@article{SavitskayaKistaubayevaIgnatovaetal.2019,
  author    = {Savitskaya, I.S. and Kistaubayeva, A.S. and Ignatova, L.V. and Digel, Ilya},
  title     = {Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells},
  series = {Heliyon},
  volume    = {5},
  journal   = {Heliyon},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2405-8440},
  doi       = {10.1016/j.heliyon.2019.e02592},
  pages     = {Artikelnummer e02592},
  year      = {2019},
  language  = {en}
}
@article{TurlybekulyPogrebnjakSukhodubetal.2019,
  author    = {Turlybekuly, Amanzhol and Pogrebnjak, Alexander and Sukhodub, L. F. and Sukhodub, Liudmyla B. and Kistaubayeva, A. S. and Savitskaya, Irina and Shokatayeva, D. H. and Bondar, Oleksandr V. and Shaimardanov, Z. K. and Plotnikov, Sergey V. and Shaimardanova, B. H. and Digel, Ilya},
  title     = {Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix},
  series = {Materials Science and Engineering C},
  volume    = {104},
  journal   = {Materials Science and Engineering C},
  number    = {Article number 109965},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.msec.2019.109965},
  year      = {2019},
  language  = {en}
}
@article{DigelWehlitzKayseretal.2018,
  author    = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, R. and Rundstedt, F. von},
  title     = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids},
  series = {Plant Pathology},
  volume    = {67},
  journal   = {Plant Pathology},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1365-3059},
  doi       = {10.1111/ppa.12750},
  pages     = {358 -- 365},
  year      = {2018},
  abstract  = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.},
  language  = {en}
}
@article{SavitskayaKistaubayevaDigeletal.2017,
  author    = {Savitskaya, I. S. and Kistaubayeva, A. S. and Digel, Ilya and Shokatayeva, D. H.},
  title     = {Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials},
  series = {Eurasian Chemico-Technological Journal},
  volume    = {19},
  journal   = {Eurasian Chemico-Technological Journal},
  number    = {3},
  issn      = {2522-4867},
  doi       = {10.18321/ectj670},
  pages     = {255 -- 264},
  year      = {2017},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{AimenovaDigelEshibaev2016,
  author    = {Aimenova, Zh. E. and Digel, Ilya and Eshibaev, А. А.},
  title     = {Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem},
  series = {KazNU Bulletin. Biology series},
  volume    = {69},
  journal   = {KazNU Bulletin. Biology series},
  number    = {4},
  publisher = {Al-Farabi Kazakh National University},
  address   = {Almaty},
  issn      = {1563-0218},
  pages     = {4 -- 11},
  year      = {2016},
  abstract  = {L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen - lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 \% higher than in the wild-growing species.},
  language  = {en}
}
@article{TuraliyevaYeshibaevSaparbekovaetal.2016,
  author    = {Turaliyeva, M. and Yeshibaev, A. and Saparbekova, A. and Akynova, L. and Abildayeva, R. and Sadenova, M. and Sartayeva, K. and Schieffer, Andre and Digel, Ilya},
  title     = {Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia},
  series = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES},
  volume    = {18},
  journal   = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES},
  number    = {2},
  publisher = {EM International},
  issn      = {0972-3005},
  pages     = {359 -- 366},
  year      = {2016},
  abstract  = {At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8\%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and {\~N}etonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.},
  language  = {en}
}
@article{AkimbekovDigelO’Herasetal.2015,
  author    = {Akimbekov, N.Sh. and Digel, Ilya and O'Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.},
  title     = {Adsorption of bacterial lipopol ysaccharides on carbonized ri ce husks obtained in the batch experiments},
  series = {KazNU Bulletin. Biology series},
  volume    = {60},
  journal   = {KazNU Bulletin. Biology series},
  number    = {No 1/2},
  issn      = {1563-0218},
  pages     = {144 -- 148},
  year      = {2015},
  language  = {en}
}
@article{ArinkinDigelPorstetal.2014,
  author    = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application},
  series = {BMC bioinformatics},
  volume    = {15},
  journal   = {BMC bioinformatics},
  number    = {55},
  issn      = {1471-2105},
  doi       = {10.1186/1471-2105-15-55},
  pages     = {1 -- 8},
  year      = {2014},
  abstract  = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.},
  language  = {en}
}
@article{MansurovJandosovKerimkulovaetal.2014,
  author    = {Mansurov, Z. A. and Jandosov, J. M. and Kerimkulova, A. R. and Azat, S. and Zhubanova, A. A. and Digel, Ilya and Savistkaya, I. S. and Akimbekov, N. S. and Kistaubaeva, A. S.},
  title     = {Nanostructured carbon materials for biomedical use},
  series = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences},
  volume    = {15 (2013)},
