@article{AkimbekovMansurovJandosovetal.2013,
  author    = {Akimbekov, Nuraly Shardarbekovich and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.},
  title     = {Wound healing activity of carbonized rice husk},
  publisher = {Trans Tech Publications, Switzerland},
  address   = {B{\"a}ch},
  year      = {2013},
  abstract  = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.},
  subject      = {Wundheilung},
  language  = {en}
}
@article{AkimbekovZhubanovaMansurovetal.2010,
  author    = {Akimbekov, N. Sh. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Use of Carbonized Rise Shell for the local treatment of wounds},
  series = {Eurasian ChemTech Journal},
  volume    = {12},
  journal   = {Eurasian ChemTech Journal},
  number    = {2},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {2522-4867},
  doi       = {10.18321/ectj35},
  pages     = {133 -- 138},
  year      = {2010},
  abstract  = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.},
  language  = {en}
}
@article{SeifarthSchehlLinderetal.2011,
  author    = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds},
  year      = {2011},
  abstract  = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@inproceedings{BayerHeschelerArtmannetal.2019,
  author    = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Treating arterial hypertension in a cell culture well},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {5 -- 6},
  year      = {2019},
  abstract  = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.},
  language  = {en}
}
@article{StadlerGarveyBocahutetal.2012,
  author    = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.},
  title     = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics},
  series = {Journal of the Royal Society Interface},
  volume    = {9},
  journal   = {Journal of the Royal Society Interface},
  number    = {76},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {1742-5689},
  doi       = {10.1098/rsif.2012.0364},
  pages     = {2845 -- 2855},
  year      = {2012},
  abstract  = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.},
  language  = {en}
}
@article{ZhubanovaDigelNojimaetal.2007,
  author    = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  year      = {2007},
  abstract  = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.},
  subject      = {Clusterion},
  language  = {en}
}
@article{DigelZhubanovaNojimaetal.2004,
  author    = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  series = {Biotechnologija : teorija i praktika (2004)},
  journal   = {Biotechnologija : teorija i praktika (2004)},
  isbn      = {1028-9399},
  pages     = {46 -- 52},
  year      = {2004},
  language  = {en}
}
@inproceedings{MansurovZhubanovaDigeletal.2008,
  author    = {Mansurov, Zulkhair and Zhubanova, Azhar A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Savitskaja, Irina S. and Kozhalakova, A. A. and Kistaubaeva, Aida S.},
  title     = {The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials},
  year      = {2008},
  abstract  = {Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties - ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.},
  subject      = {Kohlenstofffaser},
  language  = {en}
}
@article{ArtmannSchmidSchoenbein1987,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H.},
  title     = {The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Sch{\"o}nbein, H.},
  series = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987},
  journal   = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987},
  publisher = {Excerpta Medica},
  address   = {Amsterdam [u.a.]},
  isbn      = {0444809511},
  pages     = {475 -- 477},
  year      = {1987},
  language  = {en}
}
@inproceedings{ArtmannStadlerEmbsetal.2010,
  author    = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]},
  year      = {2010},
  abstract  = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@article{ArtmannKelemenPorstetal.1998,
  author    = {Artmann, Gerhard and Kelemen, Christina and Porst, Dariusz and B{\"u}ldt, G. [u.a.]},
  title     = {Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; B{\"u}ldt, G.; Chien, S.},
  series = {Biophysical Journal. 75 (1998), H. 6},
  journal   = {Biophysical Journal. 75 (1998), H. 6},
  isbn      = {1542-0086},
  pages     = {3179 -- 3183},
  year      = {1998},
  language  = {en}
}
@inproceedings{StadlerEmbsZerlinetal.2007,
  author    = {Stadler, Andreas M. and Embs, Jan P. and Zerlin, Kay and Digel, Ilya and Artmann, Gerhard and Zaccai, Joe and B{\"u}ldt, Georg},
  title     = {Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster]},
  year      = {2007},
  abstract  = {Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells},
  subject      = {Erythrozyt},
  language  = {en}
}
@article{ArtmannKelemenChien2001,
  author    = {Artmann, Gerhard and Kelemen, C. and Chien, S.},
  title     = {Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael},
  series = {Biophysical journal. 80 (2001), H. 6},
  journal   = {Biophysical journal. 80 (2001), H. 6},
  isbn      = {1542-0086},
  pages     = {2622 -- 2630},
  year      = {2001},
  language  = {en}
}
@article{ZerlinKasischkeDigeletal.2007,
  author    = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard},
  title     = {Structural transition temperature of hemoglobins correlates with species' body temperature},
  series = {European Biophysics Journal. 37 (2007), H. 1},
  journal   = {European Biophysics Journal. 37 (2007), H. 1},
  isbn      = {1432-1017},
  pages     = {1 -- 10},
  year      = {2007},
  language  = {en}
}
@book{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-642-11864-7},
  pages     = {XLI, 541 S. : Ill., graph. Darst.},
  year      = {2011},
  language  = {en}
}
@inproceedings{DigelTemizArtmannNojimaetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard},
  title     = {Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]},
  year      = {2003},
  abstract  = {Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.},
  subject      = {Clusterion},
  language  = {en}
}
@article{KurulganDemirciDemirciLinderetal.2012,
  author    = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells},
  series = {Journal of Bioscience and Bioengineering},
  volume    = {113},
  journal   = {Journal of Bioscience and Bioengineering},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1347-4421},
  doi       = {10.1016/j.jbiosc.2012.03.019},
  pages     = {212 -- 219},
  year      = {2012},
  abstract  = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.},
  language  = {en}
}
@article{ArtmannSchmidSchoenbeinGrebeetal.1988,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]},
  title     = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne},
  series = {Drug Development Research. 14 (1988), H. 3-4},
  journal   = {Drug Development Research. 14 (1988), H. 3-4},
  isbn      = {1098-2299},
  pages     = {205 -- 211},
  year      = {1988},
  language  = {en}
}
@article{ArtmannGrebeHomrighausenetal.1988,
  author    = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],},
  title     = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.},
  series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  journal   = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  publisher = {Karger [u.a.]},
  address   = {Basel [u.a.]},
  pages     = {196 -- 200},
  year      = {1988},
  language  = {en}
}
@article{TemizArtmannKurulgandemirciFıratetal.2021,
  author    = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard},
  title     = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers},
  series = {SHOCK},
  journal   = {SHOCK},
  publisher = {Wolters Kluwer},
  address   = {K{\"o}ln},
  issn      = {1540-0514},
  doi       = {10.1097/SHK.0000000000001845},
  year      = {2021},
  language  = {en}
}
@article{MaggakisKelemenDigelArtmann2005,
  author    = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard},
  title     = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility},
  series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1},
  journal   = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1},
  pages     = {324 -- 326},
  year      = {2005},
  language  = {en}
}
@article{ArtmannBaeumlerVoigtetal.2000,
  author    = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]},
  title     = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.},
  series = {Journal of Microencapsulation. 17 (2000), H. 5},
  journal   = {Journal of Microencapsulation. 17 (2000), H. 5},
  isbn      = {1464-5246},
  pages     = {651 -- 655},
  year      = {2000},
  language  = {en}
}
@inproceedings{DigelTemizArtmannNojimaetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard},
  title     = {Plasma-generated cluster ions' effects on indoor microflora : [abstract]},
  year      = {2003},
  abstract  = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.},
  subject      = {Clusterion},
  language  = {en}
}
@inproceedings{DigelTemizArtmannArtmannetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Nojima, H.},
  title     = {Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]},
  year      = {2003},
  abstract  = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.},
  subject      = {Clusterion},
  language  = {en}
}
@article{ArtmannZerlinDigeletal.2007,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.},
  title     = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{ArinkinDigelPorstetal.2014,
  author    = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application},
  series = {BMC bioinformatics},
  volume    = {15},
  journal   = {BMC bioinformatics},
  number    = {55},
  issn      = {1471-2105},
  doi       = {10.1186/1471-2105-15-55},
  pages     = {1 -- 8},
  year      = {2014},
  abstract  = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.},
  language  = {en}
}
@article{AminTemizArtmannArtmannetal.2009,
  author    = {Amin, Rashid and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Lazarovici, Philip and Lelkes, Peter I.},
  title     = {Permeability of an In Vitro Model of Blood Brain Barrier (BBB)},
  series = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]},
  journal   = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]},
  isbn      = {978-3-540-92841-6},
  pages     = {81 -- 84},
  year      = {2009},
  language  = {en}
}
@article{SadykovDigelTemizArtmannetal.2009,
  author    = {Sadykov, Rustam and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Artmann, Gerhard and Savitskaya, Irina and Zhubanova, Azhar},
  title     = {Oral lead exposure induces dysbacteriosis in rats},
  series = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  journal   = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  isbn      = {1348-9585},
  pages     = {64 -- 73},
  year      = {2009},
  language  = {en}
}
@article{MiciliValterOflazetal.2013,
  author    = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes},
  series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  volume    = {Vol. 227},
  journal   = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  number    = {No. 4},
  publisher = {Sage},
  address   = {London},
  issn      = {0046-2039 (Print) ; 2041-3033 (E-Journal)},
  pages     = {393 -- 401},
  year      = {2013},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{DigelKayserArtmann2008,
  author    = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard},
  title     = {Molecular processes in biological thermosensation},
  series = {Journal of Biophysics. 2008 (2008)},
