@masterthesis{Baierlein2023,
  type      = {Bachelor Thesis},
  author    = {Baierlein, Ellen},
  title     = {Konzerthaus Berlin : Entwicklung eines Erscheinungsbildes f{\"u}r das Konzerthaus Berlin},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {102 Seiten},
  year      = {2023},
  abstract  = {Das Konzerthaus Berlin ist einer der sch{\"o}nsten Orte Berlins f{\"u}r klassische Musik. Dabei steht das Haus auf der Schwelle zwischen langer Tradition und Moderne. Die Qualit{\"a}t an Musik, die dort gespielt wird, soll dabei f{\"u}r alle zug{\"a}nglich sein. Dies machen die unterschiedlichsten Konzerte m{\"o}glich. Um diesen modernen Anspruch auch nach außen zu kommunizieren, wurde ein neues Gestaltungskonzept f{\"u}r das Konzerthaus Berlin entwickelt. Im Fokus des neu entwickelten Corporate Designs steht der Rhythmus Gedanke, welcher sich im Headline Prinzip zeigt sowie medien{\"u}bergreifend in der Layoutgestaltung durch Groß/Klein Kontraste fortsetzt. Das Erscheinungsbild funktioniert dabei sowohl animiert als auch statisch. Musik wird dadurch visuell erfahrbar gemacht und bildet den modernen Fokuspunkt in der Gestaltung.},
  language  = {de}
}
@masterthesis{Baehr2023,
  type      = {Bachelor Thesis},
  author    = {B{\"a}hr, Luisa},
  title     = {Localution : Entwicklung eines digitalen L{\"o}sungsmodells zur Verbindung des digitalen und station{\"a}ren Handels},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {135 Seiten},
  year      = {2023},
  abstract  = {Die Nutzung des Onlinehandels steigt seit Jahren kontinuierlich an. F{\"u}r H{\"a}ndler:innen und ganz besonders f{\"u}r kleine Anbieter:innen, die zunehmend von gr{\"o}ßeren verdr{\"a}ngt werden, ist es wichtiger denn je, ihren Onlineauftritt auf den neuesten Stand zu bringen. Doch stellt dies die kleineren Anbieter:innen oftmals vor große Herausforderungen, denn der digitale Handel muss stets aktualisiert werden und kostet Zeit, Aufwand und Geld. „Localution" ist eine digitale Plattform, die es lokalen Anbieter:innen m{\"o}glich macht, mit wenig Aufwand eine Webseite aufzubauen. Zus{\"a}tzlich sind Angebote buchbar, die den station{\"a}ren Handel optimieren. F{\"u}r Konsument:innen bietet „Localution" die M{\"o}glichkeit, lokale Anbieter:innen in der N{\"a}he zu finden und Termine zu buchen.},
  language  = {de}
}
@article{CheenakulaPaulsenOttetal.2023,
  author    = {Cheenakula, Dheeraja and Paulsen, Svea and Ott, Fabian and Gr{\"o}mping, Markus},
  title     = {Operational window of a deammonifying sludge for mainstream application in a municipal wastewater treatment plant},
  series = {Water and Environment Journal},
  journal   = {Water and Environment Journal},
  number    = {Early View},
  publisher = {Wiley},
  address   = {Chichester},
  issn      = {1747-6593},
  doi       = {10.1111/wej.12898},
  pages     = {1 -- 12},
  year      = {2023},
  abstract  = {The present work aimed to study the mainstream feasibility of the deammonifying sludge of side stream of municipal wastewater treatment plant (MWWTP) in Kaster, Germany. For this purpose, the deammonifying sludge available at the side stream was investigated for nitrogen (N) removal with respect to the operational factors temperature (15-30°C), pH value (6.0-8.0) and chemical oxygen demand (COD)/N ratio (≤1.5-6.0). The highest and lowest N-removal rates of 0.13 and 0.045 kg/(m³ d) are achieved at 30 and 15°C, respectively. Different conditions of pH and COD/N ratios in the SBRs of Partial nitritation/anammox (PN/A) significantly influenced both the metabolic processes and associated N-removal rates. The scientific insights gained from the current work signifies the possibility of mainstream PN/A at WWTPs. The current study forms a solid basis of operational window for the upcoming semi-technical trails to be conducted prior to the full-scale mainstream PN/A at WWTP Kaster and WWTPs globally.},
