@article{Olbertz2016, author = {Olbertz, Klaus}, title = {{\"A}nderung des AGB-Rechts: Erforderliche Anpassung von Arbeitsvertr{\"a}gen - Insbesondere Ausschlussfristen sind betroffen}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {40}, issn = {1860-9449}, pages = {3028 -- 3032}, year = {2016}, abstract = {Der Gesetzgeber hat k{\"u}rzlich eine {\"A}nderung des Rechts der AGB beschlossen. Diese hat f{\"u}r Arbeitgeber zur Folge, dass sie ihre Muster-Arbeitsvertr{\"a}ge anpassen m{\"u}ssen, wenn sie andernfalls drohende wirtschaftliche Nachteile vermeiden wollen. Mit Wirkung zum 1.10.2016 hat der Gesetzgeber \S 309 Nr. 13 BGB neu gefasst. Nach der bisherigen Fassung waren vorformulierte Vertragsbedingungen unwirksam, die Anzeigen oder Erkl{\"a}rungen gegen{\"u}ber dem Vertragspartner an „eine strengere Form als die Schriftform" banden. Seit dem 1.10.2016 sind vorformulierte Vertragsbedingungen unwirksam, die derartige Anzeigen oder Erkl{\"a}rungen an „eine strengere Form als die Textform" binden. Diese gesetzliche Neuregelung wirkt sich maßgeblich auf die Gestaltung von Arbeitsvertr{\"a}gen aus. Dies betrifft insbesondere die in Arbeitsvertr{\"a}gen gebr{\"a}uchlichen Ausschlussfristen.}, language = {de} } @article{Olbertz2016, author = {Olbertz, Klaus}, title = {Die neue EU-Datenschutz-Grundverordnung - Allgemeiner {\"U}berblick und die einzelnen Folgen f{\"u}r den Besch{\"a}ftigtendatenschutz}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {28}, issn = {1860-9449}, pages = {2118 -- 2124}, year = {2016}, abstract = {Nach jahrelangem Ringen haben sich die zust{\"a}ndigen Institutionen der EU auf ein einheitliches Datenschutzgesetz, die Datenschutz-Grundverordnung (DS-GV), geeinigt. Diese ist am 25.5.2016 in Kraft getreten und wird nach einer zweij{\"a}hrigen {\"U}bergangszeit am 25.5.2018 f{\"u}r alle EU-Mitgliedstaaten unmittelbar verbindlich. Verst{\"o}ße hiergegen k{\"o}nnen erhebliche Sanktionen nach sich ziehen. Es drohen Bußgelder von bis zu 20 Mio. € oder bis zu 4 \% des gruppenweiten Jahresumsatzes - je nachdem, welcher Betrag h{\"o}her ist. Die betriebliche Praxis tut also gut daran, sich rechtzeitig mit den neuen Anforderungen zu befassen und diese umzusetzen. Dieser Beitrag gibt einen ersten {\"U}berblick {\"u}ber die sich aus der DS-GV ergebenden Konsequenzen f{\"u}r die betriebliche Praxis im Allgemeinen sowie im Hinblick auf die Datenverarbeitung im Besch{\"a}ftigungskontext im Besonderen.}, language = {de} } @article{Olbertz2017, author = {Olbertz, Klaus}, title = {Auswirkungen des neuen Entgelttransparenzgesetzes - Viel Aufwand f{\"u}r Unternehmen, wenig Greifbares f{\"u}r Arbeitnehmer}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {40}, issn = {1860-9449}, pages = {3068 -- 3075}, year = {2017}, language = {de} } @article{OlbertzGroth2017, author = {Olbertz, Klaus and Groth, Alexandra}, title = {Die Reform des Mutterschutzrechts - {\"U}berblick {\"u}ber die wesentlichen {\"A}nderungen}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {25}, publisher = {NWB Verlag GmbH \& Co. KG}, address = {Herne}, issn = {1860-9449}, pages = {1883 -- 1891}, year = {2017}, language = {de} } @article{OlbertzGroth2016, author = {Olbertz, Klaus and Groth, Alexandra}, title = {Elektrofahrzeuge als Dienstfahrzeuge - Arbeitgeberseitige Gestellung von Elektromobilit{\"a}t und ihre arbeitsvertraglichen Gestaltungserfordernisse}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {50}, issn = {1860-9449}, pages = {3812}, year = {2016}, abstract = {Elektromobilit{\"a}t ist das Thema der Zukunft. Schon jetzt hat es sich die Bundesregierung zur Aufgabe gemacht, hierzulande bis 2030 den Absatz von Elektroautos kontinuierlich auf sechs Mio. Fahrzeuge zu steigern. Und auch die Nachfrage nach Elektrofahrr{\"a}dern steigt zunehmend. Vor allem der derzeit durch den Gesetzgeber gew{\"a}hrte Umweltbonus sowie weitere steuerliche Anreize machen den Einsatz von Elektroautos und -fahrr{\"a}dern als Dienstfahrzeuge auch f{\"u}r Arbeitgeber zunehmend attraktiv. Will der Arbeitgeber seinen Arbeitnehmern Elektrofahrzeuge {\"u}berlassen, stellt sich die Frage nach der Gestaltung der entsprechenden {\"U}berlassungsvertr{\"a}ge. Der nachfolgende Beitrag gibt hierzu einen {\"U}berblick und beinhaltet Formulierungshilfen f{\"u}r die Vertragsgestaltung.