@article{AboulnagaZouSelmeretal.2018, author = {Aboulnaga, E. A. and Zou, H. and Selmer, Thorsten and Xian, M.}, title = {Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16}, series = {Journal of Biotechnology}, volume = {274}, journal = {Journal of Biotechnology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2018.03.007}, pages = {15 -- 27}, year = {2018}, abstract = {Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate.}, language = {en} } @article{AlbannaKotliarLuekeetal.2018, author = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander}, title = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis}, series = {Plos one}, volume = {13}, journal = {Plos one}, number = {10}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0204689}, pages = {e0204689}, year = {2018}, abstract = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.}, language = {en} } @article{AltherrBroetzDietrichetal.2018, author = {Altherr, Lena and Br{\"o}tz, Nicolas and Dietrich, Ingo and Gally, Tristan and Geßner, Felix and Kloberdanz, Hermann and Leise, Philipp and Pelz, Peter Franz and Schlemmer, Pia and Schmitt, Andreas}, title = {Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, isbn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.187}, pages = {187 -- 198}, year = {2018}, abstract = {Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.}, language = {en} } @article{AltherrEdererPfetschetal.2018, author = {Altherr, Lena and Ederer, Thorsten and Pfetsch, Marc E. and Pelz, Peter F.}, title = {Maschinelles Design eines optimalen Getriebes}, series = {ATZ - Automobiltechnische Zeitschrift}, volume = {120}, journal = {ATZ - Automobiltechnische Zeitschrift}, number = {10}, publisher = {Springer Nature}, address = {Cham}, isbn = {2192-8800}, doi = {10.1007/s35148-018-0131-3}, pages = {72 -- 77}, year = {2018}, abstract = {Nahezu 100.000 denkbare Strukturen kann ein Getriebe bei gleicher Funktion aufweisen - je nach Ganganzahl und gefordertem Freiheitsgrad. Mit dem traditionellen Ansatz bei der Entwicklung, einzelne vielversprechende Systemkonfigurationen manuell zu identifizieren und zu vergleichen, k{\"o}nnen leicht innovative und vor allem kostenminimale L{\"o}sungen {\"u}bersehen werden. Im Rahmen eines Forschungsprojekts hat die TU Darmstadt spezielle Optimierungsmethoden angewendet, um auch bei großen L{\"o}sungsr{\"a}umen zielsicher ein f{\"u}r die individuellen Zielstellungen optimales Layout zu finden.}, language = {de} } @article{AltherrJoggerstLeiseetal.2018, author = {Altherr, Lena and Joggerst, Laura and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas and Wendt, Janine}, title = {On obligations in the development process of resilient systems with algorithmic design methods}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, number = {885}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, isbn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.240}, pages = {240 -- 252}, year = {2018}, abstract = {Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer's product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.}, language = {en} } @article{AltherrLeisePfetschetal.2018, author = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas}, title = {Algorithmic design and resilience assessment of energy efficient high-rise water supply systems}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, issn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.211}, pages = {211 -- 223}, year = {2018}, abstract = {High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.}, language = {en} } @article{BabilonWilbringTappertetal.2018, author = {Babilon, Katharina and Wilbring, Daniela and Tappert, Tim and Pfaff, Raphael and Enning, Manfred}, title = {Schienenfahrzeugtechnik hands on - FH Aachen IMechE Railway Challenge}, series = {Ingenieurspiegel}, journal = {Ingenieurspiegel}, number = {2}, publisher = {Public Verlag}, address = {Bingen}, issn = {1868-5919}, pages = {20 -- 22}, year = {2018}, language = {de} } @article{BalakirskiKotliarPaulyetal.2018, author = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz}, title = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience}, series = {Dermatologic Surgery}, journal = {Dermatologic Surgery}, number = {44 (12)}, publisher = {Wolters Kluwer}, doi = {10.1097/DSS.0000000000001615}, pages = {1525 -- 1536}, year = {2018}, abstract = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.}, language = {en} } @article{BaringhausGaigall2018, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {Efficiency comparison of the Wilcoxon tests in paired and independent survey samples}, series = {Metrika}, volume = {2018}, journal = {Metrika}, number = {81}, publisher = {Springer}, address = {Berlin}, issn = {1435-926X}, doi = {10.1007/s00184-018-0661-4}, pages = {891 -- 930}, year = {2018}, abstract = {The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed.}, language = {de} } @article{BaringhausGaigallThiele2018, author = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp}, title = {Statistical inference for L²-distances to uniformity}, series = {Computational Statistics}, volume = {2018}, journal = {Computational Statistics}, number = {33}, publisher = {Springer}, address = {Berlin}, issn = {1613-9658}, doi = {10.1007/s00180-018-0820-0}, pages = {1863 -- 1896}, year = {2018}, abstract = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.