@article{Golland2022,
  author    = {Golland, Alexander},
  title     = {Aufsicht und Rechtsdurchsetzung bei unzul{\"a}ssigem Einsatz von Cookies \& Co. unter Geltung des TTDSG},
  series = {DSB Datenschutz-Berater},
  volume    = {46},
  journal   = {DSB Datenschutz-Berater},
  number    = {1},
  publisher = {Deutscher Fachverlag GmbH},
  address   = {Frankfurt a.M.},
  isbn      = {0170-7256},
  pages     = {14 -- 16},
  year      = {2022},
  language  = {de}
}
@article{PoettgenEdererAltherretal.2015,
  author    = {P{\"o}ttgen, Philipp and Ederer, Thorsten and Altherr, Lena and Pelz, Peter F.},
  title     = {Developing a control strategy for booster stations under uncertain load},
  series = {Applied Mechanics and Materials},
  volume    = {807},
  journal   = {Applied Mechanics and Materials},
  number    = {807},
  publisher = {Trans Tech Publications},
  address   = {B{\"a}ch},
  isbn      = {1662-7482},
  doi       = {10.4028/www.scientific.net/AMM.807.241},
  pages     = {241 -- 246},
  year      = {2015},
  abstract  = {Booster stations can fulfill a varying pressure demand with high energy-efficiency, because individual pumps can be deactivated at smaller loads. Although this is a seemingly simple approach, it is not easy to decide precisely when to activate or deactivate pumps. Contemporary activation controls derive the switching points from the current volume flow through the system. However, it is not measured directly for various reasons. Instead, the controller estimates the flow based on other system properties. This causes further uncertainty for the switching decision. In this paper, we present a method to find a robust, yet energy-efficient activation strategy.},
  language  = {en}
}
@article{AltherrEdererPoettgenetal.2015,
  author    = {Altherr, Lena and Ederer, Thorsten and P{\"o}ttgen, Philipp and Lorenz, Ulf and Pelz, Peter F.},
  title     = {Multicriterial optimization of technical systems considering multiple load and availability scenarios},
  series = {Applied Mechanics and Materials},
  volume    = {807},
  journal   = {Applied Mechanics and Materials},
  editor    = {Pelz, Peter F. and Groche, Peter},
  isbn      = {1660-9336},
  doi       = {10.4028/www.scientific.net/AMM.807.247},
  pages     = {247 -- 256},
  year      = {2015},
  abstract  = {Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.},
  language  = {en}
}
@article{PoettgenEdererAltherretal.2015,
  author    = {P{\"o}ttgen, Philipp and Ederer, Thorsten and Altherr, Lena and Lorenz, Ulf and Pelz, Peter F.},
  title     = {Examination and optimization of a heating circuit for energy-efficient buildings},
  series = {Energy Technology},
  volume    = {4},
  journal   = {Energy Technology},
  number    = {1},
  publisher = {WILEY-VCH Verlag},
  address   = {Weinheim},
  isbn      = {2194-4296},
  doi       = {10.1002/ente.201500252},
  pages     = {136 -- 144},
  year      = {2015},
  abstract  = {The conference center darmstadtium in Darmstadt is a prominent example of energy efficient buildings. Its heating system consists of different source and consumer circuits connected by a Zortstr{\"o}m reservoir. Our goal was to reduce the energy costs of the system as much as possible. Therefore, we analyzed its supply circuits. The first step towards optimization is a complete examination of the system: 1) Compilation of an object list for the system, 2) collection of the characteristic curves of the components, and 3) measurement of the load profiles of the heat and volume-flow demand. Instead of modifying the system manually and testing the solution by simulation, the second step was the creation of a global optimization program. The objective was to minimize the total energy costs for one year. We compare two different topologies and show opportunities for significant savings.},
  language  = {en}
}
@article{VergePoettgenAltherretal.2016,
  author    = {Verg{\´e}, Angela and P{\"o}ttgen, Philipp and Altherr, Lena and Ederer, Thorsten and Pelz, Peter F.},
  title     = {Lebensdauer als Optimierungsziel: Algorithmische Struktursynthese am Beispiel eines hydrostatischen Getriebes},
  series = {O+P - {\"O}lhydraulik und Pneumatik},
  volume    = {60},
  journal   = {O+P - {\"O}lhydraulik und Pneumatik},
  number    = {1-2},
  editor    = {Greuloch, Ivo and Weber, Manfred and Meier, Miles},
  publisher = {Vereinigte Fachverl.},
  address   = {Mainz},
  issn      = {1614-9602},
  pages     = {114 -- 121},
  year      = {2016},
  abstract  = {Verf{\"u}gbarkeit und Nachhaltigkeit sind wichtige Anforderungen bei der Planung langlebiger technischer Systeme. Meist werden bei Lebensdaueroptimierungen lediglich einzelne Komponenten vordefinierter Systeme untersucht. Ob eine optimale Lebensdauer eine g{\"a}nzlich andere Systemvariante bedingt, wird nur selten hinterfragt. Technical Operations Research (TOR) erlaubt es, aus Obermengen technischer Systeme automatisiert die lebensdaueroptimale Systemstruktur auszuw{\"a}hlen. Der Artikel zeigt dies am Beispiel eines hydrostatischen Getriebes.},
  language  = {de}
}
@article{AltherrBroetzDietrichetal.2018,
  author    = {Altherr, Lena and Br{\"o}tz, Nicolas and Dietrich, Ingo and Gally, Tristan and Geßner, Felix and Kloberdanz, Hermann and Leise, Philipp and Pelz, Peter Franz and Schlemmer, Pia and Schmitt, Andreas},
