@incollection{Fissabre2018, author = {Fissabre, Anke}, title = {Vom Schiff an Land oder von der Muschel zur Rocaille}, series = {Schwimmender Barock : Das Schiff als Repr{\"a}sentationsobjekt}, booktitle = {Schwimmender Barock : Das Schiff als Repr{\"a}sentationsobjekt}, editor = {Priesterjahn, Maike}, publisher = {Bebra Verlag}, address = {Berlin}, isbn = {978-3-89809-153-4}, pages = {59 -- 65}, year = {2018}, language = {de} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @incollection{KochPoghossianWegeetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications}, series = {Virus-Derived Nanoparticles for Advanced Technologies}, booktitle = {Virus-Derived Nanoparticles for Advanced Technologies}, editor = {Wege, Christina}, publisher = {Humana Press}, address = {New York, NY}, isbn = {978-1-4939-7808-3}, doi = {10.1007/978-1-4939-7808-3}, pages = {553 -- 568}, year = {2018}, abstract = {Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance.}, language = {en} } @incollection{Finkenberger2018, author = {Finkenberger, Isabel Maria}, title = {Schwellenreiten}, series = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, booktitle = {Prozesse reflexiven Entwerfens : Entwerfen und Forschen in Architektur und Landschaft}, editor = {Buchert, Margitta}, publisher = {JOVIS Verlag}, address = {Berlin}, isbn = {978-3-86859-558-1}, pages = {208 -- 226}, year = {2018}, language = {de} } @incollection{Klocke2018, author = {Klocke, Martina}, title = {Schulter an Schulter - Zusammenarbeit in einem differenzierten Hochschulsystem}, series = {Lehre und Lehrentwicklung an Fachhochschulen - Festschrift f{\"u}r Prof. Dr. med. W. Huhn}, booktitle = {Lehre und Lehrentwicklung an Fachhochschulen - Festschrift f{\"u}r Prof. Dr. med. W. Huhn}, publisher = {Waxmann}, address = {M{\"u}nster}, isbn = {978-3-8309-3782-1}, pages = {75 -- 80}, year = {2018}, language = {de} } @incollection{GollandSchneidereit2018, author = {Golland, Alexander and Schneidereit, Peter}, title = {Rechtliche Rahmenbedingungen des Identit{\"a}tsmangements im Cloud Computing}, series = {Identit{\"a}tsmanagement Im Cloud Computing : Evaluation {\"o}konomischer und Rechtlicher Rahmenbedingungen}, booktitle = {Identit{\"a}tsmanagement Im Cloud Computing : Evaluation {\"o}konomischer und Rechtlicher Rahmenbedingungen}, editor = {Borges, Georg and Werners, Brigitte}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-55584-2}, doi = {10.1007/978-3-662-55584-2_4}, pages = {53 -- 104}, year = {2018}, abstract = {Cloud Computing wirft in zahlreichen Rechtsbereichen neuartige juristische Fragestellungen auf. Ziel der Darstellung der rechtlichen Rahmenbedingungen ist, die das Identit{\"a}tsmanagement in der Cloud betreffenden Rechtsgrundlagen aus den unterschiedlichen Rechtsgebieten vorzustellen und einzuordnen, bevor im Rahmen des sechsten Kapitels die Darstellung der hieraus resultierenden Verpflichtungen in ihrer konkreten Form erfolgt.}, language = {de} } @incollection{HaukCzarneckiDietze2018, author = {Hauk, Joachim and Czarnecki, Christian and Dietze, Christian}, title = {Prozessorientierte Messung der Customer Experience am Beispiel der Telekommunikationsindustrie}, series = {Customer Experience im Zeitalter des Kunden : Best Practices, Lessons Learned und Forschungsergebnisse}, booktitle = {Customer Experience im Zeitalter des Kunden : Best Practices, Lessons Learned und Forschungsergebnisse}, editor = {Rusnjak, Andreas and Schallmo, Daniel R. A.}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-18961-7}, doi = {10.1007/978-3-658-18961-7_7}, pages = {195 -- 216}, year = {2018}, abstract = {Hohe Wettbewerbsintensit{\"a}t und gestiegene Kundenanforderungen erfordern bei Telekommunikationsunternehmen eine aktive Gestaltung der Customer Experience (CX). Ein wichtiger Aspekt dabei ist die CX-Messung. Traditionelle Zufriedenheitsmessungen sind oft nicht ausreichend, um die Kundenerfahrung in komplexen Prozessen vollst{\"a}ndig zu erfassen. Daher wird in diesem Kapitel eine prozess{\"u}bergreifende Referenzl{\"o}sung zur CX-Messung am Beispiel der Telekommunikationsindustrie vorgeschlagen. Ausgangspunkt ist ein industriespezifisches Prozessmodell, das sich an dem Referenzmodell eTOM orientiert. Dieses wird um Messpunkte erweitert, die Schwachstellen in Bezug auf die CX identifizieren. F{\"u}r die erkannten Schwachstellen werden {\"u}ber eine Referenzmatrix m{\"o}gliche Ausl{\"o}ser abgeleitet und anhand von typischen Gesch{\"a}ftsfallmengen bewertet. Somit ist eine direkte Zuordnung und Erfolgsmessung konkreter Maßnahmen zur Behebung der Schwachstellen m{\"o}glich. Die so entwickelte Referenzl{\"o}sung wurde im Projekt K1 bei der Deutschen Telekom erfolgreich umgesetzt. Details zur Umsetzung werden als Fallstudien dargestellt.