}, language = {en} } @article{BensbergAuthCzarnecki2018, author = {Bensberg, Frank and Auth, Gunnar and Czarnecki, Christian}, title = {Einsatz von Text Analytics zur Unterst{\"u}tzung literaturintensiver Forschungsprozesse: Konzeption, Realisierung und Lessons Learned}, series = {Anwendungen und Konzepte der Wirtschaftsinformatik}, volume = {2018}, journal = {Anwendungen und Konzepte der Wirtschaftsinformatik}, number = {8}, publisher = {AKWI}, address = {Luzern}, issn = {2296-4592}, doi = {10.26034/lu.akwi.2018.3221}, pages = {1 -- 6}, year = {2018}, abstract = {Das anhaltende Wachstum wissenschaftlicher Ver{\"o}ffentlichungen wirft die Fragestellung auf, wie Literaturana-lysen im Rahmen von Forschungsprozessen digitalisiert und somit produktiver realisiert werden k{\"o}nnen. Insbesondere in informationstechnischen Fachgebieten ist die Forschungspraxis durch ein rasant wachsendes Publikationsaufkommen gekennzeichnet. Infolgedessen bietet sich der Einsatz von Methoden der Textanalyse (Text Analytics) an, die Textdaten automatisch vorbereiten und verarbeiten k{\"o}nnen. Erkenntnisse entstehen dabei aus Analysen von Wortarten und Subgruppen, Korrelations- sowie Zeitreihenanalysen. Dieser Beitrag stellt die Konzeption und Realisierung eines Prototypen vor, mit dem Anwender bibliographische Daten aus der etablierten Literaturdatenbank EBSCO Discovery Service mithilfe textanalytischer Methoden erschließen k{\"o}nnen. Der Prototyp basiert auf dem Analysesystem IBM Watson Explorer, das Hochschulen lizenzkostenfrei zur Verf{\"u}gung steht. Potenzielle Adressaten des Prototypen sind Forschungseinrichtungen, Beratungsunternehmen sowie Entscheidungstr{\"a}ger in Politik und Unternehmenspraxis.}, language = {de} } @article{BergSchleserDelidovichetal.2018, author = {Berg, Alexander-Karl and Schleser, Markus and Delidovich, Artem and Houben, Alexander}, title = {Ultraschallunterst{\"u}tzter Schmelzklebstoffauftrag}, series = {adh{\"a}sion KLEBEN \& DICHTEN}, volume = {Volume 62}, journal = {adh{\"a}sion KLEBEN \& DICHTEN}, number = {Issue 12}, publisher = {Springer}, doi = {10.1007/s35145-018-0089-z}, pages = {32 -- 37}, year = {2018}, language = {de} } @article{BerneckerKlierSternetal.2018, author = {Bernecker, Andreas and Klier, Julia and Stern, Sebastian and Thiel, Lea}, title = {Sustaining high performance beyond public-sector pilot projects.}, number = {September 2018}, organization = {McKinsey\&Company}, year = {2018}, language = {en} } @article{BhattaraiJabbariAndingetal.2018, author = {Bhattarai, Aroj and Jabbari, Medisa and Anding, Ralf and Staat, Manfred}, title = {Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis}, series = {tm - Technisches Messen}, volume = {85}, journal = {tm - Technisches Messen}, number = {5}, publisher = {De Gruyter}, address = {Berlin}, issn = {2196-7113}, doi = {10.1515/teme-2017-0115}, pages = {331 -- 342}, year = {2018}, abstract = {Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere {\"a}ltere, mehrgeb{\"a}hrende Frauen leiden h{\"a}ufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterst{\"u}tzung durch laxe apikale B{\"a}nder. Es wird angenommen, dass eine verringerte Menge an {\"O}strogen und Progesteron im h{\"o}heren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgef{\"u}hrt wird, um laxe B{\"a}nder zu ersetzen. Y-f{\"o}rmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden w{\"a}hrend des Valsalva-Man{\"o}vers mit geschw{\"a}chtem Gewebe durchgef{\"u}hrt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, w{\"a}hrend die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnr{\"o}hrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, f{\"u}r den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelm{\"a}ßigen rechteckigen Netzporen eine bessere mechanische Unterst{\"u}tzung und eine Neupositionierung des Scheidengew{\"o}lbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelm{\"a}ßigen hexagonalen Netzporen.}, language = {en} } @article{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions}, series = {Computational and Mathematical Methods in Medicine}, volume = {2018}, journal = {Computational and Mathematical Methods in Medicine}, number = {Article ID 9518076}, publisher = {Hindawi}, address = {New York, NY}, issn = {1748-6718}, doi = {10.1155/2018/9518076}, pages = {1 -- 16}, year = {2018}, abstract = {After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5\%), adipose tissue (85\%), and smooth muscle (5\%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females.}, language = {en} } @article{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Computational comparison of different textile implants to correct apical prolapse in females}, series = {Current Directions in Biomedical Engineering}, volume = {4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, doi = {10.1515/cdbme-2018-0159}, pages = {661 -- 664}, year = {2018}, abstract = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.