@article{FinkenbergerSchlaich2014, author = {Finkenberger, Isabel Maria and Schlaich, Christoph}, title = {Mehr als Wohnen. Vom Zusammenleben in integrierten Nachbarschaften}, series = {APuZ - Aus Politik und Zeitgeschichte}, volume = {2014}, journal = {APuZ - Aus Politik und Zeitgeschichte}, number = {20-21}, publisher = {Bundeszentrale f{\"u}r politische Bildung - bpb}, address = {Bonn}, issn = {2194-3621}, pages = {46 -- 52}, year = {2014}, abstract = {Neue D{\"o}rfer braucht das Land! D{\"o}rfer in der Stadt und D{\"o}rfer auf dem Land (…). Die Planung und Gestaltung nachhaltiger Raumsysteme, die durch ein neues Verst{\"a}ndnis des gemeinschaftlichen Besitzes (und dessen Nutzung) ressourcenfressende Individualisierungstendenzen unserer Gesellschaft {\"u}berwinden, aber zugleich gr{\"o}ßtm{\"o}glichen Freiraum f{\"u}r eine individuelle Pers{\"o}nlichkeitsentfaltung zur Verf{\"u}gung stellen." Dieses Zitat der Hamburger Initiative "Wir sind Dorf" beschreibt eine aktuelle Diskussion in unserer Gesellschaft, die sowohl in der Forschung und forschungsgeleiteten Initiativen, in Politik und Planung als auch in der B{\"u}rger-schaft stattfindet. Sie wird nicht nur auf wissenschaftlichen Veranstaltungen gef{\"u}hrt, sondern auch in konkreten Projekten f{\"u}r integrative Lebenswelten, die Fragestellungen von Ern{\"a}hrung und Energieversorgung, von Arbeit und {\"O}konomie, aber auch eines neuen r{\"a}umlichen und sozialen Miteinanders einbeziehen. Anders als bei den weit verbreiteten Baugruppen geht es nicht ausschließlich um die Schaffung von Wohnraum. Die Nachbarschaftsidee verbindet das Bed{\"u}rfnis nach gemeinschaftlichem Wohnen und Wirtschaften mit einer neuen Werteorientierung, die auf pers{\"o}nlicher Verantwortungs{\"u}bernahme beruht.}, language = {de} } @article{Finkenberger2014, author = {Finkenberger, Isabel Maria}, title = {Vox populi. (Transformations-)potenziale nachkriegsmoderner Freiraumressourcen}, series = {Stadt+Gr{\"u}n}, volume = {2014}, journal = {Stadt+Gr{\"u}n}, number = {1}, publisher = {Patzer}, address = {Berlin}, issn = {0948-9770}, pages = {31 -- 35}, year = {2014}, abstract = {Heute wie damals werden die großz{\"u}gigen und offenen Siedlungsstrukturen der ersten Nachkriegsjahrzehnte mit ihrem hohen Anteil an "Gr{\"u}n" vielfach gesch{\"a}tzt und als solche nicht grundlegend hinterfragt. "Gr{\"u}n" verheißt im Allgemeinen Licht, Luft und Sonne, Freizeit und Erholung und gilt als etwas W{\"u}nschenswertes im st{\"a}dtischen Kontext. Unbeachtet bleibt, dass dem Begriff "Gr{\"u}n" zun{\"a}chst keine Eigenschaften oder Qualit{\"a}ten zugewiesen sind - er sagt noch lange nichts {\"u}ber dessen r{\"a}umliche Qualit{\"a}t, dessen Nutzbarkeit, Erreichbarkeit und Zug{\"a}nglichkeit aus. Abstandsgr{\"u}n und Straßenbegleitgr{\"u}n ist eben auch "Gr{\"u}n". Neben einer quantitativen Argumentation, welche {\"o}kologischen Aspekte wie Biotopvernetzung, Stadt- und Mikroklima ber{\"u}cksichtigt, sollten wir verst{\"a}rkt qualitativ denken und damit die Grundlage f{\"u}r einen erweiterten und wesentlich differenzierteren Diskurs {\"u}ber urbane Freir{\"a}ume ebnen.}, language = {de} } @article{YangKriechbaumerAlbrachtetal.2014, author = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn}, title = {A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans}, series = {Journal of Orthopaedic Translation}, volume = {2}, journal = {Journal of Orthopaedic Translation}, number = {4}, publisher = {Elsevier}, address = {Singapore}, issn = {2214-0328}, doi = {10.1016/j.jot.2014.07.078}, pages = {238 -- 238}, year = {2014}, language = {en} } @inproceedings{NeugebauerBrutschyMeyeretal.2014, author = {Neugebauer, Georg and Brutschy, Lucas and Meyer, Ulrike and Wetzel, Susanne}, title = {Privacy-preserving multi-party reconciliation secure in the malicious model}, series = {DPM 2013, SETOP 2013: Data Privacy Management and Autonomous Spontaneous Security}, booktitle = {DPM 2013, SETOP 2013: Data Privacy Management and Autonomous Spontaneous Security}, editor = {Garcia-Alfaro, Joaquin and Lioudakis, Georgios and Cuppens-Boulahia, Nora and Foley, Simon and Fitzgerald, William M.