@inproceedings{ElBashirDigel2009,
  author    = {ElBashir, Rasha and Digel, Ilya},
  title     = {Effect of nitric oxide gas on hydrogels : [abstract]},
  year      = {2009},
  abstract  = {The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels.},
  subject      = {Stickstoffmonoxid},
  language  = {en}
}
@article{EmonsBaadeSchoening2000,
  author    = {Emons, H. and Baade, A. and Sch{\"o}ning, Michael Josef},
  title     = {Voltammetric determination of heavy metals in microvolumes of rain water},
  series = {Electroanalysis. 12 (2000), H. 15},
  journal   = {Electroanalysis. 12 (2000), H. 15},
  isbn      = {1040-0397},
  pages     = {1171 -- 1176},
  year      = {2000},
  language  = {en}
}
@article{EmonsGlueckHuellenkremeretal.2001,
  author    = {Emons, H. and Gl{\"u}ck, O. and H{\"u}llenkremer, B. and Sch{\"o}ning, Michael Josef},
  title     = {Voltohmmetry as an alternative detection method at polycrystalline metal film electrodes},
  series = {Electroanalysis. 13 (2001), H. 8-9},
  journal   = {Electroanalysis. 13 (2001), H. 8-9},
  isbn      = {1040-0397},
  pages     = {677 -- 680},
  year      = {2001},
  language  = {en}
}
@article{EmonsGlueckSchoening2001,
  author    = {Emons, H. and Gl{\"u}ck, O. and Sch{\"o}ning, Michael Josef},
  title     = {Voltohmmetry - An alternative detection principle at ultrathin metal electrodes in solution},
  series = {Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler},
  journal   = {Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler},
  publisher = {Electrochemical Society},
  address   = {Pennington, NJ},
  isbn      = {1-56677-351-2},
  pages     = {1 -- 3},
  year      = {2001},
  language  = {en}
}
@article{EmonsHuellenkremerSchoening2001,
  author    = {Emons, H. and H{\"u}llenkremer, B. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of metal ions in aqueous solutions by voltohmmetry},
  series = {Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1},
  journal   = {Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1},
  isbn      = {0937-0633},
  pages     = {42 -- 46},
  year      = {2001},
  language  = {en}
}
@phdthesis{Engelmann2019,
  author    = {Engelmann, Ulrich M.},
  title     = {Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy},
  publisher = {Infinite Science Publishing},
  address   = {L{\"u}beck},
  isbn      = {978-3-945954-58-4},
  year      = {2019},
  language  = {en}
}
@article{EngelmannBuhlBaumannetal.2017,
  author    = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Baumann, Martin and Schmitz-Rode, Thomas and Slabu, Ioana},
  title     = {Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia},
  series = {Current Directions in Biomedical Engineering},
  volume    = {3},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {2},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2017-0096},
  pages     = {457 -- 460},
  year      = {2017},
  language  = {en}
}
@article{EngelmannBuhlDraacketal.2018,
  author    = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana},
  title     = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications},
  series = {IEEE Magnetic Letters},
  volume    = {9},
  journal   = {IEEE Magnetic Letters},
  number    = {Article number 8519617},
  publisher = {IEEE},
  address   = {New York, NY},
  issn      = {1949-307X},
  doi       = {10.1109/LMAG.2018.2879034},
  year      = {2018},
  abstract  = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.},
  language  = {en}
}
@article{EngelmannPourshahidiShalabyetal.2022,
  author    = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim},
  title     = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation},
  series = {Journal of Magnetism and Magnetic Materials},
  volume    = {563},
  journal   = {Journal of Magnetism and Magnetic Materials},
  number    = {In progress, Art. No. 169965},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-8853},
  doi       = {10.1016/j.jmmm.2022.169965},
  year      = {2022},
  abstract  = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.},
  language  = {en}
}
@article{EngelmannRoethEberbecketal.2018,
  author    = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana},
  title     = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells},
  series = {Scientific Reports},
  volume    = {8},
  journal   = {Scientific Reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-018-31553-9},
  pages     = {Article number 13210},
  year      = {2018},
  abstract  = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.},
  language  = {en}
}
@article{EngelmannSeifertMuesetal.2019,
  author    = {Engelmann, Ulrich M. and Seifert, Julian and Mues, Benedikt and Roitsch, Stefan and M{\´e}nager, Christine and Schmidt, Annette M. and Slabu, Ioana},
  title     = {Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels},
  series = {Journal of Magnetism and Magnetic Materials},
