmann, M.}, title = {Ermittlung der thermischen Leistungsf{\"a}higkeit des neuartigen multifunktionalen Verbunddeckensystems InaDeck}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen}, volume = {89}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen}, number = {3}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {116 -- 124}, year = {2014}, language = {de} } @article{LagemaatVosMaasetal.2014, author = {Lagemaat, Miriam W. and Vos, Eline K. and Maas, Marnix C. and Bitz, Andreas and Orzada, Stephan and Uden, Mark J. van and Kobus, Thiele and Heerschap, Arend and Scheenen, Tom W. J.}, title = {Phosphorus magnetic resonance spectroscopic imaging at 7 T in patients with prostate cancer}, series = {Investigative Radiology}, volume = {49}, journal = {Investigative Radiology}, number = {5}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia, Pa.}, issn = {1536-0210}, doi = {10.1097/RLI.0000000000000012}, pages = {363 -- 372}, year = {2014}, abstract = {Objectives The aim of this study was to identify characteristics of phosphorus (³¹P) spectra of the human prostate and to investigate changes of individual phospholipid metabolites in prostate cancer through in vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) at 7 T. Materials and Methods In this institutional review board-approved study, 15 patients with biopsy-proven prostate cancer underwent T₂-weighted magnetic resonance imaging and 3-dimensional ³¹P MRSI at 7 T. Voxels were selected at the tumor location, in normal-appearing peripheral zone tissue, normal-appearing transition zone tissue, and in the base of the prostate close to the seminal vesicles. Phosphorus metabolite ratios were determined and compared between tissue types. Results Signals of phosphoethanolamine (PE) and phosphocholine (PC) were present and well resolved in most ³¹P spectra in the prostate. Glycerophosphocholine signals were observable in 43\% of the voxels in malignant tissue, but in only 10\% of the voxels in normal-appearing tissue away from the seminal vesicles. In many spectra, independent of tissue type, 2 peaks resonated in the chemical shift range of inorganic phosphate, possibly representing 2 separate pH compartments. The PC/PE ratio in the seminal vesicles was highly elevated compared with the prostate in 5 patients. A considerable overlap of ³¹P metabolite ratios was found between prostate cancer and normal-appearing prostate tissue, preventing direct discrimination of these tissues. The only 2 patients with high Gleason scores tumors (≥4+5) presented with high PC and glycerophosphocholine levels in their cancer lesions. Conclusions Phosphorus MRSI at 7 T shows distinct features of phospholipid metabolites in the prostate gland and its surrounding structures. In this exploratory study, no differences in ³¹P metabolite ratios were observed between prostate cancer and normal-appearing prostate tissue possibly because of the partial volume effects of small tumor foci in large MRSI voxels.}, language = {en} } @article{TheysohnKraffEilersetal.2014, author = {Theysohn, Jens M. and Kraff, Oliver and Eilers, Kristina and Andrade, Dorian and Gerwig, Marcus and Timmann, Dagmar and Schmitt, Franz and Ladd, Mark E. and Ladd, Susanne C. and Bitz, Andreas}, title = {Vestibular effects of a 7 Tesla MRI examination compared to 1.5 T and 0 T in healthy volunteers}, series = {PLoS one}, volume = {9}, journal = {PLoS one}, number = {3}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0092104}, pages = {e92104}, year = {2014}, abstract = {Ultra-high-field MRI (7 Tesla (T) and above) elicits more temporary side-effects compared to 1.5 T and 3 T, e.g. dizziness or "postural instability" even after exiting the scanner. The current study aims to assess quantitatively vestibular performance before and after exposure to different MRI scenarios at 7 T, 1.5 T and 0 T. Sway path and body axis rotation (Unterberger's stepping test) were quantitatively recorded in a total of 46 volunteers before, 2 minutes after, and 15 minutes after different exposure scenarios: 7 T head MRI (n = 27), 7 T no RF (n = 22), 7 T only B₀ (n = 20), 7 T in \& out B₀ (n = 20), 1.5 T no RF (n = 20), 0 T (n = 15). All exposure scenarios lasted 30 minutes except for brief one minute exposure in 7 T in \& out B₀. Both measures were documented utilizing a 3D ultrasound system. During sway path evaluation, the experiment was repeated with eyes both open and closed. Sway paths for all long-lasting 7 T scenarios (normal, no RF, only B₀) with eyes closed were significantly prolonged 2 minutes after exiting the scanner, normalizing after 15 minutes. Brief exposure to 7 T B₀ or 30 minutes exposure to 1.5 T or 0 T did not show significant changes. End positions after Unterberger's stepping test were significantly changed counter-clockwise after all 7 T scenarios, including the brief in \& out B₀ exposure. Shorter exposure resulted in a smaller alteration angle. In contrast to sway path, reversal of changes in body axis rotation was incomplete after 15 minutes. 1.5 T caused no rotational changes. The results show that exposure to the 7 Tesla static magnetic field causes only a temporary dysfunction or "over-compensation" of the vestibular system not measurable at 1.5 or 0 Tesla. Radiofrequency fields, gradient switching, and orthostatic dysregulation do not seem to play a role.}, language = {en} } @article{VosLagemaatBarentszetal.2014, author = {Vos, E. K. and Lagemaat, M. W. and Barentsz, J. O. and F{\"u}tterer, J. J. and Zamecnik, P. and Roozen, H. and Orzada, S. and Bitz, Andreas and Maas, M. C. and Scheenen, T. W. J.}, title = {Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla}, series = {European Radiology}, volume = {24}, journal = {European Radiology}, number = {8}, publisher = {Springer}, address = {Cham}, issn = {1432-1084}, doi = {10.1007/s00330-014-3234-6}, pages = {1950 -- 1958}, year = {2014}, abstract = {Objectives To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T). Materials \& methods Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff's alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology. Results T2w imaging at 7T was achievable with 'satisfactory' (3/5) to 'good' (4/5) quality. Visibility of anatomical structures was predominantly scored as 'satisfactory' (3/5) and 'good' (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff's analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T. Conclusion T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.