}, language = {de} } @article{Olbertz2017, author = {Olbertz, Klaus}, title = {Aufhebungsvertr{\"a}ge und Sperrzeit beim Bezug von Arbeitslosengeld - Neue Gestaltungsm{\"o}glichkeiten aufgrund ge{\"a}nderter Gesch{\"a}ftsanweisung der Bundesagentur f{\"u}r Arbeit}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {21}, issn = {1860-9449}, pages = {1588 -- 1593}, year = {2017}, language = {de} } @article{StefanOlbertz2010, author = {Stefan, Middendorf and Olbertz, Klaus}, title = {Betriebsratswahlen 2010}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {4}, publisher = {NWB-Verlag}, address = {Herne}, issn = {1860-9449}, pages = {290 -- 297}, year = {2010}, abstract = {Die n{\"a}chsten regelm{\"a}ßigen Wahlen zum Betriebsrat (BR) stehen vor der T{\"u}r. Sie finden in der Zeit vom 1.3.2010 bis 31.5.2010 statt. Die Wahlen sind zwar vornehmlich Sache der Arbeitnehmer, allerdings sollten auch die Arbeitgeber darauf achten, dass die Wahlen korrekt ablaufen, schließlich haben die Arbeitgeber die Kosten der Wahlen zu tragen. Kommt es hierbei zu Fehlern, die schlimmstenfalls eine Wiederholung der Wahlen erfordern, hat auch f{\"u}r die hierdurch zus{\"a}tzlich entstehenden Kosten der Arbeitgeber aufzukommen. Zudem bietet die aktive und unterst{\"u}tzende Begleitung der Wahlen f{\"u}r die Arbeitgeber die Chance, die Grundlagen f{\"u}r eine konstruktive Zusammenarbeit mit dem k{\"u}nftigen Betriebsrat zu legen. Der vorliegende Beitrag erl{\"a}utert die wesentlichen Abl{\"a}ufe des Wahlverfahrens sowie die hierbei zwingend zu beachtenden Fristen.}, language = {de} } @article{OlbertzSturm2013, author = {Olbertz, Klaus and Sturm, Nora}, title = {Arbeitsrecht in der Insolvenz - Was gilt, wenn nichts mehr geht?}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {45}, publisher = {NWB Verlag}, address = {Herne}, issn = {1860-9449}, pages = {3552 -- 3559}, year = {2013}, language = {de} } @article{Olbertz2010, author = {Olbertz, Klaus}, title = {Kurzarbeit und betriebsbedingte K{\"u}ndigungen - Wissenswertes f{\"u}r die betriebliche Praxis}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {37}, publisher = {NWB-Verlag}, address = {Herne}, issn = {1860-9449}, pages = {2966 -- 2972}, year = {2010}, abstract = {Kurzarbeit war und ist eines der wesentlichen Elemente der Unternehmen, um dem durch die Finanz- und Wirtschaftskrise begr{\"u}ndeten Arbeitskr{\"a}fte{\"u}berhang begegnen zu k{\"o}nnen. Laut statistischer Mitteilung der Bundesagentur f{\"u}r Arbeit waren im Mai 2009 ca. 1,52 Mio. Arbeitnehmer in Kurzarbeit, im M{\"a}rz 2010 waren es immer noch 830.000 Arbeitnehmer, die Kurzarbeitergeld bezogen haben. Bis Ende 2010 k{\"o}nnen Arbeitgeber Kurzarbeit noch f{\"u}r die verl{\"a}ngerte H{\"o}chstbezugsdauer von bis zu 18 Monaten beantragen. Zudem hat der Bundestag am 8.7.2010 eine nochmalige Verl{\"a}ngerung der Erstattung der Sozialversicherungsbeitr{\"a}ge bis M{\"a}rz 2012 verabschiedet. Trotzdem m{\"u}ssen zahlreiche Arbeitgeber inzwischen feststellen, dass sie allein mit dem Mittel der Kurzarbeit nicht um einen Personalabbau herumkommen. Dies gilt insbesondere f{\"u}r diejenigen Unternehmen, die gleich zu Beginn der Krise im Herbst 2008 Kurzarbeit eingef{\"u}hrt haben und bei denen deshalb die damals noch geltende 24-monatige H{\"o}chstbezugsdauer im Herbst 2010 auslaufen wird}, language = {de} } @article{Olbertz2015, author = {Olbertz, Klaus}, title = {Abschlagsfreie Rente mit 63 - Die wichtigsten Fragestellungen und L{\"o}sungen f{\"u}r die Praxis}, series = {NWB - Steuer- und Wirtschaftsrecht}, journal = {NWB - Steuer- und Wirtschaftsrecht}, number = {15}, publisher = {NWB Verlag}, address = {Herne}, issn = {1860-9449}, pages = {1263 -- 1270}, year = {2015}, language = {de} } @article{KnackstedtEggertGraeweetal.2010, author = {Knackstedt, Ralf and Eggert, Mathias and Gr{\"a}we, Lena and Spittka, Jan}, title = {Forschungsportal f{\"u}r Rechtsinformatik und Informationsrecht - Weg zu einer disziplinen{\"u}bergreifenden Forschungs{\"u}bersicht}, series = {MMR - Multimedia und Recht}, journal = {MMR - Multimedia und Recht}, number = {8}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1434-596X}, pages = {528 -- 533}, year = {2010}, abstract = {Die Entwicklungen der Rechtsinformatik und des Informationsrechts zeigen, dass diese Disziplinen aktuell vor der Herausforderung stehen, eine interdisziplin{\"a}re Zusammenarbeit zwischen ihnen und anderen Disziplinen zu etablieren. Unterschiedliche Publikationskulturen erschweren die Erreichung dieses Ziels. Forschungsportale stellen themenspezifische, internetbasierte Verzeichnisse dar, die bereits vorhandene Informationen strukturiert zug{\"a}nglich machen. Sie k{\"o}nnen die Beziehungen zwischen den Disziplinen f{\"o}rdern, indem sie bereits erzielte Arbeitsergebnisse disziplinen{\"u}bergreifend bekannt machen und dadurch dazu beitragen, Synergiepotenziale und m{\"o}gliche Kooperationspartner zu identifizieren.