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-54567-2 (Print)}, doi = {10.1007/978-3-642-54568-9_12}, pages = {178 -- 193}, year = {2014}, abstract = {The problem of fair and privacy-preserving ordered set reconciliation arises in a variety of applications like auctions, e-voting, and appointment reconciliation. While several multi-party protocols have been proposed that solve this problem in the semi-honest model, there are no multi-party protocols that are secure in the malicious model so far. In this paper, we close this gap. Our newly proposed protocols are shown to be secure in the malicious model based on a variety of novel non-interactive zero-knowledge-proofs. We describe the implementation of our protocols and evaluate their performance in comparison to protocols solving the problem in the semi-honest case.}, language = {en} } @misc{EickmannEschFunkeetal.2014, author = {Eickmann, Matthias and Esch, Thomas and Funke, Harald and Abanteriba, Sylvester and Roosen, Petra}, title = {Biofuels in Aviation - Safety Implications of Bio-Ethanol Usage in General Aviation Aircraft}, year = {2014}, abstract = {Up in the clouds and above fuels and construction materials must be very carefully selected to ensure a smooth flight and touchdown. Out of around 38,000 single and dual-engined propeller aeroplanes, roughly a third are affected by a new trend in the fuel sector that may lead to operating troubles or even emergency landings: The admixture of bio-ethanol to conventional gasoline. Experiences with these fuels may be projected to alternative mixtures containing new components.}, language = {en} } @inproceedings{AltayButenwegKlinkel2014, author = {Altay, Okyay and Butenweg, Christoph and Klinkel, Sven}, title = {Vibration mitigation of wind turbine towers by a new semiactive Tuned Liquid Column Damper}, series = {6. Word Congress on Structural Control and Monitoring, 15 - 17 July, 2014 Barcelona,Spain}, booktitle = {6. Word Congress on Structural Control and Monitoring, 15 - 17 July, 2014 Barcelona,Spain}, year = {2014}, language = {en} } @inproceedings{ButenwegMeyerFehling2014, author = {Butenweg, Christoph and Meyer, Udo and Fehling, Ekkehard}, title = {INSYSME: first activities of the German partners}, series = {9th International Masonry Conference 2014 in Guimaraes, Portugal, 2014}, booktitle = {9th International Masonry Conference 2014 in Guimaraes, Portugal, 2014}, year = {2014}, language = {en} } @inproceedings{ButenwegRajan2014, author = {Butenweg, Christoph and Rajan, Sreelakshmy}, title = {Design and construction techniques of AAC masonry buildings in earthquakes regions}, series = {10 years Xella research in Building Materials : Symposium on the 4th and 5th of September, Potsdam 2014}, booktitle = {10 years Xella research in Building Materials : Symposium on the 4th and 5th of September, Potsdam 2014}, year = {2014}, language = {en} } @inproceedings{MaikeLenzWolf2014, author = {Maike, M{\"u}ller and Lenz, Laura and Wolf, Martin}, title = {Steigerung der Effektivit{\"a}t durch Prozessmodellierungs-Tools - {\"A}nderbarkeit und Transparenz von Prozessen am Beispiel der Business Simulation Apollo 13}, series = {Informatik 2014}, booktitle = {Informatik 2014}, publisher = {Gesellschaft f{\"u}r Informatik e.V.}, address = {Bonn}, isbn = {978-3-88579-626-8}, issn = {1617-5468}, pages = {357 -- 369}, year = {2014}, abstract = {Die Nutzung von Prozessmodellierungsmethoden oder - werkzeugen kann erheblichen Einfluss auf die Effektivit{\"a}t von Prozessen haben. Das gilt insbesondere f{\"u}r Situationen, in denen Personen unter Stress stehen oder unge{\"u}bt sind. In diesen F{\"a}llen geben Prozessmodelle konkrete Empfehlungen, nach denen sich die handelnden Personen richten k{\"o}nnten. In Experimenten mit der Business-Simulation Apollo 13 haben wir den Effekt eines Einsatzes von Prozessmodellierungsmethoden und -werkzeugen untersucht. Bereits bekannte Theorien (z.B. {\"u}ber geeignete Verh{\"a}ltnisse von Kommunikationsinhalten) konnten best{\"a}tigt werden. Dar{\"u}ber hinaus haben wir eine besondere Bedeutung der {\"U}bertragbarkeit von Prozessmodellen in konkrete Handlungen identifiziert.