}, language = {en} } @article{HaagZontarSchleupenetal.2014, author = {Haag, S. and Zontar, D. and Schleupen, Josef and M{\"u}ller, T. and Brecher, C.}, title = {Chain of refined perception in self-optimizing assembly of micro-optical systems}, series = {Journal of sensors and sensor systems}, volume = {3}, journal = {Journal of sensors and sensor systems}, number = {1}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, issn = {2194-878X}, doi = {10.5194/jsss-3-87-2014}, pages = {87 -- 95}, year = {2014}, abstract = {Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements - especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.}, language = {en} } @article{VerschitzButenweg2014, author = {Verschitz, Daniel and Butenweg, Christoph}, title = {Standsicherheitsnachweis von Beh{\"a}ltern f{\"u}r Kleinkl{\"a}ranlagen}, series = {ACWA aktuell}, journal = {ACWA aktuell}, number = {12 - 9/2014}, publisher = {RWTH Aachen}, address = {Aachen}, pages = {10}, year = {2014}, abstract = {Die PIA GmbH pr{\"u}ft seit fast 8 Jahren die Standsicherheit von Beh{\"a}ltern f{\"u}r Kleinkl{\"a}ranlagen. Diese bestehen in der Regel aus Kunststoff oder Beton und m{\"u}ssen {\"u}ber ihre gesamte Lebensdauer den Beanspruchungen aus Handhabung, Einbau und Betrieb standhalten. Die Standsicherheit kann nach EN 12566 wahlweise durch einen rechnerischen Nachweis oder durch einen praktischen Nachweis wie die Bruchlastpr{\"u}fung oder die Pr{\"u}fung in der Grube erfolgen.}, language = {de} } @article{ButenwegRenault2014, author = {Butenweg, Christoph and Renault, Philippe}, title = {Workshop der Gesellschaften zum EU-Projekt SHARE}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, volume = {89 (2014)}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, number = {Oktober}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {1436-4867 (E-Journal); 0005-6650 (Print)}, pages = {S2 -- S3}, year = {2014}, language = {de} } @article{MeyerButenwegFehling2014, author = {Meyer, Udo and Butenweg, Christoph and Fehling, Ekkehard}, title = {EU-Projekt INSYSME : innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, volume = {89 (2014)}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, number = {April}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {1436-4867 (E-Journal); 0005-6650 (Print)}, pages = {S14 -- S15}, year = {2014}, language = {de} } @article{ButenwegSchmittRosen2014, author = {Butenweg, Christoph and Schmitt, Timo and Rosen, Britta}, title = {Seismische Einwirkungen auf erdverlegte Rohrleitungssysteme}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik}, volume = {89 (2014)}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik}, number = {Heft 7/8}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {316 -- 324}, year = {2014}, language = {de} } @article{ButenwegMeyerFehling2014, author = {Butenweg, Christoph and Meyer, Udo and Fehling, Ekkehard}, title = {EU-Projekt INSYSME: Innovative Techniken f{\"u}r erdbebensichere Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken}, series = {Mauerwerk : European journal of masonry}, volume = {18}, journal = {Mauerwerk : European journal of masonry}, number = {2}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201400612}, pages = {78 -- 81}, year = {2014}, abstract = {Am 1. Oktober 2013 ist das auf drei Jahre angelegte EU-Forschungsprojekt INSYSME - Innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken - gestartet. Unter der Koordination der Universit{\"a}t Padua beteiligen sich 16 Partner aus sechs europ{\"a}ischen L{\"a}ndern (Deutschland, Griechenland, Italien, Portugal, Rum{\"a}nien, T{\"u}rkei). Als deutsche Partner nehmen die Arbeitsgemeinschaft Mauerziegel aus Bonn, die Universit{\"a}t Kassel sowie das Ingenieurb{\"u}ro SDA-engineering GmbH aus Herzogenrath, teil. Ziel der deutschen Partner ist die Entwicklung von innovativen Ausfachungssystemen aus monolithischem w{\"a}rmed{\"a}mmenden Ziegelmauerwerk, mit denen nicht nur eine erh{\"o}hte Erdbebensicherheit, sondern auch die sichere Erf{\"u}llung der steigenden Anforderungen aus Windbeanspruchungen gew{\"a}hrleistet werden k{\"o}nnen. Die Forschungsergebnisse sollen vom Partner SDA-engineering GmbH in die bereits seit einigen Jahren verf{\"u}gbare Softwarel{\"o}sung MINEA [1] integriert werden. Weitere Informationen stehen auf den Websites des Projektes [2] zur Verf{\"u}gung. Im vorliegenden Beitrag werden nach einer kurzen thematischen Einf{\"u}hrung die Ergebnisse von Tastversuchen an senkrecht zur Ebene belasteten Ausfachungsw{\"a}nden aus Planziegelmauerwerk vorgestellt. Im Anschluss wird das geplante Arbeitsprogramm der deutschen Partner im Projekt INSYSME beschrieben.}, language = {de} } @article{GellertButenweg2014, author = {Gellert, Christoph and Butenweg, Christoph}, title = {Seismic analysis of masonry structures in German earthquake zones according to DIN EN 1998-1}, series = {Mauerwerk : European journal of masonry}, volume = {18}, journal = {Mauerwerk : European journal of masonry}, number = {3-4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201400626}, pages = {188 -- 196}, year = {2014}, abstract = {Die Erdbeben in Albstadt 1978 (Magnitude 5,7), Roermond 1992 (Magnitude 5,9) oder in Waldkirch 2004 (Magnitude 5,1) haben verdeutlicht, dass die erdbebensichere Auslegung von Mauerwerksbauten auch in Deutschland von großer Bedeutung ist. Bereits im Jahr 1981 wurde die DIN 4149 (1981) "Bauten in deutschen Erdbebengebieten - Lastannahmen, Bemessung und Ausf{\"u}hrung {\"u}blicher Hochbauten" eingef{\"u}hrt, in der aber f{\"u}r Mauerwerksbauten nur wenige Anforderungen gestellt wurden. Diese Norm wurde durch den NABau-Arbeitsausschuss "Erdbeben; Sonderfragen" des Deutschen Instituts f{\"u}r Normung e.V. (DIN) auf Grundlage des Eurocode 8 (2004) vollst{\"a}ndig {\"u}berarbeitet und durch die DIN 4149 (2005) abgel{\"o}st, die umfangreiche Regelungen f{\"u}r die seismische Auslegung von Mauerwerksbauten enth{\"a}lt. Mittlerweile liegen die DIN EN 1998-1 (2010) und der Nationale Anhang DIN EN 1998-1/NA (2011) vor, die nach Einarbeitung der Ergebnisse der durchgef{\"u}hrten Anwendungserprobung bauaufsichtlich eingef{\"u}hrt und die DIN 4149 (2005) ersetzen werden. Der folgende Beitrag gibt einen {\"U}berblick {\"u}ber die seismische Berechnung und Bemessung von Mauerwerksbauten nach dem europ{\"a}ischen Regelwerk und illustriert deren Anwendung an einem baupraktischen Beispiel.