  language  = {en}
}
@article{HoffstadtCheenakulaNikolauszetal.2023,
  author    = {Hoffstadt, Kevin and Cheenakula, Dheeraja and Nikolausz, Marcell and Krafft, Simone and Harms, Hauke and Kuperjans, Isabel},
  title     = {Design and construction of a new reactor for flexible biomethanation of hydrogen},
  series = {Fermentation},
  volume    = {9},
  journal   = {Fermentation},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2311-5637},
  doi       = {10.3390/fermentation9080774},
  pages     = {1 -- 16},
  year      = {2023},
  abstract  = {The increasing share of renewable electricity in the grid drives the need for sufficient storage capacity. Especially for seasonal storage, power-to-gas can be a promising approach. Biologically produced methane from hydrogen produced from surplus electricity can be used to substitute natural gas in the existing infrastructure. Current reactor types are not or are poorly optimized for flexible methanation. Therefore, this work proposes a new reactor type with a plug flow reactor (PFR) design. Simulations in COMSOL Multiphysics ® showed promising properties for operation in laminar flow. An experiment was conducted to support the simulation results and to determine the gas fraction of the novel reactor, which was measured to be 29\%. Based on these simulations and experimental results, the reactor was constructed as a 14 m long, 50 mm diameter tube with a meandering orientation. Data processing was established, and a step experiment was performed. In addition, a kLa of 1 h-1 was determined. The results revealed that the experimental outcomes of the type of flow and gas fractions are in line with the theoretical simulation. The new design shows promising properties for flexible methanation and will be tested.},
  language  = {en}
}
@article{GrajewskiKleefeld2023,
  author    = {Grajewski, Matthias and Kleefeld, Andreas},
  title     = {Detecting and approximating decision boundaries in low-dimensional spaces},
  series = {Numerical Algorithms},
  volume    = {93},
  journal   = {Numerical Algorithms},
  number    = {4},
  publisher = {Springer Science+Business Media},
  address   = {Dordrecht},
  issn      = {1572-9265},
  pages     = {35 Seiten},
  year      = {2023},
  abstract  = {A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch's factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms.},
  language  = {en}
}
@techreport{SiegertBongaertsWagneretal.2022,
  author    = {Siegert, Petra and Bongaerts, Johannes and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten},
  title     = {Abschlussbericht zum Projekt zur {\"U}berwachung biotechnologischer Prozesse mittels Diacetyl-/Acetoin-Biosensor und Evaluierung von Acetoin-Reduktasen zur Verwendung in Biotransformationen},
  address   = {Aachen},
  organization    = {FH Aachen},
  pages     = {16 Seiten},
  year      = {2022},
  language  = {de}
}
@misc{OPUS4-10711,
  title     = {Dimensionen 2-2022: Magazin der FH Aachen University of Applied Sciences - Werkstatt Zukunft},
  address   = {Aachen},
  organization    = {Fachhochschule Aachen},
  pages     = {63 Seiten},
  year      = {2022},
  abstract  = {Werkstatt Zukunft - Die FH Aachen versteht sich als interdisziplin{\"a}re Ideenschmiede 04| Aufbruch ins Ungewisse 08| Mit Altpapierresten aus der Energiekrise 14| Mehr Power f{\"u}r die Energiewende 20| Pfadfinder im Datendschungel 23| Ein historischer Schritt 24| Gemeinsam vorw{\"a}rts 30| F{\"u}r eine gerechte Hochschule. F{\"u}r alle. 32| Der gr{\"u}ne Reiter 34| Vom Flugsimulator bis zum Roboter 36| Unsere Azubis sind top! 38| WIR sind ein Sportteam! 40| Effizient und sicher: Der Bergbau der Zukunft 46| Mit Sonnenlicht zu sauberem Trinkwasser 48| Neue Brandmeldeanlage f{\"u}r den Dom zu Aachen 50| Auszeichnung f{\"u}r außergew{\"o}hnliches Engagement 52| Neue Ideen f{\"u}r Schloss Lichtenburg 55| Kopfnuss 56| One-Man-Show 60| K{\"a}mpferin f{\"u}r das Sch{\"o}ne 61| Ein charmanter Diplomat 62| Teamplay f{\"u}r die Zukunft 63| Impressum},