  title     = {Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures},
  series = {Applied Mechanics and Materials},
  volume    = {885},
  journal   = {Applied Mechanics and Materials},
  publisher = {Trans Tech Publications},
  address   = {B{\"a}ch},
  isbn      = {1662-7482},
  doi       = {10.4028/www.scientific.net/AMM.885.187},
  pages     = {187 -- 198},
  year      = {2018},
  abstract  = {Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.},
  language  = {en}
}
@article{AltherrEdererLorenzetal.2014,
  author    = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp},
  title     = {Experimental validation of an enhanced system synthesis approach},
  series = {Operations Research Proceedings 2014},
  journal   = {Operations Research Proceedings 2014},
  editor    = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit},
  publisher = {Springer},
  address   = {Basel},
  isbn      = {978-3-319-28695-2},
  doi       = {10.1007/978-3-319-28697-6_1},
  pages     = {6},
  year      = {2014},
  abstract  = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.},
  language  = {en}
}
@article{GrundlachBaumannEngelmann2021,
  author    = {Grundlach, Michael and Baumann, Martin and Engelmann, Ulrich M.},
  title     = {How Multimodal Examinations Can Increase Sustainable Student Gain by Aligning Teaching and Assessment},
  series = {Current Directions in Biomedical Engineering},
  volume    = {7},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {7/2},
  editor    = {D{\"o}ssel, Olaf},
  publisher = {De Gruyter},
  address   = {Berlin},
  isbn      = {2364-5504},
  doi       = {10.1515/cdbme-2021-2019},
  pages     = {73 -- 76},
  year      = {2021},
  abstract  = {Modern industry and multi-discipline projects require highly trained individuals with resilient science and engineering back-grounds. Graduates must be able to agilely apply excellent theoretical knowledge in their subject matter as well as essential practical "hands-on" knowledge of diverse working processes to solve complex problems. To meet these demands, university education follows the concept of Constructive Alignment and thus increasingly adopts the teaching of necessary practical skills to the actual industry requirements and assessment routines. However, a systematic approach to coherently align these three central teaching demands is strangely absent from current university curricula. We demonstrate the feasibility of implementing practical assessments in a regular theory-based examination, thus defining the term "blended assessment". We assessed a course for natural science and engineering students pursuing a career in biomedical engineering, and evaluated the benefit of blended assessment exams for students and lecturers. Our controlled study assessed the physiological background of electrocardiograms (ECGs), the practical measurement of ECG curves, and their interpretation of basic pathologic alterations. To study on long time effects, students have been assessed on the topic twice with a time lag of 6 months. Our findings suggest a significant improvement in student gain with respect to practical skills and theoretical knowledge. The results of the reassessments support these outcomes. From the lecturers' point of view, blended assessment complements practical training courses while keeping organizational effort manageable. We consider blended assessment a viable tool for providing an improved student gain, industry-ready education format that should be evaluated and established further to prepare university graduates optimally for their future careers.},
  language  = {en}
}
@article{WerfelGuenthnerHapfelmeieretal.2022,
  author    = {Werfel, Stanislas and G{\"u}nthner, Roman and Hapfelmeier, Alexander and Hanssen, Henner and Kotliar, Konstantin and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning},
  series = {Cardiovascular Research},
  volume    = {118},
  journal   = {Cardiovascular Research},
  number    = {2},
  editor    = {Guzik, Tomasz J.},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {0008-6363},
  doi       = {10.1093/cvr/cvab040},
  pages     = {612 -- 621},
  year      = {2022},
  abstract  = {Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2021,
  author    = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  number    = {12},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2021.690183},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.},
  language  = {en}
}
@article{KuertenKotliarFuestetal.2021,
  author    = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas},
  title     = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study},
  series = {International Ophthalmology},
  volume    = {41},
  journal   = {International Ophthalmology},
  number    = {41},
  editor    = {Neri, Piergiorgio},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1573-2630},
  doi       = {10.1007/s10792-021-01876-0},
  pages     = {3109 -- 3119},
  year      = {2021},
  abstract  = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.},
  language  = {en}
}
@article{SunAltherrPeietal.2018,
  author    = {Sun, Hui and Altherr, Lena and Pei, Ji and Pelz, Peter F. and Yuan, Shouqi},