}, language = {de} } @article{HueningHeuermannWache2018, author = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef}, title = {Wireless CAN}, series = {Etz: Elektrotechnik \& Automation}, volume = {139}, journal = {Etz: Elektrotechnik \& Automation}, number = {10}, publisher = {VDE-Verlag}, address = {Wuppertal}, issn = {0170-1711}, pages = {22 -- 26}, year = {2018}, abstract = {In modernen elektronischen und mechatronischen Systemen, z. B. im industriellen oder automobil Bereich, kommunizieren eingebettete Steuerger{\"a}te und Sensoren vielfach {\"u}ber Bussysteme wie CAN oder LIN. Die Kommunikation findet in der Regel drahtgebunden statt, so dass der Kabelbaum f{\"u}r die Kommunikation sehr groß werden kann. Daher ist es naheliegend, Leitungen und dazugeh{\"o}rige Stecker, z. B. f{\"u}r nicht-sicherheitskritische Komfortsysteme, einzusparen und diese durch gerichtete Funkstrecken f{\"u}r kurze Entfernungen zu ersetzen. Somit k{\"o}nnten Komponenten wie ECUs oder Sensoren kabel- und steckerlos in ein Bussystem integriert werden. Zudem ist eine einfache galvanische und mechanische Trennung zu erreichen. Funk{\"u}bertragung wird bei diesen Bussystemen derzeit nicht eingesetzt, da insbesondere die Echtzeitf{\"a}higkeit und die Robustheit der vorhandenen Funksysteme nicht den Anforderungen der Anwendungen entspricht. Zudem sind bestehende Funksysteme wie WLAN oder Bluetooth im Vergleich zur konventionellen Verkabelung teuer und es besteht hierbei die M{\"o}glichkeit, dass sie ausspioniert werden k{\"o}nnen und so sensible Daten entwendet werden k{\"o}nnen. In dieser Arbeit wird eine alternative Realisierung zu den bestehenden Funksystemen vorgestellt, die aus wenigen Komponenten aufzubauen ist. Es ist eine protokolllose, echtzeitf{\"a}hige {\"U}bertragung m{\"o}glich und somit die transparente Integration in ein Bussystem wie CAN.}, language = {de} } @article{Lind2018, author = {Lind, Thorsten Patric}, title = {Neues zur Gesch{\"a}ftsf{\"u}hrerhaftung nach \S 64 GmbHG - Zugleich Anmerkung zu BGH vom 19.12.2017 - II ZR 88/16, DB 2018 S. 307, und vom 04.07.2017 - II ZR 319/15, DB 2017 S. 1959 -}, series = {Der Betrieb}, journal = {Der Betrieb}, number = {17}, publisher = {Fachmedien Otto Schmidt}, address = {D{\"u}sseldorf}, issn = {0005-9935}, pages = {1003 -- 1008}, year = {2018}, language = {de} } @article{BeckerDelfmannEggertetal.2012, author = {Becker, J{\"o}rg and Delfmann, Patrick and Eggert, Mathias and Schwittay, Sebastian}, title = {Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap}, series = {Business Research : BuR}, volume = {5}, journal = {Business Research : BuR}, number = {2}, publisher = {Springer}, address = {Heidelberg}, issn = {1866-8658}, doi = {10.1007/BF03342739}, pages = {221 -- 247}, year = {2012}, abstract = {With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking.}, language = {en} } @article{EggertKnackstedtFleischeretal.2013, author = {Eggert, Mathias and Knackstedt, Ralf and Fleischer, Stefan and Becker, J{\"o}rg}, title = {The Potential of Configurative Reference Modeling for Business to Government Reporting - A Modeling Technique and its Evaluation}, series = {e-Service Journal}, volume = {9}, journal = {e-Service Journal}, number = {1}, publisher = {Indiana University Press}, address = {Bloomington}, issn = {1528-8234}, pages = {28 -- 59}, year = {2013}, language = {en} } @article{BeverungenEggertVoigtetal.2013, author = {Beverungen, Daniel and Eggert, Mathias and Voigt, Matthias and Rosemann, Michael}, title = {Augmenting Analytical CRM Strategies with Social BI}, series = {International Journal of Business Intelligence Research (IJBIR)}, volume = {4}, journal = {International Journal of Business Intelligence Research (IJBIR)}, number = {3}, publisher = {IGI Global}, address = {Hershey}, issn = {1947-3591}, doi = {10.4018/ijbir.2013070103}, pages = {32 -- 49}, year = {2013}, language = {en} } @article{BeckerDelfmannDietrichetal.2016, author = {Becker, J{\"o}rg and Delfmann, Patrick and Dietrich, Hanns-Alexander and Steinhorst, Matthias and Eggert, Mathias}, title = {Business Process Compliance Checking — Applying and Evaluating a Generic Pattern Matching Approach for Conceptual Models in the Financial Sector}, series = {Information Systems Frontiers}, volume = {18}, journal = {Information Systems Frontiers}, number = {2}, publisher = {Springer}, address = {Berlin}, issn = {1572-9419}, doi = {10.1007/s10796-014-9529-y}, pages = {359 -- 405}, year = {2016}, abstract = {Given the strong increase in regulatory requirements for business processes the management of business process compliance becomes a more and more regarded field in IS research. Several methods have been developed to support compliance checking of conceptual models. However, their focus on distinct modeling languages and mostly linear (i.e., predecessor-successor related) compliance rules may hinder widespread adoption and application in practice. Furthermore, hardly any of them has been evaluated in a real-world setting. We address this issue by applying a generic pattern matching approach for conceptual models to business process compliance checking in the financial sector. It consists of a model query language, a search algorithm and a corresponding modelling tool prototype. It is (1) applicable for all graph-based conceptual modeling languages and (2) for different kinds of compliance rules. Furthermore, based on an applicability check, we (3) evaluate the approach in a financial industry project setting against its relevance for decision support of audit and compliance management tasks.