  language  = {de}
}
@masterthesis{Lessmann2023,
  type      = {Bachelor Thesis},
  author    = {Leßmann, Mika},
  title     = {Designing confidence : eine patient:innenzentrierte Intervention f{\"u}r belastende Behandlungssituationen - am Beispiel von Strahlentherapie},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {193 Seiten},
  year      = {2023},
  abstract  = {Krebstherapie bei Kindern ist f{\"u}r alle Beteiligten eine emotional bedr{\"u}ckende Angelegenheit. Besonders die Strahlentherapie stellt Kinder aufgrund der H{\"a}ufigkeit der Termine, der Isolation w{\"a}hrend der Bestrahlung und der Fixierung vor Herausforderungen. „nia" erm{\"o}glicht es den Angeh{\"o}rigen, w{\"a}hrend der Behandlung einen physischen Kontakt zum Kind zu halten. Zwei miteinander verbundene Zwillingsger{\"a}te registrieren die Bewegungen der H{\"a}nde und {\"u}bertragen die Ber{\"u}hrung an das jeweils andere Ger{\"a}t. Diese taktile Kommunikation sorgt f{\"u}r innere Ruhe und Verbundenheit. Vor der eigentlichen Therapie liegen die Ger{\"a}te in einem Koffer, welcher ein Modell des Behandlungsraums beinhaltet. Mithilfe dessen werden die Kinder spielerisch auf die Bestrahlung vorbereitet. So sollen sich in Zukunft weniger Kinder {\"a}ngstlich und allein einer Strahlentherapie stellen m{\"u}ssen.},
  language  = {de}
}
@masterthesis{Nahrings2023,
  type      = {Bachelor Thesis},
  author    = {Nahrings, Laura Aileen},
  title     = {Seamless Connection : die Integration eines smarten WLAN Routers in die Wohnumgebung},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {131 Seiten},
  year      = {2023},
  abstract  = {In Deutschland verf{\"u}gen mehr als 95 \% aller Haushalte {\"u}ber einen Internetzugang und das Interesse an Smart Home Anwendungen steigt. Je vernetzter das Zuhause wird, desto mehr Devices m{\"u}ssen dort ihren Platz finden. WLAN Router wirken durch ihre technische Designsprache meist wie Fremdk{\"o}rper im Raum, sodass oft versucht wird, sie zu verstecken. Das soll sich mit „Cobo", dem smarten WLAN Router, {\"a}ndern. Neben der Bereitstellung einer Internetanbindung wird er zum Hub f{\"u}r alle Smart Home Anwendungen. Als Herzst{\"u}ck des Zuhauses sorgt er f{\"u}r die Vernetzung aller Devices und schafft zudem eine Verbindung zwischen Technologie und Interior. Mit seinem minimalistischen Design und der gezielten Auswahl an Materialien und Farben f{\"u}gt sich der intelligente Router in die eigenen vier W{\"a}nde ein. „Cobo" ist kein WLAN Router, der im Schuhregal versteckt werden muss, denn er wird zum Teil der Einrichtung.},
  language  = {de}
}
@masterthesis{Rabe2023,
  type      = {Bachelor Thesis},
  author    = {Rabe, Leonie Maria},
  title     = {Wohlf{\"u}hlen in den eigenen vier W{\"a}nden : ein Produkt, welches die Wohn- und Lebensqualit{\"a}t steigert.},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {125 Seiten},
  year      = {2023},
  abstract  = {Viele Menschen f{\"u}hlen sich in ihren eigenen vier W{\"a}nden nicht wohl. Sie sind gestresst und k{\"o}nnen nicht entspannen. Ziel dieser Arbeit ist es, ein Produkt zu erschaffen, welches in seinen Funktionen und seinem Design daf{\"u}r sorgt, dass die Nutzer:innen sich zu Hause wohler f{\"u}hlen. Es soll alle Funktionen vereinen, die daf{\"u}r sorgen, dass der Alltagsstress besser bew{\"a}ltigt werden kann und man in seinem Zuhause entspannen kann und den Moment mehr genießt. Entstanden ist Iwa, ein Produkt, welches zum einen als Luftreiniger arbeitet und die Raumluft filtert und im Zusammenspiel mit Licht und Musik die Raumatmosph{\"a}re verbessert und so Stress mindert. Das Design soll genau wie die Funktionen beruhigend, entspannend und erdend wirken. Es ist angelehnt am Zen-Design. So bietet Iwa einen großen Mehrwert. Die Funktionen sorgen im Zusammenspiel mit dem Design f{\"u}r eine verbesserte Wohn- und Lebensqualit{\"a}t.},
