@article{MolinnusSorichBartzetal.2016, author = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate}, series = {Sensors and Actuators B: Chemical}, volume = {237}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.06.064}, pages = {190 -- 195}, year = {2016}, abstract = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.}, language = {en} } @article{KnobeGiesenPlateetal.2016, author = {Knobe, M. and Giesen, M. and Plate, S. and Gradl-Dietsch, G. and Buecking, B. and Eschbach, D. and Laack, Walter van and Pape, H.-C.}, title = {The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale}, series = {European Journal Of Trauma And Emergency Surgery}, volume = {42}, journal = {European Journal Of Trauma And Emergency Surgery}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {1863-9941}, doi = {10.1007/s00068-016-0693-2}, pages = {537 -- 545}, year = {2016}, abstract = {Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.}, language = {en} } @article{DollWagnerWagneretal.2016, author = {Doll, Theodor and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Sch{\"o}ning (eds.)}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201670641}, pages = {1393 -- 1394}, year = {2016}, language = {en} } @article{WagnerVornholtWerneretal.2016, author = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening}, series = {Physics in medicine}, volume = {2016}, journal = {Physics in medicine}, number = {1}, issn = {2352-4510}, doi = {10.1016/j.phmed.2016.03.001}, pages = {2 -- 7}, year = {2016}, abstract = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.}, language = {en} } @article{MiyamotoSatoAbeetal.2016, author = {Miyamoto, Ko-Ichiro and Sato, Takuya and Abe, Minami and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices}, series = {Micromachines}, volume = {7}, journal = {Micromachines}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi7070111}, pages = {111}, year = {2016}, abstract = {A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.}, language = {en} } @incollection{EversFleischhakerPalffyetal.2010, author = {Evers, J{\"o}rg and Fleischhaker, Robert and P{\´a}lffy, A. and Keitel, C.}, title = {Light propagation : From atomic to nuclear quantum optics}, series = {Modern optics and photonics: atoms and structured media}, booktitle = {Modern optics and photonics: atoms and structured media}, publisher = {World Scientific Publishing Co.}, isbn = {978-981431327-8}, doi = {10.1142/9789814313278_0001}, pages = {3 -- 15}, year = {2010}, language = {en} } @phdthesis{Fleischhaker2009, author = {Fleischhaker, Robert}, title = {Light propagation in dense and chiral media}, year = {2009}, language = {en} } @article{FleischhakerEvers2009, author = {Fleischhaker, Robert and Evers, J{\"o}rg}, title = {Phase-controlled pulse propagation in media with cross coupling of electric and magnetic probe field component}, series = {Physical Review A - Atomic, molecular, and optical physics}, volume = {80}, journal = {Physical Review A - Atomic, molecular, and optical physics}, number = {6}, issn = {1050-2947}, doi = {10.1103/PHYSREVA.80.063816}, pages = {063816}, year = {2009}, language = {en} } @article{FleischhakerEvers2008, author = {Fleischhaker, Robert and Evers, J{\"o}rg}, title = {Four-wave mixing enhanced white-light cavity}, series = {Physical Review A - Atomic, molecular, and optical physics}, volume = {78}, journal = {Physical Review A - Atomic, molecular, and optical physics}, number = {5}, issn = {0556-2791}, pages = {051802(R)}, year = {2008}, language = {en} } @article{FleischhakerEvers2008, author = {Fleischhaker, Robert and Evers, J{\"o}rg}, title = {Nonlinear effects in pulse propagation through Doppler-broadened closed-loop atomic media}, series = {Physical Review A - Atomic, molecular, and optical physics}, volume = {77}, journal = {Physical Review A - Atomic, molecular, and optical physics}, number = {4}, issn = {1050-2947}, doi = {10.1103/PhysRevA.77.043805}, pages = {043805}, year = {2008}, language = {en} } @article{FleischhakerEversDey2010, author = {Fleischhaker, Robert and Evers, J{\"o}rg and Dey, Tarak N.