  volume    = {471},
  journal   = {Journal of Magnetism and Magnetic Materials},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-8853},
  doi       = {10.1016/j.jmmm.2018.09.113},
  pages     = {486 -- 494},
  year      = {2019},
  language  = {en}
}
@article{EngelmannShalabyShashaetal.2021,
  author    = {Engelmann, Ulrich M. and Shalaby, Ahmed and Shasha, Carolyn and Krishnan, Kannan M. and Krause, Hans-Joachim},
  title     = {Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory},
  series = {Nanomaterials},
  volume    = {11},
  journal   = {Nanomaterials},
  number    = {5},
  publisher = {MDPI},
  address   = {Basel},
  isbn      = {2079-4991},
  doi       = {10.3390/nano11051257},
  pages     = {1 -- 16},
  year      = {2021},
  abstract  = {Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90\% of the frequency mixing magnetic response signal is generated by the largest 10\% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory.},
  language  = {en}
}
@incollection{EngelmannShashaSlabu2021,
  author    = {Engelmann, Ulrich M. and Shasha, Carolyn and Slabu, Ioana},
  title     = {Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating},
  series = {Magnetic nanoparticles in human health and medicine},
  booktitle = {Magnetic nanoparticles in human health and medicine},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken, New Jeersey},
  isbn      = {978-1-119-75467-1},
  pages     = {327 -- 354},
  year      = {2021},
  language  = {en}
}
@article{EngelmannShashaTeemanetal.2019,
  author    = {Engelmann, Ulrich M. and Shasha, Carolyn and Teeman, Eric and Slabu, Iona and Krishnan, Kannan M.},
  title     = {Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic N{\´e}el-Brown Langevin simulation},
  series = {Journal of Magnetism and Magnetic Materials},
  volume    = {471},
  journal   = {Journal of Magnetism and Magnetic Materials},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-8853},
  doi       = {10.1016/j.jmmm.2018.09.041},
  pages     = {450 -- 456},
  year      = {2019},
  language  = {en}
}
@article{EngelmannSimsekShalabyetal.2024,
  author    = {Engelmann, Ulrich M. and Simsek, Beril and Shalaby, Ahmed and Krause, Hans-Joachim},
  title     = {Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study},
  series = {Sensors},
  volume    = {24},
  journal   = {Sensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s24061945},
  pages     = {Artikel 1945},
  year      = {2024},
  abstract  = {Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled N{\´e}el-Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.},
  language  = {en}
}
@article{ErbayraktarYilmazTemizArtmannetal.2007,
  author    = {Erbayraktar, Zubeyde and Yilmaz, Osman and Temiz Artmann, Ayseg{\"u}l and Cehreli, Ruksan and Coker, Canan},
  title     = {Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus},
  series = {Biological Trace Element Research},
  volume    = {118},
  journal   = {Biological Trace Element Research},
  number    = {3},
  issn      = {1559-0720},
  pages     = {217 -- 226},
  year      = {2007},
  language  = {en}
}
@article{ErmelenkoYoshinobuMourzinaetal.2002,
  author    = {Ermelenko, Y. and Yoshinobu, T and Mourzina, Y. and Levichev, S. and Furuichi, K. and Vlasov, Y. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Photocurable membranes for ion-selective light-addressable potentiometric sensors},
  series = {Sensors and Actuators B. 85 (2002), H. 1-2},
  journal   = {Sensors and Actuators B. 85 (2002), H. 1-2},
  isbn      = {0925-4005},
  pages     = {79 -- 85},
  year      = {2002},
  language  = {en}
}
@article{ErmelenkoYoshinobuMourzinaetal.2001,
  author    = {Ermelenko, Y. and Yoshinobu, T. and Mourzina, Y. and Furuichi, K. and Iwasaki, H. and Vlasov, Y. and Sch{\"o}ning, Michael Josef},
  title     = {Technology of photocurable polymeric membranes for integrated LAPS},
  series = {Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan},
  journal   = {Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan},
  publisher = {Japan Association of Chemical Sensors},
  address   = {Kasuga, Fukuoka-ken},
  pages     = {66 -- 68},
  year      = {2001},
  language  = {en}
}
@article{ErmelenkoYoshinobuMourzinaetal.2002,
  author    = {Ermelenko, Y. and Yoshinobu, T. and Mourzina, Y. and Furuichi, K. and Levichev, S. and Vlasov, Y. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Lithium sensor based on the laser scanning semiconductor transducer},
  series = {Analytica Chimica Acta. 459 (2002), H. 1},
  journal   = {Analytica Chimica Acta. 459 (2002), H. 1},
  issn      = {0378-4304},
  pages     = {1 -- 9},
  year      = {2002},
  language  = {en}
}
@article{ErmelenkoYoshinobuMourzinaetal.2003,
  author    = {Ermelenko, Y. and Yoshinobu, T. and Mourzina, Y. and Sch{\"o}ning, Michael Josef and Furuichi, K. and Levichev, S. and Vlasov, Y. and Iwasaki, H.},