}, language = {de} } @article{LindEllrich2014, author = {Lind, Thorsten Patric and Ellrich, Thomas}, title = {Zur Haftung der Gl{\"a}ubigerausschussmitglieder wegen unzureichender Kassenpr{\"u}fung}, series = {Der Betrieb}, volume = {67}, journal = {Der Betrieb}, number = {49}, publisher = {Fachmedien Otto Schmidt}, address = {D{\"u}sseldorf}, issn = {0005-9935}, pages = {2819 -- 2820}, year = {2014}, language = {de} } @article{VogtMottaghyRathetal.2014, author = {Vogt, C. and Mottaghy, Darius and Rath, V. and Marquart, G. and Dijkshoorn, L. and Wolf, A. and Clauser, C.}, title = {Vertical variation in heat flow on the Kola Peninsula: palaeoclimate or fluid flow?}, series = {Geophysical Journal International}, volume = {199}, journal = {Geophysical Journal International}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1365-246X}, doi = {10.1093/gji/ggu282}, pages = {829 -- 843}, year = {2014}, abstract = {Following earlier studies, we present forward and inverse simulations of heat and fluid transport of the upper crust using a local 3-D model of the Kola area. We provide best estimates for palaeotemperatures and permeabilities, their errors and their dependencies. Our results allow discriminating between the two mentioned processes to a certain extent, partly resolving the non-uniqueness of the problem. We find clear indications for a significant contribution of advective heat transport, which, in turn, imply only slightly lower ground surface temperatures during the last glacial maximum relative to the present value. These findings are consistent with the general background knowledge of (i) the fracture zones and the corresponding fluid movements in the bedrock and (ii) the glacial history of the Kola area.}, language = {en} } @article{RathMottaghy2014, author = {Rath, V. and Mottaghy, Darius}, title = {Klimainformation aus dem Untergrund?}, series = {Geographische Rundschau}, volume = {66}, journal = {Geographische Rundschau}, number = {7-8}, publisher = {Westermann}, address = {Braunschweig}, issn = {0016-7460}, pages = {30 -- 36}, year = {2014}, language = {de} } @article{KuertenMottaghyZiegler2014, author = {K{\"u}rten, Sylvia and Mottaghy, Darius and Ziegler, Martin}, title = {Planung, Auslegung und Dimensionierung von thermo-aktiven Bauteilen am Beispiel thermo-aktiver Abdichtungselemente}, series = {Geothermie, Bohr- und Brunnentechnik}, journal = {Geothermie, Bohr- und Brunnentechnik}, publisher = {Ernst \& Sohn}, address = {Berlin}, pages = {18 -- 20}, year = {2014}, language = {de} } @article{MartinGonzalezKotliarRiosMartinezetal.2014, author = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir}, title = {Mediated-reality magnification for macular degeneration rehabilitation}, series = {Journal of Modern Optics}, volume = {61}, journal = {Journal of Modern Optics}, number = {17}, publisher = {Taylor \& Francis}, address = {London}, issn = {1362-3044}, doi = {10.1080/09500340.2014.936110}, pages = {1400 -- 1408}, year = {2014}, language = {en} } @article{HuberStreblowMuelleretal.2014, author = {Huber, M. and Streblow, R. and M{\"u}ller, D. and Lange, S. and Joneleit, R. and Sefker, T. and Rau, Sebastian and Wollert, J{\"o}rg}, title = {Funksignal{\"u}bertragung in Luftleitungen}, series = {HLH : L{\"u}ftung, Klima, Heizung, Sanit{\"a}r, Geb{\"a}udetechnik}, volume = {Bd. 65}, journal = {HLH : L{\"u}ftung, Klima, Heizung, Sanit{\"a}r, Geb{\"a}udetechnik}, number = {H. 7/8}, issn = {1436-5103}, pages = {36 -- 40}, year = {2014}, language = {de} } @article{FredebeulKreinSteingroever2014, author = {Fredebeul-Krein, Markus and Steingr{\"o}ver, Markus}, title = {Wholesale broadband access to IPTV in an NGA environment : how to deal with it from a regulatory perspective?}, series = {Telecommunications Policy}, volume = {38}, journal = {Telecommunications Policy}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0308-5961 (Print)}, doi = {doi:10.1016/j.telpol.2013.04.002}, pages = {264 -- 277}, year = {2014}, language = {en} } @article{FredebeulKrein2014, author = {Fredebeul-Krein, Markus}, title = {Ziele der Sozial- und Verteilungspolitik}, series = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Pr{\"u}fung, Berufseinstieg und Fortbildung}, volume = {43}, journal = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Pr{\"u}fung, Berufseinstieg und Fortbildung}, number = {7}, publisher = {Lange}, address = {D{\"u}sseldorf}, issn = {0340-3084}, pages = {907 -- 912}, year = {2014}, language = {de} } @article{HafnerDemetzWeickertetal.2014, author = {Hafner, David and Demetz, Oliver and Weickert, Joachim and Reißel, Martin}, title = {Mathematical Foundations and Generalisations of the Census Transform for Robust Optic Flow Computation}, series = {Journal of Mathematical Imaging and Vision}, journal = {Journal of Mathematical Imaging and Vision}, publisher = {Springer}, address = {New York}, issn = {1573-7683 (Online)}, doi = {10.1007/s10851-014-0529-9}, year = {2014}, language = {en} } @article{Sillius2014, author = {Sillius, Sarah}, title = {„Viele machen gutes Marketing, ohne es zu wissen" : zwei Experten von FH [Prof. Dr. Gert Hoepner] und RWTH Aachen [Prof. Dr. Daniel Mentzel] erkl{\"a}ren, wie Unternehmen ihre Zielgruppe besser erreichen}, series = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen}, volume = {2014}, journal = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen}, number = {3}, publisher = {IHK Aachen}, address = {Aachen}, pages = {16 -- 18}, year = {2014}, language = {de} } @article{RaueWambachGloeggleretal.2014, author = {Raue, Markus and Wambach, M. and Gl{\"o}ggler, S. and Grefen, Dana and Kaufmann, R. and Abetz, C. and Georgopanos, P. and Handge, U. A. and Mang, Thomas and Bl{\"u}mich, B. and Abetz, V.}, title = {Investigation of historical hard rubber ornaments of Charles Goodyear}, series = {Macromolecular chemistry and physics}, volume = {Vol. 215}, journal = {Macromolecular chemistry and physics}, number = {No. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1022-1352}, pages = {245 -- 254}, year = {2014}, language = {en} } @article{WallenbornRitz2014, author = {Wallenborn, Ramona and Ritz, Thomas}, title = {Mobilit{\"a}t miteinander teilen : st{\"a}dtisches eCarsharing in einer vernetzten Gesellschaft ; [vernetztes Fahren von morgen]}, series = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t}, volume = {5}, journal = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t}, number = {14 (Herbstausg.)