@article{HavermannBeylich1997, author = {Havermann, Marc and Beylich, A. E.}, title = {Performance and Limitations of the Laser-Induced Fluorescence Measurement Technique and the Established Experimental Methods for the Study of Supersonic Mixing / Havermann, M. ; Beylich, A. E.}, series = {International Journal of heat and technology. 15 (1997), H. 2}, journal = {International Journal of heat and technology. 15 (1997), H. 2}, publisher = {-}, pages = {3 -- 10}, year = {1997}, language = {en} } @article{Havermann2005, author = {Havermann, Marc}, title = {Effects of the shock tube open-end shape on vortex loops released from it / Kainuma, M. ; Havermann, M. ; Sun, M. ; Takayama, K.}, series = {Shock Waves : Proceedings of the 24th International Symposium on Shock Waves Beijing, China July 11-16, 2004 / edited by Z. Jiang}, journal = {Shock Waves : Proceedings of the 24th International Symposium on Shock Waves Beijing, China July 11-16, 2004 / edited by Z. Jiang}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-22497-6}, pages = {505 -- 510}, year = {2005}, language = {en} } @article{HavermannSeilerBolleretal.2005, author = {Havermann, Marc and Seiler, F. and Boller, F. and Mangold, P.}, title = {Operation of the ISL transonic shock tube in a high subsonic flow regime / Seiler, F. ; Havermann, M. ; Boller, F. ; Mangold, P. ; Takayama K.}, series = {Shock Waves : Proceedings of the 24th International Symposium on Shock Waves Beijing, China July 11-16, 2004 / edited by Z. Jiang}, journal = {Shock Waves : Proceedings of the 24th International Symposium on Shock Waves Beijing, China July 11-16, 2004 / edited by Z. Jiang}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-22497-6}, pages = {307 -- 312}, year = {2005}, language = {en} } @article{PichlerGeorgeSeileretal.2009, author = {Pichler, A. and George, A. and Seiler, F. and Srulijes, J. and Havermann, Marc}, title = {Doppler Picture Velocimetry (DPV) applied to hypersonics}, series = {Shock Waves [Elektronische Ressource] : 26th International Symposium on Shock Waves, Volume 1 / edited by Klaus Hannemann, Friedrich Seiler}, journal = {Shock Waves [Elektronische Ressource] : 26th International Symposium on Shock Waves, Volume 1 / edited by Klaus Hannemann, Friedrich Seiler}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-85168-4}, pages = {503 -- 508}, year = {2009}, language = {en} } @article{HavermannSeilerGeorgeetal.2003, author = {Havermann, Marc and Seiler, F. and George, A. and Leopold, F.}, title = {Planar Velocity Visualization in High-Speed Wedge Flow using Doppler Picture Velocimetry (DPV) compared with Particle Image Velocimetry (PIV) / Seiler, F. ; Havermann, M. ; George, A. ; Leopold, F. ; Srulijes, J.}, series = {Journal of Visualization. 6 (2003), H. 3}, journal = {Journal of Visualization. 6 (2003), H. 3}, publisher = {-}, isbn = {1343-8875}, pages = {253 -- 262}, year = {2003}, language = {en} } @article{HavermannHaertigReyetal.2008, author = {Havermann, Marc and Haertig, J. and Rey, C. and George, A.}, title = {PIV Measurements in Shock Tunnels and Shock Tubes / Havermann, M. ; Haertig, J. ; Rey, C. ; George, A.}, series = {Particle Image Velocimetry : New Developments and Recent Applications}, journal = {Particle Image Velocimetry : New Developments and Recent Applications}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-73528-1}, pages = {429 -- 442}, year = {2008}, language = {en} } @article{HavermannSeilerGeorgesetal.2008, author = {Havermann, Marc and Seiler, F. and Georges, A. and Srulijes, J.}, title = {Progress in Doppler picture velocimetry (DPV) / Seiler, F. ; George, A. ; Srulijes, J. ; Havermann, M.}, series = {Experiments in Fluids. 44 (2008), H. 3}, journal = {Experiments in Fluids. 44 (2008), H. 3}, publisher = {-}, isbn = {1432-1114}, pages = {389 -- 395}, year = {2008}, language = {en} } @article{HavermannHaertigReyetal.2002, author = {Havermann, Marc and Haertig, J. and Rey, C. and George, A.}, title = {Particle image velocimetry in mach 3.5 and 4.5 shock-tunnel flows / Haertig, J. ; Havermann, M. ; Rey, C. ; George, A.}, series = {AIAA journal. 40 (2002), H. 6}, journal = {AIAA journal. 40 (2002), H. 6}, publisher = {-}, isbn = {0001-1452}, pages = {1056 -- 1060}, year = {2002}, language = {en} } @article{LettiniHavermannGuidettietal.2010, author = {Lettini, Antonio and Havermann, Marc and Guidetti, Marco and Fornaciari, Andrea}, title = {Improved functionalities and energy saving potential on mobile machines combining electronics with flow sharing valve and variable displacement pump}, series = {IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010}, journal = {IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010}, publisher = {-}, isbn = {978-3-940565-92-1}, pages = {103 -- 114}, year = {2010}, language = {en} } @article{HavermannSeiler2006, author = {Havermann, Marc and Seiler, F.}, title = {Boundary Layer Influence on Supersonic Jet/Cross-Flow Interaction in Hypersonic Flow / Havermann, M. ; Seiler, F.