  title     = {The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multicomponent analysis},
  series = {Talanta. 59 (2003), H. 4},
  journal   = {Talanta. 59 (2003), H. 4},
  isbn      = {0039-9140},
  pages     = {785 -- 795},
  year      = {2003},
  language  = {en}
}
@article{ErmelenkoYoshinobuMourzinaetal.2002,
  author    = {Ermelenko, Y. and Yoshinobu, T. and Mourzina, Y. and Sch{\"o}ning, Michael Josef and Vlasov, Y. and Iwasaki, H.},
  title     = {The hybrid K+/Ca2+ sensor based on laser scanned silicon transducer for multi-component analysis},
  series = {Proceedings of ICAS 2001, IUPAC [3rd] International Congress on Analytical Sciences 2001 : August 6 - 10, 2001, Waseda University, Tokyo},
  journal   = {Proceedings of ICAS 2001, IUPAC [3rd] International Congress on Analytical Sciences 2001 : August 6 - 10, 2001, Waseda University, Tokyo},
  publisher = {Japan Society for Analytical Chemistry},
  address   = {Tokyo},
  pages     = {i777 -- i780},
  year      = {2002},
  language  = {en}
}
@inproceedings{ErmelenkoYoshinobuMourzinaetal.2003,
  author    = {Ermelenko, Y. and Yoshinobu, T. and Mourzina, Y. and Sch{\"o}ning, Michael Josef and Vlasov, Y. and Iwasaki, H.},
  title     = {A multisensor based on laser scanned silicon transducer (LSST): development and properties},
  series = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003},
  booktitle = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003},
  pages     = {72 -- 73},
  year      = {2003},
  language  = {en}
}
@article{ErmolenkoYoshinobuMourzinaetal.2004,
  author    = {Ermolenko, Y. E. and Yoshinobu, T. and Mourzina, Y. G. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Laserscanned transducer (LSST) as a multisensor system},
  series = {Sensors and Actuators B. 103 (2004), H. 1-2},
  journal   = {Sensors and Actuators B. 103 (2004), H. 1-2},
  isbn      = {0925-4005},
  pages     = {457 -- 462},
  year      = {2004},
  language  = {en}
}
@article{ErmolenkoVlasovKolodnikovetal.2004,
  author    = {Ermolenko, Y.E. and Vlasov, Y.G. and Kolodnikov, V.V. and Shabaldkin, D. A. and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef},
  title     = {Diffusion of radioactive tracers (204Tl, 110mAg) and ionic conductivity in membrane materials for the chemical sensors},
  series = {Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).},
  journal   = {Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).},
  publisher = {Forschungszentrum J{\"u}lich, Zentralbibliothek},
  address   = {J{\"u}lich},
  isbn      = {3893363629},
  pages     = {483 -- 485},
  year      = {2004},
  language  = {en}
}
@article{FassbenderSchmittSchoeningetal.2000,
  author    = {Faßbender, F. and Schmitt, G. and Sch{\"o}ning, Michael Josef and L{\"u}th, H. and Buß, G. and Schultze, J. W.},
  title     = {Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays},
  series = {Sensors and Actuators B. 68 (2000), H. 1-3},
  journal   = {Sensors and Actuators B. 68 (2000), H. 1-3},
  isbn      = {0925-4005},
  pages     = {128 -- 133},
  year      = {2000},
  language  = {en}
}
@article{FassbenderSchmittSchoeningetal.1999,
  author    = {Faßbender, F. and Schmitt, G. and Sch{\"o}ning, Michael Josef and L{\"u}th, H. and Buß, G. and Schultze, J. W.},
  title     = {Passivation and corrosion of microsensor devices exemplified at microelectrode arrays},
  series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.},
  journal   = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.},
  address   = {The Hague, The Netherlands},
  isbn      = {90-76699-02-X},
  pages     = {953 -- 956},
  year      = {1999},
  language  = {en}
}
@article{FeuchtSchoenbachLanzletal.2013,
  author    = {Feucht, Nikolaus and Sch{\"o}nbach, Etienne Michael and Lanzl, Ines and Kotliar, Konstantin and Lohmann, Chris Patrick and Maier, Mathias},
  title     = {Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease},
  series = {Clinical Ophthalmology},
  volume    = {7},
  journal   = {Clinical Ophthalmology},
  publisher = {Dove Medical Press},
  address   = {Auckland, New Zealand},
  issn      = {1177-5483},
  pages     = {173 -- 178},
  year      = {2013},
  language  = {en}
}
@article{FigueroaMirandaFengShiuetal.2018,
  author    = {Figueroa-Miranda, Gabriela and Feng, Lingyan and Shiu, Simon Chi-Chin and Dirkzwager, Roderick Marshall and Cheung, Yee-Wai and Tanner, Julian Alexander and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, Andreas and Mayer, Dirk},
  title     = {Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability},
  series = {Sensor and Actuators B: Chemical},
  volume    = {255},
  journal   = {Sensor and Actuators B: Chemical},
  number    = {P1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2017.07.117},
  pages     = {235 -- 243},
  year      = {2018},
  abstract  = {Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.},
