@inproceedings{PfeifferBalcGebhardt2021, author = {Pfeiffer, Johann and Balc, N. and Gebhardt, Andreas}, title = {Studie zur Untersuchung der Auswirkung von Fr{\"a}sbahnstrategien auf die Oberfl{\"a}chenqualit{\"a}t von mittels SLM gefertigten Metallteilen}, series = {Tagungsband 21. Nachwuchswissenschaftler*innenkonferenz}, booktitle = {Tagungsband 21. Nachwuchswissenschaftler*innenkonferenz}, publisher = {Verlag Ernst-Abbe-Hochschule Jena}, address = {Jena}, isbn = {978-3-932886-36-2}, pages = {99 -- 102}, year = {2021}, abstract = {F{\"u}r die Herstellung von metallischen Bauteilen wird in der heutigen Zeit eine Vielzahl von Verfahren auf dem Markt angeboten. Dabei stehen die additiven im Wettbewerb zu den konventionellen Verfahren. Die erreichbaren Oberfl{\"a}chenqualit{\"a}ten der additiven sind nicht mit denen spanender Verfahren vergleichbar. F{\"u}r diesen Beitrag wurde analysiert, ob sich ein mittels Selektivem Laserschmelzen (SLM) additiv hergestellter Edelstahl hinsichtlich seiner Oberfl{\"a}chenqualit{\"a}t nach der Zerspanung von einem umgeformten konventionell hergestellten Edelstahl gleicher Sorte unterscheidet.}, language = {de} } @inproceedings{Huening2021, author = {H{\"u}ning, Felix}, title = {Sustainable changes beyond covid-19 for a second semester physics course for electrical engineering students}, series = {Blended Learning in Engineering Education: challenging, enlightening - and lasting?}, booktitle = {Blended Learning in Engineering Education: challenging, enlightening - and lasting?}, isbn = {978-2-87352-023-6}, pages = {1405 -- 1409}, year = {2021}, abstract = {The course Physics for Electrical Engineering is part of the curriculum of the bachelor program Electrical Engineering at University of Applied Science Aachen. Before covid-19 the course was conducted in a rather traditional way with all parts (lecture, exercise and lab) face-to-face. This teaching approach changed fundamentally within a week when the covid-19 limitations forced all courses to distance learning. All parts of the course were transformed to pure distance learning including synchronous and asynchronous parts for the lecture, live online-sessions for the exercises and self-paced labs at home. Using these methods, the course was able to impart the required knowledge and competencies. Taking the teacher's observations of the student's learning behaviour and engagement, the formal and informal feedback of the students and the results of the exams into account, the new methods are evaluated with respect to effectiveness, sustainability and suitability for competence transfer. Based on this analysis strong and weak points of the concept and countermeasures to solve the weak points were identified. The analysis further leads to a sustainable teaching approach combining synchronous and asynchronous parts with self-paced learning times that can be used in a very flexible manner for different learning scenarios, pure online, hybrid (mixture of online and presence times) and pure presence teaching.}, language = {en} } @article{LeiseEsserEichenlaubetal.2021, author = {Leise, Philipp and Eßer, Arved and Eichenlaub, Tobias and Schleiffer, Jean-Eric and Altherr, Lena and Rinderknecht, Stephan and Pelz, Peter F.}, title = {Sustainable system design of electric powertrains - comparison of optimization methods}, series = {Engineering Optimization}, journal = {Engineering Optimization}, publisher = {Taylor \& Francis}, address = {London}, issn = {0305-215X}, doi = {10.1080/0305215X.2021.1928660}, year = {2021}, abstract = {The transition within transportation towards battery electric vehicles can lead to a more sustainable future. To account for the development goal 'climate action' stated by the United Nations, it is mandatory, within the conceptual design phase, to derive energy-efficient system designs. One barrier is the uncertainty of the driving behaviour within the usage phase. This uncertainty is often addressed by using a stochastic synthesis process to derive representative driving cycles and by using cycle-based optimization. To deal with this uncertainty, a new approach based on a stochastic optimization program is presented. This leads to an optimization model that is solved with an exact solver. It is compared to a system design approach based on driving cycles and a genetic algorithm solver. Both approaches are applied to find efficient electric powertrains with fixed-speed and multi-speed transmissions. Hence, the similarities, differences and respective advantages of each optimization procedure are discussed.