  journal   = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences},
  number    = {3},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {1562-3920},
  doi       = {10.18321/ectj224},
  pages     = {209 -- 217},
  year      = {2014},
  abstract  = {One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.},
  language  = {en}
}
@article{TuraliyevaYeshibaevDigeletal.2014,
  author    = {Turaliyeva, M. and Yeshibaev, A. and Digel, Ilya and Elibayeva, G. and Sydykova, A. and Uspabayeva, A. and Dosybayeva, G. and Zhylysbayeva, A. and Lakhanova, K.},
  title     = {Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L},
  series = {Life science journal},
  volume    = {11},
  journal   = {Life science journal},
  number    = {Spec. iss. 5s},
  publisher = {Marsland Press},
  address   = {New York},
  issn      = {1097-8135},
  doi       = {10.7537/marslsj1105s14.33},
  pages     = {171 -- 175},
  year      = {2014},
  abstract  = {The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium - F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 \% respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.},
  language  = {en}
}
@article{AkimbekovDigelOHerasetal.2014,
  author    = {Akimbekov, N.Sh. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments},
  series = {Experimental Biology},
  volume    = {60},
  journal   = {Experimental Biology},
  number    = {1/2},
  publisher = {Al-Farabi Kazakh National University},
  address   = {Almaty},
  issn      = {1563-0218},
  pages     = {144 -- 148},
  year      = {2014},
  abstract  = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.},
  language  = {en}
}
@article{AkimbekovMansurovJandosovetal.2013,
  author    = {Akimbekov, Nuraly Shardarbekovich and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.},
  title     = {Wound healing activity of carbonized rice husk},
  publisher = {Trans Tech Publications, Switzerland},
  address   = {B{\"a}ch},
  year      = {2013},
  abstract  = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.},
  subject      = {Wundheilung},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@article{MiciliValterOflazetal.2013,
  author    = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes},
  series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  volume    = {Vol. 227},
  journal   = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  number    = {No. 4},
  publisher = {Sage},
  address   = {London},
  issn      = {0046-2039 (Print) ; 2041-3033 (E-Journal)},
  pages     = {393 -- 401},
  year      = {2013},
  language  = {en}
}
@article{AkimbekovDigelTastambeketal.2013,
  author    = {Akimbekov, N. S. and Digel, Ilya and Tastambek, K. T. and Zhubanova, A. A.},
  title     = {Biocompatibility of carbonized rice husk with a rat heart cells line H9c2},
  series = {Experimental Biology},
  volume    = {59},
  journal   = {Experimental Biology},
  number    = {3/1},
  issn      = {1563-0218},
  pages     = {23 -- 25},
  year      = {2013},
  language  = {en}
}
@article{AkimbekovDigelSavitkayaetal.2013,
  author    = {Akimbekov, N.Sh. and Digel, Ilya and Savitkaya, I.S. and Zhubanova, A.A. and Tastambek, K.T.},
  title     = {Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk},
  series = {KazNU Bulletin. Biology series},
  volume    = {57},
  journal   = {KazNU Bulletin. Biology series},
  number    = {1},
  issn      = {1563-0218},
  pages     = {124 -- 127},
  year      = {2013},
  language  = {en}
}
@article{DigelAkimbekovTuralievaetal.2013,
  author    = {Digel, Ilya and Akimbekov, N. and Turalieva, M. and Mansurov, Z. and Temiz Artmann, Ayseg{\"u}l and Eshibaev, A. and Zhubanova, A.},
  title     = {Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions},
  series = {Journal of Industrial Technology and Engineering},
  volume    = {2},
  journal   = {Journal of Industrial Technology and Engineering},
  number    = {07},
  pages     = {47 -- 54},
  year      = {2013},
  language  = {en}
}
@article{AkimbekovDigelZhubanova2013,
  author    = {Akimbekov, N. Sh. and Digel, Ilya and Zhubanova, A. A.},
  title     = {Investigation the Influence of Carbonized Material Based On Rice Husk on Viability and Migration of Fibroblasts in T3B3 Cell Culture},
  series = {KazNU Bulletin. Biology series},
  volume    = {59},
  journal   = {KazNU Bulletin. Biology series},
  number    = {3/1},
  issn      = {1563-0218},
  pages     = {20 -- 23},
  year      = {2013},
  language  = {en}
}
@article{StadlerGarveyBocahutetal.2012,
  author    = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.},
  title     = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics},
  series = {Journal of the Royal Society Interface},
  volume    = {9},
  journal   = {Journal of the Royal Society Interface},
  number    = {76},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {1742-5689},
  doi       = {10.1098/rsif.2012.0364},
  pages     = {2845 -- 2855},
  year      = {2012},
  abstract  = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.},
  language  = {en}
}