}, language = {en} } @article{BirgelLeschingerWegmannetal.2018, author = {Birgel, Stefan and Leschinger, Tim and Wegmann, Kilian and Staat, Manfred}, title = {Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model}, series = {tm - Technisches Messen}, volume = {85}, journal = {tm - Technisches Messen}, number = {5}, publisher = {De Gruyter}, address = {Berlin}, issn = {2196-7113}, doi = {10.1515/teme-2017-0114}, pages = {321 -- 330}, year = {2018}, abstract = {Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und {\"u}berpr{\"u}ften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen f{\"u}r den Supraspinatus und Deltoideus. Zus{\"a}tzlich wird der Einfluss auf die Gelenkstabilit{\"a}t betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus.}, language = {en} } @article{BirklDiendorferKernetal.2018, author = {Birkl, Josef and Diendorfer, Gerhard and Kern, Alexander and Thern, Stephan}, title = {Extrem hohe Blitzstr{\"o}me}, series = {Elektropraktiker}, volume = {72}, journal = {Elektropraktiker}, number = {3}, publisher = {Huss Medien}, address = {Berlin}, pages = {217 -- 225}, year = {2018}, abstract = {Blitze sind nach wie vor eine enorme Schadensquelle f{\"u}r Personensch{\"a}den, Br{\"a}nde, mechanische Zerst{\"o}rungen und insbesondere auch {\"U}berspannungen. Das zeigen nicht zuletzt aktuelle Statistiken der Schadensversicherer. Immer wieder gibt es Meldungen {\"u}ber extrem hohe Blitzstr{\"o}me, die nat{\"u}rlich auch zu großen Sch{\"a}den und Zerst{\"o}rungen f{\"u}hren k{\"o}nnen. Dabei werden Scheitelwerte von teilweise deutlich {\"u}ber 300 kA genannt. Dies wirft Fragen auf, da die „klassische" Blitzstatistik (z. B. nach CIGRE und IEC [8][10]) bisher solche Werte nicht kennt. Diese extremen Blitzstr{\"o}me werden meist aus den Daten von Blitzortungssystemen ermittelt.}, language = {de} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @article{BungValero2018, author = {Bung, Daniel B. and Valero, Daniel}, title = {Re-aeration on stepped spillways with special consideration of entrained and entrapped air}, series = {Geosciences}, volume = {8}, journal = {Geosciences}, number = {9}, publisher = {MDPI}, address = {Basel}, issn = {2076-3263}, pages = {Article number 333}, year = {2018}, abstract = {As with most high-velocity free-surface flows, stepped spillway flows become self-aerated when the drop height exceeds a critical value. Due to the step-induced macro-roughness, the flow field becomes more turbulent than on a similar smooth-invert chute. For this reason, cascades are oftentimes used as re-aeration structures in wastewater treatment. However, for stepped spillways as flood release structures downstream of deoxygenated reservoirs, gas transfer is also of crucial significance to meet ecological requirements. Prediction of mass transfer velocities becomes challenging, as the flow regime differs from typical previously studied flow conditions. In this paper, detailed air-water flow measurements are conducted on stepped spillway models with different geometry, with the aim to estimate the specific air-water interface. Re-aeration performances are determined by applying the absorption method. In contrast to earlier studies, the aerated water body is considered a continuous mixture up to a level where 75\% air concentration is reached. Above this level, a homogenous surface wave field is considered, which is found to significantly affect the total air-water interface available for mass transfer. Geometrical characteristics of these surface waves are obtained from high-speed camera investigations. The results show that both the mean air concentration and the mean flow velocity have influence on the mass transfer. Finally, an empirical relationship for the mass transfer on stepped spillway models is proposed.}, language = {en} } @article{ButenwegMarinkovic2018, author = {Butenweg, Christoph and Marinkovic, Marko}, title = {Erdbebensicherer Anschluss von Ausfachungsmauerwerk in Stahlbetonrahmentragwerken mit Entkopplungselementen}, series = {Bauingenieur}, volume = {93}, journal = {Bauingenieur}, number = {9}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {333 -- 341}, year = {2018}, abstract = {Stahlbetonrahmentragwerke mit Mauerwerksausfachungen weisen nach Erdbebenereignissen h{\"a}ufig schwere Sch{\"a}den auf, da die Ausfachungen ohne weitere konstruktive Maßnahmen mit vollem Kontakt zum Stahlbetonrahmen eingemauert werden. Durch die unplanm{\"a}ßige Beteiligung am horizontalen Lastabtrag erfahren die Ausfachungen Belastungen in Wandebene und beeinflussen das globale Schwingungsverhalten der Rahmentragwerke. In Kombination mit den gleichzeitig auftretenden seismischen Tr{\"a}gheitskr{\"a}ften senkrecht zur Wand f{\"u}hrt dies in vielen F{\"a}llen zu einem Versagen der mit niedrigen Festigkeiten ausgef{\"u}hrten Ausfachungen. Dies war der Anlass in dem europ{\"a}ischen Forschungsprojekt INSYSME ein Entkopplungssystem zu entwickeln, mit dem Rahmen und Ausfachung durch ein spezielles Profil aus Elastomeren entkoppelt werden. Das Profil erm{\"o}glicht Relativverschiebungen zwischen Rahmen und Ausfachung und stellt gleichzeitig die Aufnahme von Belastungen senkrecht zur Wand sicher. Der Beitrag erl{\"a}utert zun{\"a}chst den Aufbau des Systems und gibt einen {\"U}berblick {\"u}ber die in Kleinbauteilversuchen ermittelten Tragf{\"a}higkeiten. Zudem werden experimentelle Untersuchungen an mit hochw{\"a}rmed{\"a}mmenden Mauerziegeln ausgefachten Stahlbetonrahmen mit und ohne Entkopplungssystem f{\"u}r getrennte und kombinierte Belastungen in und senkrecht zur Wandebene vorgestellt. Auf Grundlage einer Versuchsauswertung und eines Ergebnisvergleichs werden Wirkungsweise und Effektivit{\"a}t des entwickelten Entkopplungssystems demonstriert.