}, language = {en} } @article{BialonskiWellmerElgeretal.2006, author = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus}, title = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis}, series = {Epilepsia}, volume = {47}, journal = {Epilepsia}, issn = {0013-9580}, pages = {36}, year = {2006}, language = {en} } @article{BialonskiLehnertz2006, author = {Bialonski, Stephan and Lehnertz, Klaus}, title = {Identifying phase synchronization clusters in spatially extended dynamical systems}, series = {Physical Review E}, volume = {74}, journal = {Physical Review E}, number = {5}, issn = {2470-0053}, doi = {10.1103/PhysRevE.74.051909}, pages = {051909}, year = {2006}, language = {en} } @article{LehnertzMormannOsterhageetal.2007, author = {Lehnertz, Klaus and Mormann, Florian and Osterhage, Hannes and Andy, M{\"u}ller and Prusseit, Jens and Chernihovskyi, Anton and Staniek, Matth{\"a}us and Krug, Dieter and Bialonski, Stephan and Elger, Christian E.}, title = {State-of-the-art of seizure prediction}, series = {Journal of Clinical Neurophysiology}, volume = {24}, journal = {Journal of Clinical Neurophysiology}, number = {2}, issn = {1537-1603}, doi = {10.1097/WNP.0b013e3180336f16}, pages = {147 -- 153}, year = {2007}, language = {en} } @article{AllefeldBialonski2007, author = {Allefeld, Carsten and Bialonski, Stephan}, title = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains}, series = {Physical Review E}, volume = {76}, journal = {Physical Review E}, number = {6}, issn = {2470-0053}, doi = {10.1103/PhysRevE.76.066207}, pages = {066207}, year = {2007}, language = {en} } @article{BialonskiSchindlerElgeretal.2008, author = {Bialonski, Stephan and Schindler, K. and Elger, C. E. and Lehnertz, Klaus}, title = {Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization?}, series = {Epilepsia}, volume = {49}, journal = {Epilepsia}, issn = {0013-9580}, pages = {11 -- 11}, year = {2008}, abstract = {Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity.}, language = {en} } @article{BialonskiAllefeldWellmeretal.2008, author = {Bialonski, Stephan and Allefeld, C. and Wellmer, J. and Elger, C. and Lehnertz, K.}, title = {An approach to identify synchronization clusters within the epileptic network}, series = {Klinische Neurophysiologie}, volume = {39}, journal = {Klinische Neurophysiologie}, number = {1}, doi = {10.1055/s-2008-1072881}, pages = {A79}, year = {2008}, language = {en} } @article{SchindlerBialonskiHorstmannetal.2008, author = {Schindler, Kaspar A. and Bialonski, Stephan and Horstmann, Marie-Therese and Elger, Christian E. and Lehnertz, Klaus}, title = {Evolving functional network properties and synchronizability during human epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {18}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, issn = {1089-7682}, doi = {10.1063/1.2966112}, pages = {033119}, year = {2008}, language = {en} } @article{LehnertzBialonskiHorstmannetal.2009, author = {Lehnertz, Klaus and Bialonski, Stephan and Horstmann, Marie-Therese and Krug, Dieter and Rothkegel, Alexander and Staniek, Matth{\"a}us and Wagner, Tobias}, title = {Synchronization phenomena in human epileptic brain networks}, series = {Journal of neuroscience methods}, volume = {183}, journal = {Journal of neuroscience methods}, number = {1}, issn = {0165-0270}, doi = {10.1016/j.jneumeth.2009.05.015}, pages = {42 -- 48}, year = {2009}, language = {en} } @article{HorstmannBialonskiNoenningetal.2010, author = {Horstmann, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Prusseit, Jens and Wellmer, J{\"o}rg and Hinrichs, Hermann and Lehnertz, Klaus}, title = {State dependent properties of epileptic brain networks: Comparative graph-theoretical analyses of simultaneously recorded EEG and MEG}, series = {Clinical Neurophysiology}, volume = {121}, journal = {Clinical Neurophysiology}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1388-2457}, doi = {10.1016/j.clinph.2009.10.013}, pages = {172 -- 185}, year = {2010}, abstract = {Objective To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks.}, language = {en} } @article{BialonskiHorstmannLehnertz2010, author = {Bialonski, Stephan and Horstmann, Marie-Therese and Lehnertz, Klaus}, title = {From brain to earth and climate systems: Small-world interaction networks or not?