@article{Uibel2016, author = {Uibel, Thomas}, title = {Untersuchungen zum Spaltverhalten von Holzschrauben. Teil 1}, series = {Bauen mit Holz}, journal = {Bauen mit Holz}, number = {10}, publisher = {Rudolf M{\"u}ller}, address = {K{\"o}ln}, issn = {0005-6545}, pages = {40 -- 42}, year = {2016}, language = {de} } @article{TuraliyevaYeshibaevSaparbekovaetal.2016, author = {Turaliyeva, M. and Yeshibaev, A. and Saparbekova, A. and Akynova, L. and Abildayeva, R. and Sadenova, M. and Sartayeva, K. and Schieffer, Andre and Digel, Ilya}, title = {Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia}, series = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, volume = {18}, journal = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, number = {2}, publisher = {EM International}, issn = {0972-3005}, pages = {359 -- 366}, year = {2016}, abstract = {At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8\%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and {\~N}etonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.}, language = {en} } @article{Thomas2016, author = {Thomas, Axel}, title = {Genussrechte als Instrument der Unternehmensfinanzierung von kommunalen Wohnungs- baugesellschaften}, series = {VM Verwaltung und Management}, volume = {22}, journal = {VM Verwaltung und Management}, number = {6}, publisher = {Nomos}, address = {Baden-Baden}, issn = {0947-9856}, doi = {10.5771/0947-9856-2016-6-322}, pages = {322 -- 327}, year = {2016}, abstract = {Die kommunalen Wohnungsbaugesellschaften und ihr Gesch{\"a}ftszweck bzw. Versorgungsauftrag erfahren aus gesamtgesellschaftlichen Gr{\"u}nden aktuell einen erheblichen Bedeutungszuwachs. Der kommunale Wohnungsbau soll und muss intensiviert werden, da z.B. zunehmend Wohnungsbindungen auslaufen. Bezahlbare Neubauten fehlen speziell Familien, Senioren, Studenten und Fl{\"u}chtlingen. Um das Investitionsvolumen zu bew{\"a}ltigen, bedarf es nicht nur der F{\"o}rderkredite, sondern auch der Zuf{\"u}hrung „frischen Kapitals". Der Beitrag stellt dar, dass Genussrechte ein interessantes und oft unbekanntes Finanzierungsinstrument f{\"u}r kommunale Wohnungsbaugesellschaften mit passgenauen Ausgestaltungsm{\"o}glichkeiten sind. Mit Hilfe von Genussrechten k{\"o}nnen die notwendigen Neubau-Investitionen solide mit Quasi-Eigenkapital unterlegt werden und den sozialen Wohnungsbau wiederbeleben. Genussrechte als Hybridkapital lassen sich mangels gesetzlicher Eingrenzung exakt und individuell ebenso an die Bed{\"u}rfnisse der kommunalen Wohnungsbaugesellschaft anpassen wie an die der Gesellschafter und des jeweiligen Neubauvorhabens.}, language = {de} } @article{SvaneborgKarimiVarzanehHojdisetal.2016, author = {Svaneborg, Carsten and Karimi-Varzaneh, Hossein Ali and Hojdis, Nils and Fleck, Franz and Everaers, Ralf}, title = {Multiscale approach to equilibrating model polymer melts}, series = {Physical Review E}, volume = {94}, journal = {Physical Review E}, number = {032502}, publisher = {AIP Publishing}, address = {Melville, NY}, issn = {2470-0053}, doi = {10.1103/PhysRevE.94.032502}, year = {2016}, abstract = {We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.}, language = {en} } @article{SteinbauerFerrein2016, author = {Steinbauer, Gerald and Ferrein, Alexander}, title = {20 Years of RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0442-z}, pages = {221 -- 224}, year = {2016}, language = {en} } @article{StapenhorstDutto2016, author = {Stapenhorst, Carolin and Dutto, Andrea Alberto}, title = {Notes on conceptual learning in architecture}, series = {Cartha - The Form of Form}, journal = {Cartha - The Form of Form}, address = {Basel}, year = {2016}, language = {en} } @article{SchuellerKowalskiRaback2016, author = {Sch{\"u}ller, K. and Kowalski, Julia and Raback, P.}, title = {Curvilinear melting - A preliminary experimental and numerical study}, series = {International Journal of Heat and Mass Transfer}, journal = {International Journal of Heat and Mass Transfer}, number = {92}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0017-9310}, doi = {10.1016/j.ijheatmasstransfer.2015.09.046}, pages = {884 -- 892}, year = {2016}, abstract = {When exploring glacier ice it is often necessary to take samples or implement sensors at a certain depth underneath the glacier surface. One way of doing this is by using heated melting probes. In their common form these devices experience a straight one-dimensional downwards motion and can be modeled by standard close-contact melting theory. A recently developed melting probe however, the IceMole, achieves maneuverability by simultaneously applying a surface temperature gradient to induce a change in