}, language = {de} } @article{GollandEngling2014, author = {Golland, Alexander and Engling, Christoph}, title = {a-i3/BSI Symposium 2014: Sicherheit von Daten und Identit{\"a}ten angesichts NSA und Big Data}, series = {DSB Datenschutz-Berater}, volume = {38}, journal = {DSB Datenschutz-Berater}, number = {7-8}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, isbn = {0170-7256}, pages = {165 -- 166}, year = {2014}, language = {de} } @article{Golland2014, author = {Golland, Alexander}, title = {Datenschutz durch modulare Zertifizierung: Trusted Cloud-Pilotprojekt bringt neuen Ansatz}, series = {DSB Datenschutz-Berater}, volume = {38}, journal = {DSB Datenschutz-Berater}, number = {10}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, isbn = {0170-7256}, pages = {213 -- 215}, year = {2014}, language = {de} } @article{AltherrEdererLorenzetal.2014, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Experimental validation of an enhanced system synthesis approach}, series = {Operations Research Proceedings 2014}, journal = {Operations Research Proceedings 2014}, editor = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit}, publisher = {Springer}, address = {Basel}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_1}, pages = {6}, year = {2014}, abstract = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.}, language = {en} } @article{ButenwegSchmittRosen2014, author = {Butenweg, Christoph and Schmitt, T. and Rosen, B.}, title = {Seismische Einwirkungen auf erdverlegte Rohrleitungen}, series = {Bauingenieur}, volume = {89}, journal = {Bauingenieur}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {316 -- 324}, year = {2014}, abstract = {Die erdbebensichere Auslegung von erdverlegten Rohrleitungssystemen ist von wesentlicher Bedeutung zur Sicherstellung der Funktionalit{\"a}t der Versorgungsinfrastruktur nach einem Erdbebenereignis. Zur Vermeidung von Netzausf{\"a}llen ist es erforderlich, die r{\"a}umlich weit ausgedehnten Leitungssysteme mit geeigneten rechnerischen Modellen seismisch zu bemessen. Der vorliegende Beitrag behandelt die Beanspruchung von Rohrleitungssystemen durch seismische Welleneinwirkung und stellt geeignete N{\"a}herungsans{\"a}tze und ein detailliertes Rechenmodell f{\"u}r seismische Leitungsanalysen vor. Mit den Ans{\"a}tzen wird in Berechnungsbeispielen der Einfluss wesentlicher Parameter auf die seismisch induzierten Dehnungen in Rohrleitungssystemen untersucht.}, language = {de} } @article{HentschkeHagerHojdis2014, author = {Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils}, title = {Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers}, series = {Journal of Applied Polymer Science}, volume = {131}, journal = {Journal of Applied Polymer Science}, number = {18}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-4628}, doi = {10.1002/app.40806}, pages = {1 -- 9}, year = {2014}, abstract = {Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of "bonds" between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.}, language = {en} } @article{AkimbekovDigelOHerasetal.2014, author = {Akimbekov, N.Sh. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments}, series = {Experimental Biology}, volume = {60}, journal = {Experimental Biology}, number = {1/2}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {144 -- 148}, year = {2014}, abstract = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.}, language = {en} } @article{AkimbekovDigelZhubanova2014, author = {Akimbekov, N. Sh. and Digel, Ilya and Zhubanova, A. A.}, title = {Advantages of creation of e-books in training of specialists biologists and biotechnologists}, series = {KazNU Bulletin. Biology series.}, volume = {60}, journal = {KazNU Bulletin. Biology series.