}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {20}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {1}, publisher = {AIP Publishing}, address = {Melville, NY}, issn = {1089-7682}, doi = {10.1063/1.3360561}, pages = {013134}, year = {2010}, abstract = {We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization.}, language = {en} } @article{BialonskiWendlerLehnertz2011, author = {Bialonski, Stephan and Wendler, Martin and Lehnertz, Klaus}, title = {Unraveling spurious properties of interaction networks with tailored random networks}, series = {Plos one}, volume = {6}, journal = {Plos one}, number = {8}, publisher = {Plos}, address = {San Francisco}, doi = {10.1371/journal.pone.0022826}, pages = {e22826}, year = {2011}, abstract = {We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erd{\"o}s-R{\´e}nyi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures - known for their complex spatial and temporal dynamics - we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis.}, language = {en} } @article{KeutmannStaatLaack2018, author = {Keutmann, Sabine and Staat, Manfred and Laack, Walter van}, title = {Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall}, volume = {7}, number = {10}, publisher = {Deutscher {\"A}rzte-Verl.}, address = {K{\"o}ln}, issn = {2193-5793}, pages = {518 -- 522}, year = {2018}, abstract = {Zusammenfassung: In der Orthop{\"a}die z{\"a}hlt der therapeutische Ultraschall als Mittel zur Pr{\"a}vention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen K{\"o}rper. Um mehr Erkenntnisse {\"u}ber die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgef{\"u}hrt. Dabei entstand eine signifikante Erw{\"a}rmung des Gewebes, welche beim Probandenversuch an der Oberfl{\"a}che und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test.}, language = {de} } @article{BialonskiLehnertz2013, author = {Bialonski, Stephan and Lehnertz, Klaus}, title = {Assortative mixing in functional brain networks during epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {23}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, doi = {10.1063/1.4821915}, pages = {033139}, year = {2013}, language = {en} } @article{KuhnertBialonskiNoenningetal.2013, author = {Kuhnert, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Hinrichs, Hermann and Helmstaedter, Christoph and Lehnertz, Klaus}, title = {Incidental and intentional learning of verbal episodic material differentially modifies functional brain networks}, series = {Plos one}, volume = {8}, journal = {Plos one}, number = {11}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0080273}, pages = {e80273}, year = {2013}, abstract = {Learning- and memory-related processes are thought to result from dynamic interactions in large-scale brain networks that include lateral and mesial structures of the temporal lobes. We investigate the impact of incidental and intentional learning of verbal episodic material on functional brain networks that we derive from scalp-EEG recorded continuously from 33 subjects during a neuropsychological test schedule. Analyzing the networks' global statistical properties we observe that intentional but not incidental learning leads to a significantly increased clustering coefficient, and the average shortest path length remains unaffected. Moreover, network modifications correlate with subsequent recall performance: the more pronounced the modifications of the clustering coefficient, the higher the recall performance. Our findings provide novel insights into the relationship between topological aspects of functional brain networks and higher cognitive functions.}, language = {en} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @article{GeierBialonskiElgeretal.2015, author = {Geier, Christian and Bialonski, Stephan and Elger, Christian E. and Lehnertz, Klaus}, title = {How important is the seizure onset zone for seizure dynamics?}, series = {Seizure}, volume = {25}, journal = {Seizure}, issn = {1059-1311}, doi = {10.1016/j.seizure.2014.10.013}, pages = {160 -- 166}, year = {2015}, language = {en} } @article{GeierLehnertzBialonski2015, author = {Geier, Christian and Lehnertz, Klaus and Bialonski, Stephan}, title = {Time-dependent degree-degree correlations in epileptic brain networks: from assortative to dissortative mixing}, series = {Frontiers in Human Neuroscience}, journal = {Frontiers in Human Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2015.00462}, year = {2015}, language = {en} } @article{MulhernBialonskiKantz2015, author = {Mulhern, Colm and Bialonski, Stephan and Kantz, Holger}, title = {Extreme events due to localization of energy}, series = {Physical Review E}, volume = {91}, journal = {Physical Review E}, number = {1}, issn = {2470-0053}, doi = {10.1103/PhysRevE.91.012918}, pages = {012918}, year = {2015}, language = {en} } @article{BialonskiAnsmannKantz2015, author = {Bialonski, Stephan and Ansmann, Gerrit and Kantz, Holger}, title = {Data-driven prediction and prevention of extreme events in a spatially extended excitable system}, series = {Physical Review E}, volume = {92}, journal = {Physical Review E}, number = {4}, issn = {2470-0053}, doi = {10.1103/PhysRevE.92.042910}, pages = {042910}, year = {2015}, language = {en} } @article{BialonskiCaronSchloenetal.2016, author = {Bialonski, Stephan and Caron, David A. and Schloen, Julia and Feudel, Ulrike and Kantz, Holger and Moorthi, Stefanie D.