}, publisher = {Bundesverband eMobilit{\"a}t BEM}, address = {Berlin}, issn = {2191-5636}, pages = {92 -- 95}, year = {2014}, language = {de} } @article{RitzPisarczykSachtlebenetal.2014, author = {Ritz, Thomas and Pisarczyk, Rafael and Sachtleben, Johanna and Leßenich, Nina}, title = {Usability Engineering maßgeschneidert : Modellbaukasten zur Entwicklung gebrauchstauglicher mobiler Software}, series = {Wissenschaft trifft Praxis}, volume = {1}, journal = {Wissenschaft trifft Praxis}, number = {1}, publisher = {Begleitforschung Mittelstand-Digital c/o WIK-Consult GmbH}, address = {Bad Honnef}, issn = {2198-8544 (Print)}, pages = {79 -- 88}, year = {2014}, language = {de} } @article{Wollert2014, author = {Wollert, J{\"o}rg}, title = {Feldbustechnologie}, series = {Factory : der Durchblick in der Technik}, journal = {Factory : der Durchblick in der Technik}, publisher = {WEKA-Industriemedien}, address = {Wien}, pages = {Publ. online}, year = {2014}, language = {de} } @article{Wollert2014, author = {Wollert, J{\"o}rg}, title = {Echtzeit-Ethernet mit Standardtechnik}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin f{\"u}r die Entwicklung von Embedded-Systemen}, volume = {Bd. 63}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin f{\"u}r die Entwicklung von Embedded-Systemen}, number = {H. 12}, publisher = {WEKA-Fachmedien}, address = {Haar}, issn = {0013-5658}, pages = {28 -- 32}, year = {2014}, language = {de} } @article{Wollert2014, author = {Wollert, J{\"o}rg}, title = {Der Embedded Wireless-Report}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, publisher = {WEKA-Fachmedien}, address = {Haar}, issn = {0013-5658}, pages = {18 -- 25}, year = {2014}, language = {de} } @article{Wollert2014, author = {Wollert, J{\"o}rg}, title = {Echtzeit-Ethernet : Protokoll-Reigen}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler}, volume = {Bd. 63}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler}, number = {H. 26}, publisher = {WEKA-Fachmedien}, address = {Haar}, issn = {0013-5658}, pages = {24 -- 31}, year = {2014}, language = {de} } @article{Wollert2014, author = {Wollert, J{\"o}rg}, title = {Funkstandards f{\"u}r Sensornetzwerke}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler}, volume = {Bd. 63}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler}, number = {H. 12}, publisher = {WEKA-Fachmedien}, address = {Haar}, issn = {0013-5658}, pages = {36 -- 41}, year = {2014}, language = {de} } @article{ThomasWassenberg2014, author = {Thomas, Axel and Wassenberg, Gerd}, title = {Erfolgreich sein im Kampf um die besten Talente : Employer Branding}, series = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen}, journal = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen}, publisher = {IHK Aachen}, address = {Aachen}, year = {2014}, language = {de} } @article{Thomas2014, author = {Thomas, Axel}, title = {Generation Y}, series = {P.T. : Magazin f{\"u}r Wirtschaft und Gesellschaft}, volume = {10}, journal = {P.T. : Magazin f{\"u}r Wirtschaft und Gesellschaft}, number = {3}, publisher = {OPS Netzwerk}, address = {Leipzig}, issn = {1860-501X}, pages = {6 -- 9}, year = {2014}, language = {de} } @article{DemnyHebel2014, author = {Demny, Andreas and Hebel, Christoph}, title = {Rechnergest{\"u}tzte Ermittlung der Verbindungsfunktionsstufen und der verbindungsbezogenen Angebotsqualit{\"a}t nach den Richtlinien f{\"u}r integrierte Netzgestaltung nach RIN 2008}, series = {Straßenverkehrstechnik : Organ der Forschungsgesellschaft f{\"u}r Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der {\"O}sterreichischen Forschungsgesellschaft Straße und Verkehr ; Zeitschrift f{\"u}r Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik}, volume = {Jg. 58}, journal = {Straßenverkehrstechnik : Organ der Forschungsgesellschaft f{\"u}r Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der {\"O}sterreichischen Forschungsgesellschaft Straße und Verkehr ; Zeitschrift f{\"u}r Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik}, number = {H. 12}, publisher = {Kirschbaum Verlag}, address = {Bonn}, issn = {0039-2219}, pages = {811 -- 820}, year = {2014}, language = {de} } @article{GuoSekiMiyamotoetal.2014, author = {Guo, Yuanyuan and Seki, Kosuke and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Device simulation of the light-addressable potentiometric sensor with a novel photoexcitation method for a higher spatial resolution}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.369}, pages = {456 -- 459}, year = {2014}, abstract = {A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) realized a higher spatial resolution of chemical imaging. In this method, a modulated light probe, which generates the alternating photocurrent signal, is surrounded by a ring of constant light, which suppresses the lateral diffusion of photocarriers by enhancing recombination. A device simulation verified that a higher spatial resolution could be obtained by adjusting the gap between the modulated and constant light. It was also found that a higher intensity and a longer wavelength of constant light was more effective. However, there exists a tradeoff between the spatial resolution and the amplitude of the photocurrent, and thus, the signal-to-noise ratio. A tilted incidence of constant light was applied, which could achieve even higher resolution with a smaller loss of photocurrent.}, language = {en} } @article{SchusserBaeckerKrischeretal.2014, author = {Schusser, Sebastian and B{\"a}cker, Matthias and Krischer, M. and Wenzel, L. and Leinhos, Marcel and Poghossian, Arshak and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.689}, pages = {1314 -- 1317}, year = {2014}, abstract = {A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Schubert, J. and Zander, W. and Begoyan, V. K. and Buniatyan, V. V. and Sch{\"o}ning, Michael Josef}, title = {Chemical sensors based on a high-k perovskite oxide of barium strontium titanate}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.258}, pages = {28 -- 31}, year = {2014}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.}, language = {en} } @article{BronderWuPoghossianetal.2014, author = {Bronder, Thomas and Wu, Chunsheng and Poghossian, Arshak and Werner, Frederik and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.647}, pages = {755 -- 758}, year = {2014}, abstract = {Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).}, language = {en} } @article{MiyamotoSekiWagneretal.2014, author = {Miyamoto, K. and Seki, K. and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.563}, pages = {612 -- 615}, year = {2014}, abstract = {The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm.}, language = {en} } @article{DachwaldMikuckiTulaczyketal.2014, author = {Dachwald, Bernd and Mikucki, Jill and Tulaczyk, Slawek and Digel, Ilya and Espe, Clemens and Feldmann, Marco and Francke, Gero and Kowalski, Julia and Xu, Changsheng}, title = {IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems}, series = {Annals of Glaciology}, volume = {55}, journal = {Annals of Glaciology}, number = {65}, publisher = {Cambridge University Press}, address = {Cambridge}, issn = {1727-5644}, doi = {10.3189/2014AoG65A004}, pages = {14 -- 22}, year = {2014}, abstract = {There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.}, language = {en} } @article{Stulpe2014, author = {Stulpe, Werner}, title = {From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations}, series = {Journal of Mathematical Physics}, volume = {55}, journal = {Journal of Mathematical Physics}, number = {1}, publisher = {AIP Publishing}, address = {College Park, Md.}, issn = {222-488}, doi = {10.1063/1.4861939}, pages = {Artikel 012109}, year = {2014}, abstract = {The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered.}, language = {en} } @article{Balzer2014, author = {Balzer, Hermann}, title = {Ausgestaltung und Steuerung des Netzes von Bankbeziehungen - Update nach 25 Jahren mithilfe einer explorativen Unternehmensbefragung / Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V. unter Mitarb. von Prof. Dr. Hermann Balzer...}, series = {Zfbf : Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung}, journal = {Zfbf : Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung}, number = {H. 8}, publisher = {Springer Gabler}, address = {Wiesbaden}, issn = {0341-2687}, pages = {694 -- 723}, year = {2014}, language = {de} } @article{LevesqueSiegwolfEilmannetal.2014, author = {L{\´e}vesque, Mathieu and Siegwolf, Rolf and Eilmann, Britta and Saurer, Matthias and Rigling, Andreas}, title = {Increased water-use efficiency does not lead to enhanced tree growth under xeric and mesic conditions}, series = {New Phytologist}, volume = {203}, journal = {New Phytologist}, number = {1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1469-8137 (Online)}, doi = {10.1111/nph.12772}, pages = {94 -- 109}, year = {2014}, language = {en} } @article{EilmannSterckWegneretal.2014, author = {Eilmann, Britta and Sterck, Frank J. and Wegner, L. and de Vries, Sven M. G. and von Arx, G. and Mohren, Godefridus M. J. and den Ouden, Jan and Sass-Klaassen, Ute G. W.}, title = {Wood structural differences between northern and southern beech provenances growing at a moderate site}, series = {Tree Physiology}, volume = {34}, journal = {Tree Physiology}, number = {8}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1758-4469 (Online)}, doi = {10.1093/treephys/tpu069}, pages = {882 -- 893}, year = {2014}, language = {en} } @article{FeichtingerEilmannBuchmannetal.2014, author = {Feichtinger, Linda M. and Eilmann, Britta and Buchmann, Nina and Rigling, Andreas}, title = {Growth adjustments of conifers to drought and to century-long irrigation}, series = {Forest Ecology and Management}, volume = {2014}, journal = {Forest Ecology and Management}, number = {334}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-7042 (Online)}, doi = {10.1016/j.foreco.2014.08.008}, pages = {96 -- 105}, year = {2014}, abstract = {Our knowledge on tree responses to drought is mainly based on short-term manipulation experiments which do not capture any possible long-term adjustments in this response. Therefore, historical water channels in inner-Alpine dry valleys were used as century-long irrigation experiments to investigate adjustments in tree growth to contrasting water supply. This involved quantifying the tree-ring growth of irrigated and non-irrigated (control) Scots pine (Pinus sylvestris L.) in Valais (Switzerland), as well as European larch (Larix decidua Mill.) and black pine (Pinus nigra Arnold) in Vinschgau (Italy). Furthermore, the adjustments in radial growth of Scots pine and European larch to an abrupt stop in irrigation were analyzed. Irrigation promoted the radial growth of all tree species investigated compared to the control: (1) directly through increased soil water availability, and (2) indirectly through increased soil nutrients and humus contents in the irrigated plots. Irrigation led to a full elimination of growth responses to climate for European larch and black pine, but not for Scots pine, which might become more sensitive to drought with increasing tree size in Valais. For the control trees, the response of the latewood increment to water availability in July/August has decreased in recent decades for all species, but increased in May for Scots pine only. The sudden irrigation stop caused a drop in radial growth to a lower level for Scots pine or similar level for larch compared to the control for up to ten years. However, both tree species were then able to adjust to the new conditions and subsequently grew with similar (Scots pine) or even higher growth rates (larch) than the control. To estimate the impact of climate change on future forest development, the duration of manipulation experiments should be on longer time scales in order to capture adjustment processes and feedback mechanisms of forest ecosystems.}, language = {en} } @article{Laack2014, author = {Laack, Walter van}, title = {Nahtoderfahrungen aus medizinischer Sicht}, series = {Deutsche medizinische Wochenschrift : DMW}, volume = {Jg. 139}, journal = {Deutsche medizinische Wochenschrift : DMW}, number = {H. 51/52}, publisher = {Thieme}, address = {Stuttgart}, issn = {1439-4413 (E-Journal); 0012-0472 (Print); 1437-5982 (Print)}, doi = {10.1055/s-0034-1387363}, pages = {2651 -- 2654}, year = {2014}, abstract = {Nah- versus Nachtoderfahrungen Nahtoderfahrungen (NTE) sind ein Ph{\"a}nomen aus der Kategorie „außergew{\"o}hnliche Bewusstseinserfahrungen". Sie treten in unmittelbarer N{\"a}he des eigenen Todes auf. Oft, aber nicht immer, handelt es sich dabei um Erfahrungen von Personen, die durch {\"a}rztliche Maßnahmen wiederbelebt wurden und sp{\"a}ter davon berichten (NTE-ler). Jedoch kommen solche Ph{\"a}nomene auch bei Menschen vor, die w{\"a}hrend einer schweren Erkrankung eine lebensbedrohliche Krise haben, hiervon aber spontan genesen. Den NTE {\"a}hnlich sind auch sogenannte Nachtod-erfahrungen sowie spontane Erlebnisse, die im Rahmen anderer außergew{\"o}hnlicher Stresssituationen auftreten. Von Nachtoderfahrungen spricht man, wenn die Betroffenen anl{\"a}sslich des Todes von geliebten Angeh{\"o}rigen oder Freunden Erlebnisse haben, die inhaltlich ebenfalls, zumindest aber teilweise, denen von NTE entsprechen. Nachtoderfahrungen sowie spontane