}, language = {en} } @masterthesis{Holtschlag2021, type = {Bachelor Thesis}, author = {Holtschlag, Uli}, title = {tape foundry: Eine Distribubutionsplattform f{\"u}r studentische Schriften}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {55 Seiten}, year = {2021}, abstract = {Die »tape foundry« ist eine interdisziplin{\"a}re Distributionsplattform f{\"u}r studentische Schriften, die Studierende auf dem großen Type-Design Markt neu platziert und einen Raum zur Entfaltung gibt. Besonders durch Instagram ist die heutige Type-Designszene gr{\"o}ßer denn je und viele Entw{\"u}rfe gehen in der Maße unter. Um diesem Ph{\"a}nomen entgegenzuwirken wurde die »tape foundry« ins Leben gerufen. Sie versucht mit der Kombination aus Fotografie, Type Design und der Funktion als Kassettenlabel neue interdisziplin{\"a}re Wege zu gehen, um sich von der klassischen {\"A}sthetik abzusetzen. Die Webseite stellt sich bewusst gegen g{\"a}ngige UX/UI Standards und setzt auf neue Nutzungsprinzipien kombiniert mit einer lauten kontrastreichen Bildwelt.}, language = {de} } @masterthesis{Dressen2021, type = {Bachelor Thesis}, author = {Dreßen, Samira}, title = {Teach and Learn-Platform: eine Applikation f{\"u}r Bildungseinrichtungen, Sch{\"u}ler und Studenten}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {198 Seiten}, year = {2021}, abstract = {Die Applikation „Slot" ist eine lehrbegleitende Kommunikations- und Kooperationsplattform, die eine zeitgem{\"a}ße Lehre, Studienorganisation und Pr{\"a}sentation zul{\"a}sst. Slot dient dabei nicht nur als Hilfestellung f{\"u}r Lehrende und Lernende, sondern erm{\"o}glicht auch die vollst{\"a}ndige Durchf{\"u}hrung von effizientem Unterricht. Den Lernenden soll maximale Kontrolle zur Erarbeitung ihres Wissens und {\"U}bersichtlichkeit in der Kommunikation geboten werden. Um f{\"u}r die unterschiedlichen Nutzergruppen ein benutzerfreundliches System zu schaffen, steht eine breitgef{\"a}cherte Funktionsauswahl zur Verf{\"u}gung: Videochat, Messenger, VR-Raum, Whiteboard, Aufgaben{\"u}bersicht, Datenabgabe, Kalender, Profil und ToDo-List. Die Nutzungsm{\"o}glichkeiten k{\"o}nnen individuell auf die unterschiedlichen Nutzergruppen und deren entsprechenden Bed{\"u}rfnissen angepasst werden.}, language = {de} } @article{SeefeldtDachwald2021, author = {Seefeldt, Patric and Dachwald, Bernd}, title = {Temperature increase on folded solar sail membranes}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2020.09.026}, pages = {2688 -- 2695}, year = {2021}, language = {en} } @masterthesis{Zosgornik2021, type = {Bachelor Thesis}, author = {Zosgornik, Julia}, title = {Tempor{\"a}rer, mobiler Lebensraum: ein Wohnkonzept f{\"u}r Tinyhouses aus alten, ungenutzten Bahnwaggons}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {99 Seiten}, year = {2021}, abstract = {Das Olympiagel{\"a}nde in M{\"u}nchen wurde im Jahre 1972 durch die M{\"u}nchener S-Bahn erreichbar. Nach der Nutzung w{\"a}hrend der Olympischen Spiele wurde die Strecke weiterhin von der Linie S3angefahren, aber schließlich 1988 stillgelegt und steht seither unter Denkmalschutz. Das umfassende Gel{\"a}nde ist bis heute gut ausgebaut und bietet viel Raum f{\"u}r Freizeitaktivit{\"a}ten. Nun bietet sich dieser Standort f{\"u}r ein neues Wohnkonzept an. Aus alten, nicht mehr nutzbaren Bahnwaggons entstehen Tinyhouse-Module. Aus dem alten Olympiabahnhof der S3 wird ein neues Viertel f{\"u}r junge Leute, Studenten und alle anderen, die sich vorstellen k{\"o}nnen in einem Tinyhouse zu wohnen.}, language = {de} } @article{Gaigall2021, author = {Gaigall, Daniel}, title = {Test for Changes in the Modeled Solvency Capital Requirement of an Internal Risk Model}, series = {ASTIN Bulletin}, volume = {51}, journal = {ASTIN Bulletin}, number = {3}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, issn = {1783-1350}, doi = {10.1017/asb.2021.20}, pages = {813 -- 837}, year = {2021}, abstract = {In the context of the Solvency II directive, the operation of an internal risk model is a possible way for risk assessment and for the determination of the solvency capital requirement of an insurance company in the European Union. A Monte Carlo procedure is customary to generate a model output. To be compliant with the directive, validation of the internal risk model is conducted on the basis of the model output. For this purpose, we suggest a new test for checking whether there is a significant change in the modeled solvency capital requirement. Asymptotic properties of the test statistic are investigated and a bootstrap approximation is justified. A simulation study investigates the performance of the test in the finite sample case and confirms the theoretical results. The internal risk model and the application of the test is illustrated in a simplified example. The method has more general usage for inference of a broad class of law-invariant and coherent risk measures on the basis of a paired sample.