  language  = {de}
}
@article{LuftBremenLuft2023,
  author    = {Luft, Angela and Bremen, Sebastian and Luft, Nils},
  title     = {A cost/benefit and flexibility evaluation framework for additive technologies in strategic factory planning},
  series = {Processes},
  volume    = {11},
  journal   = {Processes},
  number    = {7},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9717},
  doi       = {10.3390/pr11071968},
  pages     = {Artikel 1968},
  year      = {2023},
  abstract  = {There is a growing demand for more flexibility in manufacturing to counter the volatility and unpredictability of the markets and provide more individualization for customers. However, the design and implementation of flexibility within manufacturing systems are costly and only economically viable if applicable to actual demand fluctuations. To this end, companies are considering additive manufacturing (AM) to make production more flexible. This paper develops a conceptual model for the impact quantification of AM on volume and mix flexibility within production systems in the early stages of the factory-planning process. Together with the model, an application guideline is presented to help planners with the flexibility quantification and the factory design process. Following the development of the model and guideline, a case study is presented to indicate the potential impact additive technologies can have on manufacturing flexibility Within the case study, various scenarios with different production system configurations and production programs are analyzed, and the impact of the additive technologies on volume and mix flexibility is calculated. This work will allow factory planners to determine the potential impacts of AM on manufacturing flexibility in an early planning stage and design their production systems accordingly.},
  language  = {en}
}
@article{JanusAchtsnichtTempeletal.2023,
  author    = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon},
  series = {Physica status solidi : pss. A, Applications and materials science},
  volume    = {220},
  journal   = {Physica status solidi : pss. A, Applications and materials science},
  number    = {22},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300 (Print)},
  doi       = {10.1002/pssa.202300081},
  pages     = {Artikel 2300081},
  year      = {2023},
  abstract  = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.},
  language  = {en}
}
@article{FalkenbergVossBottetal.2023,
  author    = {Falkenberg, Fabian and Voß, Leonie and Bott, Michael and Bongaerts, Johannes and Siegert, Petra},
  title     = {New robust subtilisins from halotolerant and halophilic Bacillaceae},
  series = {Applied Microbiology and Biotechnology},
  volume    = {107},
  journal   = {Applied Microbiology and Biotechnology},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {1432-0614},
  doi       = {10.1007/s00253-023-12553-w},
  pages     = {3939 -- 3954},
  year      = {2023},
  abstract  = {The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0-12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5\% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.},
  language  = {en}
}
@book{SeptZillingerWiechertetal.2023,
  author    = {Sept, Marcel and Zillinger, Christina and Wiechert, Johanna and Thelen, Marius},
  title     = {Aachener Online-Schriften Wirtschaft und Recht. Band 6. 01/2023},
  editor    = {Kroll-Ludwigs, Kathrin and Bassen-Metz, Yasmine and Bernecker, Andreas and Eggert, Mathias and Fritz, Thomas and Golland, Alexander and H{\"o}hne, Tim and Tran, Duc Hung and Vogt, J{\"u}rgen},
  publisher = {FH Aachen / Fachbereich Wirtschaftswissenschaften},
  address   = {Aachen},
  publisher      = {Fachhochschule Aachen},
  pages     = {265 Seiten},