}, language = {de} } @article{ButenwegMarinkovićFehlingetal.2018, author = {Butenweg, Christoph and Marinković, Marko and Fehling, Ekkehard and Pfetzing, Thomas}, title = {Stahlbetonrahmentragwerke mit Ausfachungen aus Mauerwerk unter kombinierten seismischen Belastungen in und senkrecht zur Wandebene}, series = {Bauingenieur}, volume = {93}, journal = {Bauingenieur}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, isbn = {0005-6650}, pages = {2 -- 10}, year = {2018}, language = {de} } @article{ButenwegMarinkovićKubalskietal.2018, author = {Butenweg, Christoph and Marinković, Marko and Kubalski, Thomas and Fehling, Ekkehard and Pfetzing, Thomas and Meyer, Udo}, title = {Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 1)}, series = {Ziegelindustrie international : ZI = Brick and tile industry international}, journal = {Ziegelindustrie international : ZI = Brick and tile industry international}, number = {4}, editor = {Voss, Michael}, publisher = {Bauverlag BV GmbH}, address = {G{\"u}tersloh}, issn = {0341-0552}, pages = {30 -- 39}, year = {2018}, abstract = {Im Rahmen des europ{\"a}ischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragf{\"a}higkeit durch aufwendige und kostspielige zus{\"a}tzliche Bewehrungseinlagen zu erh{\"o}hen. Erste Ergebnisse des Systems IMES f{\"u}r Belastungen in und senkrecht zu der Wandebene werden vorgestellt.}, language = {de} } @article{ButenwegMarinkovićKubalskietal.2018, author = {Butenweg, Christoph and Marinković, Marko and Kubalski, Thomas and Fehling, Ekkehard and Pfetzing, Thomas and Meyer, Udo}, title = {Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 2)}, series = {Ziegelindustrie international : ZI = Brick and tile industry international}, journal = {Ziegelindustrie international : ZI = Brick and tile industry international}, number = {6}, editor = {Voss, Michael}, publisher = {Bauverlag BV GmbH}, address = {G{\"u}tersloh}, issn = {0341-0552}, pages = {24 -- 43}, year = {2018}, abstract = {Im Rahmen des europ{\"a}ischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragf{\"a}higkeit durch aufwendige und kostspielige zus{\"a}tzliche Bewehrungseinlagen zu erh{\"o}hen. Erste Ergebnisse des Systems IMES f{\"u}r Belastungen in und senkrecht zu der Wandebene werden vorgestellt.}, language = {de} } @article{CiritsisHorbachStaatetal.2018, author = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas}, title = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo}, series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, volume = {106}, journal = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, number = {2}, publisher = {Wiley}, address = {New York, NY}, issn = {1552-4981}, doi = {10.1002/jbm.b.33877}, pages = {827 -- 833}, year = {2018}, abstract = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.}, language = {en} } @article{ConzenAlbannaWeissetal.2018, author = {Conzen, Catharina and Albanna, Walid and Weiss, Miriam and K{\"u}rten, David and Vilser, Walthard and Kotliar, Konstantin and Z{\"a}ske, Charlotte and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes}, series = {Translational Stroke Research}, journal = {Translational Stroke Research}, number = {9}, publisher = {Springer Nature}, address = {Cham}, issn = {1868-601X}, doi = {10.1007/s12975-017-0585-8}, pages = {284 -- 293}, year = {2018}, abstract = {Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.}, language = {en} } @article{DantismRoehlenWagneretal.2018, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules}, series = {physica status solidi a : applications and materials sciences}, volume = {215}, journal = {physica status solidi a : applications and materials sciences}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201800058}, pages = {Article number 1800058}, year = {2018}, abstract = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron-hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode.}, language = {en} } @article{deBloisdeZangerPaulssenetal.2018, author = {de Blois, Eric and de Zanger, Rory M. S. and Paulßen, Elisabeth and Sze Chan, Ho and Breeman, Wouter A. P.}, title = {Semi-automated system for concentrating 68Ga-eluate to obtain high molar and volume concentration of 68Ga-Radiopharmaca for preclinical applications}, series = {Nuclear Medicine and Biology}, volume = {64-65}, journal = {Nuclear Medicine and Biology}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.nucmedbio.2018.06.006}, pages = {16 -- 21}, year = {2018}, abstract = {68Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. volume restriction, activity concentration, molar activity and osmolality. Therefore, we developed a semiautomatic system specifically to overcome these problems. A difficulty appeared unexpectedly, as intrinsic trace metals derived from eluate (Zn, Fe and Cu) are concentrated as well in amounts that influence radiochemical yield and thus lower molar activity.