  title     = {Optimal booster station design and operation under uncertain load},
  series = {Applied Mechanics and Materials},
  volume    = {885},
  journal   = {Applied Mechanics and Materials},
  publisher = {Trans Tech Publications},
  address   = {B{\"a}ch},
  issn      = {1662-7482},
  doi       = {10.4028/www.scientific.net/AMM.885.102},
  pages     = {102 -- 115},
  year      = {2018},
  abstract  = {Given industrial applications, the costs for the operation and maintenance of a pump system typically far exceed its purchase price. For finding an optimal pump configuration which minimizes not only investment, but life-cycle costs, methods like Technical Operations Research which is based on Mixed-Integer Programming can be applied. However, during the planning phase, the designer is often faced with uncertain input data, e.g. future load demands can only be estimated. In this work, we deal with this uncertainty by developing a chance-constrained two-stage (CCTS) stochastic program. The design and operation of a booster station working under uncertain load demand are optimized to minimize total cost including purchase price, operation cost incurred by energy consumption and penalty cost resulting from water shortage. We find optimized system layouts using a sample average approximation (SAA) algorithm, and analyze the results for different risk levels of water shortage. By adjusting the risk level, the costs and performance range of the system can be balanced, and thus the system's resilience can be engineered},
  language  = {en}
}
@article{AltherrJoggerstLeiseetal.2018,
  author    = {Altherr, Lena and Joggerst, Laura and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas and Wendt, Janine},
  title     = {On obligations in the development process of resilient systems with algorithmic design methods},
  series = {Applied Mechanics and Materials},
  volume    = {885},
  journal   = {Applied Mechanics and Materials},
  number    = {885},
  publisher = {Trans Tech Publications},
  address   = {B{\"a}ch},
  isbn      = {1662-7482},
  doi       = {10.4028/www.scientific.net/AMM.885.240},
  pages     = {240 -- 252},
  year      = {2018},
  abstract  = {Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer's product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.},
  language  = {en}
}
@article{AltherrEdererPfetschetal.2018,
  author    = {Altherr, Lena and Ederer, Thorsten and Pfetsch, Marc E. and Pelz, Peter F.},
  title     = {Maschinelles Design eines optimalen Getriebes},
  series = {ATZ - Automobiltechnische Zeitschrift},
  volume    = {120},
  journal   = {ATZ - Automobiltechnische Zeitschrift},
  number    = {10},
  publisher = {Springer Nature},
  address   = {Cham},
  isbn      = {2192-8800},
  doi       = {10.1007/s35148-018-0131-3},
  pages     = {72 -- 77},
  year      = {2018},
  abstract  = {Nahezu 100.000 denkbare Strukturen kann ein Getriebe bei gleicher Funktion aufweisen - je nach Ganganzahl und gefordertem Freiheitsgrad. Mit dem traditionellen Ansatz bei der Entwicklung, einzelne vielversprechende Systemkonfigurationen manuell zu identifizieren und zu vergleichen, k{\"o}nnen leicht innovative und vor allem kostenminimale L{\"o}sungen {\"u}bersehen werden. Im Rahmen eines Forschungsprojekts hat die TU Darmstadt spezielle Optimierungsmethoden angewendet, um auch bei großen L{\"o}sungsr{\"a}umen zielsicher ein f{\"u}r die individuellen Zielstellungen optimales Layout zu finden.},
  language  = {de}
}
@article{RauschFriesenAltherretal.2018,
  author    = {Rausch, Lea and Friesen, John and Altherr, Lena and Meck, Marvin and Pelz, Peter F.},
  title     = {A holistic concept to design optimal water supply infrastructures for informal settlements using remote sensing data},
  series = {Remote Sensing},
  volume    = {10},
  journal   = {Remote Sensing},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  isbn      = {2072-4292},
  doi       = {10.3390/rs10020216},
  pages     = {1 -- 23},
  year      = {2018},
  abstract  = {Ensuring access to water and sanitation for all is Goal No. 6 of the 17 UN Sustainability Development Goals to transform our world. As one step towards this goal, we present an approach that leverages remote sensing data to plan optimal water supply networks for informal urban settlements. The concept focuses on slums within large urban areas, which are often characterized by a lack of an appropriate water supply. We apply methods of mathematical optimization aiming to find a network describing the optimal supply infrastructure. Hereby, we choose between different decentral and central approaches combining supply by motorized vehicles with supply by pipe systems. For the purposes of illustration, we apply the approach to two small slum clusters in Dhaka and Dar es Salaam. We show our optimization results, which represent the lowest cost water supply systems possible. Additionally, we compare the optimal solutions of the two clusters (also for varying input parameters, such as population densities and slum size development over time) and describe how the result of the optimization depends on the entered remote sensing data.},
  language  = {en}
}
@article{LeiseEsserEichenlaubetal.2021,