  year      = {2023},
  abstract  = {Inhaltsverzeichnis - Bachelorarbeiten 1. Zukunft der Rente - Kann eine Erwerbst{\"a}tigenversicherung das demografische Problem nachhaltig l{\"o}sen? - Marcel Sept | Seite 4-73 2. Die versammlungsgebundenen Aktion{\"a}rsrechte in der neuen virtuellen Hauptversammlung - eine Bewertung aus Unternehmer- und Aktion{\"a}rssicht - Christina Zillinger | Seite 74-130 3. Praxisleitfaden f{\"u}r den Arbeitgeber zum gesetzlichen Sonderk{\"u}ndigungsschutz - Was muss der Arbeitgeber tun, um durch Gesetz besonders gesch{\"u}tzten Arbeitnehmern k{\"u}ndigen zu k{\"o}nnen? - Johanna Wiechert | Seite 131-195 4. Die Steuerverg{\"u}nstigung bei Umstrukturierungen im Konzern nach \S 6a GrEStG im Lichte der aktuellen Rechtsprechung - Marius Thelen | Seite 196-265},
  language  = {de}
}
@article{MoehrenBergmannJanseretal.2023,
  author    = {M{\"o}hren, Felix and Bergmann, Ole and Janser, Frank and Braun, Carsten},
  title     = {On the influence of elasticity on propeller performance: a parametric study},
  series = {CEAS Aeronautical Journal},
  volume    = {14},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-023-00649-y},
  pages     = {311 -- 323},
  year      = {2023},
  abstract  = {The aerodynamic performance of propellers strongly depends on their geometry and, consequently, on aeroelastic deformations. Knowledge of the extent of the impact is crucial for overall aircraft performance. An integrated simulation environment for steady aeroelastic propeller simulations is presented. The simulation environment is applied to determine the impact of elastic deformations on the aerodynamic propeller performance. The aerodynamic module includes a blade element momentum approach to calculate aerodynamic loads. The structural module is based on finite beam elements, according to Timoshenko theory, including moderate deflections. Several fixed-pitch propellers with thin-walled cross sections made of both isotropic and non-isotropic materials are investigated. The essential parameters are varied: diameter, disc loading, sweep, material, rotational, and flight velocity. The relative change of thrust between rigid and elastic blades quantifies the impact of propeller elasticity. Swept propellers of large diameters or low disc loadings can decrease the thrust significantly. High flight velocities and low material stiffness amplify this tendency. Performance calculations without consideration of propeller elasticity can lead to decreased efficiency. To avoid cost- and time-intense redesigns, propeller elasticity should be considered for swept planforms and low disc loadings.},
  language  = {en}
}
@masterthesis{Hoffmann2023,
  type      = {Bachelor Thesis},
  author    = {Hoffmann, Jan-Peter},
  title     = {Schl{\"u}ter Projekt X},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {109 Seiten},
  year      = {2023},
  abstract  = {Schl{\"u}ter Projekt X ist die fiktive Reanimation des Traktorenherstellers Schl{\"u}ter. Dabei geht es darum, auf Basis der originalen Traktoren eine moderne Maschine zu entwerfen, welche die bew{\"a}hrte und beliebte Formsprache mit moderner Technologie und aktuellen Funktionen verbindet, um den Anforderungen der modernen Landwirtschaft gerecht zu werden. Dazu wurde Projekt X stark modular aufgebaut. Die Fahrzeugkabine l{\"a}sst sich um 180° drehen und gegebenenfalls durch ein vollkommen autonomes Modul austauschen. Die Reifen lassen sich bei Bedarf durch Ketten ersetzen. Projekt X wird elektronisch angetrieben, zur Vermeidung langer Ladezeiten l{\"a}sst sich der gesamte Akkublock in der Motorhaube austauschen.},
  language  = {de}
}
@article{BlockMayWetzeletal.2023,
  author    = {Block, Franziska and May, Alexander and Wetzel, Katharina and Adels, Klaudia and Elbers, Gereon and Schulze, Margit and Monakhova, Yulia},