}, language = {de} } @incollection{CzarneckiAuth2018, author = {Czarnecki, Christian and Auth, Gunnar}, title = {Prozessdigitalisierung durch Robotic 7 Process Automation}, series = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, booktitle = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, editor = {Barton, Thomas and M{\"u}ller, Christian and Seel, Christian}, publisher = {Springer}, address = {Wiesbaden}, isbn = {9783658227739}, doi = {10.1007/978-3-658-22773-9_7}, pages = {113 -- 131}, year = {2018}, abstract = {Im Rahmen der digitalen Transformation werden innovative Technologiekonzepte, wie z. B. das Internet der Dinge und Cloud Computing als Treiber f{\"u}r weitreichende Ver{\"a}nderungen von Organisationen und Gesch{\"a}ftsmodellen angesehen. In diesem Kontext ist Robotic Process Automation (RPA) ein neuartiger Ansatz zur Prozessautomatisierung, bei dem manuelle T{\"a}tigkeiten durch sogenannte Softwareroboter erlernt und automatisiert ausgef{\"u}hrt werden. Dabei emulieren Softwareroboter die Eingaben auf der bestehenden Pr{\"a}sentationsschicht, so dass keine {\"A}nderungen an vorhandenen Anwendungssystemen notwendig sind. Die innovative Idee ist die Transformation der bestehenden Prozessausf{\"u}hrung von manuell zu digital, was RPA von traditionellen Ans{\"a}tzen des Business Process Managements (BPM) unterscheidet, bei denen z. B. prozessgetriebene Anpassungen auf Ebene der Gesch{\"a}ftslogik notwendig sind. Am Markt werden bereits unterschiedliche RPA-L{\"o}sungen als Softwareprodukte angeboten. Gerade bei operativen Prozessen mit sich wiederholenden Verarbeitungsschritten in unterschiedlichen Anwendungssystemen sind gute Ergebnisse durch RPA dokumentiert, wie z. B. die Automatisierung von 35 \% der Backoffice-Prozesse bei Telefonica. Durch den vergleichsweise niedrigen Implementierungsaufwand verbunden mit einem hohen Automatisierungspotenzial ist in der Praxis (z. B. Banken, Telekommunikation, Energieversorgung) ein hohes Interesse an RPA vorhanden. Der Beitrag diskutiert RPA als innovativen Ansatz zur Prozessdigitalisierung und gibt konkrete Handlungsempfehlungen f{\"u}r die Praxis. Dazu wird zwischen modellgetriebenen und selbstlernenden Ans{\"a}tzen unterschieden. Anhand von generellen Architekturen von RPA-Systemen werden Anwendungsszenarien sowie deren Automatisierungspotenziale, aber auch Einschr{\"a}nkungen, diskutiert. Es folgt ein strukturierter Markt{\"u}berblick ausgew{\"a}hlter RPA-Produkte. Anhand von drei konkreten Anwendungsbeispielen wird die Nutzung von RPA in der Praxis verdeutlicht.}, language = {de} } @incollection{StengerAltherrMuelleretal.2018, author = {Stenger, David and Altherr, Lena and M{\"u}ller, Tankred and Pelz, Peter F.}, title = {Product family design optimization using model-based engineering techniques}, series = {Operations Research Proceedings 2017}, booktitle = {Operations Research Proceedings 2017}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-89919-0}, doi = {10.1007/978-3-319-89920-6_66}, pages = {495 -- 502}, year = {2018}, abstract = {Highly competitive markets paired with tremendous production volumes demand particularly cost efficient products. The usage of common parts and modules across product families can potentially reduce production costs. Yet, increasing commonality typically results in overdesign of individual products. Multi domain virtual prototyping enables designers to evaluate costs and technical feasibility of different single product designs at reasonable computational effort in early design phases. However, savings by platform commonality are hard to quantify and require detailed knowledge of e.g. the production process and the supply chain. Therefore, we present and evaluate a multi-objective metamodel-based optimization algorithm which enables designers to explore the trade-off between high commonality and cost optimal design of single products.