@article{KotliarHauserOrtneretal.2017, author = {Kotliar, Konstantin and Hauser, Christine and Ortner, Marion and Muggenthaler, Claudia and Diehl-Schmid, Janine and Angermann, Susanne and Hapfelmeier, Alexander and Schmaderer, Christoph and Grimmer, Timo}, title = {Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer's disease}, series = {Scientific Reports}, volume = {7}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-017-13349-5}, pages = {1 -- 11}, year = {2017}, language = {en} } @article{RietschPfaffenrotBitzetal.2017, author = {Rietsch, Stefan H. G. and Pfaffenrot, Viktor and Bitz, Andreas and Orzada, Stephan and Brunheim, Sascha and Lazik-Palm, Andrea and Theysohn, Jens M. and Ladd, Mark E. and Quick, Harald H. and Kraff, Oliver}, title = {An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T}, series = {Medical Physics}, journal = {Medical Physics}, number = {Article in press}, publisher = {Wiley}, address = {Hoboken}, issn = {0094-2405}, doi = {10.1002/mp.12612}, year = {2017}, language = {en} } @inproceedings{StrieganHajAyedFunkeetal.2017, author = {Striegan, C. and Haj Ayed, A. and Funke, Harald and Loechle, S. and Kazari, M. and Horikawa, A. and Okada, K. and Koga, K.}, title = {Numerical combustion and heat transfer simulations and validation for a hydrogen fueled "micromix" test combustor in industrial gas turbine applications}, series = {Proceedings of the ASME Turbo Expo}, booktitle = {Proceedings of the ASME Turbo Expo}, number = {Volume Part F130041-4B, 2017}, isbn = {978-079185085-5}, doi = {10.1115/GT2017-64719}, year = {2017}, language = {en} } @inproceedings{FunkeBeckmannKeinzetal.2017, author = {Funke, Harald and Beckmann, Nils and Keinz, Jan and Abanteriba, Sylvester}, title = {Numerical and Experimental Evaluation of a Dual-Fuel Dry-Low-NOx Micromix Combustor for Industrial Gas Turbine Applications}, series = {Proceedings of the ASME Turbo Expo 2017: Turbomachinery Technical Conference and Exposition. Volume 4B: Combustion, Fuels and Emissions. Charlotte, North Carolina, USA. June 26-30, 2017}, booktitle = {Proceedings of the ASME Turbo Expo 2017: Turbomachinery Technical Conference and Exposition. Volume 4B: Combustion, Fuels and Emissions. Charlotte, North Carolina, USA. June 26-30, 2017}, publisher = {ASME}, address = {New York}, isbn = {978-0-7918-5085-5}, doi = {10.1115/GT2017-64795}, year = {2017}, abstract = {The Dry-Low-NOx (DLN) Micromix combustion technology has been developed originally as a low emission alternative for industrial gas turbine combustors fueled with hydrogen. Currently the ongoing research process targets flexible fuel operation with hydrogen and syngas fuel. The non-premixed combustion process features jet-in-crossflow-mixing of fuel and oxidizer and combustion through multiple miniaturized flames. The miniaturization of the flames leads to a significant reduction of NOx emissions due to the very short residence time of reactants in the flame. The paper presents the results of a numerical and experimental combustor test campaign. It is conducted as part of an integration study for a dual-fuel (H2 and H2/CO 90/10 Vol.\%) Micromix combustion chamber prototype for application under full scale, pressurized gas turbine conditions in the auxiliary power unit Honeywell Garrett GTCP 36-300. In the presented experimental studies, the integration-optimized dual-fuel Micromix combustor geometry is tested at atmospheric pressure over a range of gas turbine operating conditions with hydrogen and syngas fuel. The experimental investigations are supported by numerical combustion and flow simulations. For validation, the results of experimental exhaust gas analyses are applied. Despite the significantly differing fuel characteristics between pure hydrogen and hydrogen-rich syngas the evaluated dual-fuel Micromix prototype shows a significant low NOx performance and high combustion efficiency. The combustor features an increased energy density that benefits manufacturing complexity and costs.}, language = {en} } @article{OrzadaBitzJohstetal.2017, author = {Orzada, Stephan and Bitz, Andreas and Johst, S{\"o}ren and Gratz, Marcel and V{\"o}lker, Maximilian N. and Kraff, Oliver and Abuelhaija, Ashraf and Fiedler, Thomas M. and Solbach, Klaus and Quick, Harald H. and Ladd, Mark E.