  author    = {Leise, Philipp and Eßer, Arved and Eichenlaub, Tobias and Schleiffer, Jean-Eric and Altherr, Lena and Rinderknecht, Stephan and Pelz, Peter F.},
  title     = {Sustainable system design of electric powertrains - comparison of optimization methods},
  series = {Engineering Optimization},
  journal   = {Engineering Optimization},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {0305-215X},
  doi       = {10.1080/0305215X.2021.1928660},
  year      = {2021},
  abstract  = {The transition within transportation towards battery electric vehicles can lead to a more sustainable future. To account for the development goal 'climate action' stated by the United Nations, it is mandatory, within the conceptual design phase, to derive energy-efficient system designs. One barrier is the uncertainty of the driving behaviour within the usage phase. This uncertainty is often addressed by using a stochastic synthesis process to derive representative driving cycles and by using cycle-based optimization. To deal with this uncertainty, a new approach based on a stochastic optimization program is presented. This leads to an optimization model that is solved with an exact solver. It is compared to a system design approach based on driving cycles and a genetic algorithm solver. Both approaches are applied to find efficient electric powertrains with fixed-speed and multi-speed transmissions. Hence, the similarities, differences and respective advantages of each optimization procedure are discussed.},
  language  = {en}
}
@article{ZabirovSchleserBucherer2021,
  author    = {Zabirov, Alexander and Schleser, Markus and Bucherer, Sebastian},
  title     = {F{\"u}ge- und Dichtkonzept f{\"u}r einen Leichtbauverbrennungsmotor},
  series = {adh{\"a}sion KLEBEN \& DICHTEN},
  volume    = {65},
  journal   = {adh{\"a}sion KLEBEN \& DICHTEN},
  number    = {11},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {2192-8681},
  doi       = {10.1007/s35145-021-0531-5},
  pages     = {12 -- 19},
  year      = {2021},
  language  = {de}
}
@article{AltherrLeisePfetschetal.2018,
  author    = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas},
  title     = {Algorithmic design and resilience assessment of energy efficient high-rise water supply systems},
  series = {Applied Mechanics and Materials},
  volume    = {885},
  journal   = {Applied Mechanics and Materials},
  publisher = {Trans Tech Publications},
  address   = {B{\"a}ch},
  issn      = {1662-7482},
  doi       = {10.4028/www.scientific.net/AMM.885.211},
  pages     = {211 -- 223},
  year      = {2018},
  abstract  = {High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.},
  language  = {en}
}
@article{MuellerLeiseLorenzetal.2020,
  author    = {M{\"u}ller, Tim M. and Leise, Philipp and Lorenz, Imke-Sophie and Altherr, Lena and Pelz, Peter F.},
  title     = {Optimization and validation of pumping system design and operation for water supply in high-rise buildings},
  series = {Optimization and Engineering},
  volume    = {2021},
  journal   = {Optimization and Engineering},
  number    = {22},
  publisher = {Springer},
  issn      = {1573-2924},
  doi       = {10.1007/s11081-020-09553-4},
  pages     = {643 -- 686},
  year      = {2020},
  abstract  = {The application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps' characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer's point of view, keeping in mind the economically important trade-off between investment and operation costs.},
  language  = {en}
}
@article{HeinEubanksLingametal.2022,
  author    = {Hein, Andreas M. and Eubanks, T. Marshall and Lingam, Manasvi and Hibberd, Adam and Fries, Dan and Schneider, Jean and Kervella, Pierre and Kennedy, Robert and Perakis, Nikolaos and Dachwald, Bernd},
  title     = {Interstellar now! Missions to explore nearby interstellar objects},
  series = {Advances in Space Research},
  volume    = {69},
  journal   = {Advances in Space Research},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0273-1177},
  doi       = {10.1016/j.asr.2021.06.052},
  pages     = {402 -- 414},
  year      = {2022},
  abstract  = {The recently discovered first hyperbolic objects passing through the Solar System, 1I/'Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.},
  language  = {en}
}
@article{KezerashviliDachwald2021,
  author    = {Kezerashvili, Roman Ya and Dachwald, Bernd},
  title     = {Preface: Solar sailing: Concepts, technology, and missions II},
  series = {Advances in Space Research},
  volume    = {67},
  journal   = {Advances in Space Research},
  number    = {9},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0273-1177},
  doi       = {10.1016/j.asr.2021.01.037},
  pages     = {2559 -- 2560},
  year      = {2021},
  language  = {en}
}
@article{SpietzSproewitzSeefeldtetal.2021,
  author    = {Spietz, Peter and Spr{\"o}witz, Tom and Seefeldt, Patric and Grundmann, Jan Thimo and Jahnke, Rico and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Reershemius, Siebo and Renger, Thomas and Ruffer, Michael and Sasaki, Kaname and Sznajder, Maciej and T{\´o}th, Norbert and Ceriotti, Matteo and Dachwald, Bernd and Macdonald, Malcolm and McInnes, Colin and Seboldt, Wolfgang and Quantius, Dominik and Bauer, Waldemar and Wiedemann, Carsten and Grimm, Christian D. and Hercik, David and Ho, Tra-Mi and Lange, Caroline and Schmitz, Nicole},