}, language = {en} } @article{DigelWehlitzKayseretal.2018, author = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, R. and Rundstedt, F. von}, title = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids}, series = {Plant Pathology}, volume = {67}, journal = {Plant Pathology}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1365-3059}, doi = {10.1111/ppa.12750}, pages = {358 -- 365}, year = {2018}, abstract = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.}, language = {en} } @article{DitzhausGaigall2018, author = {Ditzhaus, Marc and Gaigall, Daniel}, title = {A consistent goodness-of-fit test for huge dimensional and functional data}, series = {Journal of Nonparametric Statistics}, volume = {30}, journal = {Journal of Nonparametric Statistics}, number = {4}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1029-0311}, doi = {10.1080/10485252.2018.1486402}, pages = {834 -- 859}, year = {2018}, abstract = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.}, language = {en} } @article{DruckenmuellerGuentherElbers2018, author = {Druckenm{\"u}ller, Katharina and G{\"u}nther, Klaus and Elbers, Gereon}, title = {Near-infrared spectroscopy (NIRS) as a tool to monitor exhaust air from poultry operations}, series = {Science of the Total Environment}, volume = {630}, journal = {Science of the Total Environment}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0048-9697}, doi = {10.1016/j.scitotenv.2018.02.072}, pages = {536 -- 543}, year = {2018}, abstract = {Intensive poultry operation systems emit a considerable volume of inorganic and organic matter in the surrounding environment. Monitoring cleaning properties of exhaust air cleaning systems and to detect small but significant changes in emission characteristics during a fattening cycle is important for both emission and fattening process control. In the present study, we evaluated the potential of near-infrared spectroscopy (NIRS) combined with chemometric techniques as a monitoring tool of exhaust air from poultry operation systems. To generate a high-quality data set for evaluation, the exhaust air of two poultry houses was sampled by applying state-of-the-art filter sampling protocols. The two stables were identical except for one crucial difference, the presence or absence of an exhaust air cleaning system. In total, twenty-one exhaust air samples were collected at the two sites to monitor spectral differences caused by the cleaning device, and to follow changes in exhaust air characteristics during a fattening period. The total dust load was analyzed by gravimetric determination and included as a response variable in multivariate data analysis. The filter samples were directly measured with NIR spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA), and factor analysis (FA) were effective in classifying the NIR exhaust air spectra according to fattening day and origin. The results indicate that the dust load and the composition of exhaust air (inorganic or organic matter) substantially influence the NIR spectral patterns. In conclusion, NIR spectroscopy as a tool is a promising and very rapid way to detect differences between exhaust air samples based on still not clearly defined circumstances triggered during a fattening period and the availability of an exhaust air cleaning system.}, language = {en} } @article{EckertRudolphGuoetal.2018, author = {Eckert, Alexander and Rudolph, Tobias and Guo, Jiaqi and Mang, Thomas and Walther, Andreas}, title = {Exceptionally Ductile and Tough Biomimetic Artificial Nacre with Gas Barrier Function}, series = {Advanced Materials}, volume = {30}, journal = {Advanced Materials}, number = {32}, publisher = {Wiley-VCH}, doi = {10.1002/adma.201802477}, pages = {Article number 1802477}, year = {2018}, abstract = {Synthetic mimics of natural high-performance structural materials have shown great and partly unforeseen opportunities for the design of multifunctional materials. For nacre-mimetic nanocomposites, it has remained extraordinarily challenging to make ductile materials with high stretchability at high fractions of reinforcements, which is however of crucial importance for flexible barrier materials. Here, highly ductile and tough nacre-mimetic nanocomposites are presented, by implementing weak, but many hydrogen bonds in a ternary nacre-mimetic system consisting of two polymers (poly(vinyl amine) and poly(vinyl alcohol)) and natural nanoclay (montmorillonite) to provide efficient energy dissipation and slippage at high nanoclay content (50 wt\%). Tailored interactions enable exceptional combinations of ductility (close to 50\% strain) and toughness (up to 27.5 MJ m⁻³). Extensive stress whitening, a clear sign of high internal dynamics at high internal cohesion, can be observed during mechanical deformation, and the materials can be folded like paper into origami planes without fracture. Overall, the new levels of ductility and toughness are unprecedented in highly reinforced bioinspired nanocomposites and are of critical importance to future applications, e.g., as barrier materials needed for encapsulation and as a printing substrate for flexible organic electronics.}, language = {en} } @article{EdipSesovButenwegetal.2018, author = {Edip, K. and Sesov, V. and Butenweg, Christoph and Bojadjieva, J.