}, title = {Analysis of an integrated 8-Channel Tx/Rx body array for use as a body coil in 7-Tesla MRI}, series = {Frontiers in Physics}, volume = {5}, journal = {Frontiers in Physics}, number = {Jun}, issn = {2296-424X}, doi = {10.3389/fphy.2017.00017}, year = {2017}, language = {en} } @article{GaribaldiBegingCaneseetal.2017, author = {Garibaldi, F. and Beging, Stefan and Canese, R. and Carpinelli, G. and Clinthorne, N. and Colilli, S. and Cosentino, L. and Finocchiaro, P. and Giuliani, F. and Gricia, M. and Lucentini, M. and Majewski, S. and Monno, E. and Musico, P. and Santavenere, F. and T{\"o}dter, J. and Wegener, Hans-Peter and Ziemons, Karl}, title = {A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer}, series = {European Physical Journal Plus}, volume = {132}, journal = {European Physical Journal Plus}, number = {9}, publisher = {Springer}, address = {Berlin}, issn = {2190-5444}, doi = {10.1140/epjp/i2017-11662-x}, year = {2017}, language = {en} } @misc{HacklWegmannKahmannetal.2017, author = {Hackl, Michael and Wegmann, Kilian and Kahmann, Stephanie Lucina and Heinze, Nicolai and Staat, Manfred and Neiss, Wolfram F. and Scaal, Martin and M{\"u}ller, Lars P.}, title = {Reply to the letter to the editor: shortening osteotomy of the proximal radius}, series = {Knee Surgery, Sports Traumatology, Arthroscopy}, volume = {25}, journal = {Knee Surgery, Sports Traumatology, Arthroscopy}, number = {10}, doi = {10.1007/s00167-017-4666-8}, pages = {3328 -- 3329}, year = {2017}, language = {en} } @article{SrivastavaChaharSharmaetal.2017, author = {Srivastava, A. and Chahar, V. and Sharma, V. and Sun, Y. and Bol, R. and Knolle, F. and Schnug, E. and Hoyler, Friedrich and Naskar, N. and Lahiri, S. and Patnaik, R.}, title = {Study of uranium toxicity using low-background gamma-ray spectrometry}, series = {Journal of Radioanalytical and Nuclear Chemistry}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, number = {Online first}, publisher = {Springer}, address = {Berlin}, issn = {1588-2780}, doi = {10.1007/s10967-017-5466-9}, pages = {1 -- 7}, year = {2017}, language = {en} } @article{Hoettges2017, author = {H{\"o}ttges, J{\"o}rg}, title = {QKan - Management of drainage system data with QGIS}, series = {Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings}, volume = {17}, journal = {Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings}, number = {Article 13}, pages = {95 -- 100}, year = {2017}, language = {en} } @inproceedings{BreuerGuthmannSchoeningetal.2017, author = {Breuer, Lars and Guthmann, Eric and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten}, title = {Light-Stimulated Hydrogels with Incorporated Graphene Oxide as Actuator Material for Flow Control in Microfluidic Applications}, series = {Proceedings Eurosensors 2017 Conference, Paris, France, 3-6 September 2017}, booktitle = {Proceedings Eurosensors 2017 Conference, Paris, France, 3-6 September 2017}, doi = {10.3390/proceedings1040524}, pages = {1 -- 4}, year = {2017}, language = {en} } @article{SeifarthGrosseGrossmannetal.2017, author = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation}, series = {Journal of Biomaterials Applications}, volume = {32}, journal = {Journal of Biomaterials Applications}, number = {3}, publisher = {Sage}, address = {London}, issn = {1530-8022}, doi = {10.1177/0885328217723178}, pages = {321 -- 330}, year = {2017}, language = {en} } @article{AlbannaLuekeSjapicetal.2017, author = {Albanna, Walid and Lueke, Jan Niklas and Sjapic, Volha and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Sjapic, Sergej and Alpdogan, Serdan and Schneider, Toni and Schubert, Gerrit Alexander and Neumaier, Felix}, title = {Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina}, series = {Current Eye Research}, journal = {Current Eye Research}, number = {Article in press}, publisher = {Taylor \& Francis}, address = {London}, issn = {1460-2202}, doi = {10.1080/02713683.2017.1339807}, pages = {1 -- 9}, year = {2017}, language = {en} } @article{PilasYaziciSelmeretal.2017, author = {Pilas, Johanna and Yazici, Yasemen and Selmer, Thorsten and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate}, series = {Electrochimica Acta}, volume = {251}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.07.119}, pages = {256 -- 262}, year = {2017}, abstract = {The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4\% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.