melting direction and controlling the effective contact-force by means of an ice screw to stabilize its change in attitude. A modeling framework for forced curvilinear melting does not exist so far and will be the content of this paper. At first, we will extend the existing theory for quasi-stationary close-contact melting to curved trajectories. We do this by introducing a rotational mode. This additional unknown in the system implies yet the need for another model closure. Within this new framework we will focus on the effect of a variable contact-force as well as different surface temperature profiles. In order to solve for melting velocity and curvature of the melting path we present both an inverse solution strategy for the analytical model, and a more general finite element framework implemented into the open source software package ELMER. Model results are discussed and compared to experimental data conducted in laboratory tests.}, language = {de} } @article{SchwabHojdisLacayoetal.2016, author = {Schwab, Lukas and Hojdis, Nils and Lacayo, Jorge and Wilhelm, Manfred}, title = {Fourier-Transform Rheology of Unvulcanized, Carbon Black Filled Styrene Butadiene Rubber}, series = {Macromolecular Materials and Engineering}, volume = {301}, journal = {Macromolecular Materials and Engineering}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1439-2054}, doi = {10.1002/mame.201500356}, pages = {457 -- 468}, year = {2016}, abstract = {Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold.}, language = {en} } @article{SchoppDollGraeseretal.2016, author = {Schopp, Christoph and Doll, Timo and Gr{\"a}ser, Ulrich and Harzheim, Thomas and Heuermann, Holger and Kling, Rainer and Marso, Michael}, title = {Capacitively Coupled High-Pressure Lamp Using Coaxial Line Networks}, series = {IEEE Transactions on Microwave Theory and Techniques}, volume = {64}, journal = {IEEE Transactions on Microwave Theory and Techniques}, number = {10}, publisher = {IEEE}, address = {New York, NY}, issn = {0018-9480}, doi = {10.1109/TMTT.2016.2600326}, pages = {3363 -- 3368}, year = {2016}, abstract = {This paper describes the development of a capacitively coupled high-pressure lamp with input power between 20 and 43 W at 2.45 GHz, using a coaxial line network. Compared with other electrodeless lamp systems, no cavity has to be used and a reduction in the input power is achieved. Therefore, this lamp is an alternative to the halogen incandescent lamp for domestic lighting. To serve the demands of domestic lighting, the filling of the lamp is optimized over all other resulting requirements, such as high efficacy at low induced powers and fast startups. A workflow to develop RF-driven plasma applications is presented, which makes use of the hot S-parameter technique. Descriptions of the fitting process inside a circuit and FEM simulator are given. Results of the combined ignition and operation network from simulations and measurements are compared. An initial prototype is built and measurements of the lamp's lighting properties are presented along with an investigation of the efficacy optimizations using large signal amplitude modulation. With this lamp, an efficacy of 135 lmW -1 is achieved.}, language = {en} } @article{SchmidtForkmannSinkeetal.2016, author = {Schmidt, K. and Forkmann, K. and Sinke, C. and Gratz, M. and Bitz, Andreas and Bingel, U.}, title = {The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear}, series = {NeuroImage}, volume = {134}, journal = {NeuroImage}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2016.03.026}, pages = {386 -- 395}, year = {2016}, abstract = {Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity was measured in 23 healthy subjects performing a visual categorization task that was immediately followed by a surprise recognition task. During the categorization task subjects received concomitant noxious electrical stimulation on the forehead or hand. Our data show that fear ratings were significantly higher for trigeminal pain. Categorization and recognition performance did not differ between pictures that were presented with trigeminal and peripheral pain. However, object categorization in the presence of trigeminal pain was associated with stronger activity in task-relevant visual areas (lateral occipital complex, LOC), memory encoding areas (hippocampus and parahippocampus) and areas implicated in emotional processing (amygdala) compared to peripheral pain. Further, individual differences in neural activation between the trigeminal and the peripheral condition were positively related to differences in fear ratings between both conditions. Functional connectivity between amygdala and LOC was increased during trigeminal compared to peripheral painful stimulation. Fear-driven compensatory resource activation seems to be enhanced for trigeminal stimuli, presumably due to their exceptional biological relevance.