}, title = {Phytoplankton dynamics in the Southern California Bight indicate a complex mixture of transport and biology}, series = {Journal of Plankton Research}, volume = {38}, journal = {Journal of Plankton Research}, number = {4}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1464-3774}, doi = {10.1093/plankt/fbv122}, pages = {1077 -- 1091}, year = {2016}, abstract = {The stimulation and dominance of potentially harmful phytoplankton taxa at a given locale and time are determined by local environmental conditions as well as by transport to or from neighboring regions. The present study investigated the occurrence of common harmful algal bloom (HAB) taxa within the Southern California Bight, using cross-correlation functions to determine potential dependencies between HAB taxa and environmental factors, and potential links to algal transport via local hydrography and currents. A simulation study, in which Lagrangian particles were released, was used to assess travel times due to advection by prevailing ocean currents in the bight. Our results indicate that transport of some taxa may be an important mechanism for the expansion of their distributions into other regions, which was supported by mean travel times derived from our simulation study and other literature on ocean currents in the Southern California Bight. In other cases, however, phytoplankton dynamics were rather linked to local environmental conditions, including coastal upwelling events. Overall, our study shows that complex current patterns in the Southern California Bight may contribute significantly to the formation and expansion of HABs in addition to local environmental factors determining the spatiotemporal dynamics of phytoplankton blooms.}, language = {en} } @article{NgamgaBialonskiMarwanetal.2016, author = {Ngamga, Eulalie Joelle and Bialonski, Stephan and Marwan, Norbert and Kurths, J{\"u}rgen and Geier, Christian and Lehnertz, Klaus}, title = {Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data}, series = {Physics Letters A}, volume = {380}, journal = {Physics Letters A}, number = {16}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0375-9601}, doi = {10.1016/j.physleta.2016.02.024}, pages = {1419 -- 1425}, year = {2016}, abstract = {We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database.}, language = {en} } @article{KarnatakKantzBialonski2017, author = {Karnatak, Rajat and Kantz, Holger and Bialonski, Stephan}, title = {Early warning signal for interior crises in excitable systems}, series = {Physical Review E}, volume = {96}, journal = {Physical Review E}, number = {4}, issn = {2470-0053}, doi = {10.1103/PhysRevE.96.042211}, pages = {042211}, year = {2017}, language = {en} } @article{SchwabedalSippelBrandtetal.2018, author = {Schwabedal, Justus T. C. and Sippel, Daniel and Brandt, Moritz D. and Bialonski, Stephan}, title = {Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning}, doi = {10.48550/arXiv.1809.08443}, year = {2018}, abstract = {Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle.}, language = {en} } @article{SchifferFerrein2018, author = {Schiffer, Stefan and Ferrein, Alexander}, title = {ERIKA—Early Robotics Introduction at Kindergarten Age}, series = {Multimodal Technologies Interact}, volume = {2}, journal = {Multimodal Technologies Interact}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2414-4088}, doi = {10.3390/mti2040064}, pages = {15}, year = {2018}, abstract = {In this work, we report on our attempt to design and implement an early introduction to basic robotics principles for children at kindergarten age. One of the main challenges of this effort is to explain complex robotics contents in a way that pre-school children could follow the basic principles and ideas using examples from their world of experience. What sets apart our effort from other work is that part of the lecturing is actually done by a robot itself and that a quiz at the end of the lesson is done using robots as well. The humanoid robot Pepper from Softbank, which is a great platform for human-robot interaction experiments, was used to present a lecture on robotics by reading out the contents to the children making use