}, language = {en} } @article{HeinkeKnickerAlbracht2021, author = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten}, title = {Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men}, series = {Journal of Electromyography and Kinesiology}, volume = {62}, journal = {Journal of Electromyography and Kinesiology}, number = {Article 102611}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1050-6411}, doi = {10.1016/j.jelekin.2021.102611}, year = {2021}, abstract = {Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall "good" relative reliability. SRD 95\% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended.}, language = {en} } @article{WaldvogelRitzmannFreyleretal.2021, author = {Waldvogel, Janice and Ritzmann, Ramona and Freyler, Kathrin and Helm, Michael and Monti, Elena and Albracht, Kirsten and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco}, title = {The Anticipation of Gravity in Human Ballistic Movement}, series = {Frontiers in Physiology}, journal = {Frontiers in Physiology}, publisher = {Frontiers}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2021.614060}, year = {2021}, abstract = {Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.}, language = {en} } @masterthesis{Jonas2021, type = {Bachelor Thesis}, author = {Jonas, Eva Johanna}, title = {The future of work: How to create a better User Experience for distributed workforce}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {213 Seiten}, year = {2021}, abstract = {Die Nachfrage nach flexiblen Arbeitsmodellen und damit Remote Work steigt und wird zunehmend zum Kriterium bei der Jobauswahl. Trotz der vielen Vorteile gibt es in der „Remote-Arbeitswelt" aber immer noch einige Herausforderungen. Remote Arbeitende haben eine andere, teils nachteilige Erfahrung gegen{\"u}ber Kollegen vor Ort. Um daf{\"u}r eine nutzerzentrierte L{\"o}sung zu finden, lag der Fokus bei dieser Arbeit auf den Auswirkungen und Bed{\"u}rfnissen des arbeitenden Menschen. Basierend hierauf wurde ein Dienstleistungsservice konzipiert. Dieser unterst{\"u}tzt Unternehmen, Selbstst{\"a}ndige und Mitarbeitende durch passende Angebote und Dienstleistungen in den Bereichen Ausstattung, Technik, Gesundheit, Corporate Benefits u.{\"A}. Dies erm{\"o}glicht auch Arbeitgebenden Aufgaben auszulagern und die Attraktivit{\"a}t und Konkurrenzf{\"a}higkeit auf dem Arbeitsmarkt zu steigern. Das wird zuk{\"u}nftig im „war for digitals talents" immer wichtiger werden.}, language = {de} } @misc{Huebert2021, type = {Master Thesis}, author = {Huebert, Edgar}, title = {The Last Sketch}, publisher = {FH Aachen}, address = {Aachen}, pages = {65 Seiten}, year = {2021}, abstract = {Das Projekt thematisiert, in Form eines Animationsfilms, den Umgang eines Vaters mit dem Tod seines Kindes und den Versuch den Weg zur{\"u}ck zu sich selbst und ins Leben zu finden. Das Ziel war es die Emotionen der Schauspieler in einen Animationsfilm authentisch zu implementieren. Um den Animationsfilm situationsgerecht erz{\"a}hlen zu k{\"o}nnen, wurde das Verst{\"a}ndnis f{\"u}r Trauer in den Vordergrund gestellt. Dazu wurden digitale Drehs durchgef{\"u}hrt und viele Bereiche der 3D Gestaltung angewendet. Viele der Betroffenen erleben besonders in den ersten Tagen nach dem Verlust ihres Kindes nicht das notwendige Verst{\"a}ndnis f{\"u}r ihre Trauer. Diese Projektarbeit m{\"o}chte aufzeigen, wie unterschiedlich Menschen trauern und wie sie sich in ihrer Verschiedenheit verlieren k{\"o}nnen, besonders wenn es um das gemeinsame Kind geht. Wenn ein Kind im Sterben liegt, steht f{\"u}r die Eltern sein Wohlbefinden an erster Stelle. Sie wollen alles richtig machen. Der Protagonist des Films (Teo) und seine Frau Mia haben jedoch unterschiedliche Vorstellung davon, was das Richtige ist und auch nach dem Tod ihres Kindes haben sie unterschiedliche Bew{\"a}ltigungsstrategien, um mit diesem Schicksalsschlag umzugehen. Einer der Gr{\"u}nde, warum 80\% der Ehepaare sich nach so einem Schicksalsschlag trennen liegt in genau dieser Problematik, weswegen es wichtig ist, diese Thematik zu beleuchten.