}, number = {1}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {249 -- 252}, year = {2014}, abstract = {The necessity of e-books as a primary of learning, its opportunities for realization of competence during training biologist and biotechnologist specialists are determined. Definitions and requirements to the e-books, its advantages in comparison with traditional textbooks, and the ways of creation of e-books in the SunRav BookEditor program are considered.}, language = {ru} } @article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @article{ScheerMclaughlinRodeetal.2014, author = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.}, title = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057885}, pages = {1022 -- 1030}, year = {2014}, abstract = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.}, language = {en} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{LuisierLempiaeinenScherbichleretal.2014, author = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.}, title = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors}, series = {Toxicological Sciences}, volume = {139}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1094-2025}, doi = {https://doi.org/10.1093/toxsci/kfu038}, pages = {501 -- 511}, year = {2014}, abstract = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.}, language = {en} } @incollection{KrollLudwigs2014, author = {Kroll-Ludwigs, Kathrin}, title = {Einleitung vor \S 1297}, series = {B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug), ErbbauRG, HausratsVO, LPartG, ProdHaftG, UKlaG, VAHRG und WEG}, booktitle = {B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug), ErbbauRG, HausratsVO, LPartG, ProdHaftG, UKlaG, VAHRG und WEG}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, isbn = {978-3-504-47102-6}, year = {2014}, language = {de} } @incollection{KrollLudwigs2014, author = {Kroll-Ludwigs, Kathrin}, title = {Vorbemerkung vor \S 1297}, series = {B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug), ErbbauRG, HausratsVO, LPartG, ProdHaftG, UKlaG, VAHRG und WEG}, booktitle = {B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug), ErbbauRG, HausratsVO, LPartG, ProdHaftG, UKlaG, VAHRG und WEG}, editor = {Ermann, Walter and Grunewald, Barbara and Maier-Reimer, Georg}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, isbn = {978-3-504-47102-6}, year = {2014}, language = {de} } @incollection{KrollLudwigs2014, author = {Kroll-Ludwigs, Kathrin}, title = {Vorbemerkung vor \S 1353}, series = {Erman, B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug) , ErbbauRG, LPartG, ProdHaftG, VBVG, VersAus-glG und WEG}, booktitle = {Erman, B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug) , ErbbauRG, LPartG, ProdHaftG, VBVG, VersAus-glG und WEG}, editor = {Ermann, Walter, and Grunewald, Barbara and Maier-Reimer, Georg}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, isbn = {978-3-50447-102-6}, year = {2014}, language = {de} } @article{KrollLudwigsKaesling2014, author = {Kroll-Ludwigs, Kathrin and Kaesling, Katharina}, title = {Family Law and Culture in Europe: Developments, Challenges and Opportunities - Konferenz der Commission on European Family Law vom 29.-31. August 2013, Bonn}, series = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, journal = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, number = {3}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {0943-3929}, pages = {673 -- 676}, year = {2014}, abstract = {Vor dem Hintergrund zunehmender gesellschaftlicher Ver{\"a}nderungen bei den Lebens- und Familienformen hat es sich die Commission on European Family Law (CEFL) seit 2001 zum Ziel gesetzt, unverbindliche Regelungsvorschl{\"a}ge f{\"u}r ein europaweit einheitliches Familienrecht zu schaffen. Die Vorstellung und Diskussion dieser auf rechtsvergleichender Basis erstellten Principles erfolgt auf den regelm{\"a}ßig veranstalteten Tagungen der CEFL. Die nunmehr f{\"u}nfte Konferenz zum Thema „Family Law and Culture in Europe - Developments, Challenges and Opportunities" fand erstmals in Deutschland statt. Ausgerichtet wurde die Veranstaltung, zu der ca. 200 Teilnehmerinnen und Teilnehmern aus Wissenschaft und Praxis aus insgesamt 33 L{\"a}ndern angereist waren, von Nina Dethloff (Direktorin des Instituts f{\"u}r Deutsches, Europ{\"a}isches und Internationales Familienrecht an der Universit{\"a}t Bonn), Katharina Boele-Woelki (Direktorin des Utrecht Centre for European Research into Family Law und Preistr{\"a}gerin des Anneliese Maier-Forschungspreises der Alexander von Humboldt-Stiftung) und Werner Gephart (Direktor des K{\"a}te Hamburger Kollegs „Recht als Kultur").