@article{TakenagaSchneiderErbayetal.2015,
  author    = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532053},
  pages     = {1347 -- 1352},
  year      = {2015},
  abstract  = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.},
  language  = {en}
}
@article{SchusserBaeckerKrischeretal.2014,
  author    = {Schusser, Sebastian and B{\"a}cker, Matthias and Krischer, M. and Wenzel, L. and Leinhos, Marcel and Poghossian, Arshak and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.689},
  pages     = {1314 -- 1317},
  year      = {2014},
  abstract  = {A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.},
  language  = {en}
}
@article{SchoeningBiselliSelmeretal.2012,
  author    = {Sch{\"o}ning, Michael Josef and Biselli, Manfred and Selmer, Thorsten and {\"O}hlschl{\"a}ger, Peter and Baumann, Marcus and F{\"o}rster, Arnold and Poghossian, Arshak},
  title     = {Forschung „zwischen" den Disziplinen: das Institut f{\"u}r Nano- und Biotechnologien},
  series = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik},
  volume    = {Publ. online},
  journal   = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik},
  publisher = {Dr. Beyer Internet-Beratung},
  address   = {Ober-Ramstadt},
  pages     = {11 Seiten},
  year      = {2012},
  abstract  = {"Biologie trifft Mikroelektronik", das Motto des Instituts f{\"u}r Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplin{\"a}r gepr{\"a}gter Forschungsaktivit{\"a}ten. Der thematische Zusammenschluss grundst{\"a}ndiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, l{\"a}sst neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierf{\"u}r ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Molek{\"u}le und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen. Vor diesem Hintergrund b{\"u}ndelt das im Jahre 2006 gegr{\"u}ndete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergew{\"o}hnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zuk{\"u}nftig unser allt{\"a}gliches Leben ver{\"a}ndern werden. Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgew{\"a}hlten, aktuellen Forschungsprojekten skizziert.},
  language  = {de}
}
@article{TakenagaBiselliSchnitzleretal.2014,
  author    = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing},
  series = {Physica status solidi A : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330464},
  pages     = {1410 -- 1415},
  year      = {2014},
  abstract  = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.},
  language  = {en}
}
@article{SchnitzlerBiselli2005,
  author    = {Schnitzler, Thomas and Biselli, Manfred},
  title     = {Cultivo de lineas celulares de hibridoma por CF-10H5 (DSMZ ACC477) en el BIOSTAT B plus},
  series = {Noticias tecnicas del laboratorio},
  volume    = {13},
  journal   = {Noticias tecnicas del laboratorio},
  number    = {3},
  pages     = {7 -- 8},
  year      = {2005},
  language  = {es}
}
@article{WincklerKruegerSchnitzleretal.2014,
  author    = {Winckler, Silvia and Krueger, Rolf and Schnitzler, Thomas and Zang, Werner and Fischer, Rainer and Biselli, Manfred},
  title     = {A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach},
  series = {Bioprocess and biosystems engineering},
  volume    = {37},
  journal   = {Bioprocess and biosystems engineering},
  number    = {5},
  publisher = {Springer},
  address   = {Berlin, Heidelberg},
  issn      = {1615-7591 (Print) 1615-7605 (Online)},
  doi       = {10.1007/s00449-013-1062-8},
  pages     = {901 -- 912},
  year      = {2014},
  abstract  = {Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.},
  language  = {en}
}
@article{BaeckerRakowskiPoghossianetal.2013,
  author    = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis},
  series = {Journal of Biotechnology},
  volume    = {163},
  journal   = {Journal of Biotechnology},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-1656},
  doi       = {10.1016/j.jbiotec.2012.03.014},
  pages     = {371 -- 376},
  year      = {2013},
  abstract  = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.},
  language  = {en}
}
@article{BaeckerDellePoghossianetal.2011,
  author    = {B{\"a}cker, Matthias and Delle, L. and Poghossian, Arshak and Biselli, Manfred and Zang, Werner and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Electrochemical sensor array for bioprocess monitoring},
  series = {Electrochimica Acta (2011)},
  volume    = {56},
  journal   = {Electrochimica Acta (2011)},
  number    = {26},
  publisher = {Elsevier},
  address   = {Amsterdam},
  pages     = {9673 -- 9678},
  year      = {2011},
  language  = {en}
}
@article{BiselliBaeckerPoghossianetal.2010,
  author    = {Biselli, Manfred and B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Schnitzler, Thomas and Zang, Werner and Wagner, P.},
  title     = {Entwicklung eines modularen festk{\"o}rperbasierten Sensorsystems f{\"u}r die {\"U}berwachung von Zellkulturfermenationen},
  series = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)},
  journal   = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)},
  publisher = {VDE Verlag},
  address   = {Berlin},
  isbn      = {978-3-8007-3260-9},
  pages     = {688 -- 691},
  year      = {2010},
  language  = {de}
}
@article{BaeckerPoghossianSchoeningetal.2010,
  author    = {B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Schnitzler, Thomas and Biselli, Manfred and Zang, Werner and Wagner, P.},