}, language = {de} } @masterthesis{Kieker2021, type = {Bachelor Thesis}, author = {Kieker, Lea}, title = {THE LAST STOP: Eine Fotodokumentation {\"u}ber den Ort, an dem Menschen auf ihren Tod warten}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {45 Seiten}, year = {2021}, abstract = {Das Projekt thematisiert das Leben im Hospiz. Diese Arbeit liefert mittels authentischer Fotografien von R{\"a}umlichkeiten und Details sowie durch intensive Portr{\"a}ts von drei Bewohnenden einen realistischen Einblick in ein Hospiz. Durch diese Aufnahmen werden die Betrachtenden mit dem Thema „Tod" konfrontiert und es so diesem Thema n{\"a}her gebracht, um eventuelle Vorurteile einer solchen Einrichtung gegen{\"u}ber abzulegen. Innerhalb des Bildbands sieht man Fotografien von Fluren, Dekoration, R{\"a}umen und Portr{\"a}taufnahmen. Begleitend zu den Portr{\"a}tfotos der Bewohnenden finden sich im Bildband Berichte der selbigen, {\"u}ber ihre allt{\"a}glichen Gedanken im Umgang mit dem bevorstehenden eigenen Lebensende. Im Zuge der Recherche zu diesem Projekt hat außerdem ein ausf{\"u}hrliches Interview mit einer Pflegekraft des thematisierten Hospizes dabei geholfen, einen realistischen Einblick in die Arbeit vor Ort zu bekommen.}, language = {de} } @article{BerneckerBoyerGathmann2021, author = {Bernecker, Andreas and Boyer, Pierre C. and Gathmann, Christina}, title = {The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform}, series = {American Economic Journal: Economic Policy}, volume = {13}, journal = {American Economic Journal: Economic Policy}, number = {2}, publisher = {American Economic Association}, address = {Nashville, Tenn.}, issn = {1945-774X}, doi = {10.1257/pol.20190690}, pages = {26 -- 57}, year = {2021}, language = {en} } @article{HagenkampBlankeDoering2021, author = {Hagenkamp, Markus and Blanke, Tobias and D{\"o}ring, Bernd}, title = {Thermoelectric building temperature control: a potential assessment}, series = {International Journal of Energy and Environmental Engineering}, volume = {13}, journal = {International Journal of Energy and Environmental Engineering}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/s40095-021-00424-x}, pages = {241 -- 254}, year = {2021}, abstract = {This study focuses on thermoelectric elements (TEE) as an alternative for room temperature control. TEE are semi-conductor devices that can provide heating and cooling via a heat pump effect without direct noise emissions and no refrigerant use. An efficiency evaluation of the optimal operating mode is carried out for different numbers of TEE, ambient temperatures, and heating loads. The influence of an additional heat recovery unit on system efficiency and an unevenly distributed heating demand are examined. The results show that TEE can provide heat at a coefficient of performance (COP) greater than one especially for small heating demands and high ambient temperatures. The efficiency increases with the number of elements in the system and is subject to economies of scale. The best COP exceeds six at optimal operating conditions. An additional heat recovery unit proves beneficial for low ambient temperatures and systems with few TEE. It makes COPs above one possible at ambient temperatures below 0 ∘C. The effect increases efficiency by maximal 0.81 (from 1.90 to 2.71) at ambient temperature 5 K below room temperature and heating demand Q˙h=100W but is subject to diseconomies of scale. Thermoelectric technology is a valuable option for electricity-based heat supply and can provide cooling and ventilation functions. A careful system design as well as an additional heat recovery unit significantly benefits the performance. This makes TEE superior to direct current heating systems and competitive to heat pumps for small scale applications with focus on avoiding noise and harmful refrigerants.