@article{TuraliyevaYeshibaevDigeletal.2014,
  author    = {Turaliyeva, M. and Yeshibaev, A. and Digel, Ilya and Elibayeva, G. and Sydykova, A. and Uspabayeva, A. and Dosybayeva, G. and Zhylysbayeva, A. and Lakhanova, K.},
  title     = {Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L},
  series = {Life science journal},
  volume    = {11},
  journal   = {Life science journal},
  number    = {Spec. iss. 5s},
  publisher = {Marsland Press},
  address   = {New York},
  issn      = {1097-8135},
  doi       = {10.7537/marslsj1105s14.33},
  pages     = {171 -- 175},
  year      = {2014},
  abstract  = {The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium - F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 \% respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.},
  language  = {en}
}
@article{ArinkinDigelPorstetal.2014,
  author    = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application},
  series = {BMC bioinformatics},
  volume    = {15},
  journal   = {BMC bioinformatics},
  number    = {55},
  issn      = {1471-2105},
  doi       = {10.1186/1471-2105-15-55},
  pages     = {1 -- 8},
  year      = {2014},
  abstract  = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.},
  language  = {en}
}
@article{MiciliValterOflazetal.2013,
  author    = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes},
  series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  volume    = {Vol. 227},
  journal   = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  number    = {No. 4},
  publisher = {Sage},
  address   = {London},
  issn      = {0046-2039 (Print) ; 2041-3033 (E-Journal)},
  pages     = {393 -- 401},
  year      = {2013},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@article{DigelZhubanovaNojimaetal.2004,
  author    = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  series = {Biotechnologija : teorija i praktika (2004)},
  journal   = {Biotechnologija : teorija i praktika (2004)},
  isbn      = {1028-9399},
  pages     = {46 -- 52},
  year      = {2004},
  language  = {en}
}
@article{DigelDachwaldArtmannetal.2009,
  author    = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.},
  title     = {A concept of a probe for particle analysis and life detection in icy environments},
  pages     = {1 -- 24},
  year      = {2009},
  language  = {en}
}
@book{Digel1998,
  author    = {Digel, Ilya},
  title     = {Enhancement of microbial adhesion onto solid surfaces using transition metals and water-soluble polymers : academic PhD dissertation in microbiology, Division of Applied Microbiology, Department of Microbiology, Biology Faculty, Kazakh National State University, Almaty, Kazakhstan / Ilya Digel},
  address   = {Almaty},
  year      = {1998},
  language  = {en}
}
@incollection{DigelMansurovBiisenbaevetal.2012,
  author    = {Digel, Ilya and Mansurov, Zulkhair and Biisenbaev, Makhmut and Savitskaya, Irina and Kistaubaeva, Aida and Akimbekov, Nuraly and Zhubanova, Azhar},
  title     = {Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents},
  series = {Composites and Their Applications},
  booktitle = {Composites and Their Applications},
  editor    = {Hu, Ning},
  publisher = {Intech},
  address   = {London},
  isbn      = {978-953-51-0706-4},
  doi       = {10.5772/47796},
  pages     = {249 -- 272},
  year      = {2012},
  abstract  = {The fact that microorganisms prefer to grow on liquid/solid phase surfaces rather than in the surrounding aqueous phase was noticed long time ago [1]. Virtually any surface - animal, mineral, or vegetable - is a subject for microbial colonization and subsequent biofilm formation. It would be adequate to name just a few notorious examples on microbial colonization of contact lenses, ship hulls, petroleum pipelines, rocks in streams and all kinds of biomedical implants. The propensity of microorganisms to become surface-bound is so profound and ubiquitous that it vindicates the advantages for attached forms over their free-ranging counterparts [2]. Indeed, from ecological and evolutionary standpoints, for many microorganisms the surface-bound state means dwelling in nutritionally favorable, non-hostile environments [3]. Therefore, in most of natural and artificial ecosystems surface-associated microorganisms vastly outnumber organisms in suspension and often organize into complex communities with features that differ dramatically from those of free cells [4].},
  language  = {en}
}