}, title = {Development of coupled numerical model for simulation of multiphase soil}, series = {Computers and Geotechnics}, volume = {96}, journal = {Computers and Geotechnics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0266-352X}, doi = {10.1016/j.compgeo.2017.08.016}, pages = {118 -- 131}, year = {2018}, abstract = {In this paper, a coupled multiphase model considering both non-linearities of water retention curves and solid state modeling is proposed. The solid displacements and the pressures of both water and air phases are unknowns of the proposed model. The finite element method is used to solve the governing differential equations. The proposed method is demonstrated through simulation of seepage test and partially consolidation problem. Then, implementation of the model is done by using hypoplasticity for the solid phase and analyzing the fully saturated triaxial experiments. In integration of the constitutive law error controlling is improved and comparisons done accordingly. In this work, the advantages and limitations of the numerical model are discussed.}, language = {en} } @article{EngelHoltmannUlberetal.2018, author = {Engel, Mareike and Holtmann, Dirk and Ulber, Roland and Tippk{\"o}tter, Nils}, title = {Increased Biobutanol Production by Mediator-Less Electro-Fermentation}, series = {Biotechnology Journal}, journal = {Biotechnology Journal}, number = {Volume 14, Issue 4}, publisher = {Wiley-VCH}, issn = {1860-7314}, doi = {10.1002/biot.201800514}, pages = {Artikel 1800514}, year = {2018}, abstract = {A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at -600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6\% compared to 23.3\% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry.}, language = {en} } @article{EngelmannBuhlDraacketal.2018, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications}, series = {IEEE Magnetic Letters}, volume = {9}, journal = {IEEE Magnetic Letters}, number = {Article number 8519617}, publisher = {IEEE}, address = {New York, NY}, issn = {1949-307X}, doi = {10.1109/LMAG.2018.2879034}, year = {2018}, abstract = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.}, language = {en} } @article{EngelmannRoethEberbecketal.2018, author = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells}, series = {Scientific Reports}, volume = {8}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-018-31553-9}, pages = {Article number 13210}, year = {2018}, abstract = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.}, language = {en} } @article{ErmolaevNivokovMelnikovaetal.2018, author = {Ermolaev, A.P. and Nivokov, I.A. and Melnikova, L.I. and Kotliar, Konstantin}, title = {Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой}, series = {Vestnik oftalmologii}, volume = {5}, journal = {Vestnik oftalmologii}, number = {2}, publisher = {Media Sfera}, address = {Moskau}, doi = {10.17116/oftalma2018134051195}, pages = {195 -- 201}, year = {2018}, abstract = {Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.}, language = {ru} } @article{FigueroaMirandaFengShiuetal.2018, author = {Figueroa-Miranda, Gabriela and Feng, Lingyan and Shiu, Simon Chi-Chin and Dirkzwager, Roderick Marshall and Cheung, Yee-Wai and Tanner, Julian Alexander and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, Andreas and Mayer, Dirk}, title = {Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability}, series = {Sensor and Actuators B: Chemical}, volume = {255}, journal = {Sensor and Actuators B: Chemical}, number = {P1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.07.117}, pages = {235 -- 243}, year = {2018}, abstract = {Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.}, language = {en} } @article{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs}, series = {CEAS Aeronautical Journal}, volume = {10}, journal = {CEAS Aeronautical Journal}, number = {3}, publisher = {Springer}, issn = {1869-5582 print}, doi = {10.1007/s13272-018-0352-x}, pages = {843}, year = {2018}, abstract = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.}, language = {en} } @article{Fissabre2018, author = {Fissabre, Anke}, title = {Die Relevanz der historischen Bauforschung f{\"u}r neue Impulse in Stadtplanung und Architektur. Das Beispiel der Chiesa della SS. Maria Incoronata und des Servitenklosters in Sabbioneta.}, series = {archimaera}, journal = {archimaera}, number = {Nr. 7, Juli 2018}, publisher = {Archimaera}, address = {Aachen}, issn = {1865-7001}, url = {http://nbn-resolving.de/urn:nbn:de:0009-21-47067}, pages = {99 -- 105}, year = {2018}, abstract = {Durch die Bauforschung im Rahmen des mehrj{\"a}hrigen Projektes "Die Hochkorridore von Sabbioneta" konnten der Verlauf und viele Anschl{\"u}sse der hochliegenden G{\"a}nge an bestehende Bauten weitgehend gekl{\"a}rt werden. Im Bereich der Chiesa della SS. Maria Incoronata und des angrenzenden Servitenklosters f{\"u}hrten die Bauuntersuchungen zu v{\"o}llig neuen Erkenntnissen {\"u}ber den ehemaligen Verlauf des Hochkorridors und damit zu einer Neuinterpretation des baulichen Ensembles sowie seiner Bedeutung f{\"u}r die Idealstadt. Aus dieser historischen Umdeutung entstanden Ideen f{\"u}r die Umnutzung des ehemaligen Servitenklosters und seiner angrenzenden Freifl{\"a}chen, die im Rahmen von studentischen Entw{\"u}rfen am Lehrstuhl f{\"u}r Baugeschichte und Denkmalpflege in Kooperation mit dem Lehrstuhl f{\"u}r Landschaftsarchitektur der RWTH Aachen weiterentwickelt wurden. Somit stellten sich Befunde einer historisch orientierten Bauforschung mit {\"u}bergeordneter Fragestellung als neue Impulsgeber f{\"u}r Stadtplanung, Architektur und Denkmalpflege heraus.