}, language = {en} } @article{SchifferFerrein2016, author = {Schiffer, Stefan and Ferrein, Alexander}, title = {Decision-Theoretic Planning with Fuzzy Notions in GOLOG}, series = {International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems}, volume = {24}, journal = {International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems}, number = {Issue Suppl. 2}, publisher = {World Scientific}, address = {Singapur}, issn = {1793-6411}, doi = {10.1142/S0218488516400134}, pages = {123 -- 143}, year = {2016}, abstract = {In this paper we present an extension of the action language Golog that allows for using fuzzy notions in non-deterministic argument choices and the reward function in decision-theoretic planning. Often, in decision-theoretic planning, it is cumbersome to specify the set of values to pick from in the non-deterministic-choice-of-argument statement. Also, even for domain experts, it is not always easy to specify a reward function. Instead of providing a finite domain for values in the non-deterministic-choice-of-argument statement in Golog, we now allow for stating the argument domain by simply providing a formula over linguistic terms and fuzzy uents. In Golog's forward-search DT planning algorithm, these formulas are evaluated in order to find the agent's optimal policy. We illustrate this in the Diner Domain where the agent needs to calculate the optimal serving order.}, language = {en} } @article{ScheidweilerTriesch2016, author = {Scheidweiler, Robert and Triesch, Eberhard}, title = {A note on the duality between matchings and vertex covers in balanced hypergraphs}, series = {Journal of Combinatorial Optimization}, volume = {32}, journal = {Journal of Combinatorial Optimization}, number = {2}, publisher = {Springer}, address = {Berlin}, issn = {1573-2886}, doi = {10.1007/s10878-015-9887-5}, pages = {639 -- 644}, year = {2016}, abstract = {We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig's Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32-40, 1970; Fulkerson et al. in Math Progr Study 1:120-132, 1974) and Hall's Theorem (Conforti et al. in Combinatorica 16:325-329, 1996) for balanced hypergraphs.}, language = {en} } @article{ScheerWilson2016, author = {Scheer, Nico and Wilson, Ian D.}, title = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity}, series = {Drug Discovery Today}, volume = {21}, journal = {Drug Discovery Today}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2015.09.002}, pages = {250 -- 263}, year = {2016}, abstract = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.}, language = {en} } @article{RoeschKratzHeringetal.2016, author = {R{\"o}sch, C. and Kratz, F. and Hering, T. and Trautmann, S. and Umanskaya, N. and Tippk{\"o}tter, Nils and M{\"u}ller-Renno, C.M. and Ulber, Roland and Hannig, M. and Ziegler, C.}, title = {Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity}, series = {Colloids and Surfaces B: Biointerfaces}, volume = {149}, journal = {Colloids and Surfaces B: Biointerfaces}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.colsurfb.2016.09.048}, pages = {115 -- 121}, year = {2016}, abstract = {The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.}, language = {en} } @article{RothTippkoetter2016, author = {Roth, Jasmine and Tippk{\"o}tter, Nils}, title = {Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium}, series = {Cellulose Chemistry and Technology}, volume = {50}, journal = {Cellulose Chemistry and Technology}, number = {3-4}, publisher = {Editura Academiei Romane}, address = {Bukarest}, pages = {405 -- 410}, year = {2016}, abstract = {Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹.}, language = {en} } @article{RosinButenwegKlinkel2016, author = {Rosin, Julia and Butenweg, Christoph and Klinkel, Sven}, title = {Stabilit{\"a}tsnachweis f{\"u}r seismisch beanspruchte Tankbauwerke nach dem LBA/MNA-Konzept}, series = {Bauingenieur}, volume = {91}, journal = {Bauingenieur}, number = {12}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, doi = {10.37544/0005-6650-2016-12-74}, pages = {518 -- 526}, year = {2016}, abstract = {Eine seismische Anregung verursacht in einem Fl{\"u}ssigkeitstank einen kombinierten Spannungszustand, was zu einem Stabilit{\"a}tsversagen der h{\"a}ufig sehr d{\"u}nnwandigen Konstruktionen f{\"u}hren kann. F{\"u}r die Durchf{\"u}hrung von Stabilit{\"a}tsnachweisen stehen verschiedene Verfahren zur