  title     = {Paths not taken - The Gossamer roadmap's other options},
  series = {Advances in Space Research},
  volume    = {67},
  journal   = {Advances in Space Research},
  number    = {9},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0273-1177},
  doi       = {10.1016/j.asr.2021.01.044},
  pages     = {2912 -- 2956},
  year      = {2021},
  language  = {en}
}
@article{GermanMikuckiWelchetal.2021,
  author    = {German, Laura and Mikucki, Jill A. and Welch, Susan A. and Welch, Kathleen A. and Lutton, Anthony and Dachwald, Bernd and Kowalski, Julia and Heinen, Dirk and Feldmann, Marco and Francke, Gero and Espe, Clemens and Lyons, W. Berry},
  title     = {Validation of sampling antarctic subglacial hypersaline waters with an electrothermal ice melting probe (IceMole) for environmental analytical geochemistry},
  series = {International Journal of Environmental Analytical Chemistry},
  volume    = {101},
  journal   = {International Journal of Environmental Analytical Chemistry},
  number    = {15},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {0306-7319},
  doi       = {10.1080/03067319.2019.1704750},
  pages     = {2654 -- 2667},
  year      = {2021},
  abstract  = {Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe's sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2-+NO3- from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica.},
  language  = {en}
}
@article{HeiligersSchoutetensDachwald2021,
  author    = {Heiligers, Jeannette and Schoutetens, Frederic and Dachwald, Bernd},
  title     = {Photon-sail equilibria in the alpha centauri system},
  series = {Journal of Guidance, Control, and Dynamics},
  volume    = {44},
  journal   = {Journal of Guidance, Control, and Dynamics},
  number    = {5},
  issn      = {1533-3884},
  doi       = {10.2514/1.G005446},
  pages     = {1053 -- 1061},
  year      = {2021},
  language  = {en}
}
@article{HunkerGossmannRamanetal.2021,
  author    = {Hunker, Jan L. and Gossmann, Matthias and Raman, Aravind Hariharan and Linder, Peter},
  title     = {Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {111},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article number 107044},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {1056-8719},
  doi       = {10.1016/j.vascn.2021.107044},
  year      = {2021},
  language  = {en}
}
@article{TemizArtmannKurulgandemirciFıratetal.2021,
  author    = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard},
  title     = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers},
  series = {SHOCK},
  journal   = {SHOCK},
  publisher = {Wolters Kluwer},
  address   = {K{\"o}ln},
  issn      = {1540-0514},
  doi       = {10.1097/SHK.0000000000001845},
  year      = {2021},
  language  = {en}
}
@article{HeinkeKnickerAlbracht2021,
  author    = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten},
  title     = {Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men},
  series = {Journal of Electromyography and Kinesiology},
  volume    = {62},
  journal   = {Journal of Electromyography and Kinesiology},
  number    = {Article 102611},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1050-6411},
  doi       = {10.1016/j.jelekin.2021.102611},
  year      = {2021},
  abstract  = {Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall "good" relative reliability. SRD 95\% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended.},
  language  = {en}
}
@article{KlettkeHomburgGell2015,
  author    = {Klettke, Tanja and Homburg, Carsten and Gell, Sebastian},
  title     = {How to measure analyst forecast effort},
  series = {European Accounting Review},
  volume    = {24},
  journal   = {European Accounting Review},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {0963-8180},
  doi       = {10.1080/09638180.2014.909291},
  pages     = {129 -- 146},
  year      = {2015},
  abstract  = {We introduce a new way to measure the forecast effort that analysts devote to their earnings forecasts by measuring the analyst's general effort for all covered firms. While the commonly applied effort measure is based on analyst behaviour for one firm, our measure considers analyst behaviour for all covered firms. Our general effort measure captures additional information about analyst effort and thus can identify accurate forecasts. We emphasise the importance of investigating analyst behaviour in a larger context and argue that analysts who generally devote substantial forecast effort are also likely to devote substantial effort to a specific firm, even if this effort might not be captured by a firm-specific measure. Empirical results reveal that analysts who devote higher general forecast effort issue more accurate forecasts. Additional investigations show that analysts' career prospects improve with higher general forecast effort. Our measure improves on existing methods as it has higher explanatory power regarding differences in forecast accuracy than the commonly applied effort measure. Additionally, it can address research questions that cannot be examined with a firm-specific measure. It provides a simple but comprehensive way to identify accurate analysts.},
  language  = {en}
}