  language  = {en}
}
@article{FinkMarshallShahetal.2000,
  author    = {Fink, G. R. and Marshall, J. C. and Shah, N. J. and Weiss, P.H. and Halligan, P. W. and Grosse-Ruyken, M. and Ziemons, Karl and Zilles, K. and Freund, H. J.},
  title     = {Line bisection judgments implicate right parietal cortex and cerebellum as assessed by fMRI},
  series = {Neurology},
  volume    = {54},
  journal   = {Neurology},
  number    = {6},
  isbn      = {1526-632X},
  pages     = {1324 -- 1331},
  year      = {2000},
  language  = {en}
}
@article{FischerSelverGezeretal.2015,
  author    = {Fischer, Felix and Selver, M. Alper and Gezer, Sinem and Dicle, Oguz and Hillen, Walter},
  title     = {Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data},
  series = {Journal of Medical and Biological Engineering},
  volume    = {35},
  journal   = {Journal of Medical and Biological Engineering},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2199-4757},
  doi       = {10.1007/s40846-015-0097-5},
  pages     = {709 -- 723},
  year      = {2015},
  language  = {en}
}
@article{ForstKaragiannisLuebbenetal.2008,
  author    = {Forst, Thomas and Karagiannis, E. and L{\"u}bben, G. and Hohberg, C. and Sch{\"o}ndorf, T. and Dikta, Gerhard and Drexler, M. and Morcos, M. and D{\"a}nschel, W. and Borchert, M. and Pf{\"u}tzner, A.},
  title     = {Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease},
  series = {Atherosclerosis. 197 (2008), H. 1},
  journal   = {Atherosclerosis. 197 (2008), H. 1},
  issn      = {0021-9150},
  doi       = {10.1016/j.atherosclerosis.2007.05.006},
  pages     = {311 -- 317},
  year      = {2008},
  language  = {en}
}
@inproceedings{FrotscherDuongStaat2015,
  author    = {Frotscher, Ralf and Duong, Minh Tuan and Staat, Manfred},
  title     = {Simulating beating cardiomyocytes with electromechanical coupling},
  series = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)},
  booktitle = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)},
  organization    = {International Conference on Biomedical Technology <2, 2015, Hannover>},
  pages     = {1 -- 2},
  year      = {2015},
  language  = {en}
}
@incollection{FrotscherGossmannRaatschenetal.2015,
  author    = {Frotscher, Ralf and Goßmann, Matthias and Raatschen, Hans-J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred},
  title     = {Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM},
  series = {Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)},
  booktitle = {Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)},
  publisher = {Springer},
  address   = {Heidelberg},
  isbn      = {978-3-319-02534-6 ; 978-3-319-02535-3},
  pages     = {187 -- 212},
  year      = {2015},
  abstract  = {We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.},
  language  = {en}
}
@inproceedings{FrotscherGossmannTemizArtmannetal.2013,
  author    = {Frotscher, Ralf and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred},
  title     = {Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM},
  series = {1st International Conference "Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures", Minsk, Belarus, Sept. 16-20, 2013},
  booktitle = {1st International Conference "Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures", Minsk, Belarus, Sept. 16-20, 2013},
  publisher = {Verl. d. Weißruss. Staatl. Univ.},
  address   = {Minsk},
  organization    = {International Conference Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures <1, 2013, Minsk>},
  isbn      = {978-985-553-135-8},
  pages     = {165 -- 167},
  year      = {2013},
  language  = {en}
}
@inproceedings{FrotscherKochRaatschenetal.2014,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {Evaluation of a computational model for drug action on cardiac tissue},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@article{FrotscherKochStaat2015,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred},
  title     = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes},
  series = {Journal of biomechanical engineering},
  volume    = {Vol. 137},
  journal   = {Journal of biomechanical engineering},
  number    = {iss. 7},
  publisher = {ASME},
  address   = {New York},
  issn      = {1528-8951 (E-Journal); 0148-0731 (Print)},
  doi       = {10.1115/1.4030173},
  pages     = {071002-1 -- 071002-7},
  year      = {2015},
  language  = {en}
}
@article{FrotscherMuanghongDursunetal.2016,
  author    = {Frotscher, Ralf and Muanghong, Danita and Dursun, G{\"o}zde and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred},
  title     = {Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue},
  series = {Journal of Biomechanics},
  volume    = {49},
  journal   = {Journal of Biomechanics},
  number    = {12},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290 (Print)},
  doi       = {10.1016/j.jbiomech.2016.01.039},