}, title = {Phase modulation induced by cooperative effects in electromagnetically induced transparency}, series = {Physical Review A - Atomic, molecular, and optical physics}, volume = {82}, journal = {Physical Review A - Atomic, molecular, and optical physics}, number = {1}, publisher = {AIP Publishing}, address = {Melville, NY}, issn = {1050-2947}, doi = {10.1103/PhysRevA.82.013815}, pages = {013815}, year = {2010}, abstract = {We analyze the influence of dipole-dipole interactions in an electromagnetically induced transparency set up for a density at the onset of cooperative effects. To this end, we include mean-field models for the influence of local-field corrections and radiation trapping into our calculation. We show both analytically and numerically that the polarization contribution to the local field strongly modulates the phase of a weak pulse. We give an intuitive explanation for this local-field-induced phase modulation and demonstrate that it distinctively differs from the nonlinear self-phase-modulation that a strong pulse experiences in a Kerr medium.}, language = {en} } @article{FleischhakerEvers2011, author = {Fleischhaker, Robert and Evers, J{\"o}rg}, title = {A Maxwell-Schr{\"o}dinger solver for quantum optical few-level systems}, series = {Computer Physics Communications}, volume = {182}, journal = {Computer Physics Communications}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0010-4655}, doi = {10.1016/j.cpc.2010.10.018}, pages = {739 -- 747}, year = {2011}, abstract = {The msprop program presented in this work is capable of solving the Maxwell-Schr{\"o}dinger equations for one or several laser fields propagating through a medium of quantum optical few-level systems in one spatial dimension and in time. In particular, it allows to numerically treat systems in which a laser field interacts with the medium with both its electric and magnetic component at the same time. The internal dynamics of the few-level system is modeled by a quantum optical master equation which includes coherent processes due to optical transitions driven by the laser fields as well as incoherent processes due to decay and dephasing. The propagation dynamics of the laser fields is treated in slowly varying envelope approximation resulting in a first order wave equation for each laser field envelope function. The program employs an Adams predictor formula second order in time to integrate the quantum optical master equation and a Lax-Wendroff scheme second order in space and time to evolve the wave equations for the fields. The source function in the Lax-Wendroff scheme is specifically adapted to allow taking into account the simultaneous coupling of a laser field to the polarization and the magnetization of the medium. To reduce execution time, a customized data structure is implemented and explained. In three examples the features of the program are demonstrated and the treatment of a system with a phase-dependent cross coupling of the electric and magnetic field component of a laser field is shown.}, language = {en} } @article{FleischhakerKraussSchaettigeretal.2013, author = {Fleischhaker, Robert and Krauß, Nico and Sch{\"a}ttiger, Farina and Dekorsy, Thomas}, title = {Consistent characterization of semiconductor saturable absorber mirrors with singe-pulse and pump-probe spectroscopy}, series = {Optics Express}, volume = {21}, journal = {Optics Express}, number = {6}, publisher = {Optica}, address = {Washington, DC}, issn = {1094-4087}, doi = {10.1364/OE.21.006764}, pages = {6764 -- 6776}, year = {2013}, language = {en} } @inproceedings{FleischhakerGebsBudnickietal.2013, author = {Fleischhaker, Robert and Gebs, Raphael and Budnicki, Aleksander and Wolf, M. and Kleinbauer, Jochen and Sutter, Dirk H.}, title = {Compact gigawatt-class sub-picosecond Yb:YAG thin-disk regenerative chirped-pulse amplifier with high average power at up to 800 kHz}, series = {Lasers and electro-optics europe (CLEO EUROPE/IQEC) : International quantum electronics conference : 12 - 16 May 2013, Munich, GE.