@article{ZhubanovaAknazarovMansurovetal.2010, author = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly S. and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials}, year = {2010}, abstract = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.}, subject = {Kohlenstofffaser}, language = {en} } @article{WagnerWernerMiyamotoetal.2010, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.200983320}, pages = {844 -- 849}, year = {2010}, abstract = {The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy.}, language = {en} } @article{WagnerMiyamotoSchoeningetal.2010, author = {Wagner, Torsten and Miyamoto, Ko-ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging}, series = {Procedia Engineering}, volume = {5}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2010.09.161}, pages = {520 -- 523}, year = {2010}, abstract = {Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach of read out in a light-addressable potentiometric sensor (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device which allows fast and flexible generation of light patterns. With the help of these light patterns the sensor surface of the LAPS device can be read out sequentially in a raster like scheme (scanning LAPS). The DLP approach has several advantages compared to conventional scanning LAPS set-ups, e.g., the spot size, the shape and the intensity of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of measurement.}, language = {en} } @article{vonKnobelsdorfBrenkenhoffFrauenrathProthmannetal.2010, author = {von Knobelsdorf-Brenkenhoff, Florian and Frauenrath, Tobias and Prothmann, Marcel and Dieringer, Matthias A. and Hezel, Fabian and Renz, Wolfgang and Kretschel, Kerstin and Niendorf, Thoralf and Schulz-Menger, Jeanette}, title = {Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla—a pilot study}, volume = {20}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {0938-7994}, doi = {10.1007/s00330-010-1888-2}, pages = {2844 -- 2852}, year = {2010}, abstract = {Objectives Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T. Methods A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated. Results All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm. Conclusions This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T.}, language = {en} } @article{VogtMottaghyWolfetal.2010, author = {Vogt, C. and Mottaghy, Darius and Wolf, A. and Rath, V. and Pechnig, R. and Clauser, C.}, title = {Reducing temperature uncertainties by stochastic geothermal reservoir modelling}, series = {Geophysical Journal International}, volume = {181}, journal = {Geophysical Journal International}, number = {1}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1365-246X}, doi = {10.1111/j.1365-246X.2009.04498.x}, pages = {321 -- 333}, year = {2010}, abstract = {Quantifying and minimizing uncertainty is vital for simulating technically and economically successful geothermal reservoirs. To this end, we apply a stochastic modelling sequence, a Monte Carlo study, based on (i) creating an ensemble of possible realizations of a reservoir model, (ii) forward simulation of fluid flow and heat transport, and (iii) constraining post-processing using observed state variables. To generate the ensemble, we use the stochastic algorithm of Sequential Gaussian Simulation and test its potential fitting rock properties, such as thermal conductivity and permeability, of a synthetic reference model and—performing a corresponding forward simulation—state variables such as temperature. The ensemble yields probability distributions of rock properties and state variables at any location inside the reservoir. In addition, we perform a constraining post-processing in order to minimize the uncertainty of the obtained distributions by conditioning the ensemble to observed state variables, in this case temperature. This constraining post-processing works particularly well on systems dominated by fluid flow. The stochastic modelling sequence is applied to a large, steady-state 3-D heat flow model of a reservoir in The Hague, Netherlands. The spatial thermal conductivity distribution is simulated stochastically based on available logging data. Errors of bottom-hole temperatures provide thresholds for the constraining technique performed afterwards. This reduce the temperature uncertainty for the proposed target location significantly from 25 to 12 K (full distribution width) in a depth of 2300 m. Assuming a Gaussian shape of the temperature distribution, the standard deviation is 1.8 K. To allow a more comprehensive approach to quantify uncertainty, we also implement the stochastic simulation of boundary conditions and demonstrate this for the basal specific heat flow in the reservoir of The Hague. As expected, this results in a larger distribution width and hence, a larger, but more realistic uncertainty estimate. However, applying the constraining post-processing the uncertainty is again reduced to the level of the post-processing without stochastic boundary simulation. Thus, constraining post-processing is a suitable tool for reducing uncertainty estimates by observed state variables.