}, language = {de} } @book{Bernecker2014, author = {Bernecker, Andreas}, title = {Essays in Empirical Political Economics}, pages = {XI, 174 S. : Ill., graph. Darst.}, year = {2014}, language = {en} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Divided Government and the Adoption of Economic Reforms}, series = {CESifo DICE Report - Journal for Institutional Comparison}, volume = {12}, journal = {CESifo DICE Report - Journal for Institutional Comparison}, number = {4}, publisher = {Ifo Institute for Economic Research}, address = {M{\"u}nchen}, issn = {1612-0663}, pages = {47 -- 52}, year = {2014}, language = {en} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Do politicians shirk when reelection is certain? Evidence from the German parliament}, series = {European Journal of Political Economy}, volume = {36}, journal = {European Journal of Political Economy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0176-2680}, doi = {10.1016/j.ejpoleco.2014.07.001}, pages = {55 -- 70}, year = {2014}, abstract = {Does stiffer electoral competition reduce political shirking? For a micro-analysis of this question, I construct a new data set spanning the years 2005 to 2012 covering biographical and political information about German Members of Parliament (MPs), including their attendance rates in voting sessions. For the parliament elected in 2009, I show that indeed opposition party MPs who expect to face a close race in their district show significantly and relevantly lower absence rates in parliament beforehand. MPs of governing parties seem not to react significantly to electoral competition. These results are confirmed by an analysis of the parliament elected in 2005, by several robustness checks, and also by employing an instrumental variable strategy exploiting convenient peculiarities of the German electoral system. The study also shows how MPs elected via party lists react to different levels of electoral competition.}, language = {en} } @inproceedings{Behbahani2014, author = {Behbahani, Mehdi}, title = {An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress}, series = {Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014}, booktitle = {Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014}, pages = {Paper 125}, year = {2014}, language = {en} } @article{Tran2014, author = {Tran, Duc Hung}, title = {Multiple corporate governance attributes and the cost of capital - Evidence from Germany}, series = {The British Accounting Review}, volume = {46}, journal = {The British Accounting Review}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0890-8389}, doi = {https://doi.org/10.1016/j.bar.2014.02.003}, pages = {179 -- 197}, year = {2014}, abstract = {This paper investigates the extent to which corporate governance affects the cost of debt and equity capital of German exchange-listed companies. I examine corporate governance along three dimensions: financial information quality, ownership structure and board structure. The results suggest that firms with high levels of financial transparency and bonus compensations face lower cost of equity. In addition, block ownership is negatively related to firms' cost of equity when the blockholders are other firms, managers or founding-family members. Consistent with the conjecture that agency costs increase with firm size, I find significant cost of debt effects only in the largest German companies. Here, the creditors demand lower cost of debt from firms with block ownerships held by corporations or banks. My findings demonstrate that a uniform set of governance attributes is unlikely to satisfy suppliers of debt and equity capital equally.