}, booktitle = {Lasers and electro-optics europe (CLEO EUROPE/IQEC) : International quantum electronics conference : 12 - 16 May 2013, Munich, GE.}, publisher = {IEEE Computer Society}, isbn = {978-1-4799-0593-5}, doi = {10.1109/CLEOE-IQEC.2013.6801054}, pages = {1}, year = {2013}, language = {en} } @inproceedings{HecklWeilerFleischhakeretal.2014, author = {Heckl, O. H. and Weiler, Sascha and Fleischhaker, Robert and Gebs, Raphael and Budnicki, Aleksander and Wolf, M. and Kleinbauer, Jochen and Russ, S. and Kumkar, M. and Sutter, Dirk H.}, title = {Industry-grade high average power femtosecond light source}, series = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)}, booktitle = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)}, editor = {Heisterkamp, Alexander and Herman, Peter R. and Meunier, Michael and Nolte, Stefan}, publisher = {SPIE, International Society for Optical Engineering}, doi = {10.1117/12.2039337}, pages = {89720P -- 89720P-7}, year = {2014}, language = {en} } @inproceedings{PrickingGebsFleischhakeretal.2015, author = {Pricking, Sebastian and Gebs, Raphael and Fleischhaker, Robert and Kleinbauer, Jochen and Budnicki, Aleksander and Sutter, Dirk and Killi, Alexander and Weiler, Sascha and Mielke, M. and Beaudou, B. and Debord, B. and Gerome, F. and Benabid, F.}, title = {Hollow core fiber delivery of sub-ps pulses from a TruMicro 5000 Femto edition thin disk amplifier}, series = {High-power laser materials processing: Lasers, beam delivery, diagnostics, and applications IV : 7 Februar 2015, San Francisco, USA. - (SPIE proceedings series ; 9356)}, booktitle = {High-power laser materials processing: Lasers, beam delivery, diagnostics, and applications IV : 7 Februar 2015, San Francisco, USA. - (SPIE proceedings series ; 9356)}, editor = {Dorsch, Friedhelm}, publisher = {SPIE, International Society for Optical Engineering}, organization = {The international society for optical engineering, SPIE <2, 2015, San Francisco, CA>}, isbn = {978-162841446-2}, issn = {0277-786X}, doi = {10.1117/12.2079289}, pages = {935602}, year = {2015}, language = {en} } @article{MahmoudiFleischhakerSahraietal.2008, author = {Mahmoudi, Mohammad and Fleischhaker, Robert and Sahrai, Mostafa and Evers, J{\"o}rg}, title = {Group velocity control in the ultraviolet domain via interacting dark-state resonances}, series = {Journal of physics B: Atomic, molecular and optical physics}, volume = {41}, journal = {Journal of physics B: Atomic, molecular and optical physics}, number = {2}, issn = {0953-4075}, doi = {10.1088/0953-4075/41/2/025504}, pages = {25504 -- 25600}, year = {2008}, language = {en} } @inproceedings{Huening2016, author = {H{\"u}ning, Felix}, title = {Power Semiconductors for the automotive 48V board net}, series = {PCIM Europe 2016 Conference Proceedings}, booktitle = {PCIM Europe 2016 Conference Proceedings}, publisher = {VDE Verl.}, address = {Berlin}, isbn = {978-3-8007-4186-1}, pages = {1963 -- 1969}, year = {2016}, language = {en} } @inproceedings{SchreiberKraftZuendorf2016, author = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Cost-efficient quality assurance of natural language processing tools through continuous monitoring with continuous integration}, series = {3rd International Workshop on Software Engineering Research and Industrial Practice}, booktitle = {3rd International Workshop on Software Engineering Research and Industrial Practice}, doi = {10.1145/2897022.2897029}, pages = {46 -- 52}, year = {2016}, language = {en} } @article{WegmannHacklStaatetal.2016, author = {Wegmann, Kilian and Hackl, Michael and Staat, Manfred and Mayer, Katharina and M{\"u}ller, Lars-Peter}, title = {Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4079-0}, pages = {58 -- 59}, year = {2016}, abstract = {While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.