@article{GamellaZakharchenkoGuzetal.2017, author = {Gamella, Maria and Zakharchenko, Andrey and Guz, Nataliia and Masi, Madeline and Minko, Sergiy and Kolpashchikov, Dmitry M. and Iken, Heiko and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {2}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201600389}, pages = {398 -- 408}, year = {2017}, abstract = {An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at -1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals.}, language = {en} } @inproceedings{GranatHoefkenSchuba2017, author = {Granat, Andreas and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Intrusion Detection of the ICS Protocol EtherCAT}, pages = {1 -- 5}, year = {2017}, abstract = {Control mechanisms like Industrial Controls Systems (ICS) and its subgroup SCADA (Supervisory Control and Data Acquisition) are a prerequisite to automate industrial processes. While protection of ICS on process management level is relatively straightforward - well known office IT security mechanisms can be used - protection on field bus level is harder to achieve as there are real-time and production requirements like 24x7 to consider. One option to improve security on field bus level is to introduce controls that help to detect and to react on attacks. This paper introduces an initial set of intrusion detection mechanisms for the field bus protocol EtherCAT. To this end existing Ethernet attack vectors including packet injection and man-in-the-middle attacks are tested in an EtherCAT environment, where they could interrupt the EtherCAT network and may even cause physical damage. Based on the signatures of such attacks, a preprocessor and new rule options are defined for the open source intrusion detection system Snort demonstrating the general feasibility of intrusion detection on field bus level.}, language = {en} } @inproceedings{SchwankeHoefkenSchuba2017, author = {Schwanke, Peter and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Security Analysis of the ADS Protocol of a Beckhoff CX2020 PLC}, pages = {1 -- 5}, year = {2017}, abstract = {ICSs (Industrial Control Systems) and its subset SCADA systems (Supervisory Control and Data Acquisition) are getting exposed to a constant stream of new threats. The increasing importance of IT security in ICS requires viable methods to assess the security of ICS, its individual components, and its protocols. This paper presents a security analysis with focus on the communication protocols of a single PLC (Programmable Logic Controller). The PLC, a Beckhoff CX2020, is examined and new vulnerabilities of the system are revealed. Based on these findings recommendations are made to improve security of the Beckhoff system and its protocols.}, language = {en} } @article{BronderPoghossianKeusgenetal.2017, author = {Bronder, Thomas and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors}, series = {tm - Technisches Messen}, volume = {84}, journal = {tm - Technisches Messen}, number = {10}, publisher = {De Gruyter}, address = {Oldenbourg}, doi = {10.1515/teme-2017-0015}, pages = {628 -- 634}, year = {2017}, abstract = {In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.}, language = {en} } @article{ArreolaOberlaenderMaetzkowetal.2017, author = {Arreola, Julio and Oberl{\"a}nder, Jan and M{\"a}tzkow, M. and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Surface functionalization for spore-based biosensors with organosilanes}, series = {Electrochimica Acta}, volume = {241}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.04.157}, pages = {237 -- 243}, year = {2017}, abstract = {In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.}, language = {en} } @inproceedings{ThurnGebhardt2017, author = {Thurn, Laura and Gebhardt, Andreas}, title = {Arousing Enthusiasm for STEM: Teaching 3D Printing Technology}, series = {Conference Proceedings: New Perspectives in Science Education}, booktitle = {Conference Proceedings: New Perspectives in Science Education}, publisher = {liberiauniversitaria.it}, address = {Padua}, isbn = {978-88-6292-847-2}, pages = {87 -- 92}, year = {2017}, language = {en} } @article{FiedlerLaddBitz2017, author = {Fiedler, Thomas M. and Ladd, Mark E. and Bitz, Andreas}, title = {RF safety assessment of a bilateral four-channel transmit/receive 7 Tesla breast coil: SAR versus temperature limits}, series = {Medical Physics}, volume = {44}, journal = {Medical Physics}, number = {1}, doi = {10.1002/mp.12034}, pages = {143 -- 157}, year = {2017}, language = {en} } @article{NoureddineKraffLaddetal.2017, author = {Noureddine, Yacine and Kraff, Oliver and Ladd, Mark E. and Wrede, Karsten H. and Chen, Bixia and Quick, Harald H. and Schaefers, Gregor and Bitz, Andreas}, title = {In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla}, series = {Magnetic Resonance in Medicine}, journal = {Magnetic Resonance in Medicine}, number = {Early view}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.26650}, pages = {14 Seiten}, year = {2017}, language = {en} } @article{FiedlerLaddBitz2017, author = {Fiedler, Thomas M. and Ladd, Mark E. and Bitz, Andreas}, title = {SAR Simulations \& Safety}, series = {NeuroImage}, journal = {NeuroImage}, number = {Epub ahead of print}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2017.03.035}, year = {2017}, language = {en} } @article{DammSauerbornFendetal.2017, author = {Damm, Marc Andr{\´e} and Sauerborn, Markus and Fend, Thomas and Herrmann, Ulf}, title = {Optimisation of a urea selective catalytic reduction system with a coated ceramic mixing element}, series = {Journal of ceramic science and technology}, volume = {8}, journal = {Journal of ceramic science and technology}, number = {1}, publisher = {G{\"o}ller}, address = {Baden-Baden}, isbn = {2190-9385 (Print)}, issn = {2190-9385 (Online)}, doi = {10.4416/JCST2016-00056}, pages = {19 -- 24}, year = {2017}, language = {en} } @article{HonarvarfardGamellaChannaveerappaetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Channaveerappa, Devika and Darie, Costel C. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {Electrochemically Stimulated Insulin Release from a Modified Graphene-functionalized Carbon Fiber Electrode}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700095}, pages = {1543 -- 1553}, year = {2017}, abstract = {A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9-10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of -1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.}, language = {en} } @article{ZangeSchopenAlbrachtetal.2017, author = {Zange, Jochen and Schopen, Kathrin and Albracht, Kirsten and Gerlach, Darius A. and Frings-Meuthen, Petra and Maffiuletti, Nicola A. and Bloch, Wilhelm and Rittweger, J{\"o}rn}, title = {Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial}, series = {Plos one}, volume = {12}, journal = {Plos one}, number = {2}, doi = {10.1371/journal.pone.0171562}, year = {2017}, language = {en} } @article{HacklWegmannKahmannetal.2017, author = {Hackl, Michael and Wegmann, Kilian and Kahmann, Stephanie Lucina and Heinze, Nicolai and Staat, Manfred and Neiss, Wolfram F. and Scaal, Martin and M{\"u}ller, Lars P.}, title = {Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow}, series = {Knee Surgery, Sports Traumatology, Arthroscopy}, volume = {25}, journal = {Knee Surgery, Sports Traumatology, Arthroscopy}, number = {7}, publisher = {Springer}, address = {Berlin}, issn = {1433-7347}, doi = {10.1007/s00167-017-4468-z}, pages = {2280 -- 2288}, year = {2017}, language = {en} } @inproceedings{KesslerBalcGebhardtetal.2017, author = {Kessler, Julia and Balc, Nicolae and Gebhardt, Andreas and Abbas, Karim}, title = {Basic research on lattice structures focused on the reliance of the cross sectional area and additional coatings}, series = {The 4th International Conference on Computing and Solutions in Manufacturing Engineering 2016 - CoSME'16}, booktitle = {The 4th International Conference on Computing and Solutions in Manufacturing Engineering 2016 - CoSME'16}, edition = {Vol. 94}, doi = {10.1051/matecconf/20179403008}, pages = {7 S.}, year = {2017}, language = {en} } @article{NeuJanserKhatibietal.2017, author = {Neu, Eugen and Janser, Frank and Khatibi, Akbar A. and Orifici, Adrian C.}, title = {Fully Automated Operational Modal Analysis using multi-stage clustering}, series = {Mechanical Systems and Signal Processing}, volume = {Vol. 84, Part A}, journal = {Mechanical Systems and Signal Processing}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0888-3270}, doi = {10.1016/j.ymssp.2016.07.031}, pages = {308 -- 323}, year = {2017}, language = {en} } @article{PoghossianWernerBuniatyanetal.2017, author = {Poghossian, Arshak and Werner, Frederik and Buniatyan, V. V. and Wagner, Torsten and Miamoto, K. and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk}, series = {Sensor and Actuators B: Chemical}, journal = {Sensor and Actuators B: Chemical}, number = {244}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.01.047}, pages = {1071 -- 1079}, year = {2017}, abstract = {The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.}, language = {en} } @article{KatzPoghossianSchoening2017, author = {Katz, Evgeny and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics}, series = {Analytical and Bioanalytical Chemistry}, volume = {409}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer}, address = {Berlin}, issn = {1618-2650}, doi = {10.1007/s00216-016-0079-7}, pages = {81 -- 94}, year = {2017}, abstract = {The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a "filter" system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.}, language = {en} } @article{AlexopoulosHoffschmidt2017, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Advances in solar tower technology}, series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, volume = {6}, journal = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2041-840X}, doi = {10.1002/wene.217}, pages = {1 -- 19}, year = {2017}, language = {en} } @inproceedings{SchleupenEngemannBagherietal.2017, author = {Schleupen, Josef and Engemann, Heiko and Bagheri, Mohsen and Kallweit, Stephan and Dahmann, Peter}, title = {Developing a climbing maintenance robot for tower and rotor blade service of wind turbines}, series = {Advances in Robot Design and Intelligent Control : Proceedings of the 25th Conference on Robotics in Alpe-Adria-Danube Region (RAAD16)}, booktitle = {Advances in Robot Design and Intelligent Control : Proceedings of the 25th Conference on Robotics in Alpe-Adria-Danube Region (RAAD16)}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-49058-8}, doi = {10.1007/978-3-319-49058-8_34}, pages = {310 -- 319}, year = {2017}, language = {en} } @article{KilicRaatschenKoerfgenetal.2017, author = {Kilic, S. A. and Raatschen, Hans-J{\"u}rgen and K{\"o}rfgen, B. and Apaydin, N. M. and Astaneh-Asl, A.}, title = {FE Model of the Fatih Sultan Mehmet Suspension Bridge Using Thin Shell Finite Elements}, series = {Arabian Journal for Science and Engineering}, volume = {42}, journal = {Arabian Journal for Science and Engineering}, number = {3}, publisher = {Springer Nature}, issn = {2191-4281}, doi = {10.1007/s13369-016-2316-y}, pages = {1103 -- 1116}, year = {2017}, abstract = {This paper presents the results of an eigenvalue analysis of the Fatih Sultan Mehmet Bridge. A high-resolution finite element model was created directly from the available design documents. All physical properties of the structural components were included in detail, so no calibration to the measured data was necessary. The deck and towers were modeled with shell elements. A nonlinear static analysis was performed before the eigenvalue calculation. The calculated natural frequencies and corresponding mode shapes showed good agreement with the available measured ambient vibration data. The calculation of the effective modal mass showed that nine modes had single contributions higher than 5 \% of the total mass. They were in a frequency range up to 1.2 Hz. The comparison of the results for the torsional modes especially demonstrated the advantage of using thin shell finite elements over the beam modeling approach.}, language = {en} }