of its speech synthesis capability. A quiz in a Runaround-game-show style after the lecture activated the children to recap the contents they acquired about how mobile robots work in principle. In this quiz, two LEGO Mindstorm EV3 robots were used to implement a strongly interactive scenario. Besides the thrill of being exposed to a mobile robot that would also react to the children, they were very excited and at the same time very concentrated. We got very positive feedback from the children as well as from their educators. To the best of our knowledge, this is one of only few attempts to use a robot like Pepper not as a tele-teaching tool, but as the teacher itself in order to engage pre-school children with complex robotics contents.}, language = {en} } @article{HueningHeuermannWacheetal.2018, author = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef and Jajo, Rami Audisho}, title = {A new wireless sensor interface using dual-mode radio}, series = {Journal of Sensors and Sensor Systems : JSSS}, volume = {Volume 7}, journal = {Journal of Sensors and Sensor Systems : JSSS}, number = {2}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, doi = {10.5194/jsss-7-507-2018}, pages = {507 -- 515}, year = {2018}, abstract = {The integration of sensors is one of the major tasks in embedded, control and "internet of things" (IoT) applications. For the integration mainly digital interfaces are used, starting from rather simple pulse-width modulation (PWM) interface to more complex interfaces like CAN (Controller Area Network). Even though these interfaces are tethered by definition, a wireless realization is highly welcome in many applications to reduce cable and connector cost, increase the flexibility and realize new emerging applications like wireless control systems. Currently used wireless solutions like Bluetooth, WirelessHART or IO-Link Wireless use dedicated communication standards and corresponding higher protocol layers to realize the wireless communication. Due to the complexity of the communication and the protocol handling, additional latency and jitter are introduced to the data communication that can meet the requirements for many applications. Even though tunnelling of other bus data like CAN data is generally also possible the latency and jitter prevent the tunnelling from being transparent for the bus system. Therefore a new basic technology based on dual-mode radio is used to realize a wireless communication on the physical layer only, enabling a reliable and real-time data transfer. As this system operates on the physical layer it is independent of any higher layers of the OSI (open systems interconnection) model. Hence it can be used for several different communication systems to replace the tethered physical layer. A prototype is developed and tested for real-time wireless PWM, SENT (single-edge nibble transmission) and CAN data transfer with very low latency and jitter.}, language = {en} } @article{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Computational comparison of different textile implants to correct apical prolapse in females}, series = {Current Directions in Biomedical Engineering}, volume = {4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, doi = {10.1515/cdbme-2018-0159}, pages = {661 -- 664}, year = {2018}, abstract = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.}, language = {en} } @article{HorbachStaat2018, author = {Horbach, Andreas and Staat, Manfred}, title = {Optical strain measurement for the modeling of surgical meshes and their porosity}, series = {Current Directions in Biomedical Engineering}, volume = {Band 4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0045}, pages = {181 -- 184}, year = {2018}, abstract = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.}, language = {en} } @article{Fissabre2018, author = {Fissabre, Anke}, title = {Die Relevanz der historischen Bauforschung f{\"u}r neue Impulse in Stadtplanung und Architektur. Das Beispiel der Chiesa della SS. Maria Incoronata und des Servitenklosters in Sabbioneta.}, series = {archimaera}, journal = {archimaera}, number = {Nr. 7, Juli 2018}, publisher = {Archimaera}, address = {Aachen}, issn = {1865-7001}, url = {http://nbn-resolving.de/urn:nbn:de:0009-21-47067}, pages = {99 -- 105}, year = {2018}, abstract = {Durch die Bauforschung im Rahmen des mehrj{\"a}hrigen Projektes "Die Hochkorridore von Sabbioneta" konnten der Verlauf und viele Anschl{\"u}sse der hochliegenden G{\"a}nge an bestehende Bauten weitgehend gekl{\"a}rt werden. Im Bereich der Chiesa della SS. Maria Incoronata und des angrenzenden Servitenklosters f{\"u}hrten die Bauuntersuchungen zu v{\"o}llig neuen Erkenntnissen {\"u}ber den ehemaligen Verlauf des Hochkorridors und damit zu einer Neuinterpretation des baulichen Ensembles sowie seiner Bedeutung f{\"u}r die Idealstadt. Aus dieser historischen Umdeutung entstanden Ideen f{\"u}r die Umnutzung des ehemaligen Servitenklosters und seiner angrenzenden Freifl{\"a}chen, die im Rahmen von studentischen Entw{\"u}rfen am Lehrstuhl f{\"u}r Baugeschichte und Denkmalpflege in Kooperation mit dem Lehrstuhl f{\"u}r Landschaftsarchitektur der RWTH Aachen weiterentwickelt wurden. Somit stellten sich Befunde einer historisch orientierten Bauforschung mit {\"u}bergeordneter Fragestellung als neue Impulsgeber f{\"u}r Stadtplanung, Architektur und Denkmalpflege heraus.