  journal   = {Journal of Biophysics. 2008 (2008)},
  isbn      = {1687-8000},
  pages     = {1 -- 9},
  year      = {2008},
  language  = {en}
}
@article{Artmann1995,
  author    = {Artmann, Gerhard},
  title     = {Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael},
  series = {Biorheology. 32 (1995), H. 5},
  journal   = {Biorheology. 32 (1995), H. 5},
  isbn      = {0006-355x},
  pages     = {553 -- 570},
  year      = {1995},
  language  = {en}
}
@article{ArtmannSungHornetal.1997,
  author    = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]},
  title     = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu},
  series = {Biophysical journal. 72 (1997), H. 3},
  journal   = {Biophysical journal. 72 (1997), H. 3},
  isbn      = {1542-0086},
  pages     = {1434 -- 1441},
  year      = {1997},
  language  = {en}
}
@article{BeckerWallangArtmannetal.2008,
  author    = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.},
  title     = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis},
  series = {International Journal of Artificial Organs, The},
  volume    = {31},
  journal   = {International Journal of Artificial Organs, The},
  number    = {7},
  issn      = {0391-3988},
  pages     = {583 -- 583},
  year      = {2008},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{ArtmannDigelLinderetal.2008,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz},
  title     = {Mechanism of haemoglobin sensing body temperature},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {754 -- 754},
  year      = {2008},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1046 -- 1047},
  year      = {2004},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{EijckDemmelArtmannetal.2011,
  author    = {Eijck, Lambert van and Demmel, Franz and Artmann, Gerhard and Stadtler, Andreas Maximilian},
  title     = {Macromolecular dynamics in red blood cells investigated using neutron spectroscopy},
  series = {Journal of the Royal Society Interface},
  volume    = {8},
  journal   = {Journal of the Royal Society Interface},
  number    = {57},
  publisher = {The Royal Society},
  address   = {London},
  isbn      = {1742-5689},
  pages     = {590 -- 600},
  year      = {2011},
  language  = {en}
}
@article{ArtmannTrzewikSchmidSchoenbein2000,
  author    = {Artmann, Gerhard and Trzewik, J. and Schmid-Sch{\"o}nbein, G. W.},
  title     = {Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Sch{\"o}nbein, G. W.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {521 -- 522},
  year      = {2000},
  language  = {en}
}
@article{ArtmannZhouStacheBuettneretal.2002,
  author    = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]},
  title     = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.},
  series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  isbn      = {0140-0118},
  pages     = {698 -- 703},
  year      = {2002},
  language  = {en}
}
@article{ArtmannSchmidSchoenbeinSchroederetal.1988,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]},
  title     = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.},
  series = {Arzneimittelforschung. 38 (1988), H. 5},
  journal   = {Arzneimittelforschung. 38 (1988), H. 5},
  isbn      = {0004-4172},
  pages     = {710 -- 716},
  year      = {1988},
  language  = {en}
}
@inproceedings{DigelLeimenaDachwaldetal.2010,
  author    = {Digel, Ilya and Leimena, W. and Dachwald, Bernd and Linder, Peter and Porst, Dariusz and Kayser, Peter and Funke, O. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {In-situ biological decontamination of an ice melting probe : [abstract]},
  year      = {2010},
  abstract  = {The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.},
  subject      = {Sonde},
  language  = {en}
}
@article{ArtmannGorbatenkovaPanasenko2000,
  author    = {Artmann, Gerhard and Gorbatenkova, E. A. and Panasenko, O. M.},
  title     = {Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.},
  series = {Membrane and cell biology. 13 (2000), H. 4},
  journal   = {Membrane and cell biology. 13 (2000), H. 4},
  isbn      = {1023-6597},
  pages     = {537 -- 546},
  year      = {2000},
  language  = {en}
}
@article{LinderDigelTemizArtmannetal.2007,
  author    = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard},
  title     = {High-throughput testing of mechanical forces generated in thin cell and tissue layers},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{LiShiLandsmannetal.1998,
  author    = {Li, Anlan and Shi, Young de and Landsmann, B. and Schankowski-Bouvier, P. and Dikta, Gerhard and Bauer, U. and Artmann, Gerhard},
  title     = {Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract},
  series = {Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5},
  journal   = {Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5},
  isbn      = {1745-7254},
  pages     = {417 -- 421},
  year      = {1998},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{ArtmannDigelZerlinetal.2009,
  author    = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Hemoglobin senses body temperature},
  series = {European Biophysics Journal},
  volume    = {38},
  journal   = {European Biophysics Journal},
  number    = {5},
  isbn      = {0175-7571},
  pages     = {589 -- 600},
  year      = {2009},
  language  = {en}
}
@article{StadlerDigelArtmannetal.2008,
  author    = {Stadler, A. M. and Digel, Ilya and Artmann, Gerhard and Embs, Jan P. and Zaccai, Joe and B{\"u}ldt, Georg},
  title     = {Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature},
  series = {Biophysical Journal. 95 (2008), H. 11},
  journal   = {Biophysical Journal. 95 (2008), H. 11},
  isbn      = {1542-0086},
  pages     = {5449 -- 5461},
  year      = {2008},
  language  = {en}
}