}, language = {en} } @article{RoehlenPilasSchoeningetal.2017, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Sch{\"o}ning, Michael Josef and Selmer, Thorsten}, title = {Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid}, series = {Applied Biochemistry and Biotechnology}, volume = {183}, journal = {Applied Biochemistry and Biotechnology}, publisher = {Springer}, address = {Berlin}, issn = {1559-0291}, doi = {10.1007/s12010-017-2578-1}, pages = {566 -- 581}, year = {2017}, abstract = {Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM-1 (L-malate biosensor) and 0.4 μA mM-1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0-10.0 mM with a sensitivity of 0.09 μA mM-1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.}, language = {en} } @article{HonarvarfardGamellaPoghossianetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer}, series = {Applied Materials Today}, volume = {9}, journal = {Applied Materials Today}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-9407}, doi = {10.1016/j.apmt.2017.08.003}, pages = {266 -- 270}, year = {2017}, abstract = {An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte-insulator-semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @incollection{TranTranMatthiesetal.2017, author = {Tran, N. T. and Tran, Thanh Ngoc and Matthies, M. G. and Stavroulakis, G. E. and Staat, Manfred}, title = {Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming}, series = {Advances in Direct Methods for Materials and Structures}, booktitle = {Advances in Direct Methods for Materials and Structures}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-59810-9}, doi = {10.1007/978-3-319-59810-9_6}, pages = {85 -- 103}, year = {2017}, abstract = {In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis.}, language = {en} } @article{TranMottaghyArltKoerferetal.2017, author = {Tran, Linda and Mottaghy, K. and Arlt-K{\"o}rfer, Sabine and Waluga, Christian and Behbahani, Mehdi}, title = {An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system}, series = {Biomedizinische Technik}, volume = {62}, journal = {Biomedizinische Technik}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0013-5585}, doi = {10.1515/bmt-2015-0034}, pages = {383 -- 392}, year = {2017}, language = {en} } @article{SchollMoraisGabrieletal.2017, author = {Scholl, Fabio and Morais, Paulo and Gabriel, Rayla and Sch{\"o}ning, Michael Josef and Siqueira, Jose Roberto, Jr. and Caseli, Luciano}, title = {Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications}, series = {Applied Materials \& Interfaces}, volume = {9}, journal = {Applied Materials \& Interfaces}, number = {36}, publisher = {ACS}, address = {Washington}, issn = {1944-8252}, doi = {10.1021/acsami.7b08095}, pages = {31054 -- 31066}, year = {2017}, abstract = {In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV-vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte-insulator-semiconductor (EIS) sensor device. The presence of CNTs in the enzyme-lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.}, language = {en} } @article{WernerMiyamotoWagneretal.2017, author = {Werner, Frederik and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor}, series = {Sensor and Actuators B: Chemical}, volume = {248}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.02.057}, pages = {961 -- 965}, year = {2017}, abstract = {To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.}, language = {en} } @article{MiyamotoHayashiSakamotoetal.2017, author = {Miyamoto, Ko-ichiro and Hayashi, Kosuke and Sakamoto, Azuma and Werner, Frederik and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {A high-Q resonance-mode measurement of EIS capacitive sensor by elimination of series resistance}, series = {Sensor and Actuators B: Chemical}, volume = {248}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.03.002}, pages = {1006 -- 1010}, year = {2017}, abstract = {An EIS capacitive sensor is a semiconductor-based potentiometric sensor, which is sensitive to the ion concentration or pH value of the solution in contact with the sensing surface. To detect a small change in the ion concentration or pH, a small capacitance change must be detected. Recently, a resonance-mode measurement was proposed, in which an inductor was connected to the EIS capacitive sensor and the resonant frequency was correlated with the pH value. In this study, the Q factor of the resonant circuit was enhanced by canceling the internal resistance of the reference electrode and the internal resistance of the inductor coil with the help of a bypass capacitor and a negative impedance converter, respectively. 1\% variation of the signal in the developed system corresponded to a pH change of 3.93 mpH, which was about 1/12 of the conventional method, suggesting a better performance in detection of a small pH change.}, language = {en} }