NTE-{\"a}hnliche Erlebnisse unterscheiden sich jedoch von den echten NTE zumeist sowohl quantitativ als auch qualitativ. Unter einem quantitativen Unterschied versteht man in diesem Zusammenhang eine in der Regel geringer ausgepr{\"a}gte Komplexit{\"a}t, als sie sehr vielen NTE zu eigen ist. Da sich aber auch viele NTE selbst bez{\"u}glich ihrer Komplexit{\"a}t unterscheiden, ist der Hauptunterschied qualitativer Natur: Echte NTE besitzen gegen{\"u}ber den anderen hier erw{\"a}hnten Ph{\"a}nomenen eine gr{\"o}ßere inhaltliche und emotionale Tiefe. Sie begleiten die Betroffenen anschließend ein Leben lang - zumeist mit positiven, in Einzelf{\"a}llen aber auch mit negativen Folgen, die bis zu einem sp{\"a}teren Suizid reichen k{\"o}nnen. Die genannten außergew{\"o}hnlichen Bewusstseinsph{\"a}nomene lassen sich in ihrer Gesamtheit bei rund 5 \% der Bev{\"o}lkerung finden. NTE im Speziellen haben hiervon einen durchaus bedeutenden Anteil. Je nach Studie geben zwischen 18 \% und 40 \% aller Personen, die reanimiert wurden, an, w{\"a}hrenddessen eine NTE erlebt zu haben. Dass nicht alle eine solche Erfahrung machen, wird von Kritikern gern dahingehend interpretiert, NTE seien rein physiologischer und keineswegs spiritueller Natur. Jedoch sollte man bedenken, dass im Fall einer rein neurophysiologischen Grundlage von NTE dann bei jedem ein solches Ph{\"a}nomen zu erwarten w{\"a}re, so wie beispielsweise auch die Symptome einer Hypoglyk{\"a}mie im Wesentlichen immer dieselben sind.}, language = {de} } @article{LeandroBungCarvalho2014, author = {Leandro, J. and Bung, Daniel B. and Carvalho, R.}, title = {Measuring void fraction and velocity fields of a stepped spillway for skimming flow using non-intrusive methods}, series = {Experiments in fluids}, journal = {Experiments in fluids}, number = {55}, publisher = {Springer Nature}, address = {Heidelberg}, issn = {0723-4864 (Print) ; 1432-1114 (Online)}, doi = {10.1007/s00348-014-1732-6}, pages = {Art. 1732}, year = {2014}, language = {en} } @article{RatkeMilowLisinskietal.2014, author = {Ratke, Lorenz and Milow, Barbara and Lisinski, Susanne and Hoepfner, Sandra}, title = {On an effect of fine ceramic particles on the structure of aerogels}, series = {Microgravity science and technology}, volume = {26}, journal = {Microgravity science and technology}, publisher = {Springer Nature}, address = {Heidelberg}, issn = {0938-0108 ; 1875-0494}, doi = {10.1007/s12217-014-9380-2}, pages = {103 -- 110}, year = {2014}, language = {en} } @article{AlmajhdiSengerAmeretal.2014, author = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter}, title = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)}, series = {PLOS one}, volume = {11}, journal = {PLOS one}, number = {9}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0113461}, pages = {e113461}, year = {2014}, abstract = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.}, language = {en} } @article{BaeckerSchusserPoghossianetal.2014, author = {B{\"a}cker, Matthias and Schusser, Sebastian and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins}, series = {GIT Labor-Fachzeitschrift}, journal = {GIT Labor-Fachzeitschrift}, number = {2}, publisher = {Wiley}, issn = {0016-3538}, pages = {28 -- 30}, year = {2014}, language = {de} } @article{FiedlerHennMelcher2014, author = {Fiedler, Gerda and Henn, Gudrun and Melcher, Karin}, title = {ANPAK - ein semesterbegleitender Anpassungskurs}, series = {Zeitschrift f{\"u}r Hochschulentwicklung}, volume = {9}, journal = {Zeitschrift f{\"u}r Hochschulentwicklung}, number = {4}, publisher = {{\"O}GHD}, address = {Wien}, issn = {2219-6994}, pages = {85 -- 100}, year = {2014}, abstract = {In Folge mehrj{\"a}hriger statistischer Untersuchungen an der FH Aachen ist unter anderem ein Eingangstest entstanden, der als Diagnosetool f{\"u}r einen erfolgreichen Studieneinstieg verwendet wird. Es hat sich herausgestellt, dass ein Testergebnis von weniger als 25 (von maximal 56 erreichbaren) Punkten die Chance auf einen erfolgreichen Studieneinstieg deutlich verringert. Ungef{\"a}hr die H{\"a}lfte aller Erstsemester hat weniger als 25 Punkte im Eingangstest. Weniger als 20 \% dieser Gruppe bestehen innerhalb eines Jahres die Klausur Mathematik 1. Die investierte Zeit von zwei Semestern ist mit Blick auf den Wissenszuwachs und damit letztendlich den Studienerfolg nicht effizient genutzt. Deshalb haben wir im WS 2013/14 einen semesterbegleitenden Anpassungskurs f{\"u}r diese Gruppe installiert. Ziel eines solchen Kurses ist es, die Student/innen innerhalb eines Jahres in die Lage zu versetzen, nach zwei Semestern problemlos den Vorlesungen in Mathematik zu folgen. Dieser Artikel beschreibt das Konzept dieses Anpassungskurses und zeigt erste Ergebnisse und Probleme des Pilotdurchgangs auf.}, language = {de} } @article{Timme2014, author = {Timme, Michael}, title = {BGH: Geltendmachung von Sachm{\"a}ngeln bei Wohnungseigentum}, series = {LMK : Fachdienst Zivilrecht : Kommentierte BGH-Rechtsprechung}, volume = {2014}, journal = {LMK : Fachdienst Zivilrecht : Kommentierte BGH-Rechtsprechung}, number = {5}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1611-1095}, year = {2014}, language = {de} } @article{KluczkaEcksteinAlexopoulosetal.2014, author = {Kluczka, Sven and Eckstein, Julian and Alexopoulos, Spiros and Vaeßen, Christiane and Roeb, Martin}, title = {Process simulation for solar steam and dry reforming}, series = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference}, volume = {49}, journal = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102 (E-Journal)}, doi = {10.1016/j.egypro.2014.03.092}, pages = {850 -- 859}, year = {2014}, abstract = {In co-operation with the German Aerospace Center, the Solar-Institut J{\"u}lich has been analyzing the different technologies that are available for methanol production from CO2 using solar energy. The aim of the project is to extract CO2 from industrial exhaust gases or directly from the atmosphere to recycle it by use of solar energy. Part of the study was the modeling and simulating of a methane reformer for the production of synthesis gas, which can be operated by solar or hybrid heat sources. The reformer has been simplified in such a way that the model is accurate and enables fast calculations. The developed pseudo-homogeneous one- dimensional model can be regarded as a kind of counter-current heat exchanger and is able to incorporate a steam reforming reaction as well as a dry reforming reaction.