@article{ArtmannZerlinDigeletal.2007,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.},
  title     = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{Digel2010,
  author    = {Digel, Ilya},
  title     = {In-situ biological decontamination of an ice melting probe},
  year      = {2010},
  language  = {en}
}
@article{KurulganDemirciLinderDemircietal.2009,
  author    = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {307 -- 308},
  year      = {2009},
  language  = {en}
}
@article{ArtmannDigelLinderetal.2008,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz},
  title     = {Mechanism of haemoglobin sensing body temperature},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {754 -- 754},
  year      = {2008},
  language  = {en}
}
@article{StadlerZerlinDigeletal.2008,
  author    = {Stadler, Andreas M. and Zerlin, Kay and Digel, Ilya and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard},
  title     = {Dynamics and interactions of hemoglobin in red blood cells},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {724 -- 724},
  year      = {2008},
  language  = {en}
}
@article{DigelDemirciTemizArtmannetal.2004,
  author    = {Digel, Ilya and Demirci, Taylan and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K.},
  title     = {Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs)},
  series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {982 -- 983},
  year      = {2004},
  language  = {en}
}
@article{DigelTemizArtmannNishikawaetal.2004,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Artmann, Gerhard},
  title     = {Cluster air-ion effects on bacteria and moulds},
  series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1040 -- 1041},
  year      = {2004},
  language  = {en}
}
@article{MaggakisKelemenDigelArtmann2005,
  author    = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard},
  title     = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility},
  series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1},
  journal   = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1},
  pages     = {324 -- 326},
  year      = {2005},
  language  = {en}
}
@article{BogoyavlenskiyBerezinOgnevaetal.1999,
  author    = {Bogoyavlenskiy, A. P. and Berezin, V. E. and Ogneva, A. V. and Tolmacheva, V. P. and Digel, Ilya and Khudyakova, S. S.},
  title     = {Immunostimulating activity of a saponin-containing extract of Saponaria officinalis},
  series = {Voprosy virusologii},
  volume    = {44},
  journal   = {Voprosy virusologii},
  number    = {5},
  issn      = {0507-4088},
  pages     = {229 -- 232},
  year      = {1999},
  language  = {en}
}
@article{DigelTrzewikDemircietal.2004,
  author    = {Digel, Ilya and Trzewik, J{\"u}rgen and Demirci, Taylan and Temiz Artmann, Ayseg{\"u}l},
  title     = {Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.},
  series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1042 -- 1043},
  year      = {2004},
  language  = {en}
}
@article{DigelTemizArtmannNishikawaetal.2005,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Cook, M.},
  title     = {Bactericidal effects of plasma-generated cluster ions},
  series = {Medical and Biological Engineering and Computing. 43 (2005), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 43 (2005), H. 6},
  isbn      = {1741-0444},
  pages     = {800 -- 807},
  year      = {2005},
  language  = {en}
}
@article{TrzewikTemizArtmannLinderetal.2004,
  author    = {Trzewik, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Linder, Peter and Demirci, T. and Digel, Ilya and Artmann, Gerhard},
  title     = {Evaluation of lateral mechanical tension in thin-film tissue constructs},
  series = {Annals of Biomedical Engineering. 32 (2004), H. 9},
  journal   = {Annals of Biomedical Engineering. 32 (2004), H. 9},
  isbn      = {1573-9686},
  pages     = {1243 -- 1251},
  year      = {2004},
  language  = {en}
}
@article{ZerlinKasischkeDigeletal.2007,
  author    = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard},
  title     = {Structural transition temperature of hemoglobins correlates with species' body temperature},
  series = {European Biophysics Journal. 37 (2007), H. 1},
  journal   = {European Biophysics Journal. 37 (2007), H. 1},
  isbn      = {1432-1017},
  pages     = {1 -- 10},
  year      = {2007},
  language  = {en}
}
@article{DigelKurulganDemirciLinderetal.2007,
  author    = {Digel, Ilya and Kurulgan Demirci, Eylem and Linder, Peter and Kayser, Peter},