  pages     = {2428 -- 2435},
  year      = {2016},
  abstract  = {We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.},
  language  = {en}
}
@inproceedings{FrotscherRaatschenStaat2012,
  author    = {Frotscher, Ralf and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues},
  series = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012},
  booktitle = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012},
  editor    = {Holzapfel, Gerhard A.},
  publisher = {Verlag d. Technischen Universit{\"a}t Graz},
  address   = {Graz},
  isbn      = {978-3-85125-223-1},
  year      = {2012},
  language  = {en}
}
@inproceedings{FrotscherRaatschenStaat2012,
  author    = {Frotscher, Ralf and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {Application of an edge-based smoothed finite element method on geometrically non-linear plates of non-linear material},
  series = {Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)},
  booktitle = {Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)},
  editor    = {Eberhardsteiner, J.},
  year      = {2012},
  language  = {en}
}
@article{FrotscherStaat2014,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {Stresses produced by different textile mesh implants in a tissue equivalent},
  series = {BioNanoMaterials},
  volume    = {15},
  journal   = {BioNanoMaterials},
  number    = {1-2},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)},
  doi       = {10.1515/bnm-2014-0003},
  pages     = {25 -- 30},
  year      = {2014},
  abstract  = {Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.},
  language  = {en}
}
@incollection{FrotscherStaat2018,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action},
  series = {Biological, Physical and Technical Basics of Cell Engineering},
  booktitle = {Biological, Physical and Technical Basics of Cell Engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7904-7},
  doi       = {10.1007/978-981-10-7904-7_10},
  pages     = {233 -- 250},
  year      = {2018},
  abstract  = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.},
  language  = {en}
}
@inproceedings{FrotscherStaat2015,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {An electromechanical model for cardiac tissue constructs},
  series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  organization    = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>},
  pages     = {1 -- 4},
  year      = {2015},
  language  = {en}
}
@inproceedings{FrotscherStaat2015,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {Homogenization of a cardiac tissue construct},
  series = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France},
  booktitle = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France},
  editor    = {Nithiarasu, Perumal},
  publisher = {CMBE},
  address   = {[s.l.]},
  issn      = {2227-9385},
  pages     = {645 -- 648},
  year      = {2015},
  language  = {en}
}
@article{FuestKotliarWalteretal.2014,
  author    = {Fuest, Matthias and Kotliar, Konstantin and Walter, Peter and Plange, Niklas},
  title     = {Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry},
  series = {Ophthalmic and physiological optics},
  volume    = {34},
  journal   = {Ophthalmic and physiological optics},
  number    = {4},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1475-1313 (E-Journal); 0275-5408 (Print)},
  doi       = {10.1111/opo.12134},
  pages     = {438 -- 444},
  year      = {2014},
  language  = {en}
}
@article{FuruichiYoshinobuErmelenkoetal.2001,
  author    = {Furuichi, K. and Yoshinobu, T. and Ermelenko, T. and Mourzina, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef},
  title     = {Simultaneous visualization of multiple ions by the chemical imaging sensor},
  series = {Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan},
  journal   = {Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan},
  publisher = {Japan Association of Chemical Sensors},
  address   = {Kasuga, Fukuoka-ken},
  pages     = {399 -- 401},
  year      = {2001},
  language  = {en}
}
@inproceedings{FoersterStockMontanarietal.2006,
  author    = {F{\"o}rster, Arnold and Stock, J{\"u}rgen and Montanari, Simone and Lepsa, Mihail Ion and L{\"u}th, Hans},
  title     = {Fabrication and characterisation of GaAs Gunn Diode Chips for applications at 77 GHz in automotive industry},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1462},
  year      = {2006},
  abstract  = {GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The electrical investigations have revealed the functionality of the hot electron injector. An optimized layer structure could fulfill the requirements in adaptive cruise control (ACC) systems at 77 GHz with typical output power between 50 and 90 mW.},
  subject      = {Biosensor},
  language  = {en}
}
@phdthesis{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {On selected problems in multivariate analysis},