}, language = {en} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Gestaltung des Anstellungsvertrags - Der Compliance-Beauftragte}, series = {Arbeit und Arbeitsrecht : AuA}, journal = {Arbeit und Arbeitsrecht : AuA}, number = {7}, publisher = {Huss Medien}, address = {Berlin}, issn = {0323-4568}, pages = {400 -- 403}, year = {2014}, abstract = {Ein Compliance-Beauftragter soll daf{\"u}r Sorge tragen, dass aus dem Unternehmen heraus keine Rechtsverletzungen begangen werden. Aber welche rechtlichen Notwendigkeiten und M{\"o}glichkeiten resultieren daraus f{\"u}r die Gestaltung des Anstellungsvertrags?}, language = {de} } @misc{Olbertz2014, author = {Olbertz, Klaus}, title = {Arbeitnehmereigenschaft des mitarbeitenden Gesellschafters einer GmbH}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {532 -- 532}, year = {2014}, language = {de} } @misc{Olbertz2014, author = {Olbertz, Klaus}, title = {Kein Anspruch auf Tarifgehaltserh{\"o}hungen bei K{\"u}ndigung des in Bezug genommenen Anerkennungstarifvertrags}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {377 -- 377}, year = {2014}, language = {de} } @misc{Olbertz2014, author = {Olbertz, Klaus}, title = {Vorbesch{\"a}ftigungszeiten als Leiharbeitnehmer z{\"a}hlen f{\"u}r K{\"u}ndigungsschutz grunds{\"a}tzlich nicht mit}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {423 -- 423}, year = {2014}, language = {de} } @misc{Olbertz2014, author = {Olbertz, Klaus}, title = {Arbeitszeitbetrug rechtfertigt fristlose K{\"u}ndigung auch bei langer Betriebszugeh{\"o}rigkeit}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {465 -- 465}, year = {2014}, language = {de} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Der neue gesetzliche Mindestlohn - was gilt und was Unternehmen k{\"u}nftig beachten m{\"u}ssen}, series = {Gesellschafts- und Wirtschaftsrecht : GWR}, journal = {Gesellschafts- und Wirtschaftsrecht : GWR}, issn = {1868-1816}, pages = {521 -- 524}, year = {2014}, abstract = {Ab dem 1.1.2015 ist es soweit: Deutschland erh{\"a}lt einen fl{\"a}chendeckenden und weitgehend branchenunabh{\"a}ngigen gesetzlichen Mindestlohn. Danach haben grunds{\"a}tzlich alle abh{\"a}ngig besch{\"a}ftigten Arbeitnehmer einen Anspruch auf eine Entlohnung von wenigstens 8,50 EUR brutto je Arbeitsstunde. Die Auswirkungen d{\"u}rften enorm sein. Das Bundesministerium f{\"u}r Arbeit und Soziales geht jedenfalls davon aus, dass aufgrund der Einf{\"u}hrung des gesetzlichen Mindestlohns mehrere Millionen Besch{\"a}ftigte einen h{\"o}heren Lohn beanspruchen k{\"o}nnen. Der nachfolgende Beitrag gibt einen {\"U}berblick {\"u}ber die wesentlichen Inhalte des gesetzlichen Mindestlohns und Hinweise f{\"u}r Anwendungsprobleme in der betrieblichen Praxis.}, language = {de} } @article{Olbertz2014, author = {Olbertz, Klaus}, title = {Die arbeitsrechtliche Stellung des Prokuristen - Handelsrechtlicher Kompetenzzuwachs mit arbeitsrechtlichen Konsequenzen}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {21}, publisher = {NWB-Verlag}, address = {Herne}, issn = {1860-9449}, pages = {1591 -- 1596}, year = {2014}, abstract = {Die Besch{\"a}ftigung von Prokuristen ist g{\"a}ngige betriebliche Praxis. Unternehmen stehen dabei immer wieder vor der Frage, ob und welche Arbeitnehmer sie zu Prokuristen bestellen sollen. Nicht selten bleiben hierbei die arbeitsrechtlichen Konsequenzen, die mit der Bestellung eines Arbeitnehmers zum Prokuristen einhergehen k{\"o}nnen, unber{\"u}cksichtigt, wie diverse Gerichtsentscheidungen zeigen. Dieser Beitrag soll einen {\"U}berblick {\"u}ber die arbeitsrechtlichen Folgen bei der Besch{\"a}ftigung von Prokuristen geben und der betrieblichen Praxis somit gleichzeitig als Entscheidungshilfe dienen, wenn es um das Ob und Wie der m{\"o}glichen Bestellung eines Arbeitnehmers zum Prokuristen geht.