  title     = {Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts},
  series = {Medical and Biological Engineering and Computing. 45 (2007), H. 1},
  journal   = {Medical and Biological Engineering and Computing. 45 (2007), H. 1},
  isbn      = {1741-0444},
  pages     = {91 -- 97},
  year      = {2007},
  language  = {en}
}
@article{DigelMaggakisKelemenZerlinetal.2006,
  author    = {Digel, Ilya and Maggakis-Kelemen, Christina and Zerlin, Kay and Linder, Peter},
  title     = {Body temperature-related structural transitions of monotremal and human hemoglobin},
  series = {Biophysical Journal. 91 (2006), H. 8},
  journal   = {Biophysical Journal. 91 (2006), H. 8},
  isbn      = {1542-0086},
  pages     = {3014 -- 3021},
  year      = {2006},
  language  = {en}
}
@article{DigelKayserArtmann2008,
  author    = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard},
  title     = {Molecular processes in biological thermosensation},
  series = {Journal of Biophysics. 2008 (2008)},
  journal   = {Journal of Biophysics. 2008 (2008)},
  isbn      = {1687-8000},
  pages     = {1 -- 9},
  year      = {2008},
  language  = {en}
}
@article{ZerlinDigelStadleretal.2007,
  author    = {Zerlin, Kay and Digel, Ilya and Stadler, Andreas M. and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard},
  title     = {Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions},
  series = {Regenerative medicine. 2 (2007), H. 5},
  journal   = {Regenerative medicine. 2 (2007), H. 5},
  isbn      = {1746-0751},
  pages     = {573 -- 573},
  year      = {2007},
  language  = {en}
}
@article{DigelZerlinTemizArtmannetal.2007,
  author    = {Digel, Ilya and Zerlin, Kay and Temiz Artmann, Ayseg{\"u}l and Engels, S.},
  title     = {Protein dynamics in thermosensation},
  series = {Regenerative medicine. 2 (2007), H. 5},
  journal   = {Regenerative medicine. 2 (2007), H. 5},
  isbn      = {1746-0751},
  pages     = {533 -- 533},
  year      = {2007},
  language  = {en}
}
@article{StadlerEmbsDigeletal.2008,
  author    = {Stadler, Andreas M. and Embs, Jan P. and Digel, Ilya and Artmann, Gerhard and Unruh, Tobias and B{\"u}ldt, Georg and Zaccai, Guiseppe},
  title     = {Cytoplasmic water and hydration layer dynamics in human red blood cells},
  series = {Journal of the American Chemical Society. 50 (2008), H. 130},
  journal   = {Journal of the American Chemical Society. 50 (2008), H. 130},
  isbn      = {1520-5126},
  pages     = {16852 -- 16853},
  year      = {2008},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia (2010)},
  journal   = {Science of Central Asia (2010)},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{StadlerDigelEmbsetal.2009,
  author    = {Stadler, Andreas M. and Digel, Ilya and Embs, Jan P. and Unruh, Tobias and Tehei, M. and Zaccai, G. and B{\"u}ldt, G. and Artmann, Gerhard},
  title     = {From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature},
  series = {Biophysical Journal. 96 (2009), H. 12},
  journal   = {Biophysical Journal. 96 (2009), H. 12},
  publisher = {Cell Press},
  address   = {Cambridge, Mass.},
  isbn      = {0006-3495},
  pages     = {5073 -- 5081},
  year      = {2009},
  language  = {en}
}
@article{KurzLinderTrzewiketal.2010,
  author    = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes},
  series = {Medical and Biological Engineering and Computing},
  volume    = {48},
  journal   = {Medical and Biological Engineering and Computing},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1741-0444},
  doi       = {10.1007/s11517-009-0552-y},
  pages     = {59 -- 65},
  year      = {2010},
  abstract  = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.},
  language  = {en}
}
@article{Digel2008,
  author    = {Digel, Ilya},
  title     = {Controlling microbial adhesion : a surface engineering approach},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-540-75408-4},
  pages     = {601 -- 625},
  year      = {2008},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{DigelTemizArtmann2011,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {The emperor's new body : seeking for a blueprint of limb regeneration in humans},
  series = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.},
  journal   = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-642-11864-7},
  pages     = {3 -- 37},
  year      = {2011},
  language  = {en}
}
@article{Digel2011,
  author    = {Digel, Ilya},
  title     = {Primary thermosensory events in cells},