}, language = {en} } @article{MuellerHirschfeldLambertzetal.2014, author = {M{\"u}ller, Martin and Hirschfeld, Julian and Lambertz, Rita and Schulze Lohoff, Andreas and Lustfeld, Hans and Pfeifer, Heinz and Reißel, Martin}, title = {Validation of a novel method for detecting and stabilizing malfunctioning areas in fuel cell stacks}, series = {Journal of power sources}, volume = {272}, journal = {Journal of power sources}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2755 (E-Journal); 0378-7753 (Print)}, doi = {10.1016/j.jpowsour.2014.08.045}, pages = {225 -- 232}, year = {2014}, abstract = {In this paper a setup for detecting malfunctioning areas of MEAs in fuel cell stacks is described. Malfunctioning areas generate electric cross currents inside bipolar plates. To exploit this we suggest bipolar plates consisting not of two but of three layers. The third one is a highly conducting layer and segmented such that the cross currents move along the segments to the surface of the stack where they can be measured by an inductive sensor. With this information a realistic model can be used to detect the malfunctioning area. Furthermore the third layer will prevent any current inhomogeneity of a malfunctioning cell to spread to neighbouring cells in the stack. In this work the results of measurements in a realistic cell setup will be compared with the results obtained in simulation studies with the same configuration. The basis for the comparison is the reliable characterisation of the electrical properties of the cell components and the implication of these results into the simulation model. The experimental studies will also show the limits in the maximum number of segments, which can be used for a reliable detection of cross currents.}, language = {en} } @article{HandtkeVollandMethlingetal.2014, author = {Handtke, Stefan and Volland, Sonja and Methling, Karen and Albrecht, Dirk and Becher, D{\"o}rte and Nehls, Jenny and Bongaerts, Johannes and Maurer, Karl-Heinz and Lalk, Michael and Liesegang, Heiko and Voigt, Birgit and Daniel, Rolf and Hecker, Michael}, title = {Cell physiology of the biotechnological relevant bacterium Bacillus pumilus - An omics-based approach}, series = {Journal of Biotechnology}, journal = {Journal of Biotechnology}, number = {192(A)}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2014.08.028}, pages = {204 -- 214}, year = {2014}, abstract = {Members of the species Bacillus pumilus get more and more in focus of the biotechnological industry as potential new production strains. Based on exoproteome analysis, B. pumilus strain Jo2, possessing a high secretion capability, was chosen for an omics-based investigation. The proteome and metabolome of B. pumilus cells growing either in minimal or complex medium was analyzed. In total, 1542 proteins were identified in growing B. pumilus cells, among them 1182 cytosolic proteins, 297 membrane and lipoproteins and 63 secreted proteins. This accounts for about 43\% of the 3616 proteins encoded in the B. pumilus Jo2 genome sequence. By using GC-MS, IP-LC/MS and H NMR methods numerous metabolites were analyzed and assigned to reconstructed metabolic pathways. In the genome sequence a functional secretion system including the components of the Sec- and Tat-secretion machinery was found. Analysis of the exoproteome revealed secretion of about 70 proteins with predicted secretion signals. In addition, selected production-relevant genome features such as restriction modification systems and NRPS clusters of B. pumilus Jo2 are discussed.}, language = {en} } @article{MuribYeapMartensetal.2014, author = {Murib, Mohammed Sharif and Yeap, Weng-Siang and Martens, Daan and Bienstman, Peter and Ceuninck, Ward de and Grinsven, Bart van and Sch{\"o}ning, Michael Josef and Michiels, Luc and Haenen, Ken and Ameloot, Marcel and Serpeng{\"u}zel, Ali and Wagner, Patrick}, title = {Photonic detection and characterization of DNA using sapphire microspheres}, series = {Journal of biomedical optics}, volume = {19}, journal = {Journal of biomedical optics}, number = {9}, publisher = {SPIE}, address = {Bellingham}, issn = {1560-2281 (E-Journal); 1083-3668 (Print)}, doi = {10.1117/1.JBO.19.9.097006}, pages = {097006}, year = {2014}, abstract = {A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.}, language = {en} } @article{SiqueiraMolinnusBegingetal.2014, author = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef}, title = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection}, series = {Analytical chemistry}, volume = {86}, journal = {Analytical chemistry}, number = {11}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac500458s}, pages = {5370 -- 5375}, year = {2014}, abstract = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.}, language = {en} } @article{SrivastavaLahiriMaitietal.2014, author = {Srivastava, A. and Lahiri, S. and Maiti, M. and Knolle, F. and Hoyler, Friedrich and Scherer, Ulrich W. and Schnug, E. W.}, title = {Study of naturally occurring radioactive material (NORM) in top soil of Punjab State from the North Western part of India}, series = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {2014}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, number = {302}, publisher = {Springer Nature}, address = {Basel}, issn = {1588-2780 (E-Journal); 0022-4081 (Print); 0134-0719 (Print); 0236-5731 (Print); 1417-2097 (Print)}, doi = {0.1007/s10967-014-3450-1}, pages = {1049 -- 1052}, year = {2014}, language = {en} } @article{FateriGebhardtThuemmleretal.2014, author = {Fateri, Miranda and Gebhardt, Andreas and Th{\"u}mmler, Stefan and Thurn, Laura}, title = {Experimental investigation on selective laser melting of glass}, series = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014}, volume = {56 (2014)}, journal = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1875-3892 (E-Journal); 1875-3884 (Print)}, doi = {10.1016/j.phpro.2014.08.118}, pages = {357 -- 364}, year = {2014}, language = {en} } @article{NachtrodtTietschMostaccietal.2014, author = {Nachtrodt, Frederik and Tietsch, Wolfgang and Mostacci, Domiziano and Scherer, Ulrich W.}, title = {Set-up and first operation of a plasma oven for treatment of low level radioactive wastes}, series = {Nuclear technology and radiation protection}, volume = {29}, journal = {Nuclear technology and radiation protection}, number = {Suppl.}, publisher = {VINČA Institute of Nuclear Sciences}, address = {Belgrad}, issn = {1451-3994}, doi = {10.2298/NTRP140SS47N}, pages = {47 -- 51}, year = {2014}, language = {en} } @article{MalechaKlubertHeinenFuchs2014, author = {Malecha, Hartmut and Klubert, J. and Heinen-Fuchs, Sabine}, title = {Laserscanning passe? 