}, language = {en} } @article{HacklLeschingerStaatetal.2016, author = {Hackl, Michael and Leschinger, T. and Staat, Manfred and M{\"u}ller, Lars-Peter and Wegmann, Kilian}, title = {Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {130 -- 131}, year = {2016}, abstract = {Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.}, language = {en} } @article{HacklKahmannWegmannetal.2016, author = {Hackl, Michael and Kahmann, Stephanie Lucina and Wegmann, Kilian and Ries, Christian and Staat, Manfred and M{\"u}ller, Lars-Peter}, title = {Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint?}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {128 -- 129}, year = {2016}, abstract = {Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue. While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint.}, language = {en} } @article{HacklMuellerStaatetal.2016, author = {Hackl, Michael and M{\"u}ller, Lars-Peter and Staat, Manfred and Kahmann, Stephanie Lucina and Wegmann, Kilian}, title = {Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {148 -- 149}, year = {2016}, abstract = {Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.}, language = {en} } @inproceedings{KasperSchiffelsKrafftetal.2016, author = {Kasper, Katharina and Schiffels, Johannes and Krafft, Simone and Kuperjans, Isabel and Elbers, Gereon and Selmer, Thorsten}, title = {Biogas Production on Demand Regulated by Butyric Acid Addition}, series = {IOP Conference Series: Earth and Environmental Science. Bd. 32}, volume = {32}, booktitle = {IOP Conference Series: Earth and Environmental Science. Bd. 32}, issn = {1755-1315}, doi = {10.1088/1755-1315/32/1/012009}, pages = {012009/1 -- 012009/4}, year = {2016}, language = {en} } @inproceedings{StollenwerkRiekeDahmenetal.2016, author = {Stollenwerk, Dominik and Rieke, Christian and Dahmen, Markus and Pieper, Martin}, title = {Biogas Production Modelling : A Control System Engineering Approach}, series = {IOP Conference Series: Earth and Environmental Science. Bd. 32}, booktitle = {IOP Conference Series: Earth and Environmental Science. Bd. 32}, issn = {1755-1315}, doi = {10.1088/1755-1315/32/1/012008}, pages = {012008/1 -- 012008/4}, year = {2016}, language = {en} } @book{GebhardtHoetter2016, author = {Gebhardt, Andreas and H{\"o}tter, Jan-Steffen}, title = {Additive manufacturing : 3D printing for prototyping and manufacturing}, publisher = {Hanser Publishers}, address = {Munich}, isbn = {978-1-56990-582-1 ; 978-1-56990-583-8}, pages = {591 S.}, year = {2016}, language = {en} } @inproceedings{KahmannHacklWegmannetal.2016, author = {Kahmann, Stephanie and Hackl, Michael and Wegmann, Kilian and M{\"u}ller, Lars-Peter and Staat, Manfred}, title = {Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, doi = {10.17185/duepublico/40821}, pages = {7 -- 8}, year = {2016}, abstract = {The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient's quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student's t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly.}, language = {en} } @inproceedings{JungStaat2016, author = {Jung, Alexander and Staat, Manfred}, title = {Computing olympic gold: Ski jumping as an example}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-06-6}, doi = {10.17185/duepublico/40821}, pages = {54 -- 55}, year = {2016}, language = {en} } @inproceedings{BhattaraiStaat2016, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Female pelvic floor dysfunction: progress weakening of the support system}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, doi = {10.17185/duepublico/40821}, pages = {11 -- 12}, year = {2016}, abstract = {The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders.}, language = {en} } @article{PookhalilAmoabedinyTabeshetal.2016, author = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow}, title = {A new approach for semiempirical modeling of mechanical blood trauma}, series = {The international journal of artificial organs}, volume = {39}, journal = {The international journal of artificial organs}, number = {4}, publisher = {Sage}, address = {London}, issn = {1724-6040}, doi = {10.5301/ijao.5000474}, pages = {171 -- 177}, year = {2016}, abstract = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.