}, language = {en} } @article{UllrichGrottkeRossaintetal.2010, author = {Ullrich, Sebastian and Grottke, Oliver and Rossaint, Rolf and Staat, Manfred and Deserno, Thomas M. and Kuhlen, Torsten}, title = {Virtual Needle Simulation with Haptics for Regional Anaesthesia}, pages = {1 -- 3}, year = {2010}, language = {en} } @article{TurekHeidenGuoetal.2010, author = {Turek, Monik and Heiden, Wolfgang and Guo, Sharon and Riesen, Alfred and Schubert, J{\"u}rgen and Zander, Willi and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {817 -- 823}, year = {2010}, language = {en} } @article{TranStaat2010, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method}, pages = {1 -- 7}, year = {2010}, language = {en} } @article{TippkoetterRoikaewUlberetal.2010, author = {Tippk{\"o}tter, Nils and Roikaew, Wipa and Ulber, Roland and Hoffmann, Alexander and Denzler, Hans-J{\"o}rg and Buchholz, Heinrich}, title = {Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food}, series = {Biotechnology Progress}, volume = {26}, journal = {Biotechnology Progress}, number = {3}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {8756-7938}, doi = {10.1002/btpr.384}, pages = {756 -- 762}, year = {2010}, abstract = {Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.}, language = {en} } @article{StaatSponagelNguyen2010, author = {Staat, Manfred and Sponagel, Stefan and Nguyen, Nhu Huynh}, title = {Experiment and material model for soft tissue materials}, series = {Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ...}, journal = {Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ...}, publisher = {CRC Press}, address = {Boca Raton [u.a.]}, isbn = {978-0-415-56327-7}, pages = {465 -- 470}, year = {2010}, language = {en} } @article{SrivastavaSinghAggarwaletal.2010, author = {Srivastava, Alok and Singh, Virendra and Aggarwal, Pranav and Schneeweiss, F. and Scherer, Ulrich W. and Friedrich, W.}, title = {Optical studies of insulating polymers for radiation dose monitoring}, series = {Indian Journal of Pure and Applied Physics}, volume = {48}, journal = {Indian Journal of Pure and Applied Physics}, number = {11}, publisher = {Council Of Scientific And Industrial Research (CSIR), National Institute Of Science Communication and Policy Research (NIScPR)}, address = {New Delhi}, isbn = {0019-5596}, pages = {782 -- 786}, year = {2010}, abstract = {The optical study carried out on insulating polymers namely polyethyleneterephthalate (PET) and polyvinylchloride (PVC) has been described. The polymers are exposed to different radiation doses by exposing them to swift heavy ions of carbon (90 MeV), silicon (120 MeV) and nickel (100 MeV) which influence on their optical properties. The studies show that amongst the investigated polymers, PVC and PET have potential for application as dosimeter beyond a threshold dose which is strongly dependent on the nature of the material and the radiation type. The optical micrographs show a distinct change in colour of the sample with increase in radiation dose.}, language = {en} } @article{SpelthahnSchaffrathCoppeetal.2010, author = {Spelthahn, Heiko and Schaffrath, Sophie and Coppe, Thomas and Rufi, Frederic and Sch{\"o}ning, Michael Josef}, title = {Development of an electrolyte-insulator-semiconductor (EIS) based capacitive heavy metal sensor for the detection of Pb2+ und Cd2+ ions}, series = {Physica status solidi (a) : applications and material science}, volume = {207}, journal = {Physica status solidi (a) : applications and material science}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.200983306}, pages = {930 -- 934}, year = {2010}, abstract = {Chalcogenide glass materials as membranes for potentiometric sensors for chemical analysis in solutions have been studied since more than 20 years. In this work, an electrolyte-insulator-semiconductor structure was combined with chalcogenide glass membranes