@article{JungStaat2020,
  author    = {Jung, Alexander and Staat, Manfred},
  title     = {Erratum to "Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue" [GAMM-Mitteilungen, (2019), 42, 4, 10.1002/gamm.201900002]},
  series = {GAMM-Mitteilungen},
  volume    = {43},
  journal   = {GAMM-Mitteilungen},
  number    = {4},
  publisher = {Wiley-VCH GmbH},
  address   = {Weinheim},
  issn      = {1522-2608},
  doi       = {10.1002/gamm.202000011},
  year      = {2020},
  language  = {en}
}
@article{Timme2021,
  author    = {Timme, Michael},
  title     = {Rechtsprechungs{\"u}bersicht zum Wohnraummietrecht},
  series = {Monatsschrift f{\"u}r Deutsches Recht},
  volume    = {75},
  journal   = {Monatsschrift f{\"u}r Deutsches Recht},
  number    = {1},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  issn      = {2194-4202},
  doi       = {10.9785/mdtr-2021-750113},
  pages     = {6 -- 11},
  year      = {2021},
  language  = {de}
}
@article{BraunChengDoweyetal.2021,
  author    = {Braun, Sebastian and Cheng, Chi-Tsun and Dowey, Steve and Wollert, J{\"o}rg},
  title     = {Performance evaluation of skill-based order-assignment in production environments with multi-agent systems},
  series = {IEEE Journal of Emerging and Selected Topics in Industrial Electronics},
  journal   = {IEEE Journal of Emerging and Selected Topics in Industrial Electronics},
  number    = {Early Access},
  publisher = {IEEE},
  address   = {New York},
  issn      = {2687-9735},
  doi       = {10.1109/JESTIE.2021.3108524},
  year      = {2021},
  abstract  = {The fourth industrial revolution introduces disruptive technologies to production environments. One of these technologies are multi-agent systems (MASs), where agents virtualize machines. However, the agent's actual performances in production environments can hardly be estimated as most research has been focusing on isolated projects and specific scenarios. We address this gap by implementing a highly connected and configurable reference model with quantifiable key performance indicators (KPIs) for production scheduling and routing in single-piece workflows. Furthermore, we propose an algorithm to optimize the search of extrema in highly connected distributed systems. The benefits, limits, and drawbacks of MASs and their performances are evaluated extensively by event-based simulations against the introduced model, which acts as a benchmark. Even though the performance of the proposed MAS is, on average, slightly lower than the reference system, the increased flexibility allows it to find new solutions and deliver improved factory-planning outcomes. Our MAS shows an emerging behavior by using flexible production techniques to correct errors and compensate for bottlenecks. This increased flexibility offers substantial improvement potential. The general model in this paper allows the transfer of the results to estimate real systems or other models.},
  language  = {en}
}
@article{Olbertz2021,
  author    = {Olbertz, Klaus},
  title     = {Vertragsgestaltungen bei der Besch{\"a}ftigung von Rentnern in Unternehmen : (Befristete) Besch{\"a}ftigungsverh{\"a}ltnisse als sinnvolles Instrument zum Schließen von Personall{\"u}cken},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {25},
  issn      = {0028-3460},
  pages     = {1810 -- 1817},
  year      = {2021},
  language  = {de}
}
@article{Olbertz2021,
  author    = {Olbertz, Klaus},
  title     = {Die Flexibilisierung von Arbeitszeit durch den Abruf von Arbeit : M{\"o}glichkeiten und Grenzen arbeitsvertraglicher Gestaltung zur Vermeidung von „Leerlaufzeiten"},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {15},
  issn      = {0028-3460},
  pages     = {1055 -- 1063},
  year      = {2021},
  abstract  = {Die Arbeitswelt ist im Umbruch. Der Bedarf an flexiblen Arbeitszeitmodellen nimmt stetig zu, wobei die Corona-Pandemie dieses Bed{\"u}rfnis nochmals versch{\"a}rft hat. Gerade auch in kleineren und mittleren Unternehmen w{\"a}chst die Notwendigkeit, den Einsatz der Besch{\"a}ftigten m{\"o}glichst bedarfsgerecht zu steuern, also bei guter Auftragslage mehr Arbeitszeit abzurufen und bei ausbleibenden Auftr{\"a}gen die Arbeitszeit zu reduzieren und somit bezahlte „Leerlaufzeiten" zu vermeiden. Der Gesetzgeber stellt den Arbeitgebern hierf{\"u}r das Instrument der sog. Abrufarbeit ( \S 12 Teilzeit- und Befristungsgesetz - TzBfG ) zur Verf{\"u}gung. In dem nachfolgenden Beitrag werden M{\"o}glichkeiten und Grenzen der Abrufarbeit skizziert und konkrete arbeitsvertragliche Gestaltungsm{\"o}glichkeiten aufgezeigt.},
  language  = {de}
}
@article{Olbertz2021,
  author    = {Olbertz, Klaus},
  title     = {Wichtige arbeitsrechtliche Entwicklungen im Jahr 2020 : Der Jahresr{\"u}ckblick auf alles Wissenswerte im Arbeitsrecht des vergangenen Jahres},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {10},
  issn      = {0028-3460},
  pages     = {703 -- 715},
  year      = {2021},
