@article{KowollikSchnitzlerBisellietal.2010, author = {Kowollik, Silvia and Schnitzler, Thomas and Biselli, Manfred and Krueger, R. and Zang, Werner and Peuscher, A. and Schillberg, S. and Fischer, R.}, title = {Die Rolle des Respirationsquotienten in der Zellkulturfermentation}, series = {Chemie Ingenieur Technik}, volume = {82}, journal = {Chemie Ingenieur Technik}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {Chemie Ingenieur Tec}, doi = {10.1002/cite.201050393}, pages = {1505 -- 1506}, year = {2010}, abstract = {In der biopharmazeutischen Industrie werden rekombinante Proteine und monoklonale Antik{\"o}rper in Zellkulturfermentationen produziert, da nur humane oder tierische Zelllinien {\"u}ber die F{\"a}higkeit der Glykosylierung verf{\"u}gen. Um hohe Produktausbeuten in ausgezeichneter Qualit{\"a}t zu erzielen, ist eine funktionst{\"u}chtige Prozesskontrolle unerl{\"a}sslich. Hierzu wurde in Kooperation mit der Firma Hitec Zang GmbH die HiSense� Pr{\"a}zisionsabgasanalytik entwickelt, die auf Basis der vollautomatischen Ermittlung des Respirationsquotienten (RQ; Verh{\"a}ltnis vonKohlendioxidbildungsrate (CER) zu Sauerstoffaufnahmerate (OTR)) einen Fermentationsprozess nicht-invasiv {\"u}berwacht. Der RQ kann in Hybridoma- und CHO-Zellen (s. Abb.) in sowohl serumhaltigen als auch serumfreien Medien erfolgreich ermittelt werden. Hier spiegeln die CER und die OTR das Wachstumsverhalten der kultivierten CHO-Zellen wider. Der RQ nimmt dabei Werte zwischen 0,9 und 1,2 an. Dies l{\"a}sst auf verschiedene Stoffwechselaktivit{\"a}ten schließen. Da die momentane industrielle Prozesskontrolle auf gemessenen Sauerstoffaufnahmeraten oder entsprechende Offline-Analytiken der Metaboliten basieren, soll durch die vollautomatische RQ-Ermittlung ein neues Verfahren zur Fermentations{\"u}berwachung etabliert werden. Bisher war diese, in bakteriellen Kultivierungen standardisierte Methode, aufgrund der schwierigen CER-Berechnung bei Zellkulturen keine ad{\"a}quate Alternative.}, language = {de} } @article{SchmittSchollCaietal.2010, author = {Schmitt, Robert and Scholl, Ingrid and Cai, Yu and Xia, Ji and Dziwoki, Paul and Harding, Martin and Pavim, Alberto}, title = {Machine vision system for inline inspection in carbide insert production}, series = {Proceedings of the 36th International MATADOR Conference}, journal = {Proceedings of the 36th International MATADOR Conference}, publisher = {Springer}, address = {Berlin}, isbn = {978-1-84996-431-9}, doi = {10.1007/978-1-84996-432-6_77}, pages = {339 -- 342}, year = {2010}, abstract = {In steps of the production chain of carbide inserts, such as unloading or packaging, the conformity test of the insert type is done manually, which causes a statistic increase of errors due to monotony and fatigue of the worker and the wide variety of the insert types. A machine vision system is introduced that captures digital frames of the inserts in the production line, analyses inspects automatically and measures four quality features: coating colour, edge radius, plate shape and chip-former geometry. This new method has been tested on several inserts of different types and has shown that the prevalent insert types can be inspected and robustly classified in real production environment and therefore improves the manufacturing automation.}, language = {en} } @article{WagnerWernerMiyamotoetal.2010, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.200983320}, pages = {844 -- 849}, year = {2010}, abstract = {The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy.}, language = {en} } @article{FredebeulKreinKnoben2010, author = {Fredebeul-Krein, Markus and Knoben, Werner}, title = {Long term risk sharing contracts as an approach to establish public-private partnerships for investment into next generation access networks}, series = {Telecommunications Policy}, volume = {34}, journal = {Telecommunications Policy}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0308-5961}, doi = {10.1016/j.telpol.2010.07.011}, pages = {528 -- 539}, year = {2010}, abstract = {This paper develops an investment/pricing model for the deployment of basic broadband networks which, along with other applications, is applicable to public-private partnership