}, language = {de} } @article{FissabreWilson2018, author = {Fissabre, Anke and Wilson, Ariane}, title = {Der Turm mit zehn Spornen - Ein in Monthoiron gebauter Entwurf von Leonardo Da Vinci?}, series = {In situ: Zeitschrift f{\"u}r Architekturgeschichte}, journal = {In situ: Zeitschrift f{\"u}r Architekturgeschichte}, number = {1}, publisher = {Wernersche Verlagsgesellschaft}, address = {Worms}, issn = {1866-959X}, pages = {65 -- 82}, year = {2018}, language = {de} } @article{FranzenPindersPfaffetal.2018, author = {Franzen, Julius and Pinders, Erik and Pfaff, Raphael and Enning, Manfred}, title = {RailCrowd's virtual fleets: Make most of your asset data}, series = {Deine Bahn}, journal = {Deine Bahn}, number = {9}, publisher = {Bahn-Fachverlag}, address = {Berlin}, issn = {0948-7263}, pages = {11 -- 13}, year = {2018}, abstract = {For smaller railway operators or those with a diverse fleet, it can be difficult to collect sufficient data to improve maintenance programs. At the same time, new rules such as entity in charge of maintenance - ECM - regulations impose an additional workload by requiring a dedicated maintenance management system and specific reports. The RailCrowd platform sets out to facilitate compliance with ECM and similar regulations while at the same time pooling anonymised fleet data across operators to form virtual fleets, providing greater data insights.}, language = {en} } @article{FunkeBeckmannKeinzetal.2018, author = {Funke, Harald and Beckmann, Nils and Keinz, Jan and Abanteriba, Sylvester}, title = {Comparison of Numerical Combustion Models for Hydrogen and Hydrogen-Rich Syngas Applied for Dry-Low-Nox-Micromix-Combustion}, series = {Journal of Engineering for Gas Turbines and Power}, volume = {140}, journal = {Journal of Engineering for Gas Turbines and Power}, number = {8}, publisher = {ASME}, address = {New York, NY}, issn = {0742-4795}, doi = {10.1115/1.4038882}, pages = {9 Seiten}, year = {2018}, abstract = {The Dry-Low-NOx (DLN) Micromix combustion technology has been developed as low emission combustion principle for industrial gas turbines fueled with hydrogen or syngas. The combustion process is based on the phenomenon of jet-in-crossflow-mixing (JICF). Fuel is injected perpendicular into the air-cross-flow and burned in a multitude of miniaturized, diffusion-like flames. The miniaturization of the flames leads to a significant reduction of NOx emissions due to the very short residence time of reactants in the flame. In the Micromix research approach, computational fluid dynamics (CFD) analyses are validated toward experimental results. The combination of numerical and experimental methods allows an efficient design and optimization of DLN Micromix combustors concerning combustion stability and low NOx emissions. The paper presents a comparison of several numerical combustion models for hydrogen and hydrogen-rich syngas. They differ in the complexity of the underlying reaction mechanism and the associated computational effort. The performance of a hybrid eddy-break-up (EBU) model with a one-step global reaction is compared to a complex chemistry model and a flamelet generated manifolds (FGM) model, both using detailed reaction schemes for hydrogen or syngas combustion. Validation of numerical results is based on exhaust gas compositions available from experimental investigation on DLN Micromix combustors. The conducted evaluation confirms that the applied detailed combustion mechanisms are able to predict the general physics of the DLN-Micromix combustion process accurately. The FGM method proved to be generally suitable to reduce the computational effort while maintaining the accuracy of detailed chemistry.}, language = {en} } @article{Golland2018, author = {Golland, Alexander}, title = {Das neue kirchliche Datenschutzrecht - Herausforderungen f{\"u}r Unternehmen der Privatwirtschaft}, series = {DSB Datenschutz-Berater}, volume = {42}, journal = {DSB Datenschutz-Berater}, number = {9}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, isbn = {0170-7256}, pages = {179 -- 181}, year = {2018}, language = {de} } @article{Golland2018, author = {Golland, Alexander}, title = {Gemeinsame Verantwortlichkeit in mehrstufigen Verarbeitungsszenarien}, volume = {21}, number = {7-8}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, issn = {1434-6354}, pages = {433 -- 438}, year = {2018}, abstract = {Die Rechtsfigur der gemeinsamen Verantwortlichkeit besch{\"a}ftigt die datenschutzrechtliche Literatur seit Langem. Die Bestimmung der Verantwortlichkeit bei arbeitsteiligen Verarbeitungsverfahren, welche vor allem bei heutigen Plattformdiensten {\"u}blich sind, ist komplex: Stets sind mehrere Akteure beteiligt und in der Regel werden durch die Handlung eines Beteiligten mehrere Verarbeitungsschritte ausgel{\"o}st. Nun hat sich der EuGH in einem in mehrfacher Hinsicht bemerkenswerten Urteil ge{\"a}ußert.