Verf{\"u}gung. {\"U}blicherweise werden aus Gr{\"u}nden der Einfachheit spannungsbasierte Verfahren angewendet. Diese sind f{\"u}r Einheitslastf{\"a}lle experimentell abgesichert, wobei eine {\"U}bertragung auf kombinierte Spannungszust{\"a}nde wie im Erdbebenfall nur begrenzt m{\"o}glich ist. Alternativ kann ein globales, numerisches Konzept, das LBA/MNA-Verfahren, angewendet werden. Das Verfahren kombiniert eine materiell nichtlineare Berechnung (MNA) mit einer linearen Beulanalyse (LBA) und erfasst die Interaktion verschiedener gleichzeitig auftretender Beanspruchungen implizit im Nachweis. Dieser Beitrag demonstriert die Anwendung der Verfahren am Beispiel verschiedener Tankgeometrien mit H{\"o}he/Radius-Verh{\"a}ltnissen zwischen 1 ≤ H/R ≤ 2 und Radius/Tankwand-Verh{\"a}ltnissen zwischen 500 ≤ R/t ≤ 1000 und diskutiert zus{\"a}tzlich die Defizite der spannungsbasierten Nachweisverfahren.}, language = {de} } @article{RieperGebhardtStucker2016, author = {Rieper, Harald and Gebhardt, Andreas and Stucker, Brent}, title = {Selective Laser Melting of the Eutectic Silver-Copper Alloy Ag 28 wt \% Cu}, series = {RTejournal - Forum f{\"u}r Rapid Technologie}, volume = {13}, journal = {RTejournal - Forum f{\"u}r Rapid Technologie}, issn = {1614-0923}, url = {http://nbn-resolving.de/nbn:de:0009-2-44141}, year = {2016}, abstract = {The aim of this work was to perform a detailed investigation of the use of Selective Laser Melting (SLM) technology to process eutectic silver-copper alloy Ag 28 wt. \% Cu (also called AgCu28). The processing occurred with a Realizer SLM 50 desktop machine. The powder analysis (SEM-topography, EDX, particle distribution) was reported as well as the absorption rates for the near-infrared (NIR) spectrum. Microscope imaging showed the surface topography of the manufactured parts. Furthermore, microsections were conducted for the analysis of porosity. The Design of Experiments approach used the response surface method in order to model the statistical relationship between laser power, spot distance and pulse time.}, language = {en} } @article{RegerDoeringKuhnhenne2016, author = {Reger, V. and D{\"o}ring, Bernd and Kuhnhenne, M.}, title = {Passive und aktive Maßnahmen zur Fl{\"a}chenk{\"u}hlung im Stahl(leicht)bau}, series = {Bauingenieur}, volume = {91}, journal = {Bauingenieur}, number = {Jul/Aug}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, doi = {10.37544/0005-6650-2016-07-08-63}, pages = {309 -- 316}, year = {2016}, abstract = {Mit steigenden D{\"a}mmstandards und h{\"o}heren Komfortanforderungen der Nutzer ger{\"a}t die Problematik der sommerlichen {\"U}berhitzung zunehmend in den Fokus. Um die {\"U}berhitzung m{\"o}glichst gering zu halten, sind Maßnahmen und L{\"o}sungen zu entwickeln, die den potenziellen K{\"u}hlbedarf eines Geb{\"a}udes vermeiden sowie reduzieren. Im Rahmen des europ{\"a}ischen Forschungsprojektes BATIMASS wurden Techniken untersucht, die die sommerliche Raumtemperatur ohne zus{\"a}tzliche K{\"u}hlung (passiv) oder aber mit energieeffizienter wasserbasierter Fl{\"a}chenk{\"u}hlung (aktiv) reduzieren und die besonders f{\"u}r Geb{\"a}ude in Stahl(leicht)bauweise geeignet sind. Daf{\"u}r wurde die Methodik der thermisch {\"a}quivalenten Decke weiterentwickelt, um das thermische Verhalten von Profilblechdecken in Geb{\"a}uden f{\"u}r beide L{\"o}sungsans{\"a}tze analysieren zu k{\"o}nnen. Dar{\"u}ber hinaus wurde der Einsatz von Phasenwechselmaterial (PCM) zur Steigerung der Speicherf{\"a}higkeit von leichten Decken mit besonders geringer thermischer Masse in Simulationen sowie im Labor untersucht und bewertet.}, language = {de} } @article{PookhalilAmoabedinyTabeshetal.2016, author = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow}, title = {A new approach for semiempirical modeling of mechanical blood trauma}, series = {The international journal of artificial organs}, volume = {39}, journal = {The international journal of artificial organs}, number = {4}, publisher = {Sage}, address = {London}, issn = {1724-6040}, doi = {10.5301/ijao.5000474}, pages = {171 -- 177}, year = {2016}, abstract = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.}, language = {en} } @article{PinkenburgSchiffelsSelmer2016, author = {Pinkenburg, Olaf and Schiffels, Johannes and Selmer, Thorsten}, title = {Das CoLibry-Konzept - ein Werkzeugkasten f{\"u}r die Synthetische Biologie: Bioproduktion}, series = {BIOspektrum}, volume = {22}, journal = {BIOspektrum}, number = {6}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/s12268-016-0734-8}, pages = {593 -- 595}, year = {2016}, abstract = {Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.}, language = {de} }