prepared by means of the pulsed laser deposition technique. Depending on the membrane composition a selectivity to different ions (Cd2+ and Pb2+) is achieved. The different sensor membranes have been physically characterised using microscopy, ellipsometry, profilometry, atomic force microscopy (AFM), scanning electron microscopy (SEM) and Rutherford backscattering spectrometry (RBS). The electrochemical behaviour has been investigated via capacitance/voltage (C/V) and constant capacitance (ConCap) measurements and results in a Cd2+ sensitivity of 23.1 ± 0.6 mV per decade in a linear range from 7 × 10-6 to 10-2 mol/l and 24.4 ± 0.5 mV per decade in a linear range from 5 × 10-6 to 10-2 mol/l for Pb2+, respectively.}, language = {en} } @article{SiqueiraBaeckerPoghossianetal.2010, author = {Siqueira, Jos{\´e} R. Jr. and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices}, series = {Physica status solidi (a). 207 (2010), H. 4}, journal = {Physica status solidi (a). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {781 -- 786}, year = {2010}, language = {en} } @article{SiqueiraMakiPaulovichetal.2010, author = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor}, series = {Analytical Chemistry (2010)}, journal = {Analytical Chemistry (2010)}, isbn = {0003-2700}, pages = {61 -- 65}, year = {2010}, language = {en} } @article{SchoeningKirchnerNgetal.2010, author = {Sch{\"o}ning, Michael Josef and Kirchner, Patrick and Ng, Yue Ann and Spelthahn, Heiko and Schneider, Andreas and Henkel, Hartmut and Friedrich, Peter and Kolstad, Jens and Berger, J{\"o}rg and Keusgen, Michael}, title = {Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {787 -- 792}, year = {2010}, language = {en} } @article{ScholzLeyDachwaldetal.2010, author = {Scholz, A. and Ley, Wilfried and Dachwald, Bernd and Miau, J. J. and Juang, J. C.}, title = {Flight results of the COMPASS-1 picosatellite mission}, series = {Acta Astronautica}, volume = {76}, journal = {Acta Astronautica}, number = {9-10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0094-5765}, doi = {10.1016/j.actaastro.2010.06.040}, pages = {1289 -- 1298}, year = {2010}, abstract = {The mission of the COMPASS-1 picosatellite is to take pictures of the earth, to validate a space-borne GPS receiver developed by the German Aerospace Center, and to verify the proper operation of the magnetic attitude control system in orbit. The spacecraft was launched on April 28, 2008 from the Indian space port Sriharikota, as part of the PSLV-C9 world record launch that simultaneously brought ten satellites into orbit. The mission operations were carried out from the ground stations in Aachen and Tainan. Arising difficulties in the communication link were overcome with the support of individuals from the amateur radio community. After several months of mission operation, abundant housekeeping and mission data has been commanded, received and analyzed and is presented in this paper.}, language = {en} } @article{SchmittSchollCaietal.2010, author = {Schmitt, Robert and Scholl, Ingrid and Cai, Yu and Xia, Ji and Dziwoki, Paul and Harding, Martin and Pavim, Alberto}, title = {Machine vision system for inline inspection in carbide insert production}, series = {Proceedings of the 36th International MATADOR Conference}, journal = {Proceedings of the 36th International MATADOR Conference}, publisher = {Springer}, address = {Berlin}, isbn = {978-1-84996-431-9}, doi = {10.1007/978-1-84996-432-6_77}, pages = {339 -- 342}, year = {2010}, abstract = {In steps of the production chain of carbide inserts, such as unloading or packaging, the conformity test of the insert type is done manually, which causes a statistic increase of errors due to monotony and fatigue of the worker and the wide variety of the insert types. A machine vision system is introduced that captures digital frames of the inserts in the production line, analyses inspects automatically and measures four quality features: coating colour, edge radius, plate shape and chip-former geometry. This new method has been tested on several inserts of different types and has shown that the prevalent insert types can be inspected and robustly classified in real production environment and therefore improves the manufacturing automation.