projects. In particular, a new investment model is suggested to be used for finance deployment over a longer term by enabling both private and public investors to participate in the roll-out of next generation access (NGA) infrastructure. This so-called "long-term risk sharing concept" has several notable benefits compared with the traditional regulatory approach. Above all, the model enables both private operators and public authorities to share the risk of investing in NGA infrastructure. Thus the model offers a way for public authorities to achieve a timely and countrywide roll-out of NGA networks, including in areas where NGA investment would otherwise not occur.}, language = {en} } @article{FredebeulKrein2010, author = {Fredebeul-Krein, Markus}, title = {Wirtschaftskrise : Staatliche F{\"o}rderung von glasfaserbasierten Breitbandnetzen?}, series = {Wirtschaftsdienst}, volume = {90}, journal = {Wirtschaftsdienst}, number = {2}, publisher = {ZBW}, address = {Berlin}, issn = {0043-6275}, pages = {113 -- 117}, year = {2010}, abstract = {Glasfaserbasierte Breitbandnetze werden in Deutschland auch aufgrund der Wirtschaftskrise nur sehr z{\"o}gerlich ausgebaut. Markus Fredebeul-Krein h{\"a}lt eine staatliche Subventionierung der Breitbandnetze nur bedingt f{\"u}r gerechtfertigt. Private Investoren ben{\"o}tigen jedoch dringend Planungssicherheit durch verl{\"a}ssliche Regulierungsvorschriften.}, language = {de} } @article{FredebeulKrein2010, author = {Fredebeul-Krein, Markus}, title = {Die Abschaffung der Studiengeb{\"u}hren ist der falsche Weg!}, series = {Der Ordnungspolitische Kommentar}, journal = {Der Ordnungspolitische Kommentar}, year = {2010}, language = {de} } @article{FredebeulKrein2010, author = {Fredebeul-Krein, Markus}, title = {Sollen die Studiengeb{\"u}hren wieder abgeschafft werden?}, series = {Bildungsgerechtigkeit in der Begabtenf{\"o}rderung. Ein Widerspruch in sich?}, journal = {Bildungsgerechtigkeit in der Begabtenf{\"o}rderung. Ein Widerspruch in sich?}, editor = {Bartoldus, Beate and John-Ohnesorg, Marei}, publisher = {Friedrich-Ebert-Stiftung}, address = {Berlin}, isbn = {978-3-86872-423-3}, pages = {124 -- 129}, year = {2010}, abstract = {In den letzten Jahren haben in Deutschland mehrere Bundesl{\"a}nder Studiengeb{\"u}hren eingef{\"u}hrt. Seitdem wird in der Politik heftig {\"u}ber das F{\"u}r und Wider diskutiert. Von den Gegnern wird h{\"a}ufig das Argument vorgebracht, Studiengeb{\"u}hren seien sozial ungerecht und w{\"u}rden insbesondere einkommensschwache Bev{\"o}lkerungsschichten von einem Studium abhalten. Best{\"a}tigt werden sie von den Zahlen aus Umfragen, denen zufolge {\"u}ber 70 Prozent derjenigen, die sich gegen ein Studium entscheiden, finanzielle Gr{\"u}nde f{\"u}r einen Studienverzicht anf{\"u}hren. Bef{\"u}rworter halten dem entgegen, Studiengeb{\"u}hren seien angesichts knapper {\"o}ffentlicher Kassen unbedingt notwendig, da nur so die Qualit{\"a}t der Lehre aufrechterhalten bzw. verbessert werden k{\"o}nne. Zudem w{\"u}rden Studiengeb{\"u}hren die sozialen Bildungsbarrieren keineswegs erh{\"o}hen, was auch daran erkennbar sei, dass infolge der Studiengeb{\"u}hren die Zahl der Studierenden nicht zur{\"u}ckgegangen ist. Der vorliegende Artikel leistet einen Beitrag zu dieser Debatte, indem er die an einer Hochschule in Nordrhein-Westfalen gesammelten Erfahrungen mit Studiengeb{\"u}hren auswertet}, language = {de} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, Julian A. and Lustfeld, Hans and Reißel, Martin and Steffen, Bernhard}, title = {A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, publisher = {Wiley}, address = {London}, issn = {0363-907X}, doi = {10.1002/er.1662}, pages = {293 -- 301}, year = {2010}, abstract = {A novel scheme for detecting inhomogeneous internal currents in a fuel cell stack is presented. In this paper the scheme is investigated for the case that the flow field plates consist of graphite. Then plates of high conductivity, e.g. aluminium between the flow field plates together with small slits in these plates have three effects: (a) Whenever a local inhomogeneity of the electric current occurs at a particular cell in the stack, this will induce a surface current close to that