  title     = {What is the best spectroscopic method for simultaneous analysis of organic acids and (poly)saccharides in biological matrices: Example of Aloe vera extracts?},
  series = {Talanta Open},
  volume    = {7},
  journal   = {Talanta Open},
  number    = {Art. No. 100220},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2666-8319},
  doi       = {10.1016/j.talo.2023.100220},
  pages     = {1 -- 9},
  year      = {2023},
  abstract  = {Several species of (poly)saccharides and organic acids can be found often simultaneously in various biological matrices, e.g., fruits, plant materials, and biological fluids. The analysis of such matrices sometimes represents a challenging task. Using Aloe vera (A. vera) plant materials as an example, the performance of several spectro-scopic methods (80 MHz benchtop NMR, NIR, ATR-FTIR and UV-vis) for the simultaneous analysis of quality parameters of this plant material was compared. The determined parameters include (poly)saccharides such as aloverose, fructose and glucose as well as organic acids (malic, lactic, citric, isocitric, acetic, fumaric, benzoic and sorbic acids). 500 MHz NMR and high-performance liquid chromatography (HPLC) were used as the reference methods. UV-vis data can be used only for identification of added preservatives (benzoic and sorbic acids) and drying agent (maltodextrin) and semiquantitative analysis of malic acid. NIR and MIR spectroscopies combined with multivariate regression can deliver more informative overview of A. vera extracts being able to additionally quantify glucose, aloverose, citric, isocitric, malic, lactic acids and fructose. Low-field NMR measurements can be used for the quantification of aloverose, glucose, malic, lactic, acetic, and benzoic acids. The benchtop NMR method was successfully validated in terms of robustness, stability, precision, reproducibility and limit of detection (LOD) and quantification (LOQ), respectively. All spectroscopic techniques are useful for the screening of (poly)saccharides and organic acids in plant extracts and should be applied according to its availability as well as information and confidence required for the specific analytical goal. Benchtop NMR spectroscopy seems to be the most feasible solution for quality control of A. vera products.},
  language  = {en}
}
@article{HaegerWirgesTanzmannetal.2023,
  author    = {Haeger, Gerrit and Wirges, Jessika and Tanzmann, Nicole and Oyen, Sven and Jolmes, Tristan and Jaeger, Karl-Erich and Sch{\"o}rken, Ulrich and Bongaerts, Johannes and Siegert, Petra},
  title     = {Chaperone assisted recombinant expression of a mycobacterial aminoacylase in Vibrio natriegens and Escherichia coli capable of N-lauroyl-L-amino acid synthesis},
  series = {Microbial Cell Factories},
  journal   = {Microbial Cell Factories},
  number    = {22},
  publisher = {Springer Nature},
  issn      = {1475-2859},
  doi       = {10.1186/s12934-023-02079-1},
  pages     = {Article number: 77 (2023)},
  year      = {2023},
  abstract  = {Background Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as strong surfactants and emulsifiers, with application in cosmetic industries. Heterologous expression of these enzymes, however, is often hampered, limiting their use in industrial processes. Results We identified a novel mycobacterial aminoacylase gene from Mycolicibacterium smegmatis MKD 8, cloned and expressed it in Escherichia coli and Vibrio natriegens using the T7 overexpression system. The recombinant enzyme was prone to aggregate as inclusion bodies, and while V. natriegens Vmax™ could produce soluble aminoacylase upon induction with isopropyl β-d-1-thiogalactopyranoside (IPTG), E. coli BL21 (DE3) needed autoinduction with lactose to produce soluble recombinant protein. We successfully conducted a chaperone co-expression study in both organisms to further enhance aminoacylase production and found that overexpression