}, series = {Notes on Numerical Fluid Mechanics and Multidisciplinary Design. 92 (2006)}, journal = {Notes on Numerical Fluid Mechanics and Multidisciplinary Design. 92 (2006)}, publisher = {-}, isbn = {1612-2909}, pages = {281 -- 288}, year = {2006}, language = {en} } @article{BaeckerRaueSchusseretal.2012, author = {B{\"a}cker, Matthias and Raue, Markus and Schusser, Sebastian and Jeitner, C. and Breuer, L. and Wagner, P. and Poghossian, Arshak and F{\"o}rster, Arnold and Mang, Thomas and Sch{\"o}ning, Michael Josef}, title = {Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100763}, pages = {839 -- 845}, year = {2012}, abstract = {Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.}, language = {en} } @article{FunkeRobinson2007, author = {Funke, Harald and Robinson, A. E.}, title = {Development of a new test rig for a micro scale hydrogen combustion chamber}, series = {Proceedings of the 2nd European Conference for Aero-Space Sciences : July 1 - 6, 2007, Brussels, Belgium}, journal = {Proceedings of the 2nd European Conference for Aero-Space Sciences : July 1 - 6, 2007, Brussels, Belgium}, publisher = {-}, pages = {1 -- 8}, year = {2007}, language = {en} } @article{AbouzarPoghossianCherstvyetal.2012, author = {Abouzar, Maryam H. and Poghossian, Arshak and Cherstvy, Andrey G. and Pedraza, Angela M. and Ingebrandt, Sven and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100710}, pages = {925 -- 934}, year = {2012}, abstract = {Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.}, language = {en} } @article{BaeckerRakowskiPoghossianetal.2013, author = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis}, series = {Journal of Biotechnology}, volume = {163}, journal = {Journal of Biotechnology}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2012.03.014}, pages = {371 -- 376}, year = {2013}, abstract = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.}, language = {en} } @article{GrinsvenBonStrauvenetal.2012, author = {Grinsven, Bart van and Bon, Natalie vanden and Strauven, Hannelore and Grieten, Lars and Murib, Mohammed and Jim{\´e}nez Monroy, Kathia L. and Janssens, Stoffel D. and Haenen, Ken and Sch{\"o}ning, Michael Josef and Vermeeren, Veronique and Ameloot, Marcel and Michiels, Luc and Thoelen, Ronald and Ceuninck, Ward de and Wagner, Patrick}, title = {Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.}, series = {ACS Nano}, volume = {6}, journal = {ACS Nano}, number = {3}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1936-086X}, doi = {10.1021/nn300147e}, pages = {2712 -- 2721}, year = {2012}, abstract = {In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.}, language = {en} } @article{AridaAlhaddadSchoening2011, author = {Arida, Hassan A. and Al-haddad, Ameera and Sch{\"o}ning, Michael Josef}, title = {New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode}, series = {International Journal of Electrochemical Science. 6 (2011), H. 9}, journal = {International Journal of Electrochemical Science. 6 (2011), H. 9}, isbn = {1452-3981}, pages = {3858 -- 3867}, year = {2011}, language = {en} } @article{SpiessWilfriedAlvarezetal.2011, author = {Spiess, Elmar and Wilfried, Reichardt and Alvarez, Gerardo and Gottrup, Marcus and {\"O}hlschl{\"a}ger, Peter}, title = {An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma}, series = {Molecular Therapy}, volume = {20}, journal = {Molecular Therapy}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1525-0016}, pages = {555 -- 564}, year = {2011}, language = {en} } @article{HeuermannHillebrandSadeghfam2008, author = {Heuermann, Holger and Hillebrand, J{\"u}rgen and Sadeghfam, Arash}, title = {Novel Concept of a Digital SigmaDelta-PLL-Phase-Shift-Modulator / Hillebrand, J{\"u}rgen ; Sadeghfam, Arash ; Heuermann, Holger}, isbn = {978-3-8007-3086-5}, pages = {123 -- 126}, year = {2008}, language = {en} } @article{ImmelGrothHuhnetal.2011, author = {Immel, Timo A. and Groth, Ulrich and Huhn, Thomas and {\"O}hlschl{\"a}ger, Peter}, title = {Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice}, series = {PLoS ONE}, volume = {6}, journal = {PLoS ONE}, number = {3}, publisher = {Plos}, address = {San Francisco, California, US}, doi = {10.1371/journal.pone.0017869}, pages = {e17869}, year = {2011}, abstract = {The anticancer activity of titanium complexes has been known since the groundbreaking studies of K{\"o}pf and K{\"o}pf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.}, language = {en} } @article{LeursMezoOehlschlaegeretal.2012, author = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena}, title = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety}, series = {Peptide Science}, volume = {98}, journal = {Peptide Science}, number = {1}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-0282}, doi = {10.1002/bip.21640}, pages = {1 -- 10}, year = {2012}, abstract = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.}, language = {en} }