}, language = {de} } @article{Golland2018, author = {Golland, Alexander}, title = {Der r{\"a}umliche Anwendungsbereich der DS-GVO}, series = {DuD Datenschutz und Datensicherheit}, volume = {42}, journal = {DuD Datenschutz und Datensicherheit}, number = {6}, publisher = {Springer}, address = {Heidelberg}, isbn = {1862-2607}, pages = {351 -- 357}, year = {2018}, abstract = {Die Datenschutz-Grundverordnung (DS-GVO) regelt in ihrem Art. 3 das r{\"a}umlich anwendbare Datenschutzrecht und zielt dabei gerade auch auf Angebote nichteurop{\"a}ischer Diensteanbieter ab. Die bisherige Diskussion konzentriert sich bislang in erster Linie darauf, das eingef{\"u}hrte Marktortprinzip zu thematisieren; das weitgehend unangetastete Niederlassungsprinzip und vor allem die Probleme, die sich durch dessen unver{\"a}nderte Beibehaltung ergeben, werden dagegen nicht er{\"o}rtert. Der folgende Beitrag versucht sich an einer systematischen Analyse eines teils kontrovers, teils kaum diskutierten Themas.}, language = {de} } @article{Golland2018, author = {Golland, Alexander}, title = {Das Kopplungsverbot in der Datenschutz-Grundverordnung Anwendungsbereich, {\"o}konomische Auswirkungen auf Web 2.0-Dienste und L{\"o}sungsvorschlag}, series = {MMR Multimedia und Recht}, volume = {21}, journal = {MMR Multimedia und Recht}, number = {3}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {1434-596X}, pages = {130 -- 135}, year = {2018}, abstract = {Das Kopplungsverbot fristete - obwohl in rechtswissenschaftlicher Literatur seit jeher diskutiert - unter der Geltung des BDSG ein Schattendasein. Mit der Datenschutz-Grundverordnung (DS-GVO) ist eine {\"A}nderung absehbar: Der neue Art. EWG_DSGVO Artikel 7 Abs. EWG_DSGVO Artikel 7 Absatz 4 DS-GVO stellt klar, dass die Leistungserbringung nicht von der Einwilligungserteilung abh{\"a}ngig gemacht werden darf. Doch dieses scheinbare Novum des Datenschutzrechts wirft zahlreiche Fragen auf. W{\"a}hrend vor allem Vertreter der unternehmerischen Praxis die Anwendung des Kopplungsverbots in zahlreichen Konstellationen ablehnen, beschw{\"o}ren dessen Apologeten das Ende s{\"a}mtlicher „datenfinanzierten" Dienste herauf. Der vorliegende Beitrag gibt Einblick in die Regelungstiefe einer Norm, die das Web 2.0 revolutionieren k{\"o}nnte, und schl{\"a}gt eine L{\"o}sung vor, die dem Schutz der Privatsph{\"a}re des Betroffenen und den wirtschaftlichen Interessen von Diensteanbietern gleichermaßen gerecht wird.}, language = {de} } @article{Golland2018, author = {Golland, Alexander}, title = {Umsetzung der Datenschutz-Grundverordnung - Neue Herausforderungen f{\"u}r Unternehmen}, series = {NWB Rechnungswesen - BBK}, journal = {NWB Rechnungswesen - BBK}, number = {1}, isbn = {0340-9848}, pages = {35 -- 39}, year = {2018}, abstract = {Nach einem intensiven politischen Diskurs wurde im vergangenen Jahr die Datenschutz-Grundverordnung (DSGVO) verabschiedet. Die DSGVO ersetzt zum 25.5.2018 die bislang geltende, aus dem Jahre 1995 stammende Datenschutz-Richtlinie 95/46/EG. Die Novellierung des Datenschutzrechts bringt zahlreiche neue Anforderungen mit sich. Unternehmen sind daher gezwungen, sich auf die {\"A}nderungen einzustellen, ihre datenschutzrelevanten Prozesse im Hinblick auf die neuen Anforderungen zu {\"u}berpr{\"u}fen und bis zum Mai 2018 an der DSGVO auszurichten. Der Beitrag gibt einen kurzen {\"U}berblick {\"u}ber die zentralen Aspekte der Datenschutzreform und die damit einhergehenden Herausforderungen f{\"u}r Unternehmen.}, language = {de} } @article{GoettenFingerHavermannetal.2018, author = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bill, C.}, title = {On the flight performance impact of landing gear drag reduction methods for unmanned air vehicles}, series = {Deutscher Luft- und Raumfahrtkongress 2018}, journal = {Deutscher Luft- und Raumfahrtkongress 2018}, publisher = {DGLR}, address = {Bonn}, doi = {10.25967/480058}, pages = {11 S.}, year = {2018}, abstract = {The flight performance impact of three different landing gear configurations on a small, fixed-wing UAV is analyzed with a combination of RANS CFD calculations and an incremental flight performance algorithm. A standard fixed landing gear configuration is taken as a baseline, while the influence of retracting the landing gear or applying streamlined fairings is investigated. A retraction leads to a significant parasite drag reduction, while also fairings promise large savings. The increase in lift-to-drag ratio is reduced at high lift coefficients due to the influence of induced drag. All configurations are tested on three different design missions with an incremental flight performance algorithm. A trade-off study is performed using the retracted or faired landing gear's weight increase as a variable. The analysis reveals only small mission performance gains as the aerodynamic improvements are negated by weight penalties. A new workflow for decision-making is presented that allows to estimate if a change in landing gear configuration is beneficial for a small UAV.}, language = {en} } @article{HeinkeKnickerAlbracht2018, author = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten}, title = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes}, series = {Isokinetics and Exercise Science}, volume = {26}, journal = {Isokinetics and Exercise Science}, number = {4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1878-5913}, doi = {10.3233/IES-184111}, pages = {265 -- 274}, year = {2018}, abstract = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.}, language = {en} }