  title     = {Entwicklung eines modularen festk{\"o}rperbasierten Sensorsystems f{\"u}r die {\"U}berwachung von Zellkulturfermentationen},
  series = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)},
  journal   = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)},
  publisher = {VDE Verlag},
  address   = {Berlin},
  isbn      = {978-3-8007-3260-9},
  pages     = {688 -- 698},
  year      = {2010},
  language  = {de}
}
@article{BaeckerPouyeshmanSchnitzleretal.2011,
  author    = {B{\"a}cker, Matthias and Pouyeshman, S. and Schnitzler, Thomas and Poghossian, Arshak and Wagner, Patrick and Biselli, Manfred and Sch{\"o}ning, Michael Josef},
  title     = {A silicon-based multi-sensor chip for monitoring of fermentation processes},
  series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6},
  journal   = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1862-6319},
  pages     = {1364 -- 1369},
  year      = {2011},
  language  = {en}
}
@article{KowollikSchnitzlerBisellietal.2010,
  author    = {Kowollik, S. and Schnitzler, Thomas and Biselli, Manfred and Krueger, R. and Zang, Werner and Peuscher, A. and Schillberg, S. and Fischer, R.},
  title     = {Die Rolle des Respirationsquotienten in der Zellkulturfermentation},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  isbn      = {Chemie Ingenieur Tec},
  pages     = {1505 -- 1506},
  year      = {2010},
  language  = {de}
}
@article{BaeckerKowollikSchnitzleretal.2009,
  author    = {B{\"a}cker, Matthias and Kowollik, Silvia and Schnitzler, Thomas and Wang, J. and Poghossian, Arshak and Zang, Werner and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Entwicklung eines festk{\"o}rperbasierten Sensorsystems f{\"u}r die Bioprozessautomatisierung},
  series = {9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]},
  journal   = {9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]},
  publisher = {TUDpress},
  address   = {Dresden},
  isbn      = {978-3-941298-44-6},
  pages     = {197 -- 200},
  year      = {2009},
  language  = {de}
}
@article{BaeckerBegingBisellietal.2009,
  author    = {B{\"a}cker, Matthias and Beging, Stefan and Biselli, Manfred and Poghossian, Arshak and Wang, J. and Zang, Werner and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Concept for a solid-state multi-parameter sensor system for cell-culture monitoring},
  series = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI},
  journal   = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0013-4686},
  pages     = {6107 -- 6112},
  year      = {2009},
  language  = {en}
}
@article{BorkKelemenBisellietal.2000,
  author    = {Bork, M. and Kelemen, C. and Biselli, Manfred and Artmann, Gerhard},
  title     = {Biophysikalische Charakterisierung ex vivo kultivierter menschlicher Erythrozythen},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {471 -- 472},
  year      = {2000},
  language  = {de}
}
@article{WagnerMolinaBisellietal.2007,
  author    = {Wagner, Torsten and Molina, R. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells},
  series = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)},
  journal   = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)},
  publisher = {IEEE},
  address   = {Piscataway},
  isbn      = {1-4244-0841-5},
  pages     = {1107 -- 1110},
  year      = {2007},
  language  = {en}
}
@article{BiselliHilbertNoll2001,
  author    = {Biselli, Manfred and Hilbert, U. and Noll, T.},
  title     = {Cultivation of Human HCMV Specific Lymphocytes - An Example for Adoptive Immunotherapy / Hilbert, U. ; Biselli, M. ; Noll, T.},
  series = {Animal cell technology : from target to market ; Tyl{\"o}sand, Sweden, June 10 - 14, 2001 / ed. by E. Lindner-Olsson ...},
  journal   = {Animal cell technology : from target to market ; Tyl{\"o}sand, Sweden, June 10 - 14, 2001 / ed. by E. Lindner-Olsson ...},
  publisher = {Kluwer},
  address   = {Dordrecht},
  isbn      = {1-4020-0264-5},
  pages     = {558 -- 561},
  year      = {2001},
  language  = {en}
}
@article{BiselliKlyushnichenkoRodenbrocketal.1998,
  author    = {Biselli, Manfred and Klyushnichenko, Vadim and Rodenbrock, Anja and Th{\"o}mmes, J{\"o}rg},
  title     = {Analysis of Hybridoma Cell Culture Processes by SDS-Gel Capillary Electrophoresis and matrix-assisted laser desorption ionization-time-of-flight MS / Vadim Klyushnichenko, Anja Rodenbrock, J{\"o}rg Th{\"o}mmes, Maria-Regina Kula, Holger Heine, Manfred Biselli},
  series = {Biotechnology and Applied Biochemistry. 27 (1998), H. 3},
  journal   = {Biotechnology and Applied Biochemistry. 27 (1998), H. 3},
  isbn      = {0885-4513},
  pages     = {181 -- 188},
  year      = {1998},
  language  = {en}
}
@article{BiselliNoll1998,
  author    = {Biselli, Manfred and Noll, T.},
  title     = {Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells / Noll, T.; Biselli, M.},
  series = {Journal of Biotechnology. 63 (1998), H. 3},
  journal   = {Journal of Biotechnology. 63 (1998), H. 3},
  isbn      = {0168-1656},
  pages     = {187 -- 198},
  year      = {1998},
  language  = {en}
}
@article{BiselliJelinekSchmidtetal.2001,
  author    = {Biselli, Manfred and Jelinek, N. and Schmidt, S. and Noll, T.},
  title     = {Bioreaktoren zur Kultivierung blutbildender Zellen / Jelinek, N. ; Schmidt, S. ; Noll, T. ; Biselli, M.},
  series = {Bioforum. 24 (2001), H. 6},
  journal   = {Bioforum. 24 (2001), H. 6},
  isbn      = {0940-0079},
  pages     = {418 -- 419},
  year      = {2001},
  language  = {de}
}