}, language = {de} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @misc{Jacobs2014, author = {Jacobs, Stephan}, title = {Es gibt keine nichtfunktionalen Tests. Es gibt nur nichtfunktionale Anforderungen!}, pages = {27 Folien}, year = {2014}, language = {de} } @article{Wilke2014, author = {Wilke, Thomas}, title = {Gebaute Geschichte in Turin}, series = {Kunsttexte.de}, volume = {2014}, journal = {Kunsttexte.de}, number = {1}, publisher = {Humboldt-Universit{\"a}t zu Berlin}, address = {Berlin}, issn = {1618-8101}, doi = {10.18452/7197}, pages = {13 Seiten}, year = {2014}, abstract = {St{\"a}dte sind Stein gewordene Geschichte. Ihre realisierte Form erm{\"o}glicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der f{\"u}hrenden Barockmetropolen Europas beeinflusste.}, language = {de} } @article{HoehrPaulssenBenardetal.2014, author = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul}, title = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron}, series = {Nuclear medicine and biology}, volume = {41}, journal = {Nuclear medicine and biology}, number = {5}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-9614}, doi = {10.1016/j.nucmedbio.2013.12.016}, pages = {401 -- 406}, year = {2014}, abstract = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.}, language = {en} } @article{JoerissenHeger2014, author = {J{\"o}rissen, J{\"o}rg and Heger, Michael}, title = {Zur Wirkung hochschuldidaktisch fundierter und in den Fachbereichen verankerter Lehrveranstaltungsevaluation}, series = {Qualit{\"a}t in der Wissenschaft (QiW)}, volume = {8}, journal = {Qualit{\"a}t in der Wissenschaft (QiW)}, number = {2+3}, publisher = {Universit{\"a}tsverlag Webler}, address = {Bielefeld}, issn = {1860-3041}, pages = {70 -- 80}, year = {2014}, language = {de} } @inproceedings{AlKaidyUlberTippkoetter2014, author = {Al-Kaidy, H. and Ulber, R. and Tippk{\"o}tter, Nils}, title = {A platform technology for the automated reaction control in magnetizable micro-fluidic droplets}, series = {Biomaterials - made in bioreactors : book of abstracts, May 26 - 28, 2014, Radisson Blu Park Hotel and Conference Dentre, Radebeul, Germany}, booktitle = {Biomaterials - made in bioreactors : book of abstracts, May 26 - 28, 2014, Radisson Blu Park Hotel and Conference Dentre, Radebeul, Germany}, publisher = {DECHEMA}, address = {Frankfurt am Main}, pages = {21 -- 22}, year = {2014}, language = {en} } @misc{AlKaidyTippkoetterUlber2014, author = {Al-Kaidy, Huschyar and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Vorrichtung und Verfahren zur Bestimmung des Kontaktwinkels eines fl{\"u}ssigen oder mit Fl{\"u}ssigkeit gef{\"u}llten K{\"o}rpers [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt}, address = {M{\"u}nchen}, pages = {13 Seiten}, year = {2014}, abstract = {Die vorliegende Erfindung betrifft eine Vorrichtung und ein Verfahren zur Bestimmung des Kontaktwinkels eines fl{\"u}ssigen oder mit Fl{\"u}ssigkeit gef{\"u}llten K{\"o}rpers. Dieser besteht aus einem Tr{\"a}ger (1) und einer damit verbundenen, in einem Winkelbereich von mehr als 0° bis maximal 90° neigbaren Ebene (8) mit einer darin ausgebildeten Abrollbahn (9) f{\"u}r den fl{\"u}ssigen oder mit Fl{\"u}ssigkeit gef{\"u}llten K{\"o}rper. An der Ebene (8) sind mehrere Sensoren (11, 12) zur Erfassung der Rolldauer des K{\"o}rpers entlang der Rollstrecke angeordnet. Erfindungsgem{\"a}ß ist vorgesehen, dass die Einstellung des Neigungswinkels der Ebene (8) {\"u}ber ein Winkelmessger{\"a}t (10) erfolgt, wodurch ein Abrollwinkel erfassbar ist, bei dem der K{\"o}rper in Bewegung ger{\"a}t. Aus der Rolldauer, der Rollstrecke und dem Abrollwinkel wird der Kontaktwinkel des K{\"o}rpers ermittelt.}, language = {de} } @article{TippkoetterDuweWiesenetal.2014, author = {Tippk{\"o}tter, Nils and Duwe, Anna-Maria and Wiesen, Sebastian and Sieker, Tim and Ulber, Roland}, title = {Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids}, series = {Bioresource Technology}, volume = {167}, journal = {Bioresource Technology}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.biortech.2014.06.052}, pages = {447 -- 455}, year = {2014}, abstract = {The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10\% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9\%, 17\% and 23\% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17\% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23\% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹.}, language = {en} } @article{AlKaidyDuweHusteretal.2014, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Sieker, Tim and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnologie und Bioverfahrenstechnik - Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {12}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201400083}, pages = {2215 -- 2225}, year = {2014}, abstract = {Biotechnologie und die mit ihr verbundenen technischen Prozesse pr{\"a}gen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und t{\"a}glichen Gebrauchsg{\"u}tern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verst{\"a}ndnis zellul{\"a}rer Vorg{\"a}nge k{\"o}nnen mittlerweile Produktionsst{\"a}mme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik k{\"o}nnen so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.}, language = {de} } @article{WiesenTippkoetterMuffleretal.2014, author = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Nils and Ulber, Roland}, title = {Adsorptive Vorbehandlung von Rohglycerin f{\"u}r die 1,3-Propandiol Fermentation mit Clostridium diolis}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {1-2}, publisher = {Wiley-VCH}, address = {Weinheim}, doi = {10.1002/cite.201300080}, pages = {129 -- 135}, year = {2014}, abstract = {Bei der Gewinnung von Fetts{\"a}uren aus Pflanzen{\"o}len, z. B. zur Herstellung von Biopolymeren, oder bei der Biodiesel- und Seifenproduktion, f{\"a}llt Glycerin als Nebenprodukt an. Bei der Biokonversion dieses Rohstoffes zu 1,3-Propandiol wird der Produktionsorganismus Clostridium diolis durch Verunreinigungen im Rohglycerin gehemmt. Als inhibierende Substanzen konnten freie Fetts{\"a}uren identifiziert werden. Mithilfe eines adsorptiven Aufarbeitungsverfahrens ist es gelungen, die Fetts{\"a}uren zu entfernen und die Konversionseffizienz zu 1,3-Propandiol zu erh{\"o}hen.}, language = {de} } @article{TippkoetterWollnySucketal.2014, author = {Tippk{\"o}tter, Nils and Wollny, Steffen and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense}, series = {Engineering in Life Sciences}, volume = {14}, journal = {Engineering in Life Sciences}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1618-2863}, doi = {10.1002/elsc.201300113}, pages = {425 -- 432}, year = {2014}, abstract = {A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.}, language = {en} } @article{PasteurTippkoetterKampeisetal.2014, author = {Pasteur, Aline and Tippk{\"o}tter, Nils and Kampeis, Percy and Ulber, Roland}, title = {Optimization of high gradient magnetic separation filter units for the purification of fermentation products}, series = {IEEE TRANSACTIONS ON MAGNETICS}, volume = {50}, journal = {IEEE TRANSACTIONS ON MAGNETICS}, number = {10}, publisher = {IEEE}, address = {New York, NY}, issn = {0018-9464}, doi = {10.1109/TMAG.2014.2325535}, pages = {Artikel 5000607}, year = {2014}, abstract = {High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments.}, language = {en} } @book{SchulteZurhausen2014, author = {Schulte-Zurhausen, Manfred}, title = {Organisation}, edition = {6., {\"u}berarb. und aktualisierte Aufl.}, publisher = {Vahlen}, address = {M{\"u}nchen}, isbn = {978-3-8006-4689-0}, pages = {XVI, 687 S. : graph. Darst.}, year = {2014}, language = {de} } @inproceedings{SchirraBauschatWatmuff2014, author = {Schirra, Julian and Bauschat, J.-Michael and Watmuff, J.H.}, title = {Accurate induced drag prediction for highly non-planar lifting systems}, series = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, booktitle = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, pages = {4 Seiten}, year = {2014}, abstract = {The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved.}, language = {en} }