}, language = {en} } @incollection{RoethPielen2018, author = {R{\"o}th, Thilo and Pielen, Michael}, title = {Personal Public Vehicle - ein urbanes Fahrzeugkonzept f{\"u}r die „Shared Mobility" der Zukunft}, series = {Karosseriebautage Hamburg 2018, 16. ATZ-Fachtagung}, booktitle = {Karosseriebautage Hamburg 2018, 16. ATZ-Fachtagung}, publisher = {Springer Vieweg}, address = {Wiesbaden}, doi = {10.1007/978-3-658-22038-9_13}, pages = {189 -- 199}, year = {2018}, abstract = {Die urbane Mobilit{\"a}t ist im Wandel und insbesondere neue innovative Gesch{\"a}ftsmodelle werden einen wesentlichen Teil zur L{\"o}sung von k{\"u}nftigen Mobilit{\"a}tsbed{\"u}rfnissen beitragen. Die sogenannte „Shared Mobility" gilt aktuell neben der Elektrifizierung des Antriebes und autonomem Fahrzeugtechnologien als einer der wichtigsten Trendthemen in der Automobilindustrie. Neue Mobilit{\"a}tsdienstleistungen verlangen dabei verst{\"a}rkt auch neue Fahrzeugkonzepte.}, language = {de} } @incollection{MuellerAltherrAholaetal.2018, author = {M{\"u}ller, Tim M. and Altherr, Lena and Ahola, Marja and Schabel, Samuel and Pelz, Peter F.}, title = {Optimizing pressure screen systems in paper recycling: optimal system layout, component selection and operation}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18499-5}, doi = {10.1007/978-3-030-18500-8_44}, pages = {355 -- 361}, year = {2018}, abstract = {Around 60\% of the paper worldwide is made from recovered paper. Especially adhesive contaminants, so called stickies, reduce paper quality. To remove stickies but at the same time keep as many valuable fibers as possible, multi-stage screening systems with several interconnected pressure screens are used. When planning such systems, suitable screens have to be selected and their interconnection as well as operational parameters have to be defined considering multiple conflicting objectives. In this contribution, we present a Mixed-Integer Nonlinear Program to optimize system layout, component selection and operation to find a suitable trade-off between output quality and yield.}, language = {en} } @incollection{SchneiderWisselinkCzarnecki2018, author = {Schneider, Dominik and Wisselink, Frank and Czarnecki, Christian}, title = {Nutzen und Rahmenbedingungen 5 informationsgetriebener Gesch{\"a}ftsmodelle des Internets der Dinge}, series = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, booktitle = {Digitalisierung in Unternehmen: von den theoretischen Ans{\"a}tzen zur praktischen Umsetzung}, editor = {Barton, Thomas and M{\"u}ller, Christian and Seel, Christian}, publisher = {Springer}, address = {Wiesbaden}, isbn = {9783658227739}, doi = {10.1007/978-3-658-22773-9_5}, pages = {67 -- 85}, year = {2018}, abstract = {Im Kontext der zunehmenden Digitalisierung wird das Internet der Dinge (englisch: Internet of Things, IoT) als ein technologischer Treiber angesehen, durch den komplett neue Gesch{\"a}ftsmodelle im Zusammenspiel unterschiedlicher Akteure entstehen k{\"o}nnen. Identifizierte Schl{\"u}sselakteure sind unter anderem traditionelle Industrieunternehmen, Kommunen und Telekommunikationsunternehmen. Letztere sorgen mit der Bereitstellung von Konnektivit{\"a}t daf{\"u}r, dass kleine Ger{\"a}te mit winzigen Batterien nahezu {\"u}berall und direkt an das Internet angebunden werden k{\"o}nnen. Es sind schon viele IoT-Anwendungsf{\"a}lle auf dem Markt, die eine Vereinfachung f{\"u}r Endkunden darstellen, wie beispielsweise Philips Hue Tap. Neben Gesch{\"a}ftsmodellen basierend auf Konnektivit{\"a}t besteht ein großes Potenzial f{\"u}r informationsgetriebene Gesch{\"a}ftsmodelle, die bestehende Gesch{\"a}ftsmodelle unterst{\"u}tzen sowie weiterentwickeln k{\"o}nnen. Ein Beispiel daf{\"u}r ist der IoT-Anwendungsfall Park and Joy der Deutschen Telekom AG, bei dem Parkpl{\"a}tze mithilfe von Sensoren vernetzt und Autofahrer in Echtzeit {\"u}ber verf{\"u}gbare Parkpl{\"a}tze informiert werden. Informationsgetriebene Gesch{\"a}ftsmodelle k{\"o}nnen auf Daten aufsetzen, die in IoT-Anwendungsf{\"a}llen erzeugt werden. Zum Beispiel kann ein Telekommunikationsunternehmen Mehrwert sch{\"o}pfen, indem es aus Daten entscheidungsrelevantere Informationen - sogenannte Insights - ableitet, die zur Steigerung der Entscheidungsagilit{\"a}t genutzt werden. Außerdem k{\"o}nnen Insights monetarisiert werden. Die Monetarisierung von Insights kann nur nachhaltig stattfinden, wenn sorgf{\"a}ltig gehandelt wird und Rahmenbedingungen ber{\"u}cksichtigt werden. In diesem Kapitel wird das Konzept informationsgetriebener Gesch{\"a}ftsmodelle erl{\"a}utert und anhand des konkreten Anwendungsfalls Park and Joy verdeutlicht. Dar{\"u}ber hinaus werden Nutzen, Risiken und Rahmenbedingungen diskutiert.