}, language = {de} } @article{RuppSchulzeKuperjans2018, author = {Rupp, Matthias and Schulze, Sven and Kuperjans, Isabel}, title = {Comparative life cycle analysis of conventional and hybrid heavy-duty trucks}, series = {World electric vehicle journal}, volume = {9}, journal = {World electric vehicle journal}, number = {2}, publisher = {MDPI}, address = {Basel}, issn = {2032-6653}, doi = {10.3390/wevj9020033}, pages = {Article No. 33}, year = {2018}, abstract = {Heavy-duty trucks are one of the main contributors to greenhouse gas emissions in German traffic. Drivetrain electrification is an option to reduce tailpipe emissions by increasing energy conversion efficiency. To evaluate the vehicle's environmental impacts, it is necessary to consider the entire life cycle. In addition to the daily use, it is also necessary to include the impact of production and disposal. This study presents the comparative life cycle analysis of a parallel hybrid and a conventional heavy-duty truck in long-haul operation. Assuming a uniform vehicle glider, only the differing parts of both drivetrains are taken into account to calculate the environmental burdens of the production. The use phase is modeled by a backward simulation in MATLAB/Simulink considering a characteristic driving cycle. A break-even analysis is conducted to show at what mileage the larger CO2eq emissions due to the production of the electric drivetrain are compensated. The effect of parameter variation on the break-even mileage is investigated by a sensitivity analysis. The results of this analysis show the difference in CO2eq/t km is negative, indicating that the hybrid vehicle releases 4.34 g CO2eq/t km over a lifetime fewer emissions compared to the diesel truck. The break-even analysis also emphasizes the advantages of the electrified drivetrain, compensating the larger emissions generated during production after already a distance of 15,800 km (approx. 1.5 months of operation time). The intersection coordinates, distance, and CO2eq, strongly depend on fuel, emissions for battery production and the driving profile, which lead to nearly all parameter variations showing an increase in break-even distance.}, language = {en} } @article{deBloisdeZangerPaulssenetal.2018, author = {de Blois, Eric and de Zanger, Rory M. S. and Paulßen, Elisabeth and Sze Chan, Ho and Breeman, Wouter A. P.}, title = {Semi-automated system for concentrating 68Ga-eluate to obtain high molar and volume concentration of 68Ga-Radiopharmaca for preclinical applications}, series = {Nuclear Medicine and Biology}, volume = {64-65}, journal = {Nuclear Medicine and Biology}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.nucmedbio.2018.06.006}, pages = {16 -- 21}, year = {2018}, abstract = {68Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. volume restriction, activity concentration, molar activity and osmolality. Therefore, we developed a semiautomatic system specifically to overcome these problems. A difficulty appeared unexpectedly, as intrinsic trace metals derived from eluate (Zn, Fe and Cu) are concentrated as well in amounts that influence radiochemical yield and thus lower molar activity.}, language = {en} } @article{JildehOberlaenderKirchneretal.2018, author = {Jildeh, Zaid B. and Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations}, series = {physica status solidi (a): applications and materials science}, volume = {215}, journal = {physica status solidi (a): applications and materials science}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201700920}, pages = {Artikel 1700920}, year = {2018}, abstract = {In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.}, language = {en} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @article{FissabreWilson2018, author = {Fissabre, Anke and Wilson, Ariane}, title = {Der Turm mit zehn Spornen - Ein in Monthoiron gebauter Entwurf von Leonardo Da Vinci?}, series = {In situ: Zeitschrift f{\"u}r Architekturgeschichte}, journal = {In situ: Zeitschrift f{\"u}r Architekturgeschichte}, number = {1}, publisher = {Wernersche Verlagsgesellschaft}, address = {Worms}, issn = {1866-959X}, pages = {65 -- 82}, year = {2018}, language = {de} }