  series = {Transient receptor potential channels / Md. Shahidul Islam, ed.},
  journal   = {Transient receptor potential channels / Md. Shahidul Islam, ed.},
  publisher = {Springer},
  address   = {Dordrecht [u.a.]},
  isbn      = {978-94-007-0264-6},
  pages     = {451 -- 468},
  year      = {2011},
  language  = {en}
}
@article{KurulganDemirciDemirciLinderetal.2012,
  author    = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells},
  series = {Journal of Bioscience and Bioengineering},
  volume    = {113},
  journal   = {Journal of Bioscience and Bioengineering},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1347-4421},
  doi       = {10.1016/j.jbiosc.2012.03.019},
  pages     = {212 -- 219},
  year      = {2012},
  abstract  = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.},
  language  = {en}
}
@article{LeimenaArtmannDachwaldetal.2010,
  author    = {Leimena, W. and Artmann, Gerhard and Dachwald, Bernd and Temiz Artmann, Ayseg{\"u}l and Gossmann, Matthias and Digel, Ilya},
  title     = {Feasibility of an in-situ microbial decontamination of an ice-melting probe},
  series = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2},
  journal   = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2},
  isbn      = {1562-3920},
  pages     = {145 -- 150},
  year      = {2010},
  language  = {en}
}
@book{DigelZhubanovaAkimbekov2012,
  author    = {Digel, Ilya and Zhubanova, Azhar Ahmetovna and Akimbekov, Nuraly Shardarbekovich},
  title     = {Visual Virology},
  address   = {Almaty},
  isbn      = {978-601-247-298-1},
  pages     = {144 S. : zahlr. Ill.},
  year      = {2012},
  language  = {en}
}
@article{LinderDigelTemizArtmannetal.2007,
  author    = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard},
  title     = {High-throughput testing of mechanical forces generated in thin cell and tissue layers},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{DemirciKurulganDemirciTrzewiketal.2009,
  author    = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l},
  title     = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {311 -- 312},
  year      = {2009},
  language  = {en}
}
@article{StadlerGarveyBocahutetal.2012,
  author    = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.},
  title     = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics},
  series = {Journal of the Royal Society Interface},
  volume    = {9},
  journal   = {Journal of the Royal Society Interface},
  number    = {76},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {1742-5689},
  doi       = {10.1098/rsif.2012.0364},
  pages     = {2845 -- 2855},
  year      = {2012},
  abstract  = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{SadykovDigelTemizArtmannetal.2009,
  author    = {Sadykov, Rustam and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Artmann, Gerhard and Savitskaya, Irina and Zhubanova, Azhar},
  title     = {Oral lead exposure induces dysbacteriosis in rats},
  series = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  journal   = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  isbn      = {1348-9585},
  pages     = {64 -- 73},
  year      = {2009},
  language  = {en}
}
@article{ArtmannDigelZerlinetal.2009,
  author    = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Hemoglobin senses body temperature},
  series = {European Biophysics Journal},
  volume    = {38},
  journal   = {European Biophysics Journal},
  number    = {5},
  isbn      = {0175-7571},
  pages     = {589 -- 600},
  year      = {2009},
  language  = {en}
}
@article{StadlerDigelArtmannetal.2008,
  author    = {Stadler, A. M. and Digel, Ilya and Artmann, Gerhard and Embs, Jan P. and Zaccai, Joe and B{\"u}ldt, Georg},
  title     = {Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature},
  series = {Biophysical Journal. 95 (2008), H. 11},
  journal   = {Biophysical Journal. 95 (2008), H. 11},
  isbn      = {1542-0086},
  pages     = {5449 -- 5461},
  year      = {2008},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{TemizArtmannLinderKayseretal.2005,
  author    = {Temiz Artmann, Ayseg{\"u}l and Linder, Peter and Kayser, Peter and Digel, Ilya},
  title     = {NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts},
  series = {Methods and findings in Experimental and Clinical Pharmacology. 27 (2005), H. 6},
  journal   = {Methods and findings in Experimental and Clinical Pharmacology. 27 (2005), H. 6},
  isbn      = {0379-0355},
  pages     = {391 -- 394},
  year      = {2005},
  language  = {en}
}