of chaperones GroEL/S enhanced aminoacylase activity in the cell-free extract 1.8-fold in V. natriegens and E. coli. Eventually, E. coli ArcticExpress™ (DE3), which co-expresses cold-adapted chaperonins Cpn60/10 from Oleispira antarctica, cultivated at 12 °C, rendered the most suitable expression system for this aminoacylase and exhibited twice the aminoacylase activity in the cell-free extract compared to E. coli BL21 (DE3) with GroEL/S co-expression at 20 °C. The purified aminoacylase was characterized based on hydrolytic activities, being most stable and active at pH 7.0, with a maximum activity at 70 °C, and stability at 40 °C and pH 7.0 for 5 days. The aminoacylase strongly prefers short-chain acyl-amino acids with smaller, hydrophobic amino acid residues. Several long-chain amino acids were fairly accepted in hydrolysis as well, especially N-lauroyl-L-methionine. To initially evaluate the relevance of this aminoacylase for the synthesis of N-acyl-amino acids, we demonstrated that lauroyl-methionine can be synthesized from lauric acid and methionine in an aqueous system. Conclusion Our results suggest that the recombinant enzyme is well suited for synthesis reactions and will thus be further investigated.},
  language  = {en}
}
@article{LaarmannThomaMischetal.2023,
  author    = {Laarmann, Lukas and Thoma, Andreas and Misch, Philipp and R{\"o}th, Thilo and Braun, Carsten and Watkins, Simon and Fard, Mohammad},
  title     = {Automotive safety approach for future eVTOL vehicles},
  series = {CEAS Aeronautical Journal},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer Nature},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-023-00655-0},
  pages     = {11 Seiten},
  year      = {2023},
  abstract  = {The eVTOL industry is a rapidly growing mass market expected to start in 2024. eVTOL compete, caused by their predicted missions, with ground-based transportation modes, including mainly passenger cars. Therefore, the automotive and classical aircraft design process is reviewed and compared to highlight advantages for eVTOL development. A special focus is on ergonomic comfort and safety. The need for further investigation of eVTOL's crashworthiness is outlined by, first, specifying the relevance of passive safety via accident statistics and customer perception analysis; second, comparing the current state of regulation and certification; and third, discussing the advantages of integral safety and applying the automotive safety approach for eVTOL development. Integral safety links active and passive safety, while the automotive safety approach means implementing standardized mandatory full-vehicle crash tests for future eVTOL. Subsequently, possible crash impact conditions are analyzed, and three full-vehicle crash load cases are presented.},
  language  = {en}
}
@article{PfaffBabilon2023,
  author    = {Pfaff, Raphael and Babilon, Katharina},
  title     = {Railway Challenge - moderne Auflage der Rainhill Trials?},
  series = {Eisenbahntechnische Rundschau : ETR ; Impulsgeber f{\"u}r das System Bahn},
  volume    = {2023},
  journal   = {Eisenbahntechnische Rundschau : ETR ; Impulsgeber f{\"u}r das System Bahn},
  number    = {4},
  publisher = {DVV Media Group},
  address   = {Hamburg},
  issn      = {0013-2845},
  pages     = {55 -- 58},
  year      = {2023},
  abstract  = {Die IMechE Railway Challenge wird j{\"a}hrlich in Stapleford, Großbritannien ausgetragen. Im Rahmen der Challenge entwickeln und bauen Studierende eine Lokomotive und vergleichen sich in verschiedenen Disziplinen, darunter eine automatisierte Zielbremsung, optimale Energier{\"u}ckgewinnung beim Bremsen und minimale Ger{\"a}uschemissionen. Neben diesen und weiteren technischen Wettbewerbsdisziplinen treten die Fahrzeuge und die Teams auch in nicht-technischen Disziplinen wie einer Business Case Challenge an.},
  language  = {de}
}