  abstract  = {Im Anschluss an die arbeitsrechtlichen Jahres{\"u}bersichten der vergangenen Jahre (NWB 5/2019 S. 266; NWB 8/2020 S. 557) gibt der nachfolgende Beitrag einen {\"U}berblick {\"u}ber relevante Entwicklungen im Arbeitsrecht des Jahres 2020. Der erste Teil besch{\"a}ftigt sich hierbei mit gesetzlichen {\"A}nderungen. Neben Regelungen, die auf die COVID-19-Pandemie zur{\"u}ckgef{\"u}hrt werden k{\"o}nnen, hat der Gesetzgeber auch andere Vorhaben umgesetzt. So wurde u. a. das Arbeitnehmerentsenderecht reformiert. F{\"u}r Diskussionen sorgt(e) zudem das Gesetzesvorhaben zur Regelung mobiler Arbeit. Im zweiten Teil werden f{\"u}r die Praxis wichtige h{\"o}chstrichterliche Gerichtsentscheidungen zum Arbeitsrecht erl{\"a}utert, alphabetisch sortiert von A (wie Antidiskriminierungsrecht) bis U (wie Urlaub).},
  language  = {de}
}
@article{Olbertz2021,
  author    = {Olbertz, Klaus},
  title     = {Die Dienstreisezeit als Arbeitszeit - oder doch nicht? : Zur arbeitgeberfreundlichen Bewertung von Dienstreisezeiten durch das Bundesarbeitsgericht},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {1},
  issn      = {0028-3460},
  pages     = {38 -- 44},
  year      = {2021},
  abstract  = {Der arbeitsrechtlich richtige Umgang mit Zeiten einer Dienstreise kann in der betrieblichen Praxis Probleme bereiten. Ob die Reisezeiten als solche Arbeitszeit i. S. des Arbeitszeitgesetzes (ArbZG ) darstellen, also bspw. auf die t{\"a}gliche H{\"o}chstarbeitszeit angerechnet werden m{\"u}ssen oder nicht, ist oftmals genauso unklar wie die Frage, ob und inwieweit Reisezeiten verg{\"u}tungspflichtig sind. Aber auch, ob ein Arbeitnehmer {\"u}berhaupt zur Durchf{\"u}hrung einer Dienstreise verpflichtet werden kann, ist ein m{\"o}glicher Anlass von Streitigkeiten zwischen den Arbeitsvertragsparteien, wie verschiedene Gerichtsentscheidungen zeigen. Der nachfolgende Beitrag beantwortet die aufgeworfenen Fragen und gibt hierzu einen praxisorientierten {\"U}berblick.},
  language  = {de}
}
@article{Olbertz2020,
  author    = {Olbertz, Klaus},
  title     = {Wenn der „leitende" Angestellte doch nur ein „normaler" Arbeitnehmer ist ... : Zur Rechtsstellung leitender Angestellter, zu Fehleinsch{\"a}tzungen des Arbeitgebers und Praxishinweisen},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {32},
  publisher = {NWB-Verl.},
  address   = {Herne},
  issn      = {0028-3460},
  pages     = {2397 -- 2406},
  year      = {2020},
  language  = {de}
}
@article{Olbertz2020,
  author    = {Olbertz, Klaus},
  title     = {GmbH-Gesch{\"a}ftsf{\"u}hrer: das eine Mal Arbeitnehmer, das andere Mal nicht : Arbeits- und sozialrechtliche Anwendung von Schutzvorschriften auf den Gesch{\"a}ftsf{\"u}hrer von A bis Z},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {19},
  publisher = {NWB-Verl.},
  address   = {Herne},
  issn      = {0028-3460},
  pages     = {1431 -- 1441},
  year      = {2020},
  language  = {de}
}
@article{Olbertz2020,
  author    = {Olbertz, Klaus},
  title     = {Jahresr{\"u}ckblick Arbeitsrecht 2019 : Gesetzes{\"a}nderungen und insbesondere im Zeichen des Befristungs- und Urlaubsrechts stehende h{\"o}chstrichterliche Rechtsprechung},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {8},
  publisher = {NWB-Verl.},
  address   = {Herne},
  issn      = {0028-3460},
  pages     = {557 -- 569},
  year      = {2020},
  abstract  = {In Fortschreibung des Jahresr{\"u}ckblicks 2018 (Olbertz, NWB 5/2019 S. 266 ) skizziert der vorliegende Beitrag die j{\"u}ngsten nennenswerten Entwicklungen im Arbeitsrecht des Jahres 2019. Im Bereich der Gesetzgebung, mit dem sich der erste Teil des Beitrags befasst, betrifft dies etwa das Fachkr{\"a}fteeinwanderungsgesetz, die angestoßenen Schutzvorschriften f{\"u}r Whistleblower oder das gesetzlich verankerte Recht auf Br{\"u}ckenteilzeit. In der arbeitsrechtlichen h{\"o}chstrichterlichen Rechtsprechung stand das Jahr 2019 insbesondere im Zeichen des Befristungs- und des Urlaubsrechts. Was hier und dar{\"u}ber hinaus wegweisend war, zeigt der zweite Teil des Beitrags.},
  language  = {de}
}
@article{Olbertz2019,
  author    = {Olbertz, Klaus},
  title     = {Die arbeitsvertragliche Vereinbarung von Vertragsstrafen : Anforderungen an wirksame Vertragsstrafenabreden in Formulararbeitsvertr{\"a}gen beachten},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {45},
  issn      = {0028-3460},
  pages     = {3302 -- 3308},
  year      = {2019},
  language  = {de}
}
@article{Olbertz2019,
  author    = {Olbertz, Klaus},
  title     = {Die Optionen des Arbeitgebers nach Krankmeldung des Arbeitnehmers : Ein {\"U}berblick {\"u}ber die Rechte und Pflichten des Arbeitgebers bei Arbeitsunf{\"a}higkeit des Mitarbeiters},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {30},
  issn      = {0028-3460},
  pages     = {2222 -- 2229},
  year      = {2019},
  language  = {de}
}
@article{Olbertz2019,
  author    = {Olbertz, Klaus},
  title     = {Rechtssichere Vereinbarungen von K{\"u}ndigungsfristen im Arbeitsvertrag : Weitestgehende Abdingbarkeit gesetzlicher Vorgaben erm{\"o}glicht passgenaue Gestaltungen},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {23},
  issn      = {0028-3460},
  pages     = {1693 -- 1699},
  year      = {2019},
  language  = {de}
}
@article{Olbertz2019,
  author    = {Olbertz, Klaus},
  title     = {Auslandsentsendungen im arbeitsrechtlichen Zusammenhang : Ausgestaltung eines Entsendungsvertrags und mitbestimmungsrechtliche Aspekte},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {19},
  issn      = {0028-3460},
  pages     = {1400 -- 1406},