  doi       = {10.15488/14304},
  pages     = {17 Seiten},
  year      = {2023},
  abstract  = {Selected problems in the field of multivariate statistical analysis are treated. Thereby, one focus is on the paired sample case. Among other things, statistical testing problems of marginal homogeneity are under consideration. In detail, properties of Hotelling's T² test in a special parametric situation are obtained. Moreover, the nonparametric problem of marginal homogeneity is discussed on the basis of possibly incomplete data. In the bivariate data case, properties of the Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic on the basis of partly not identically distributed data are investigated. Similar testing problems are treated within the scope of the application of a result for the empirical process of the concomitants for partly categorial data. Furthermore, testing changes in the modeled solvency capital requirement of an insurance company by means of a paired sample from an internal risk model is discussed. Beyond the paired sample case, a new asymptotic relative efficiency concept based on the expected volumes of multidimensional confidence regions is introduced. Besides, a new approach for the treatment of the multi-sample goodness-of-fit problem is presented. Finally, a consistent test for the treatment of the goodness-of-fit problem is developed for the background of huge or infinite dimensional data.},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {Allocating and forecasting changes in risk},
  series = {Journal of risk},
  volume    = {25},
  journal   = {Journal of risk},
  number    = {3},
  editor    = {AitSahlia, Farid},
  publisher = {Infopro Digital Risk},
  address   = {London},
  issn      = {1755-2842},
  doi       = {10.21314/JOR.2022.048},
  pages     = {1 -- 24},
  year      = {2023},
  abstract  = {We consider time-dependent portfolios and discuss the allocation of changes in the risk of a portfolio to changes in the portfolio's components. For this purpose we adopt established allocation principles. We also use our approach to obtain forecasts for changes in the risk of the portfolio's components. To put the approach into practice we present an implementation based on the output of a simulation. Allocation is illustrated with an example portfolio in the context of Solvency II. The quality of the forecasts is investigated with an empirical study.},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {On the applicability of several tests to models with not identically distributed random effects},
  series = {Statistics : A Journal of Theoretical and Applied Statistics},
  volume    = {57},
  journal   = {Statistics : A Journal of Theoretical and Applied Statistics},
  publisher = {Taylor \& Francis},
  address   = {London},
  isbn      = {0323-3944},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2023.2193748},
  pages     = {14 Seiten},
  year      = {2023},
  abstract  = {We consider Kolmogorov-Smirnov and Cram{\´e}r-von-Mises type tests for testing central symmetry, exchangeability, and independence. In the standard case, the tests are intended for the application to independent and identically distributed data with unknown distribution. The tests are available for multivariate data and bootstrap procedures are suitable to obtain critical values. We discuss the applicability of the tests to random effects models, where the random effects are independent but not necessarily identically distributed and with possibly unknown distributions. Theoretical results show the adequacy of the tests in this situation. The quality of the tests in models with random effects is investigated by simulations. Empirical results obtained confirm the theoretical findings. A real data example illustrates the application.},
  language  = {en}
}
@article{Gaigall2020,
  author    = {Gaigall, Daniel},
  title     = {Rothman-Woodroofe symmetry test statistic revisited},
  series = {Computational Statistics \& Data Analysis},
  volume    = {2020},
  journal   = {Computational Statistics \& Data Analysis},
  number    = {142},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-9473},
  doi       = {10.1016/j.csda.2019.106837},
  pages     = {Artikel 106837},
  year      = {2020},
  abstract  = {The Rothman-Woodroofe symmetry test statistic is revisited on the basis of independent but not necessarily identically distributed random variables. The distribution-freeness if the underlying distributions are all symmetric and continuous is obtained. The results are applied for testing symmetry in a meta-analysis random effects model. The consistency of the procedure is discussed in this situation as well. A comparison with an alternative proposal from the literature is conducted via simulations. Real data are analyzed to demonstrate how the new approach works in practice.},
  language  = {en}
}