}, language = {en} } @article{BreuerRaueStrobeletal.2016, author = {Breuer, Lars and Raue, Markus and Strobel, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten}, title = {Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.201533056}, pages = {1520 -- 1525}, year = {2016}, abstract = {Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.}, language = {en} } @article{DantismTakenagaWagneretal.2016, author = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Patrick and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.201533043}, pages = {1479 -- 1485}, year = {2016}, abstract = {On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable "down times" during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.}, language = {en} } @article{BayonValeroGarciaBartualetal.2016, author = {Bayon, Arnau and Valero, Daniel and Garcia-Bartual, Rafael and Vall{\´e}s-Mor{\´a}n, Francisco Jos{\´e} and L{\´o}pez-Jim{\´e}nez, P. Amparo}, title = {Performance assessment of OpenFOAM and FLOW-3D in the numerical modeling of a low Reynolds number hydraulic jump}, series = {Environmental Modelling \& Software}, volume = {80}, journal = {Environmental Modelling \& Software}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1364-8152}, doi = {10.1016/j.envsoft.2016.02.018}, pages = {322 -- 335}, year = {2016}, abstract = {A comparative performance analysis of the CFD platforms OpenFOAM and FLOW-3D is presented, focusing on a 3D swirling turbulent flow: a steady hydraulic jump at low Reynolds number. Turbulence is treated using RANS approach RNG k-ε. A Volume Of Fluid (VOF) method is used to track the air-water interface, consequently aeration is modeled using an Eulerian-Eulerian approach. Structured meshes of cubic elements are used to discretize the channel geometry. The numerical model accuracy is assessed comparing representative hydraulic jump variables (sequent depth ratio, roller length, mean velocity profiles, velocity decay or free surface profile) to experimental data. The model results are also compared to previous studies to broaden the result validation. Both codes reproduced the phenomenon under study concurring with experimental data, although special care must be taken when swirling flows occur. Both models can be used to reproduce the hydraulic performance of energy dissipation structures at low Reynolds numbers.}, language = {en} } @inproceedings{NakagawaKallweitMichauxetal.2016, author = {Nakagawa, Masaki and Kallweit, Stephan and Michaux, Frank and Hojo, Teppei}, title = {Typical Velocity Fields and Vortical Structures around a Formula One Car, based on Experimental Investigations using Particle Image Velocimetry}, series = {SAE International Journal of Passenger Cars - Mechanical Systems}, booktitle = {SAE International Journal of Passenger Cars - Mechanical Systems}, issn = {1946-4002}, doi = {10.4271/2016-01-1611}, pages = {18 S.}, year = {2016}, language = {en} } @inproceedings{Wollert2015, author = {Wollert, J{\"o}rg}, title = {Wireless systems for machinery safety : Requirements and solutions for wireless real time systems}, series = {16th International Conference on Research and Education in Mechatronics (REM), 2015}, booktitle = {16th International Conference on Research and Education in Mechatronics (REM), 2015}, isbn = {978-3-945728-01-7}, doi = {10.1109/REM.2015.7380377}, pages = {88 -- 91}, year = {2015}, language = {en} } @inproceedings{ButenwegKleemannAltayetal.2013, author = {Butenweg, Christoph and Kleemann, Anne and Altay, Okyay and Renault, Philippe}, title = {Simulation of impact-loads on reinforced concrete structural elements}, series = {22nd International Conference on Structural Mechanics in Reactor Technology 2013 : (SMiRT 22) ; San Francisco, California, USA, 18 - 23 August 2013}, booktitle = {22nd International Conference on Structural Mechanics in Reactor Technology 2013 : (SMiRT 22) ; San Francisco, California, USA, 18 - 23 August 2013}, organization = {International Conference on Structural Mechanics in Reactor Technology, SMIRT <22, 2013, San Francisco, Calif.