  year      = {2019},
  language  = {de}
}
@article{Olbertz2019,
  author    = {Olbertz, Klaus},
  title     = {Arbeitsrechtliche Akzente der Gesetzgebung und Rechtsprechung in 2018 : Ein kurzweiliger R{\"u}ckblick auf das Arbeitsrecht des vergangenen Jahres},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {5},
  issn      = {0028-3460},
  pages     = {266 -- 279},
  year      = {2019},
  language  = {de}
}
@article{HerrmannSchwarzenbartDittmannGabrieletal.2019,
  author    = {Herrmann, Ulf and Schwarzenbart, Marc and Dittmann-Gabriel, S{\"o}ren and May, Martin},
  title     = {Hochtemperatur-W{\"a}rmespeicher f{\"u}r die Strom- und W{\"a}rmewende},
  series = {Solarzeitalter : Politik, Kultur und {\"O}konomie erneuerbarer Energien},
  volume    = {31},
  journal   = {Solarzeitalter : Politik, Kultur und {\"O}konomie erneuerbarer Energien},
  number    = {2},
  issn      = {0937-3802},
  pages     = {18 -- 23},
  year      = {2019},
  language  = {de}
}
@article{MeyerHaenelBeehetal.2020,
  author    = {Meyer, S. and H{\"a}nel, Matthias and Beeh, B. and Dittmann-Gabriel, S{\"o}ren and Dluhosch, R. and May, Martin and Herrmann, Ulf and [und 5 weitere],},
  title     = {Multifunktionaler thermischer Stromspeicher f{\"u}r die Strom- und W{\"a}rmeversorgung der Industrie von morgen},
  series = {ETG Journal / Energietechnische Gesellschaft im VDE (ETG)},
  volume    = {2020},
  journal   = {ETG Journal / Energietechnische Gesellschaft im VDE (ETG)},
  number    = {1},
  issn      = {2625-9907},
  pages     = {6 -- 9},
  year      = {2020},
  language  = {de}
}
@article{HacklBuessKammerlohretal.2021,
  author    = {Hackl, Michael and Buess, Eduard and Kammerlohr, Sandra and Nacov, Julia and Staat, Manfred and Leschinger, Tim and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model},
  series = {The american journal of sports medicine},
  volume    = {49},
  journal   = {The american journal of sports medicine},
  number    = {12},
  publisher = {Sage},
  address   = {London},
  issn      = {1552-3365},
  doi       = {10.1177/03635465211031506},
  pages     = {3212 -- 3217},
  year      = {2021},
  abstract  = {Background: Additional stabilization of the "comma sign" in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair. Purpose: This in vitro investigation aimed to investigate the influence of a comma sign-directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair. Study Design: Controlled laboratory study. Methods: A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups. Results: The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596). Conclusion: The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading. Clinical Relevance: The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.},
  language  = {en}
}
@article{BrockhausBehbahaniMurisetal.2021,
  author    = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.},
  title     = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept},
  series = {Artificial Organs},
  volume    = {45},
  journal   = {Artificial Organs},
  number    = {12},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1525-1594},
  doi       = {10.1111/aor.14046},
  pages     = {1513 -- 1521},
  year      = {2021},
  abstract  = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.},
  language  = {en}
}
@article{NeumaierWeissVeldemanetal.2021,
  author    = {Neumaier, Felix and Weiss, Miriam and Veldeman, Michael and Kotliar, Konstantin and Wiesmann, Martin and Schulze-Steinen, Henna and H{\"o}llig, Anke and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - preliminary findings from an observational cohort study},
  series = {Clinical Neurology and Neurosurgery},
  volume    = {208},
  journal   = {Clinical Neurology and Neurosurgery},
  number    = {Article No.: 106870},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0303-8467},
  doi       = {10.1016/j.clineuro.2021.106870},
  year      = {2021},
  abstract  = {Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.},
  language  = {en}
}
@article{HugenrothBorchardtRitteretal.2021,
  author    = {Hugenroth, Kristin and Borchardt, Ralf and Ritter, Philine and Groß‑Hardt, Sascha and Meyns, Bart and Verbelen, Tom and Steinseifer, Ulrich and Kaufmann, Tim A. S. and Engelmann, Ulrich M.},
  title     = {Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  number    = {Art. No. 16800},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-96397-2},
  pages     = {1 -- 12},
  year      = {2021},
  abstract  = {Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5\% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6\%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.},
  language  = {en}
}
@article{PoghossianSchoening2021,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Recent progress in silicon-based biologically sensitive field-effect devices},
  series = {Current Opinion in Electrochemistry},
  journal   = {Current Opinion in Electrochemistry},
  number    = {Article number: 100811},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2451-9103},
  doi       = {10.1016/j.coelec.2021.100811},
  year      = {2021},
  abstract  = {Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor's recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.},
  language  = {en}
}