}, language = {en} } @inproceedings{KernImaniVashianiTimmermanns2021, author = {Kern, Alexander and Imani Vashiani, Anahita and Timmermanns, Tobias}, title = {Threat for human beings due to touch voltages and body currents caused by direct lightning strikes in case of non-isolated lightning protection systems using natural components}, series = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, booktitle = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, publisher = {IEEE}, isbn = {978-1-6654-2346-5}, doi = {10.1109/ICLPandSIPDA54065.2021.9627465}, pages = {8 Seiten}, year = {2021}, abstract = {For typical cases of non-isolated lightning protection systems (LPS) the impulse currents are investigated which may flow through a human body directly touching a structural part of the LPS. Based on a basic LPS model with conventional down-conductors especially the cases of external and internal steel columns and metal fa{\c{c}}ades are considered and compared. Numerical simulations of the line quantities voltages and currents in the time domain are performed with an equivalent circuit of the entire LPS. As a result it can be stated that by increasing the number of conventional down-conductors and external steel columns the threat for a human being can indeed be reduced, but not down to an acceptable limit. In case of internal steel columns used as natural down-conductors the threat can be reduced sufficiently, depending on the low-resistive connection of the steel columns to the lightning equipotential bonding or the earth termination system, resp. If a metal fa{\c{c}}ade is used the threat for human beings touching is usually very low, if the fa{\c{c}}ade is sufficiently interconnected and multiply connected to the lightning equipotential bonding or the earth termination system, resp.}, language = {en} } @article{KoehlerRoepkeWolf2021, author = {K{\"o}hler, Klemens and R{\"o}pke, Ren{\´e} and Wolf, Martin}, title = {Through a mirror darkly - On the obscurity of teaching goals in game-based learning in IT security}, series = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, journal = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, publisher = {Springer}, address = {Cham}, doi = {10.1007/978-3-030-72132-9_6}, pages = {61 -- 73}, year = {2021}, abstract = {Teachers and instructors use very specific language communicating teaching goals. The most widely used frameworks of common reference are the Bloom's Taxonomy and the Revised Bloom's Taxonomy. The latter provides distinction of 209 different teaching goals which are connected to methods. In Competence Developing Games (CDGs - serious games to convey knowledge) and in IT security education, a two- or three level typology exists, reducing possible learning outcomes to awareness, training, and education. This study explores whether this much simpler framework succeeds in achieving the same range of learning outcomes. Method wise a keyword analysis was conducted. The results were threefold: 1. The words used to describe teaching goals in CDGs on IT security education do not reflect the whole range of learning outcomes. 2. The word choice is nevertheless different from common language, indicating an intentional use of language. 3. IT security CDGs use different sets of terms to describe learning outcomes, depending on whether they are awareness, training, or education games. The interpretation of the findings is that the reduction to just three types of CDGs reduces the capacity to communicate and think about learning outcomes and consequently reduces the outcomes that are intentionally achieved.}, language = {en} } @article{HugenrothNeidlinEngelmannetal.2021, author = {Hugenroth, Kristin and Neidlin, Michael and Engelmann, Ulrich M. and Kaufmann, Tim A. S. and Steinseifer, Ulrich and Heilmann, Torsten}, title = {Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk-Reduced Placement: an In Silico Proof-of-Concept}, series = {Artificial Organs}, journal = {Artificial Organs}, number = {Accepted Article}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.13964}, year = {2021}, language = {en} } @article{MolinnusDrinicIkenetal.2021, author = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef}, title = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk}, series = {Biosensors and Bioelectronics}, volume = {183}, journal = {Biosensors and Bioelectronics}, number = {Art. 113204}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2021.113204}, year = {2021}, language = {en} } @article{BechtSchollmayerMonakhovaetal.2021, author = {Becht, Alexander and Schollmayer, Curd and Monakhova, Yulia and Holzgrabe, Ulrike}, title = {Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis}, series = {Analytical and Bioanalytical Chemistry}, volume = {413}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer Nature}, issn = {1618-2650}, doi = {10.1007/s00216-021-03249-z}, pages = {3107 -- 3118}, year = {2021}, abstract = {Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6\%/99.6\% and 98.7/100\% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.}, language = {en} }