}, language = {de} } @incollection{DigelAkimbekovKistaubayevaetal.2018, author = {Digel, Ilya and Akimbekov, Nuraly Sh. and Kistaubayeva, Aida and Zhubanova, Azhar A.}, title = {Microbial Sampling from Dry Surfaces: Current Challenges and Solutions}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_19}, pages = {421 -- 456}, year = {2018}, abstract = {Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms' recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling.}, language = {en} } @incollection{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Mechanics of soft tissue reactions to textile mesh implants}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_11}, pages = {251 -- 275}, year = {2018}, abstract = {For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment.}, language = {en} } @incollection{DuweTippkoetterUlber2018, author = {Duwe, A. and Tippk{\"o}tter, Nils and Ulber, R.}, title = {Lignocellulose-Biorefinery: Ethanol-Focused}, series = {Biorefineries}, booktitle = {Biorefineries}, publisher = {Springer}, address = {Cham}, doi = {10.1007/10_2016_72}, pages = {177 -- 215}, year = {2018}, abstract = {The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described.}, language = {en} } @incollection{SchoeningWagnerPoghossianetal.2018, author = {Sch{\"o}ning, Michael Josef and Wagner, Torsten and Poghossian, Arshak and Miyamoto, K.I. and Werner, C.F. and Krause, S. and Yoshinobu, T.}, title = {Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging}, series = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, booktitle = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {9780128097397}, pages = {295 -- 308}, year = {2018}, language = {en} } @incollection{DuongSeifarthTemizArtmannetal.2018, author = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred}, title = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_9}, pages = {209 -- 232}, year = {2018}, abstract = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.}, language = {en} } @incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @incollection{ChwallekGoelzerReichert2018, author = {Chwallek, Constanze and G{\"o}lzer, Kaan and Reichert, Walter}, title = {Faymonville - Wachstum als Komplexit{\"a}tstreiber}, series = {Fallstudienkompendium Hidden Champions - Innovationen f{\"u}r den Weltmarkt}, booktitle = {Fallstudienkompendium Hidden Champions - Innovationen f{\"u}r den Weltmarkt}, publisher = {Springer Gabler}, isbn = {978-3-658-17829-1}, doi = {10.1007/978-3-658-17829-1_18}, pages = {299 -- 312}, year = {2018}, abstract = {Die Fallstudie FAYMONVILLE besch{\"a}ftigt sich damit, wie es dem Familienunternehmen Faymonville aus Ostbelgien gelungen ist, sich zu einem der f{\"u}hrenden Hersteller in seiner Branche zu entwickeln. Die gezielte Identifizierung neuer M{\"a}rkte, die Fokussierung auf die relevanten Kundenbed{\"u}rfnisse und eine konsistente Produktpolitik mit einem abgestimmten Fertigungskonzept legen die Grundsteine f{\"u}r den Erfolg. Das vorliegende Fallbeispiel zeigt anschaulich, wie es gelingen kann, den prinzipiellen Widerspruch zwischen wirtschaftlicher und kundenindividueller Fertigung erfolgreich aufzul{\"o}sen.}, language = {de} } @incollection{Czarnecki2018, author = {Czarnecki, Christian}, title = {Establishment of a central process governance organization combined with operational process improvements : Insights from a BPM Project at a leading telecommunications operator in the Middle East}, series = {Business process management cases : digital innovation and business transformation in practice}, booktitle = {Business process management cases : digital innovation and business transformation in practice}, editor = {vom Brocke, Jan and Mendling, Jan}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-58306-8}, doi = {10.1007/978-3-319-58307-5}, pages = {57 -- 76}, year = {2018}, abstract = {Because of customer churn, strong competition, and operational inefficiencies, the telecommunications operator ME Telco (fictitious name due to confidentiality) launched a strategic transformation program that included a Business Process Management (BPM) project. Major problems were silo-oriented process management and missing cross-functional transparency. Process improvements were not consistently planned and aligned with corporate targets. Measurable inefficiencies were observed on an operational level, e.g., high lead times and reassignment rates of the incident management process.}, language = {en} }