@article{Knueppel2002, author = {Kn{\"u}ppel, Mark}, title = {Pro-Forma-Angaben}, series = {Handbuch der Bilanzierung : das gesamte Wissen zur Rechnungslegung nach HGB, EStG und IFRS / Federmann, Rudolf ; Gnam, Arnulf ; Ammedick, Oliver}, journal = {Handbuch der Bilanzierung : das gesamte Wissen zur Rechnungslegung nach HGB, EStG und IFRS / Federmann, Rudolf ; Gnam, Arnulf ; Ammedick, Oliver}, publisher = {Haufe}, address = {Freiburg}, pages = {1950 -- 1952}, year = {2002}, language = {de} } @article{Knueppel2012, author = {Kn{\"u}ppel, Mark}, title = {Außerbilanzielle Korrekturen}, series = {Handbuch der Bilanzierung online}, journal = {Handbuch der Bilanzierung online}, editor = {Federmann, Rudolf and Kußmaul, Heinz and M{\"u}ller, Stefan}, publisher = {Haufe}, address = {Freiburg}, issn = {0172-0392}, year = {2012}, language = {de} } @article{KnoedlerRuehlEmontsetal.2019, author = {Kn{\"o}dler, Matthias and R{\"u}hl, Clemens and Emonts, Jessica and Buyel, Johannes Felix}, title = {Seasonal weather changes affect the yield and quality of recombinant proteins produced in transgenic tobacco plants in a greenhouse setting}, series = {Frontiers in Plant Science}, journal = {Frontiers in Plant Science}, number = {10}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-462X (online-ressource)}, doi = {10.3389/fpls.2019.01245}, pages = {13 Seiten}, year = {2019}, abstract = {Transgenic plants have the potential to produce recombinant proteins on an agricultural scale, with yields of several tons per year. The cost-effectiveness of transgenic plants increases if simple cultivation facilities such as greenhouses can be used for production. In such a setting, we expressed a novel affinity ligand based on the fluorescent protein DsRed, which we used as a carrier for the linear epitope ELDKWA from the HIV-neutralizing antibody 2F5. The DsRed-2F5-epitope (DFE) fusion protein was produced in 12 consecutive batches of transgenic tobacco (Nicotiana tabacum) plants over the course of 2 years and was purified using a combination of blanching and immobilized metal-ion affinity chromatography (IMAC). The average purity after IMAC was 57 ± 26\% (n = 24) in terms of total soluble protein, but the average yield of pure DFE (12 mg kg-1) showed substantial variation (± 97 mg kg-1, n = 24) which correlated with seasonal changes. Specifically, we found that temperature peaks (>28°C) and intense illuminance (>45 klx h-1) were associated with lower DFE yields after purification, reflecting the loss of the epitope-containing C-terminus in up to 90\% of the product. Whereas the weather factors were of limited use to predict product yields of individual harvests conducted for each batch (spaced by 1 week), the average batch yields were well approximated by simple linear regression models using two independent variables for prediction (illuminance and plant age). Interestingly, accumulation levels determined by fluorescence analysis were not affected by weather conditions but positively correlated with plant age, suggesting that the product was still expressed at high levels, but the extreme conditions affected its stability, albeit still preserving the fluorophore function. The efficient production of intact recombinant proteins in plants may therefore require adequate climate control and shading in greenhouses or even cultivation in fully controlled indoor farms.}, language = {en} } @article{KnoxBruggemannGossmannetal.2020, author = {Knox, Ronald and Bruggemann, Andrea and Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter}, title = {Combining physiological relevance and throughput for in vitro cardiac contractility measurement}, series = {Biophysical Journal}, volume = {118}, journal = {Biophysical Journal}, number = {Issue 3, Supplement 1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0006-3495}, doi = {10.1016/j.bpj.2019.11.3104}, pages = {570a}, year = {2020}, abstract = {Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these.}, language = {en} } @article{KnobeGiesenPlateetal.2016, author = {Knobe, M. and Giesen, M. and Plate, S. and Gradl-Dietsch, G. and Buecking, B. and Eschbach, D. and Laack, Walter van and Pape, H.