cell perpendicular to the averaged current. This current can be detected. (b) The plates of high conductivity completely prevent the inhomogeneities from spreading to neighbouring cells. (c) Even at the particular cell the inhomogeneity is suppressed as far as possible. Thus this scheme leads to much better diagnostic possibilities and at the same time reduces electric instabilities to an extent, where they probably become harmless. This scheme will first be explained for a simple model to clarify the idea. However, very precise three dimensional computations using realistic parameters are presented, corroborating the results of the simple model.}, language = {en} } @article{ScholzLeyDachwaldetal.2010, author = {Scholz, A. and Ley, Wilfried and Dachwald, Bernd and Miau, J. J. and Juang, J. C.}, title = {Flight results of the COMPASS-1 picosatellite mission}, series = {Acta Astronautica}, volume = {76}, journal = {Acta Astronautica}, number = {9-10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0094-5765}, doi = {10.1016/j.actaastro.2010.06.040}, pages = {1289 -- 1298}, year = {2010}, abstract = {The mission of the COMPASS-1 picosatellite is to take pictures of the earth, to validate a space-borne GPS receiver developed by the German Aerospace Center, and to verify the proper operation of the magnetic attitude control system in orbit. The spacecraft was launched on April 28, 2008 from the Indian space port Sriharikota, as part of the PSLV-C9 world record launch that simultaneously brought ten satellites into orbit. The mission operations were carried out from the ground stations in Aachen and Tainan. Arising difficulties in the communication link were overcome with the support of individuals from the amateur radio community. After several months of mission operation, abundant housekeeping and mission data has been commanded, received and analyzed and is presented in this paper.}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, Julian A. and Lustfeld, Hans and Reißel, Martin and Steffen, Bernhard}, title = {Tomographic diagnostics of current distributions in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, publisher = {Wiley}, address = {London}, issn = {0363-907X}, doi = {10.1002/er.1634}, pages = {284 -- 292}, year = {2010}, abstract = {A novel tomographic scheme for analysing the state of any single membrane electrode assembly (MEA) in a stack is suggested. Plates of very high conductivity placed between every fuel cell and slitted in an appropriate manner cause surface currents at well-defined locations of the stack. We show that knowing these surface currents, information about anomalies of the currents in a MEA can be obtained using the methods of tomography. The results are mathematically not unique. However, when assuming plausible defect structures, one can exclude improbable deficiencies by applying a special form of simulated annealing. We present numerical calculations of typical examples demonstrating that the essential defects of the MEA in any single cell of the stack can be detected and their extent can be determined.}, language = {en} } @article{FredebeulKrein2010, author = {Fredebeul-Krein, Markus}, title = {Studiengeb{\"u}hren sind sozial gerecht}, series = {INSM-{\"O}konomenblog}, journal = {INSM-{\"O}konomenblog}, publisher = {INSM}, address = {Berlin}, year = {2010}, language = {de} } @article{Schermutzki2010, author = {Schermutzki, Margret}, title = {In Modulen lehren, lernen und pr{\"u}fen}, series = {In Modulen lehren, lernen und pr{\"u}fen. Herausforderungen an die Hochschuldidaktik}, journal = {In Modulen lehren, lernen und pr{\"u}fen. Herausforderungen an die Hochschuldidaktik}, editor = {Terbuyken, Gregor}, publisher = {Evangelische Akademie Loccum}, address = {Rehburg-Loccum}, isbn = {978-3-8172-7809-1}, pages = {81 -- 106}, year = {2010}, language = {de} } @article{SchneiderSchneider2010, author = {Schneider, Bettina and Schneider, Wilhelm}, title = {Die Konzernrechnungslegung}, series = {Das Wirtschaftsstudium : wisu}, volume = {39}, journal = {Das Wirtschaftsstudium : wisu}, number = {7}, publisher = {Lange}, address = {D{\"u}sseldorf}, issn = {0340-3084}, pages = {938 -- 942}, year = {2010}, language = {de} }