}, language = {en} } @article{SchlamannYoonMaderwaldetal.2010, author = {Schlamann, Marc and Yoon, Min-Suk and Maderwald, Stefan and Pietrzyk, Thomas and Bitz, Andreas and Gerwig, Marcus and Forsting, Michael and Ladd, Susanne C. and Ladd, Mark E. and Kastrup, Oliver}, title = {Short term effects of magnetic resonance imaging on excitability of the motor cortex at 1.5T and 7T}, series = {Academic Radiology}, volume = {17}, journal = {Academic Radiology}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1076-6332}, doi = {10.1016/j.acra.2009.10.004}, pages = {277 -- 281}, year = {2010}, abstract = {Rationale and Objectives The increasing spread of high-field and ultra-high-field magnetic resonance imaging (MRI) scanners has encouraged new discussion of the safety aspects of MRI. Few studies have been published on possible cognitive effects of MRI examinations. The aim of this study was to examine whether changes are measurable after MRI examinations at 1.5 and 7 T by means of transcranial magnetic stimulation (TMS). Materials and Methods TMS was performed in 12 healthy, right-handed male volunteers. First the individual motor threshold was specified, and then the cortical silent period (SP) was measured. Subsequently, the volunteers were exposed to the 1.5-T MRI scanner for 63 minutes using standard sequences. The MRI examination was immediately followed by another TMS session. Fifteen minutes later, TMS was repeated. Four weeks later, the complete setting was repeated using a 7-T scanner. Control conditions included lying in the 1.5-T scanner for 63 minutes without scanning and lying in a separate room for 63 minutes. TMS was performed in the same way in each case. For statistical analysis, Wilcoxon's rank test was performed. Results Immediately after MRI exposure, the SP was highly significantly prolonged in all 12 subjects at 1.5 and 7 T. The motor threshold was significantly increased. Fifteen minutes after the examination, the measured value tended toward normal again. Control conditions revealed no significant differences. Conclusion MRI examinations lead to a transient and highly significant alteration in cortical excitability. This effect does not seem to depend on the strength of the static magnetic field.}, language = {en} } @article{SchlamannVoigtMaderwaldetal.2010, author = {Schlamann, Marc and Voigt, Melanie A. and Maderwald, Stefan and Bitz, Andreas and Kraff, Oliver and Ladd, Susanne C. and Ladd, Mark E. and Forsting, Michael and Wilhelm, Hans}, title = {Exposure to high-field MRI does not affect cognitive function}, series = {Journal of Magnetic Resonance Imaging}, volume = {31}, journal = {Journal of Magnetic Resonance Imaging}, number = {5}, publisher = {Wiley-Liss}, address = {New York}, issn = {1522-2586}, doi = {10.1002/jmri.22065}, pages = {1061 -- 1066}, year = {2010}, abstract = {Purpose To assess potential cognitive deficits under the influence of static magnetic fields at various field strengths some studies already exist. These studies were not focused on attention as the most vulnerable cognitive function. Additionally, mostly no magnetic resonance imaging (MRI) sequences were performed. Materials and Methods In all, 25 right-handed men were enrolled in this study. All subjects underwent one MRI examination of 63 minutes at 1.5 T and one at 7 T within an interval of 10 to 30 days. The order of the examinations was randomized. Subjects were referred to six standardized neuropsychological tests strictly focused on attention immediately before and after each MRI examination. Differences in neuropsychological variables between the timepoints before and after each MRI examination were assessed and P-values were calculated Results Only six subtests revealed significant differences between pre- and post-MRI. In these tests the subjects achieved better results in post-MRI testing than in pre-MRI testing (P = 0.013-0.032). The other tests revealed no significant results. Conclusion The improvement in post-MRI testing is only explicable as a result of learning effects. MRI examinations, even in ultrahigh-field scanners, do not seem to have any persisting influence on the attention networks of human cognition immediately after exposure.}, language = {en} } @article{ScheerRossKapelyukhetal.2010, author = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland}, title = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice}, series = {Drug Metabolism and Disposition}, volume = {38}, journal = {Drug Metabolism and Disposition}, number = {7}, publisher = {ASPET}, address = {Bethesda}, issn = {1521-009X}, doi = {10.1124/dmd.109.031872}, pages = {1046 -- 1053}, year = {2010}, abstract = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.}, language = {en} }