-C.}, title = {The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale}, series = {European Journal Of Trauma And Emergency Surgery}, volume = {42}, journal = {European Journal Of Trauma And Emergency Surgery}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {1863-9941}, doi = {10.1007/s00068-016-0693-2}, pages = {537 -- 545}, year = {2016}, abstract = {Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.}, language = {en} } @article{KnobbeSchoeningPoghossianetal.2004, author = {Knobbe, D.-T. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Mourzina, Y.}, title = {Charakterisierung von kapazitiven EMISSensoren mittels Impedanzspektroskopie, Kapazit{\"a}ts-Spannungs- und Konstant-Kapazit{\"a}ts-Messung}, series = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik}, journal = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik}, publisher = {VDI}, address = {D{\"u}sseldorf}, isbn = {3-18-091829-2}, pages = {851 -- 854}, year = {2004}, language = {de} } @article{Knepper1985, author = {Knepper, Ludger}, title = {Der moderne Luftfrachtverkehr - leistungsfaehig durch seine bodengebundenen Umschlagssysteme}, pages = {60 -- 69}, year = {1985}, language = {de} } @article{Knepper1985, author = {Knepper, Ludger}, title = {Hochregallager fuer Luftfracht - 365 Tage pro Jahr in Betrieb}, series = {Foerdern und Heben. 35 (1985), H. 5}, journal = {Foerdern und Heben. 35 (1985), H. 5}, isbn = {0341-2636}, pages = {363 -- 366}, year = {1985}, language = {de} } @article{Knepper1984, author = {Knepper, Ludger}, title = {Integrierte Hochregallager als materialflusstechnische Knotenpunkte moderner Produktions- und Umschlaganlagen}, pages = {93 -- 100}, year = {1984}, language = {de} } @article{Knepper1983, author = {Knepper, Ludger}, title = {Verstaerkte materialflusstechnische Integration von Hochregallagern in Produktions- und Umschlaganlagen}, pages = {219 -- 224}, year = {1983}, language = {de} } @article{Knepper1981, author = {Knepper, Ludger}, title = {Im neuen Lufthansa-Frachtterminal: vom Hochregallager direkt ins Flugzeug}, series = {Foerdermittel Journal. Kennzifferzeitschrift fuer Materialfluss, Lager und Transport. 13 (1981), H. 7/8}, journal = {Foerdermittel Journal. Kennzifferzeitschrift fuer Materialfluss, Lager und Transport. 13 (1981), H. 7/8}, isbn = {0013-5674}, pages = {22 -- 24}, year = {1981}, language = {de} } @article{Knepper1984, author = {Knepper, Ludger}, title = {Integrierte Hochregallager als materialflusstechnische Knotenpunkte moderner Produktions- und Umschlaganlagen}, series = {Deutsche Hebe- und Foerdertechnik. 30 (1984), H. 12}, journal = {Deutsche Hebe- und Foerdertechnik. 30 (1984), H. 12}, isbn = {0012-0278}, pages = {88 -- 93}, year = {1984}, language = {de} } @article{Knepper1996, author = {Knepper, Ludger}, title = {Simulation: Vom reinen Planungswerkzeug zum Betriebsf{\"u}hrungs-Instrument}, series = {Foerdern und Heben. 46 (1996), H. 3}, journal = {Foerdern und Heben. 46 (1996), H. 3}, isbn = {0341-2636}, pages = {158 -- 160}, year = {1996}, language = {de} } @article{KnackstedtEggertGraeweetal.2010, author = {Knackstedt, Ralf and Eggert, Mathias and Gr{\"a}we, Lena and Spittka, Jan}, title = {Forschungsportal f{\"u}r Rechtsinformatik und Informationsrecht - Weg zu einer disziplinen{\"u}bergreifenden Forschungs{\"u}bersicht}, series = {MMR - Multimedia und Recht}, journal = {MMR - Multimedia und Recht}, number = {8}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1434-596X}, pages = {528 -- 533}, year = {2010}, abstract = {Die Entwicklungen der Rechtsinformatik und des Informationsrechts zeigen, dass diese Disziplinen aktuell vor der Herausforderung stehen, eine interdisziplin{\"a}re Zusammenarbeit zwischen ihnen und anderen Disziplinen zu etablieren. Unterschiedliche Publikationskulturen erschweren die Erreichung dieses Ziels. Forschungsportale stellen themenspezifische, internetbasierte Verzeichnisse dar, die bereits vorhandene Informationen strukturiert zug{\"a}nglich machen. Sie k{\"o}nnen die Beziehungen zwischen den Disziplinen f{\"o}rdern, indem sie bereits erzielte Arbeitsergebnisse disziplinen{\"u}bergreifend bekannt machen und dadurch dazu beitragen, Synergiepotenziale und m{\"o}gliche Kooperationspartner zu identifizieren.