>}, pages = {1 -- 10}, year = {2013}, language = {en} } @inproceedings{ButenwegRosinKubalski2013, author = {Butenweg, Christoph and Rosin, Julia and Kubalski, Thomas}, title = {Seismic response of conventional and base-isolated liquid storage tanks}, series = {International Conference on Earthquake Engineering : 29.-31.05.2013, Skopje, Mazedonien}, booktitle = {International Conference on Earthquake Engineering : 29.-31.05.2013, Skopje, Mazedonien}, organization = {International Conference on Earthquake Engineering <2013, Skopje>}, pages = {1 -- 8}, year = {2013}, language = {en} } @inproceedings{GellertNordaButenweg2008, author = {Gellert, Christoph and Norda, Hannah and Butenweg, Christoph}, title = {Nonlinear behaviour of masonry under cyclic loading}, series = {7th European Conference on Structural Dynamics, EURODYN 2008 : 7-9 July 2008, Southampton}, booktitle = {7th European Conference on Structural Dynamics, EURODYN 2008 : 7-9 July 2008, Southampton}, organization = {European Conference on Structural Dynamics, EURODYN <7, 2008, Southampton>}, pages = {1 -- 12}, year = {2008}, language = {en} } @inproceedings{RenaultButenweg2005, author = {Renault, Philippe and Butenweg, Christoph}, title = {Seismic vulnerability assessment of bridges}, series = {First Munich Bridge Assessment Conference, MBAC 2005 : Munich, 20.-25. June 2005}, booktitle = {First Munich Bridge Assessment Conference, MBAC 2005 : Munich, 20.-25. June 2005}, organization = {Munich Bridge Assessment Conference <1, 2005>}, pages = {1 -- 16}, year = {2005}, language = {en} } @inproceedings{ButenwegKuhlmannLopezetal.2003, author = {Butenweg, Christoph and Kuhlmann, Winfried and Lopez, M. and Fernandez, S.}, title = {Seismic vulnerability assessment of the Aachen Cathedral based on measurements and numerical simulations}, series = {International Conference on Earthquake Engineering to mark 40 years from Catastrophic 1963 Skopje Earthquake, Skopje 2003}, booktitle = {International Conference on Earthquake Engineering to mark 40 years from Catastrophic 1963 Skopje Earthquake, Skopje 2003}, organization = {International conference in earthquake engineering to mark 40 years from catastrophic 1963 Skopje earthquake <2003, Skopje>}, pages = {1 -- 8}, year = {2003}, language = {en} } @inproceedings{WagnerNohButenwegetal.2002, author = {Wagner, R. and Noh, S.-Y. and Butenweg, Christoph and Meskouris, Konstantin}, title = {Seismic excited granular material silos}, series = {Structural dynamics - EURODYN 2002 : proceedings of the 4th [i.e. 5th] International Conference on Structural Dynamics, Munich, Germany, 2 - 5 September 2002 / ed. by H. Grundmann ...}, booktitle = {Structural dynamics - EURODYN 2002 : proceedings of the 4th [i.e. 5th] International Conference on Structural Dynamics, Munich, Germany, 2 - 5 September 2002 / ed. by H. Grundmann ...}, publisher = {Balkema}, address = {Lisse}, organization = {European Conference on Structural Dynamics, EURODYN <5, 2002, M{\"u}nchen>}, isbn = {90-5809-511-8}, pages = {253 -- 258}, year = {2002}, language = {en} } @inproceedings{ChudobaButenwegKuhlmann2002, author = {Chudoba, Rostislav and Butenweg, Christoph and Kuhlmann, Wolfram}, title = {Technical information system for collaborative material research}, series = {Sixth International Conference on Computational Structures Technology : [Prague, Czech Republic, 4 - 6 September 2002]}, booktitle = {Sixth International Conference on Computational Structures Technology : [Prague, Czech Republic, 4 - 6 September 2002]}, organization = {International Conference on Computational Structures Technology <6, 2002, Prag>}, pages = {1 -- 11}, year = {2002}, language = {en} } @inproceedings{DalguerChurilovButenwegetal.2014, author = {Dalguer, Luis A. and Churilov, Sergey and Butenweg, Christoph and Renault, Philippe and Hyun, An Jun}, title = {Dynamic analysis of a reinforced concrete electrical nuclear building of SMART 2013 project subjected to earthquake excitation using ABAQUS}, series = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, booktitle = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, organization = {Workshop SMART2013 <2014, Paris>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{AltayButenwegKlinkeletal.2014, author = {Altay, Okyay and Butenweg, Christoph and Klinkel, Sven and Taddei, Francesca}, title = {Vibration mitigation of wind turbine towers by tuned liquid column dampers}, series = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, booktitle = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, address = {Porto}, organization = {European Conference on Structural Dynamics, EURODYN <9, 2014, Porto>}, isbn = {978-972-752-165-4}, pages = {1531 -- 1538}, year = {2014}, language = {en} } @inproceedings{EdipGarevskiButenwegetal.2014, author = {Edip, Kemal and Garevski, Mihail and Butenweg, Christoph and Sheshov, Vlatko and Bojadjieva, Julijana and Gjorgjiev, Igor}, title = {New coupled finite-infinite element approach for wave propagation simulation of unbounded soil media}, series = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 2}, booktitle = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 2}, publisher = {Curran Associates, Inc.}, address = {Red Hook, NY}, organization = {European Conference on Earthquake Engineering and Seismology <2, 2014, Istanbul>}, isbn = {978-1-5108-1021-1}, pages = {1556 -- 1561}, year = {2014}, language = {en} } @article{WuPoghossianBronderetal.2016, author = {Wu, Chunsheng and Poghossian, Arshak and Bronder, Thomas and Sch{\"o}ning, Michael Josef}, title = {Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor}, series = {Sensors and Actuators B: Chemical}, journal = {Sensors and Actuators B: Chemical}, number = {229}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.02.004}, pages = {506 -- 512}, year = {2016}, abstract = {A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.}, language = {en} } @article{ArreolaMaetzkowDuranetal.2016, author = {Arreola, Julio and M{\"a}tzkow, Malte and Dur{\´a}n, Marlena Palomar and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimization of the immobilization of bacterial spores on glass substrates with organosilanes}, series = {Physica status solidi (A) : Applications and materials science}, volume = {213}, journal = {Physica status solidi (A) : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532914}, pages = {1463 -- 1470}, year = {2016}, abstract = {Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.}, language = {en} } @inproceedings{RosinHenneboehlButenweg2014, author = {Rosin, Julia and Henneb{\"o}hl, Benedickt and Butenweg, Christoph}, title = {Global buckling analysis of cylindrical liquid storage tanks under earthquake loading}, series = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6}, booktitle = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6}, publisher = {Curran Associates, Inc.}, address = {Red Hook, NY}, organization = {European Conference on Earthquake Engineering and Seismology <2, 2014, Istanbul>}, isbn = {978-1-5108-1021-1}, pages = {5270 -- 5281}, year = {2014}, language = {en} } @inproceedings{RosinButenweg2014, author = {Rosin, Julia and Butenweg, Christoph}, title = {Seismic isolation of cylindrical liquid storage tanks}, series = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, booktitle = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, address = {Porto}, organization = {European Conference on Structural Dynamics, EURODYN <9, 2014, Porto>}, isbn = {978-972-752-165-4}, pages = {3145 -- 3152}, year = {2014}, language = {en} } @incollection{FissabreWilson2016, author = {Fissabre, Anke and Wilson, Ariane}, title = {"Lehmbaupropaganda" : On the tradition of earth building literature}, series = {Earth Construction and Tradition. Vol. I}, booktitle = {Earth Construction and Tradition. Vol. I}, editor = {Feiglstorfer, Hubert}, publisher = {IVA Institut f{\"u}r vergleichende Architekturforschung}, address = {Wien}, isbn = {978-3-900265-34-2}, pages = {47 -- 69}, year = {2016}, language = {en} }