3-D-Oberfl{\"a}chenmodelle aus Bilddaten und deren messtechnischer Nutzen}, series = {Wasserwirtschaft}, volume = {Jg. 104}, journal = {Wasserwirtschaft}, number = {Nr. 9}, publisher = {Springer Vieweg}, address = {Wiesbaden}, issn = {0043-0978}, pages = {32 -- 35}, year = {2014}, language = {de} } @article{StadlerGarveyEmbsetal.2014, author = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe}, title = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study}, series = {Biochimica et biophysica acta (BBA): General Subjects}, volume = {1840}, journal = {Biochimica et biophysica acta (BBA): General Subjects}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-8006 (E-Journal); 0304-4165 (Print)}, doi = {10.1016/j.bbagen.2014.06.007}, pages = {2989 -- 2999}, year = {2014}, language = {en} } @article{HoltrupSadeghfamHeuermannetal.2014, author = {Holtrup, S. and Sadeghfam, Arash and Heuermann, Holger and Awakowicz, P.}, title = {Characterization and optimization technique for microwave-driven high-intensity discharge lamps using hot S-parameters}, series = {IEEE transactions on microwave theories and techniques}, volume = {62}, journal = {IEEE transactions on microwave theories and techniques}, number = {10}, publisher = {IEEE}, address = {New York}, issn = {0018-9480}, doi = {10.1109/TMTT.2014.2342652}, pages = {2471 -- 2480}, year = {2014}, abstract = {High-intensity discharge lamps can be driven by radio-frequency signals in the ISM frequency band at 2.45 GHz, using a matching network to transform the impedance of the plasma to the source impedance. To achieve an optimal operating condition, a good characterization of the lamp in terms of radio frequency equivalent circuits under operating conditions is necessary, enabling the design of an efficient matching network. This paper presents the characterization technique for such lamps and presents the design of the required matching network. For the characterization, a high-intensity discharge lamp was driven by a monofrequent large signal at 2.45 GHz, whereas a frequency sweep over 300 MHz was performed across this signal to measure so-called small-signal hot S-parameters using a vector network analyzer. These parameters are then used as an equivalent load in a circuit simulator to design an appropriate matching network. Using the measured data as a black-box model in the simulation results in a quick and efficient method to simulate and design efficient matching networks in spite of the complex plasma behavior. Furthermore, photometric analysis of high-intensity discharge lamps are carried out, comparing microwave operation to conventional operation.}, language = {en} } @article{KhaydukovaZadorozhnayaKirsanovetal.2014, author = {Khaydukova, M. M. and Zadorozhnaya, O. A. and Kirsanov, D. O. and Iken, Heiko and Rolka, David and Sch{\"o}ning, Michael Josef and Babain, V. A. and Vlasov, Yu. G. and Legin, A. V.}, title = {Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes}, series = {Russian journal of applied chemistry}, volume = {87}, journal = {Russian journal of applied chemistry}, number = {3}, publisher = {Springer}, address = {Dordrecht}, issn = {1608-3296 (E-Journal); 1070-4272 (Print)}, doi = {10.1134/S1070427214030112}, pages = {307 -- 314}, year = {2014}, abstract = {The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution.}, language = {en} } @article{GuoMiyamotoWagneretal.2014, author = {Guo, Yuanyuan and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution}, series = {Sensors and actuators B: Chemical}, volume = {204}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.08.016}, pages = {659 -- 665}, year = {2014}, abstract = {As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.}, language = {en} } @article{AlhwarinFerreinScholl2014, author = {Alhwarin, Faraj and Ferrein, Alexander and Scholl, Ingrid}, title = {IR stereo kinect: improving depth images by combining structured light with IR stereo}, pages = {1 -- 9}, year = {2014}, language = {en} } @article{FrotscherStaat2014, author = {Frotscher, Ralf and Staat, Manfred}, title = {Stresses produced by different textile mesh implants in a tissue equivalent}, series = {BioNanoMaterials}, volume = {15}, journal = {BioNanoMaterials}, number = {1-2}, publisher = {De Gruyter}, address = {Berlin}, issn = {2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)}, doi = {10.1515/bnm-2014-0003}, pages = {25 -- 30}, year = {2014}, abstract = {Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.}, language = {en} } @article{GebhardtHoetterZiebura2014, author = {Gebhardt, Andreas and H{\"o}tter, Jan-Steffen and Ziebura, Dawid}, title = {Impact of SLM build parameters on the surface quality}, series = {RTejournal - Forum f{\"u}r Rapid Technologien}, volume = {11 (2014)}, journal = {RTejournal - Forum f{\"u}r Rapid Technologien}, number = {1}, issn = {1614-0923}, pages = {1 -- 14}, year = {2014}, language = {de} } @article{GebhardtFateri2014, author = {Gebhardt, Andreas and Fateri, Miranda}, title = {3D-Drucken und die Anwendungen}, series = {RTejournal - Forum f{\"u}r Rapid Technologie}, volume = {11 (2014)}, journal = {RTejournal - Forum f{\"u}r Rapid Technologie}, number = {1}, issn = {1614-0923}, pages = {1 -- 9}, year = {2014}, language = {de} } @article{RiedelKartchemnikSchoeningetal.2014, author = {Riedel, Marc and Kartchemnik, Julia and Sch{\"o}ning, Michael Josef and Lisdat, Fred}, title = {Impedimetric DNA detection - steps forward to sensorial application}, series = {Analytical chemistry}, volume = {86 (2014)}, journal = {Analytical chemistry}, number = {15}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac501800q}, pages = {7867 -- 7874}, year = {2014}, abstract = {This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.}, language = {en} } @article{MansurovJandosovKerimkulovaetal.2014, author = {Mansurov, Z. A. and Jandosov, J. M. and Kerimkulova, A. R. and Azat, S. and Zhubanova, A. A. and Digel, Ilya and Savistkaya, I. S. and Akimbekov, N. S. and Kistaubaeva, A. S.}, title = {Nanostructured carbon materials for biomedical use}, series = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, volume = {15 (2013)}, journal = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, number = {3}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {1562-3920}, doi = {10.18321/ectj224}, pages = {209 -- 217}, year = {2014}, abstract = {One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.}, language = {en} }