}, language = {de} } @article{KluczkaEcksteinAlexopoulosetal.2014, author = {Kluczka, Sven and Eckstein, Julian and Alexopoulos, Spiros and Vaeßen, Christiane and Roeb, Martin}, title = {Process simulation for solar steam and dry reforming}, series = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference}, volume = {49}, journal = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102 (E-Journal)}, doi = {10.1016/j.egypro.2014.03.092}, pages = {850 -- 859}, year = {2014}, abstract = {In co-operation with the German Aerospace Center, the Solar-Institut J{\"u}lich has been analyzing the different technologies that are available for methanol production from CO2 using solar energy. The aim of the project is to extract CO2 from industrial exhaust gases or directly from the atmosphere to recycle it by use of solar energy. Part of the study was the modeling and simulating of a methane reformer for the production of synthesis gas, which can be operated by solar or hybrid heat sources. The reformer has been simplified in such a way that the model is accurate and enables fast calculations. The developed pseudo-homogeneous one- dimensional model can be regarded as a kind of counter-current heat exchanger and is able to incorporate a steam reforming reaction as well as a dry reforming reaction.}, language = {en} } @article{KlubertMalechaSparla2018, author = {Klubert, Joachim and Malecha, Hartmut and Sparla, Peter}, title = {Modernisierung der geod{\"a}tischen Messtechnik der Urfttalsperre}, series = {Wasserwirtschaft}, volume = {108}, journal = {Wasserwirtschaft}, number = {10}, publisher = {Springer Vieweg}, address = {Wiesbaden}, issn = {0043-0978}, pages = {14 -- 18}, year = {2018}, language = {de} } @article{KloockPoghossianSchumacheretal.2006, author = {Kloock, Joachim P. and Poghossian, Arshak and Schumacher, K. and Rosenkranz, C. and Schultze, J. W. and M{\"u}ller-Veggian, Mattea and Sch{\"o}ning, Michael Josef}, title = {Funktionspr{\"u}fung und Charakterisierung von ionensensitiven Feldeffekttransistoren (ISFETs) auf Waferebene mittels Mikrotropfenzelle f{\"u}r den zuk{\"u}nftigen Einsatz in der Sensorproduktion}, series = {Sensoren und Messsysteme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14. M{\"a}rz 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl}, journal = {Sensoren und Messsysteme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14. M{\"a}rz 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl}, publisher = {VDE-Verl.}, address = {Berlin}, isbn = {3-8007-2939-3}, pages = {257 -- 260}, year = {2006}, language = {de} } @article{KloockMourzinaYoshinobuetal.2002, author = {Kloock, Joachim P. and Mourzina, Y.G. and Yoshinobu, T. and Schubert, J. and Sch{\"o}ning, Michael Josef}, title = {Chalkogenidglassensoren f{\"u}r die Schwermetallanalytik}, series = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....}, journal = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....}, publisher = {VDE-Verl.}, address = {Berlin [u.a.]}, isbn = {3-8007-2675-0}, pages = {395 -- 398}, year = {2002}, language = {de} } @article{KloockMourzinaErmolenkoetal.2004, author = {Kloock, Joachim P. and Mourzina, Y.G. and Ermolenko, Y. and Doll, T. and Schubert, J. and Sch{\"o}ning, Michael Josef}, title = {Inorganic thin-film sensor membranes with PLD-prepared chalcogenide glasses: Challenges and implementation}, series = {Sensors. 4 (2004), H. 10}, journal = {Sensors. 4 (2004), H. 10}, isbn = {1424-8220}, pages = {156 -- 162}, year = {2004}, language = {en} } @article{KloockMourzinaSchubertetal.2004, author = {Kloock, Joachim P. and Mourzina, Y. and Schubert, J. and Ermelenko, Y. and Sch{\"o}ning, Michael Josef}, title = {Pulsed laser deposition: A tool for fabricating thin-film microsensors}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {1032 -- 1033}, year = {2004}, language = {en} }